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Volumn 18, Issue 3, 2015, Pages 423-439

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A2A RECEPTOR; AMYLOID PRECURSOR PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; 1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; ACTIVITY REGULATED CYTOSKELETAL-ASSOCIATED PROTEIN; CYTOSKELETON PROTEIN; INDOLE DERIVATIVE; NERVE PROTEIN; SEROTONIN 4 RECEPTOR; SEROTONIN ANTAGONIST; SULFONAMIDE;

EID: 84923833075     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3930     Document Type: Article
Times cited : (216)

References (85)
  • 1
    • 0035209620 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors
    • Fredholm, B.B., IJzerman, A.P., Jacobson, K.A., Klotz, K.N. & Linden, J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol. Rev. 53, 527-552 (2001).
    • (2001) Pharmacol. Rev. , vol.53 , pp. 527-552
    • Fredholm, B.B.1    IJzerman, A.P.2    Jacobson, K.A.3    Klotz, K.N.4    Linden, J.5
  • 2
    • 34248576759 scopus 로고    scopus 로고
    • Physiology and pathophysiology of purinergic neurotransmission
    • Burnstock, G. Physiology and pathophysiology of purinergic neurotransmission. Physiol. Rev. 87, 659-797 (2007).
    • (2007) Physiol. Rev. , vol.87 , pp. 659-797
    • Burnstock, G.1
  • 3
    • 83455244457 scopus 로고    scopus 로고
    • Adenosine A2A receptor in the monkey basal ganglia: Ultrastructural localization and colocalization with the metabotropic glutamate receptor 5 in the striatum
    • Bogenpohl, J.W., Ritter, S.L., Hall, R.A. & Smith, Y. Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and colocalization with the metabotropic glutamate receptor 5 in the striatum. J. Comp. Neurol. 520, 570-589 (2012).
    • (2012) J. Comp. Neurol. , vol.520 , pp. 570-589
    • Bogenpohl, J.W.1    Ritter, S.L.2    Hall, R.A.3    Smith, Y.4
  • 4
    • 36249032646 scopus 로고    scopus 로고
    • Adenosine A2A receptors and brain injury: Broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation
    • Chen, J.F. et al. Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation. Prog. Neurobiol. 83, 310-331 (2007).
    • (2007) Prog. Neurobiol. , vol.83 , pp. 310-331
    • Chen, J.F.1
  • 5
    • 28244434101 scopus 로고    scopus 로고
    • Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia
    • Saura, J. et al. Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia. J. Neurochem. 95, 919-929 (2005).
    • (2005) J. Neurochem. , vol.95 , pp. 919-929
    • Saura, J.1
  • 6
    • 67649797862 scopus 로고    scopus 로고
    • Adenosine A(2A) receptor mediates microglial process retraction
    • Orr, A.G., Orr, A.L., Li, X.J., Gross, R.E. & Traynelis, S.F. Adenosine A(2A) receptor mediates microglial process retraction. Nat. Neurosci. 12, 872-878 (2009).
    • (2009) Nat. Neurosci. , vol.12 , pp. 872-878
    • Orr, A.G.1    Orr, A.L.2    Li, X.J.3    Gross, R.E.4    Traynelis, S.F.5
  • 8
    • 41149160406 scopus 로고    scopus 로고
    • Up-regulation of adenosine receptors in the frontal cortex in Alzheimer's disease
    • Albasanz, J.L., Perez, S., Barrachina, M., Ferrer, I. & Martin, M. Up-regulation of adenosine receptors in the frontal cortex in Alzheimer's disease. Brain Pathol. 18, 211-219 (2008).
    • (2008) Brain Pathol. , vol.18 , pp. 211-219
    • Albasanz, J.L.1    Perez, S.2    Barrachina, M.3    Ferrer, I.4    Martin, M.5
  • 9
    • 84951905228 scopus 로고    scopus 로고
    • A2A adenosine receptor deletion is protective in a mouse model of Tauopathy
    • published online, 2 December
    • Laurent, C. et al. A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. Mol. Psychiatry published online, doi:10.1038/mp.2014.151 (2 December 2014).
    • (2014) Mol. Psychiatry
    • Laurent, C.1
  • 10
    • 84863337843 scopus 로고    scopus 로고
    • Alzheimer mechanisms and therapeutic strategies
    • Huang, Y. & Mucke, L. Alzheimer mechanisms and therapeutic strategies. Cell 148, 1204-1222 (2012).
