-
1
-
-
0032900953
-
Biochemical, cellular and pharmacological aspects of the multidrug transporter
-
Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, and Gottesman MM (1999) Biochemical, cellular and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 39:361-398.
-
(1999)
Annu Rev Pharmacol Toxicol
, vol.39
, pp. 361-398
-
-
Ambudkar, S.V.1
Dey, S.2
Hrycyna, C.A.3
Ramachandra, M.4
Pastan, I.5
Gottesman, M.M.6
-
2
-
-
0030004763
-
Co-operative, competitive and noncompetitive interactions between modulators of P-glycoprotein
-
Ayesh S, Shao Y-M, and Stein WD (1996) Co-operative, competitive and noncompetitive interactions between modulators of P-glycoprotein. Biochim Biophys Acta 1316:8-18.
-
(1996)
Biochim Biophys Acta
, vol.1316
, pp. 8-18
-
-
Ayesh, S.1
Shao, Y.-M.2
Stein, W.D.3
-
3
-
-
0032560635
-
Mutations in the nucleotide-binding sites of P-glycoprotein that affect substrate specificity modulate substrate-induced adenosine triphosphatase activity
-
Beaudet L, Urbatsch IL, and Gros P (1998) Mutations in the nucleotide-binding sites of P-glycoprotein that affect substrate specificity modulate substrate-induced adenosine triphosphatase activity. Biochemistry 37:9073-9082.
-
(1998)
Biochemistry
, vol.37
, pp. 9073-9082
-
-
Beaudet, L.1
Urbatsch, I.L.2
Gros, P.3
-
4
-
-
0027411538
-
Modulation of drug cytotoxicity in wild-type and multidrug-resistant tumor cells by stereoisomeric series of C-20′-vinblastine congeners that lack antimicrotubule activity
-
Borman LS, Bornmann WG, and Kuehne ME (1993) Modulation of drug cytotoxicity in wild-type and multidrug-resistant tumor cells by stereoisomeric series of C-20′-vinblastine congeners that lack antimicrotubule activity. Cancer Chemother Pharmacol 31:343-349.
-
(1993)
Cancer Chemother Pharmacol
, vol.31
, pp. 343-349
-
-
Borman, L.S.1
Bornmann, W.G.2
Kuehne, M.E.3
-
5
-
-
0027214172
-
Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis
-
Bourgeois S, Gruol DJ, Newby RF, and Rajah FM (1993) Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis. Mol Endocrinol 7:840-851.
-
(1993)
Mol Endocrinol
, vol.7
, pp. 840-851
-
-
Bourgeois, S.1
Gruol, D.J.2
Newby, R.F.3
Rajah, F.M.4
-
6
-
-
0026669363
-
Characterization of the azidopine and vinblastine binding site of P-glycoprotein
-
Bruggemann EP, Currier SJ, Gottesman MM, and Pastan I (1992) Characterization of the azidopine and vinblastine binding site of P-glycoprotein. J Biol Chem 267:21020-21026.
-
(1992)
J Biol Chem
, vol.267
, pp. 21020-21026
-
-
Bruggemann, E.P.1
Currier, S.J.2
Gottesman, M.M.3
Pastan, I.4
-
7
-
-
0024971222
-
Two different regions ofphosphoglycoprotein are photoaffinity labeled by azidopine
-
Bruggemann EP, Germann UA, Gottesman MM, and Pastan I (1989) Two different regions ofphosphoglycoprotein are photoaffinity labeled by azidopine. J Biol Chem 264:15483-15488.
-
(1989)
J Biol Chem
, vol.264
, pp. 15483-15488
-
-
Bruggemann, E.P.1
Germann, U.A.2
Gottesman, M.M.3
Pastan, I.4
-
8
-
-
0025191307
-
Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins
-
Chen CJ, Clark D, Ueda K, Pastan I, Gottesman MM, and Roninson IB (1990) Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J Biol Chem 265:506-514.
