Synthesis of new steroidal inhibitors of P-glycoprotein-mediated multidrug resistance and biological evaluation on K562/R7 erythroleukemia cells

Journal of Medicinal Chemistry

Volumn 58, Issue 4, 2015, Pages 1832-1845

  De Ravel, Marc Rolland ^a   Alameh, Ghina ^a   Melikian, Maxime ^a   Mahiout, Zahia ^a   Emptoz Bonneton, Agnès ^a   Matera, Eva Laure ^a   Lomberget, Thierry ^a   Barret, Roland ^a   Rocheblave, Luc ^a   Walchshofer, Nadia ^a   Beltran, Sonia ^a   El Jawad, Lucienne ^a   Mappus, Elisabeth ^a   Grenot, Catherine ^a   Pugeat, Michel ^a   Dumontet, Charles ^a   Le Borgne, Marc ^a   Cuilleron, Claude Yves ^a  

^a UNIVERSITÉ LYON 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; DAUNORUBICIN; DOXORUBICIN; GLYCOPROTEIN; HYDROXYL GROUP; MIFEPRISTONE; MULTIDRUG RESISTANCE PROTEIN; OXYGEN; PROGESTERONE DERIVATIVE; TETRAHYDROPYRANYL ETHER; VERAPAMIL; PROGESTERONE;

ARTICLE; CANCER RESISTANCE; CHEMOSENSITIZATION; CONTROLLED STUDY; DIASTEREOISOMER; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; ERYTHROLEUKEMIA CELL; ESTERIFICATION; HUMAN; HUMAN CELL; IC50; OPTICAL ROTATION; PROTEIN TRANSPORT; STIMULATION; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG EFFECTS; DRUG RESISTANCE; K562 CELL LINE; LEUKEMIA, ERYTHROBLASTIC, ACUTE; METABOLISM; MULTIDRUG RESISTANCE; PATHOLOGY; SYNTHESIS; TUMOR CELL CULTURE;

CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; K562 CELLS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; P-GLYCOPROTEIN; PROGESTERONE; TUMOR CELLS, CULTURED;

EID: 84923914311     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501676v     Document Type: Article

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