    • (2012) Cell , vol.148 , pp. 1204-1222
    • Huang, Y.1    Mucke, L.2
  • 11
    • 33847613885 scopus 로고    scopus 로고
    • Inflammatory processes in Alzheimer's disease
    • Heneka, M.T. & O'Banion, M.K. Inflammatory processes in Alzheimer's disease. J. Neuroimmunol. 184, 69-91 (2007).
    • (2007) J. Neuroimmunol. , vol.184 , pp. 69-91
    • Heneka, M.T.1    O'Banion, M.K.2
  • 12
    • 0029013727 scopus 로고
    • Staging of Alzheimer's disease-related neurofibrillary changes
    • Braak, H. & Braak, E. Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol. Aging 16, 271-278 (1995).
    • (1995) Neurobiol. Aging , vol.16 , pp. 271-278
    • Braak, H.1    Braak, E.2
  • 13
    • 38149129457 scopus 로고    scopus 로고
    • A transcriptome database for astrocytes, neurons and oligodendrocytes: A new resource for understanding brain development and function
    • Cahoy, J.D. et al. A transcriptome database for astrocytes, neurons and oligodendrocytes: a new resource for understanding brain development and function. J. Neurosci. 28, 264-278 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 264-278
    • Cahoy, J.D.1
  • 14
    • 33749574058 scopus 로고    scopus 로고
    • Subcellular distributions of adenosine A1 and A2A receptors in the rat dorsomedial nucleus of the solitary tract at the level of the area postrema
    • Pickel, V.M., Chan, J., Linden, J. & Rosin, D.L. Subcellular distributions of adenosine A1 and A2A receptors in the rat dorsomedial nucleus of the solitary tract at the level of the area postrema. Synapse 60, 496-509 (2006).
    • (2006) Synapse , vol.60 , pp. 496-509
    • Pickel, V.M.1    Chan, J.2    Linden, J.3    Rosin, D.L.4
  • 15
    • 79960051903 scopus 로고    scopus 로고
    • Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens
    • Lazarus, M. et al. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. J. Neurosci. 31, 10067-10075 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 10067-10075
    • Lazarus, M.1
  • 16
    • 0036293742 scopus 로고    scopus 로고
    • Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation
    • Bajenaru, M.L. et al. Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol. Cell. Biol. 22, 5100-5113 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5100-5113
    • Bajenaru, M.L.1
  • 17
    • 4644244882 scopus 로고    scopus 로고
    • Developmental expression of glial fibrillary acidic protein mRNA in mouse forebrain germinal zones: Implications for stem cell biology
    • Fox, I.J. et al. Developmental expression of glial fibrillary acidic protein mRNA in mouse forebrain germinal zones: implications for stem cell biology. Brain Res. Dev. Brain Res. 153, 121-125 (2004).
    • (2004) Brain Res. Dev. Brain Res. , vol.153 , pp. 121-125
    • Fox, I.J.1
  • 18
    • 84876309874 scopus 로고    scopus 로고
    • ABCA1 influences neuroinflammation and neuronal death
    • Karasinska, J.M. et al. ABCA1 influences neuroinflammation and neuronal death. Neurobiol. Dis. 54, 445-455 (2013).
    • (2013) Neurobiol. Dis. , vol.54 , pp. 445-455
    • Karasinska, J.M.1
  • 19
    • 80053067805 scopus 로고    scopus 로고
    • Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis
    • Stenzel, D. et al. Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis. Development 138, 4451-4463 (2011).
    • (2011) Development , vol.138 , pp. 4451-4463
    • Stenzel, D.1
  • 20
    • 39749188753 scopus 로고    scopus 로고
    • Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
    • Yamanaka, K. et al. Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat. Neurosci. 11, 251-253 (2008).
    • (2008) Nat. Neurosci. , vol.11 , pp. 251-253
    • Yamanaka, K.1
  • 21
    • 7044233126 scopus 로고    scopus 로고
    • GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain
    • Garcia, A.D., Doan, N.B., Imura, T., Bush, T.G. & Sofroniew, M.V. GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nat. Neurosci. 7, 1233-1241 (2004).
    • (2004) Nat. Neurosci. , vol.7 , pp. 1233-1241
    • Garcia, A.D.1    Doan, N.B.2    Imura, T.3    Bush, T.G.4    Sofroniew, M.V.5
  • 22
    • 84862776724 scopus 로고    scopus 로고
    • Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes
    • Matos, M. et al. Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes. Glia 60, 702-716 (2012).
    • (2012) Glia , vol.60 , pp. 702-716
    • Matos, M.1
  • 23
    • 37549021899 scopus 로고    scopus 로고
    • Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses
    • Rebola, N., Lujan, R., Cunha, R.A. & Mulle, C. Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses. Neuron 57, 121-134 (2008).