-
(1990)
J Biol Chem
, vol.265
, pp. 506-514
-
-
Chen, C.J.1
Clark, D.2
Ueda, K.3
Pastan, I.4
Gottesman, M.M.5
Roninson, I.B.6
-
9
-
-
0035503608
-
P-glycoprotein does not reduce substrate concentration from the extracellular leaflet of the plasma membrane in living cells
-
Chen Y, Pant AC, and Simon SM (2001) P-glycoprotein does not reduce substrate concentration from the extracellular leaflet of the plasma membrane in living cells. Cancer Res 61:7763-7769.
-
(2001)
Cancer Res
, vol.61
, pp. 7763-7769
-
-
Chen, Y.1
Pant, A.C.2
Simon, S.M.3
-
10
-
-
0030861297
-
Localization of the iodomycin binding site in hamster P-glycoprotein
-
Demmer A, Thole H, Kubesch P, Brandt T, Raida M, Fislage R, and Tummler B (1997) Localization of the iodomycin binding site in hamster P-glycoprotein. J Biol Chem 272:20913-20919.
-
(1997)
J Biol Chem
, vol.272
, pp. 20913-20919
-
-
Demmer, A.1
Thole, H.2
Kubesch, P.3
Brandt, T.4
Raida, M.5
Fislage, R.6
Tummler, B.7
-
11
-
-
0030924052
-
Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein
-
Dey S, Ramachandra M, Pastan I, Gottesman MM, and Ambudkar SV (1997) Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein. Proc Natl Acad Sci USA 94:10594-10599.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 10594-10599
-
-
Dey, S.1
Ramachandra, M.2
Pastan, I.3
Gottesman, M.M.4
Ambudkar, S.V.5
-
12
-
-
0032956955
-
Mechanism of action of P-glycoprotein in relation to passive membrane permeation
-
Eytan GD and Kuchel PW (1999) Mechanism of action of P-glycoprotein in relation to passive membrane permeation. Int Rev Cytol 190:175-250.
-
(1999)
Int Rev Cytol
, vol.190
, pp. 175-250
-
-
Eytan, G.D.1
Kuchel, P.W.2
-
14
-
-
0036364467
-
Multidrug resistance in cancer: Role of ATP-dependent transporters
-
Gottesman MM, Fojo T, and Bates SE (2002) Multidrug resistance in cancer: Role of ATP-dependent transporters. Nat Rev Cancer 2:48-58.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 48-58
-
-
Gottesman, M.M.1
Fojo, T.2
Bates, S.E.3
-
15
-
-
0027216104
-
Major photoaffinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12
-
Greenberger LM (1993) Major photoaffinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12. J Biol Chem 268:11417-11425.
-
(1993)
J Biol Chem
, vol.268
, pp. 11417-11425
-
-
Greenberger, L.M.1
-
17
-
-
0034954447
-
The use of a novel taxane-based P-glycoprotein inhibitor to identify mutations that alter the interaction of the protein with paclitaxel
-
Gruol DJ, Bernd J, Phippard AE, Ojima I, and Bernacki RJ (2001) The use of a novel taxane-based P-glycoprotein inhibitor to identify mutations that alter the interaction of the protein with paclitaxel. Mol Pharmacol 60:104-113.
-
(2001)
Mol Pharmacol
, vol.60
, pp. 104-113
-
-
Gruol, D.J.1
Bernd, J.2
Phippard, A.E.3
Ojima, I.4
Bernacki, R.J.5
-
18
-
-
0031058658
-
Chemosensitizing steroids: Glucocorticoid receptor agonists capable of inhibiting P-glycoprotein function
-
Gruol DJ and Bourgeois S (1997) Chemosensitizing steroids: Glucocorticoid receptor agonists capable of inhibiting P-glycoprotein function. Cancer Res 57:720-727.
-
(1997)
Cancer Res
, vol.57
, pp. 720-727
-
-
Gruol, D.J.1
Bourgeois, S.2
-
19
-
-
0033213781
-
Profound differences in the transport of steroids by two mouse P-glycoproteins
-
Gruol DJ, Vo QD, and Zee MC (1999) Profound differences in the transport of steroids by two mouse P-glycoproteins. Biochem Pharmacol 58:1191-1199.
