Reversal of multidrug resistance and increase in plasma membrane fluidity in CHO cells with R-verapamil and bile salts

European Journal of Cancer

Volumn 37, Issue 5, 2001, Pages 660-667

  Schuldes, H ^a,c   Dolderer, J H ^a,b   Zimmer, G ^a   Knobloch, J ^a   Bickeboller R ^a   Jonas, D ^a   Woodcock, B G ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b Nordwest Hospital   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Bile salts; Cell membrane fluidity; Chinese hamster ovary cells; Multidrug resistance; R verapamil

Indexed keywords

CISPLATIN; DOXORUBICIN; GLYCOPROTEIN P; MITOMYCIN; TAUROCHENODEOXYCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID; VERAPAMIL;

ANIMAL CELL; ARTICLE; CELL MEMBRANE FLUIDITY; CELL PROLIFERATION; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG TRANSPORT; ELECTRON SPIN RESONANCE; GROWTH RATE; MEMBRANE STRUCTURE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CHO CELLS; CISPLATIN; CRICETINAE; CRICETULUS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; MEMBRANE FLUIDITY; MITOMYCIN; OVARIAN NEOPLASMS; TAUROCHENODEOXYCHOLIC ACID; TUMOR CELLS, CULTURED; VERAPAMIL;

EID: 0035091515     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(00)00450-0     Document Type: Article

References (34)

1. The biochemistry of P-glycoprotein-mediated multidrug resistance
2. Reversal mechanism of multidrug resisance by verapamil: Direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells
3. The role of drug-lipid interactions in the biological activity of modulators of multidrug resistance
4. Permeability of lipid bilayer to anthracycline derivatives. Role of the bilayer composition and of the temperature
5. Analysis of drug transport kinetics in multidrug-resistant cells using a novel coumarin-vinblastin compound
6. Potentiation of anticancer-drug cytotoxicity by multidrugresistance chemosensitizers involves alterations in membrane fluidity leading to increased membrane permeability
7. Plasma membrane lipid structural order in doxorubicin-sensitive and-resistant P388 cells
8. Resistance modulation in CHO cells by R-verapamil and bile salts is associated with physical and chemical changes in the cell membrane
9. A comparison of membrane properties and compositon between cell lines selected and transfected for multidrug resistance
10. Increased accumulation of drugs in a multidrug resistant cell line by alteration of membrane biophysical properties
11. Relationship between plasma membrane fluidity and R-verapamil action in CHO cells
12. Modulation of P-glycoprotein mediated drug transport by alteration in lipid fluidity of rat liver canalicular membrane vesicles
13. i homeostasis in multidrug-resistant (MDR) cells: Further characterization of a series of MDR cell lines expressing different levels of p-glycoprotein
14. Cytostatic sensitivity and MDR in bladder carcinoma cells: Implications for tumor therapy
15. The hydrophobic-hydrophilic balance of bile salts. Inverse correlation between reverse-phase high performance liquid chromatographic mobilities and micellar cholesterol-solubilizing capacities
16. Structural changes in vesicle membranes and mixed micelles of various lipid compositions after binding of different bile salts
17. Molecular aspects of membrane stabilization by ursodeoxycholate
18. Determination of molecular associations of some hydrophobic and hydrophilic bile acids by infrared and Raman spectroscopy
19. Ursodeoxycholate stabilizes phospholipid-rich membranes and mimics the effect of cholesterol: Investigations on large unilamellar vesicles
20. The barrier domain for solute permeation varies with lipid bilayer phase structure
21. Reduced permeability in CHO cells as a mechanism of resistance to coichicine
22. Pharmacological modification of multi-drug resistance (MDR) in vitro detected by a novel fluorometric microculture cytotoxicity assay. Reversal of resistance and selective cytotoxic actions of cyclosporin A and verapamil on MDR leukemia T-cells
23. Electron spin resonance
24. Instrumental aspects of spin labeling
25. A summary and evaluation of spin labels used as probes for biological membrane structure
26. Spin-label measurement of membrane-bound enzymes
27. Lipid structural order parameters (reciprocal of fluidity) in biomembranes derived from steady-state fluorescence polarization measurements
28. Influence of pH on sulfhydryl groups and fluidity of the miochondrial membrane
29. Overview of the role of lipoate in the enzyme complexes of energy metabolism and reducing equivalents
30. Oxidative stress, loose-coupling
31. Characterisation and functional reconstitution of the multidrug transporter
32. Studies on plasma membranes. 3. Mg2+-ATPase, (Na+-K+-Mg2+)-ATPase and 5′-nucleotidase activity of plasma membranes
33. In vitro effect of bile salts on rat liver plasma membrane, lipid fluidity, and ATPase activity
34. The multidrug transporter, a double-edged sword