    • (2008) Neuron , vol.57 , pp. 121-134
    • Rebola, N.1    Lujan, R.2    Cunha, R.A.3    Mulle, C.4
  • 24
    • 0033793530 scopus 로고    scopus 로고
    • Role of hippocampal signaling pathways in long-term memory formation of a nonassociative learning task in the rat
    • Vianna, M.R. et al. Role of hippocampal signaling pathways in long-term memory formation of a nonassociative learning task in the rat. Learn. Mem. 7, 333-340 (2000).
    • (2000) Learn. Mem. , vol.7 , pp. 333-340
    • Vianna, M.R.1
  • 25
    • 0030841177 scopus 로고    scopus 로고
    • Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor
    • Ledent, C. et al. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 388, 674-678 (1997).
    • (1997) Nature , vol.388 , pp. 674-678
    • Ledent, C.1
  • 26
    • 17644376524 scopus 로고    scopus 로고
    • A crucial role for forebrain adenosine A(2A) receptors in amphetamine sensitization
    • Bastia, E. et al. A crucial role for forebrain adenosine A(2A) receptors in amphetamine sensitization. Neuropsychopharmacology 30, 891-900 (2005).
    • (2005) Neuropsychopharmacology , vol.30 , pp. 891-900
    • Bastia, E.1
  • 27
    • 0026061059 scopus 로고
    • The concentration of glial fibrillary acidic protein increases with age in the mouse and rat brain
    • O'Callaghan, J.P. & Miller, D.B. The concentration of glial fibrillary acidic protein increases with age in the mouse and rat brain. Neurobiol. Aging 12, 171-174 (1991).
    • (1991) Neurobiol. Aging , vol.12 , pp. 171-174
    • O'Callaghan, J.P.1    Miller, D.B.2
  • 28
    • 84863487053 scopus 로고    scopus 로고
    • Aging impairs hippocampusdependent long-term memory for object location in mice
    • Wimmer, M.E., Hernandez, P.J., Blackwell, J. & Abel, T. Aging impairs hippocampusdependent long-term memory for object location in mice. Neurobiol. Aging 33, 2220-2224 (2012).
    • (2012) Neurobiol. Aging , vol.33 , pp. 2220-2224
    • Wimmer, M.E.1    Hernandez, P.J.2    Blackwell, J.3    Abel, T.4
  • 29
    • 33750496896 scopus 로고    scopus 로고
    • Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories
    • Plath, N. et al. Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron 52, 437-444 (2006).
    • (2006) Neuron , vol.52 , pp. 437-444
    • Plath, N.1
  • 30
    • 68349103200 scopus 로고    scopus 로고
    • Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors
    • Alexander, G.M. et al. Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron 63, 27-39 (2009).
    • (2009) Neuron , vol.63 , pp. 27-39
    • Alexander, G.M.1
  • 31
    • 44449176620 scopus 로고    scopus 로고
    • Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor
    • Chang, W.C. et al. Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor. PLoS ONE 2, e1317 (2007).
    • (2007) PLoS ONE , vol.2
    • Chang, W.C.1
  • 32
    • 34250317399 scopus 로고    scopus 로고
    • Synaptic islands defined by the territory of a single astrocyte
    • Halassa, M.M., Fellin, T., Takano, H., Dong, J.H. & Haydon, P.G. Synaptic islands defined by the territory of a single astrocyte. J. Neurosci. 27, 6473-6477 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 6473-6477
    • Halassa, M.M.1    Fellin, T.2    Takano, H.3    Dong, J.H.4    Haydon, P.G.5
  • 33
    • 84879477475 scopus 로고    scopus 로고
    • Genetic background affects human glial fibrillary acidic protein promoter activity
    • Bai, X. et al. Genetic background affects human glial fibrillary acidic protein promoter activity. PLoS ONE 8, e66873 (2013).
    • (2013) PLoS ONE , vol.8
    • Bai, X.1
  • 34
    • 84864479496 scopus 로고    scopus 로고
    • Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator
    • Han, H.J. et al. Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator. J. Neurosci. 32, 10574-10586 (2012).
    • (2012) J. Neurosci. , vol.32 , pp. 10574-10586
    • Han, H.J.1
  • 35
    • 34147092581 scopus 로고    scopus 로고
    • Schemas and memory consolidation
    • Tse, D. et al. Schemas and memory consolidation. Science 316, 76-82 (2007).