-
(1999)
Biochem Pharmacol
, vol.58
, pp. 1191-1199
-
-
Gruol, D.J.1
Vo, Q.D.2
Zee, M.C.3
-
21
-
-
0015576785
-
Differentiated functions expressed by cultured mouse lymphoma cells. II. Theta antigen, surface immunoglobulin and a receptor on cells of a thymoma cell line
-
Harris AW, Bankhurst AD, Mason S, and Warner NL (1973) Differentiated functions expressed by cultured mouse lymphoma cells. II. Theta antigen, surface immunoglobulin and a receptor on cells of a thymoma cell line. J Immunol 110:431-438.
-
(1973)
J Immunol
, vol.110
, pp. 431-438
-
-
Harris, A.W.1
Bankhurst, A.D.2
Mason, S.3
Warner, N.L.4
-
23
-
-
0034858151
-
Identification and localization of three photobinding sites of iodoarylazidoprazosin in hamster P-glycoprotein
-
Isenberg B, Thole H, Tummler B, and Demmer A (2001) Identification and localization of three photobinding sites of iodoarylazidoprazosin in hamster P-glycoprotein. Eur J Biochem 268:2629-2634.
-
(2001)
Eur J Biochem
, vol.268
, pp. 2629-2634
-
-
Isenberg, B.1
Thole, H.2
Tummler, B.3
Demmer, A.4
-
24
-
-
0030815278
-
Drug resistance conferred by MDR1 expression in spheroids formed by glioblastoma cell lines
-
Kolchinsky A and Roninson IB (1997) Drug resistance conferred by MDR1 expression in spheroids formed by glioblastoma cell lines. Anticancer Res 17:3321-3377.
-
(1997)
Anticancer Res
, vol.17
, pp. 3321-3377
-
-
Kolchinsky, A.1
Roninson, I.B.2
-
25
-
-
0032700184
-
Determining the structure and mechanism of the human multidrug resistance P-glycoprotein using cysteine-scanning mutagenesis and thiol-modification techniques
-
Loo TW and Clarke DM (1999) Determining the structure and mechanism of the human multidrug resistance P-glycoprotein using cysteine-scanning mutagenesis and thiol-modification techniques. Biochim Biophys Acta 1461:315-325.
-
(1999)
Biochim Biophys Acta
, vol.1461
, pp. 315-325
-
-
Loo, T.W.1
Clarke, D.M.2
-
26
-
-
0034051662
-
The Packing of the Transmembrane Segments of Human Multidrug Resistance P-glycoprotein Is Revealed by Disulfide Cross-linking Analysis
-
Loo TW and Clarke DM (2000) The Packing of the Transmembrane Segments of Human Multidrug Resistance P-glycoprotein Is Revealed by Disulfide Cross-linking Analysis. J Biol Chem 275:5253-5256.
-
(2000)
J Biol Chem
, vol.275
, pp. 5253-5256
-
-
Loo, T.W.1
Clarke, D.M.2
-
27
-
-
0035805573
-
Defining the drug-binding site in the human multi-drug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS- verapamil
-
Loo TW and Clarke DM (2001) Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS- verapamil. J Biol Chem 276:14972-14979.
-
(2001)
J Biol Chem
, vol.276
, pp. 14972-14979
-
-
Loo, T.W.1
Clarke, D.M.2
-
28
-
-
0033862765
-
Communication between multiple drug binding sites on P-glycoprotein
-
Martin C, Berridge G, Higgins CF, Mistry P, Charlton P, and Callaghan R (2000) Communication between multiple drug binding sites on P-glycoprotein. Mol Pharmacol 58:624-632.
