RU49953: A non-hormonal steroid derivative that potently inhibits P-glycoprotein and reverts cellular multidrug resistance

Cellular and Molecular Life Sciences

Volumn 60, Issue 3, 2003, Pages 526-535

  Perez Victoria, F J ^a   Conseil, G ^b   Munoz Martinez, F ^a   Perez Victoria, J M ^a,b   Dayan, G ^b   Marsaud, V ^c   Castanys, S ^a   Gamarro, F ^a   Renoir, J M ^c   Di Pietro, A ^b  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b INSTITUT DE BIOLOGIE ET CHIMIE DES PROTÉINES   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Drug transport; Drug binding site; Hormone receptor; Modulator; Multidrug resistance; P glycoprotein; RU49953; Steroid derivative

Indexed keywords

11 [4 (2 DIMETHYLAMINOETHOXY)PHENYL]ESTRADIOL; ANTIGESTAGEN; AZIDOPINE; ESTRADIOL DERIVATIVE; GLYCOPROTEIN P; HORMONE RECEPTOR; METRIBOLONE; MIFEPRISTONE; PROGESTERONE DERIVATIVE; RU 39010; RU 39616; RU 48659; RU 49953; RU 50641; VERAPAMIL; VINBLASTINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG TRANSPORT; EMBRYO; GENETIC TRANSFECTION; IC 50; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PHOTOAFFINITY LABELING;

3T3 CELLS; ANIMALS; AZIDES; DAUNORUBICIN; DIHYDROPYRIDINES; DRUG RESISTANCE, MULTIPLE; ENZYME INHIBITORS; MICE; MIFEPRISTONE; P-GLYCOPROTEIN; VINBLASTINE;

ANIMALIA;

EID: 0344511821     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000180300044     Document Type: Article

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