    • (2007) Science , vol.316 , pp. 76-82
    • Tse, D.1
  • 36
    • 0034213718 scopus 로고    scopus 로고
    • High-level neuronal expression of Aβ1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation
    • Mucke, L. et al. High-level neuronal expression of Aβ1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J. Neurosci. 20, 4050-4058 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 4050-4058
    • Mucke, L.1
  • 37
    • 58149391968 scopus 로고    scopus 로고
    • Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies
    • Ji, B. et al. Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies. J. Neurosci. 28, 12255-12267 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 12255-12267
    • Ji, B.1
  • 38
    • 1642555780 scopus 로고    scopus 로고
    • Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: Evidence for augmentation of a 42-specific gamma secretase
    • Jankowsky, J.L. et al. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum. Mol. Genet. 13, 159-170 (2004).
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 159-170
    • Jankowsky, J.L.1
  • 39
    • 33846538660 scopus 로고    scopus 로고
    • Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
    • Yoshiyama, Y. et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53, 337-351 (2007).
    • (2007) Neuron , vol.53 , pp. 337-351
    • Yoshiyama, Y.1
  • 40
    • 0030741533 scopus 로고    scopus 로고
    • Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis
    • Sullivan, P.M. et al. Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. J. Biol. Chem. 272, 17972-17980 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 17972-17980
    • Sullivan, P.M.1
  • 41
    • 84863244650 scopus 로고    scopus 로고
    • Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD
    • Han, J. et al. Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD. Cell 148, 1039-1050 (2012).
    • (2012) Cell , vol.148 , pp. 1039-1050
    • Han, J.1
  • 42
    • 79952305803 scopus 로고    scopus 로고
    • Astrocyte-neuron lactate transport is required for long-term memory formation
    • Suzuki, A. et al. Astrocyte-neuron lactate transport is required for long-term memory formation. Cell 144, 810-823 (2011).
    • (2011) Cell , vol.144 , pp. 810-823
    • Suzuki, A.1
  • 43
    • 33646522699 scopus 로고    scopus 로고
    • Glia-derived D-serine controls NMDA receptor activity and synaptic memory
    • Panatier, A. et al. Glia-derived D-serine controls NMDA receptor activity and synaptic memory. Cell 125, 775-784 (2006).
    • (2006) Cell , vol.125 , pp. 775-784
    • Panatier, A.1
  • 44
    • 84864200035 scopus 로고    scopus 로고
    • Oligodendroglia metabolically support axons and contribute to neurodegeneration
    • Lee, Y. et al. Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature 487, 443-448 (2012).
    • (2012) Nature , vol.487 , pp. 443-448
    • Lee, Y.1
  • 45
    • 2342548650 scopus 로고    scopus 로고
    • Four classes of intercellular channels between glial cells in the CNS
    • Altevogt, B.M. & Paul, D.L. Four classes of intercellular channels between glial cells in the CNS. J. Neurosci. 24, 4313-4323 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 4313-4323
    • Altevogt, B.M.1    Paul, D.L.2
  • 46
    • 0034923094 scopus 로고    scopus 로고
    • The role and regulation of adenosine in the central nervous system
    • Dunwiddie, T.V. & Masino, S.A. The role and regulation of adenosine in the central nervous system. Annu. Rev. Neurosci. 24, 31-55 (2001).
    • (2001) Annu. Rev. Neurosci. , vol.24 , pp. 31-55
    • Dunwiddie, T.V.1    Masino, S.A.2
  • 47
    • 84893807162 scopus 로고    scopus 로고
    • Post-study caffeine administration enhances memory consolidation in humans
    • Borota, D. et al. Post-study caffeine administration enhances memory consolidation in humans. Nat. Neurosci. 17, 201-203 (2014).
    • (2014) Nat. Neurosci. , vol.17 , pp. 201-203
    • Borota, D.1
  • 48
    • 84875249226 scopus 로고    scopus 로고
    • Decay happens: The role of active forgetting in memory
    • Hardt, O., Nader, K. & Nadel, L. Decay happens: the role of active forgetting in memory. Trends Cogn. Sci. 17, 111-120 (2013).
    • (2013) Trends Cogn. Sci. , vol.17 , pp. 111-120
    • Hardt, O.1    Nader, K.2    Nadel, L.3
  • 49
    • 0025024730 scopus 로고
    • Cyclic AMP-induced shape changes of astrocytes are accompanied by rapid depolymerization of actin
    • Goldman, J.E. & Abramson, B. Cyclic AMP-induced shape changes of astrocytes are accompanied by rapid depolymerization of actin. Brain Res. 528, 189-196 (1990).
    • (1990) Brain Res. , vol.528 , pp. 189-196
    • Goldman, J.E.1    Abramson, B.2
  • 50
    • 67649966626 scopus 로고    scopus 로고
    • 2+-activated, CREB-dependent transcription in astrocytes
    • 2+-activated, CREB-dependent transcription in astrocytes. Glia 57, 828-834 (2009).
