Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

PLoS Genetics

Volumn 11, Issue 1, 2015, Pages

  Gao, Rui ^a   Liu, Yongping ^a,h   Silva Fernandes, Anabela ^b,c   Fang, Xiang ^a   Paulucci Holthauzen, Adriana ^d   Chatterjee, Arpita ^a   Zhang, Hang L ^a   Matsuura, Tohru ^e   Choudhary, Sanjeev ^a   Ashizawa, Tetsuo ^f   Koeppen, Arnulf H ^g   Maciel, Patricia ^b,c   Hazra, Tapas K ^a   Sarkar, Partha S ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF MINHO   (Portugal)

^c UNIVERSITY OF MINHO   (Portugal)

^d UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^e JICHI MEDICAL UNIVERSITY   (Japan)

^f UNIVERSITY OF FLORIDA   (United States)

^g STRATTON VA MEDICAL CENTER   (United States)

^h The First People s Hospital of Changde City)   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 3; ATM PROTEIN; GENOMIC DNA; PHOSPHATASE; POLYNUCLEOTIDE KINASE 3' PHOSPHATASE; PROTEIN KINASE C DELTA; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; ATM PROTEIN, HUMAN; ATXN3 PROTEIN, HUMAN; DNA LIGASE; NERVE PROTEIN; NUCLEAR PROTEIN; PHOSPHOTRANSFERASE; PNKP PROTEIN, HUMAN; PROTEIN AGGREGATE; REPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ASSAY; ENZYME INACTIVATION; HUMAN; HUMAN TISSUE; MOLECULAR DYNAMICS; MOUSE; NERVE DEGENERATION; NONHUMAN; PROTEIN AGGREGATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; BIOSYNTHESIS; GENETICS; MACHADO JOSEPH DISEASE; METABOLISM; PATHOLOGY; TRINUCLEOTIDE REPEAT;

APOPTOSIS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; ATAXIN-3; DNA DAMAGE; DNA REPAIR; DNA REPAIR ENZYMES; HUMANS; MACHADO-JOSEPH DISEASE; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN AGGREGATES; PROTEIN KINASE C-DELTA; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 84924389975     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004834     Document Type: Article

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