-
(2000)
Mol Pharmacol
, vol.58
, pp. 624-632
-
-
Martin, C.1
Berridge, G.2
Higgins, C.F.3
Mistry, P.4
Charlton, P.5
Callaghan, R.6
-
29
-
-
0028128286
-
Localization of the forskolin labeling sites to both halves of P-glycoprotein: Similarity of the sites labeled by forskolin and prazosin
-
Morris DI, Greenberger LM, Bruggemann EP, Cardarelli C, Gottesman MM, Pastan I, and Seamon KB (1995) Localization of the forskolin labeling sites to both halves of P-glycoprotein: Similarity of the sites labeled by forskolin and prazosin. Mol Pharmacol 46:329-337.
-
(1995)
Mol Pharmacol
, vol.46
, pp. 329-337
-
-
Morris, D.I.1
Greenberger, L.M.2
Bruggemann, E.P.3
Cardarelli, C.4
Gottesman, M.M.5
Pastan, I.6
Seamon, K.B.7
-
30
-
-
0032528254
-
Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents
-
Pascaud C, Garrigos M, and Orlowski S (1998) Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents. Biochem J 333:351-358.
-
(1998)
Biochem J
, vol.333
, pp. 351-358
-
-
Pascaud, C.1
Garrigos, M.2
Orlowski, S.3
-
31
-
-
0025193531
-
Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells
-
Raviv Y, Pollard HB, Bruggemann EP, Pastan I, and Gottesman MM (1990) Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells. J Biol Chem 265:3975-3980.
-
(1990)
J Biol Chem
, vol.265
, pp. 3975-3980
-
-
Raviv, Y.1
Pollard, H.B.2
Bruggemann, E.P.3
Pastan, I.4
Gottesman, M.M.5
-
32
-
-
0007003697
-
Mammalian multidrug-resistance gene: Correlation of exon organization with structural domains and duplication of an ancestral gene
-
Raymond M and Gros P (1989) Mammalian multidrug-resistance gene: Correlation of exon organization with structural domains and duplication of an ancestral gene. Proc Natl Acad Sci USA 86:6488-6492.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 6488-6492
-
-
Raymond, M.1
Gros, P.2
-
33
-
-
17944370228
-
Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle
-
Rosenberg MF, Velarde G, Ford RC, Martin C, Berridge G, Kerr ID, Callaghan R, Schmidlin A, Wooding C, Linton KJ, et al. (2001) Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle. EMBO (Eur Mol Biol Organ) J 20:5615-5625.
-
(2001)
EMBO (Eur Mol Biol Organ) J
, vol.20
, pp. 5615-5625
-
-
Rosenberg, M.F.1
Velarde, G.2
Ford, R.C.3
Martin, C.4
Berridge, G.5
Kerr, I.D.6
Callaghan, R.7
Schmidlin, A.8
Wooding, C.9
Linton, K.J.10
-
34
-
-
0030976879
-
P-glycoprotein substrates and antagonists cluster into two distinct groups
-
Scala S, Akhmed N, Rao US, Paull K, Lan LB, Dickstein B, Lee JS, Elgemeie GH, Stein WD, and Bates SE (1997) P-glycoprotein substrates and antagonists cluster into two distinct groups. Mol Pharmacol 51:1024-1033.
-
(1997)
Mol Pharmacol
, vol.51
, pp. 1024-1033
-
-
Scala, S.1
Akhmed, N.2
Rao, U.S.3
Paull, K.4
Lan, L.B.5
Dickstein, B.6
Lee, J.S.7
Elgemeie, G.H.8
Stein, W.D.9
Bates, S.E.10
-
35
-
-
0035824388
-
Structural mechanisms of QacR induction and multidrug recognition
-
Schumacher MA, Miller MC, Grkovic S, Brown MH, Skurray RA, and Brennan RG (2001) Structural mechanisms of QacR induction and multidrug recognition. Science (Wash DC) 294:2158-2163.
-
(2001)
Science (Wash DC)
, vol.294
, pp. 2158-2163
-
-
Schumacher, M.A.1
Miller, M.C.2
Grkovic, S.3
Brown, M.H.4
Skurray, R.A.5
Brennan, R.G.6
-
36
-
-
0033083015
-
Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site
-
Shapiro AB, Fox K, Lam P, and Ling V (1999) Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site. Eur J Biochem 259:841-850.
-
(1999)
Eur J Biochem
, vol.259
, pp. 841-850
-
-
Shapiro, A.B.1
Fox, K.2
Lam, P.3
Ling, V.4
-
37
-
-
0032523929
-
Transport of LDS-751 from the cytoplasmic leaflet of the plasma membrane by the rhodamine-123-selective site of P-glycoprotein
-
Shapiro AB and Ling V (1998) Transport of LDS-751 from the cytoplasmic leaflet of the plasma membrane by the rhodamine-123-selective site of P-glycoprotein. Eur J Biochem 254:181-188.
-
(1998)
Eur J Biochem
, vol.254
, pp. 181-188
-
-
Shapiro, A.B.1
Ling, V.2
-
38
-
-
0028264893
-
The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate
-
Spoelstra EC, Westerhoff HV, Pinedo HM, Dekker H, and Lankelma J (1994) The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate. Eur J Biochem 221:363-373.
-
(1994)
Eur J Biochem
, vol.221
, pp. 363-373
-
-
Spoelstra, E.C.1
Westerhoff, H.V.2
Pinedo, H.M.3
Dekker, H.4
Lankelma, J.5
-
39
-
-
0025991731
-
Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells
-
Tamai I and Safa AR (1991) Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells. J Biol Chem 266:16796-16800.
-
(1991)
J Biol Chem
, vol.266
, pp. 16796-16800
-
-
Tamai, I.1
Safa, A.R.2
-
40
-
-
0031160937
-
Multidrug transporters from bacteria to man: Similarities in structure and function
-
van Veen HW and Konings WN (1997) Multidrug transporters from bacteria to man: Similarities in structure and function. Semin Cancer Biol 8:183-191.
-
(1997)
Semin Cancer Biol
, vol.8
, pp. 183-191
-
-
Van Veen, H.W.1
Konings, W.N.2
-
41
-
-
0033575293
-
Identification of P-glycoprotein mutations causing a loss of steroid recognition and transport
-
Vo QD and Gruol DJ (1999) Identification of P-glycoprotein mutations causing a loss of steroid recognition and transport. J Biol Chem 274:20318-20327.
-
(1999)
J Biol Chem
, vol.274
, pp. 20318-20327
-
-
Vo, Q.D.1
Gruol, D.J.2
-
42
-
-
0032508365
-
Identification of the domains of photoincorporation of the 3′-and 7-benzophenone analogues of Taxol in the carboxyl-terminal half of murine mdr1b P-glycoprotein
-
Wu Q, Bounaud PY, Kuduk SD, Yang CP, Ojima I, Horwitz SB, and Orr GA (1998) Identification of the domains of photoincorporation of the 3′-and 7-benzophenone analogues of Taxol in the carboxyl-terminal half of murine mdr1b P-glycoprotein. Biochemistry 37:11272-11279.
-
(1998)
Biochemistry
, vol.37
, pp. 11272-11279
-
-
Wu, Q.1
Bounaud, P.Y.2
Kuduk, S.D.3
Yang, C.P.4
Ojima, I.5
Horwitz, S.B.6
Orr, G.A.7
-
43
-
-
0028901538
-
Functional evidence that transmembrane 12 and the loop between transmembrane 11 and 12 form part of the drug-binding domain in P-glycoprotein encoded by MDR1
-
Zhang X, Collins KI, and Greenberger LM (1995) Functional evidence that transmembrane 12 and the loop between transmembrane 11 and 12 form part of the drug-binding domain in P-glycoprotein encoded by MDR1. JBiol Chem 270:5441-5448.
-
(1995)
JBiol Chem
, vol.270
, pp. 5441-5448
-
-
Zhang, X.1
Collins, K.I.2
Greenberger, L.M.3
|