    • (2009) Glia , vol.57 , pp. 828-834
    • Murray, P.D.1    Kingsbury, T.J.2    Krueger, B.K.3
  • 51
    • 0033232779 scopus 로고    scopus 로고
    • A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice
    • Chen, J.F. et al. A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice. J. Neurosci. 19, 9192-9200 (1999).
    • (1999) J. Neurosci. , vol.19 , pp. 9192-9200
    • Chen, J.F.1
  • 52
    • 8544260349 scopus 로고    scopus 로고
    • Interferon-gamma induced medulloblastoma in the developing cerebellum
    • Lin, W. et al. Interferon-gamma induced medulloblastoma in the developing cerebellum. J. Neurosci. 24, 10074-10083 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 10074-10083
    • Lin, W.1
  • 53
    • 48449105746 scopus 로고    scopus 로고
    • Engineering GPCR signaling pathways with RASSLs
    • Conklin, B.R. et al. Engineering GPCR signaling pathways with RASSLs. Nat. Methods 5, 673-678 (2008).
    • (2008) Nat. Methods , vol.5 , pp. 673-678
    • Conklin, B.R.1
  • 54
    • 39549099297 scopus 로고    scopus 로고
    • Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass
    • Hsiao, E.C. et al. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc. Natl. Acad. Sci. USA 105, 1209-1214 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 1209-1214
    • Hsiao, E.C.1
  • 55
    • 58549112040 scopus 로고    scopus 로고
    • Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss
    • Halassa, M.M. et al. Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss. Neuron 61, 213-219 (2009).
    • (2009) Neuron , vol.61 , pp. 213-219
    • Halassa, M.M.1
  • 56
    • 33847421779 scopus 로고    scopus 로고
    • Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes
    • Sweger, E.J., Casper, K.B., Scearce-Levie, K., Conklin, B.R. & McCarthy, K.D. Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes. J. Neurosci. 27, 2309-2317 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 2309-2317
    • Sweger, E.J.1    Casper, K.B.2    Scearce-Levie, K.3    Conklin, B.R.4    McCarthy, K.D.5
  • 57
    • 26444552361 scopus 로고    scopus 로고
    • Astrocytic purinergic signaling coordinates synaptic networks
    • Pascual, O. et al. Astrocytic purinergic signaling coordinates synaptic networks. Science 310, 113-116 (2005).
    • (2005) Science , vol.310 , pp. 113-116
    • Pascual, O.1
  • 58
    • 84893469844 scopus 로고    scopus 로고
    • Abnormal intracellular calcium signaling and SNARE-dependent exocytosis contributes to SOD1G93A astrocyte-mediated toxicity in amyotrophic lateral sclerosis
    • Kawamata, H. et al. Abnormal intracellular calcium signaling and SNARE-dependent exocytosis contributes to SOD1G93A astrocyte-mediated toxicity in amyotrophic lateral sclerosis. J. Neurosci. 34, 2331-2348 (2014).
    • (2014) J. Neurosci. , vol.34 , pp. 2331-2348
    • Kawamata, H.1
  • 59
    • 84916631384 scopus 로고    scopus 로고
    • Neuronal transgene expression in dominant-negative SNARE mice
    • Fujita, T. et al. Neuronal transgene expression in dominant-negative SNARE mice. J. Neurosci. 34, 16594-16604 (2014).
    • (2014) J. Neurosci. , vol.34 , pp. 16594-16604
    • Fujita, T.1
  • 60
    • 84926364084 scopus 로고    scopus 로고
    • Looks can be deceiving: Reconsidering the evidence for gliotransmission
    • Sloan, S.A. & Barres, B.A. Looks can be deceiving: Reconsidering the evidence for gliotransmission. Neuron 84, 1112-1115 (2014).
    • (2014) Neuron , vol.84 , pp. 1112-1115
    • Sloan, S.A.1    Barres, B.A.2
  • 61
    • 0028875687 scopus 로고
    • Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease
    • Rockenstein, E.M. et al. Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease. J. Biol. Chem. 270, 28257-28267 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 28257-28267
    • Rockenstein, E.M.1
  • 62
    • 34548264782 scopus 로고    scopus 로고
    • Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
    • Palop, J.J. et al. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron 55, 697-711 (2007).
    • (2007) Neuron , vol.55 , pp. 697-711
    • Palop, J.J.1
  • 63
    • 1542291105 scopus 로고    scopus 로고
    • Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice
    • Sullivan, P.M., Mace, B.E., Maeda, N. & Schmechel, D.E. Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice. Neuroscience 124, 725-733 (2004).
    • (2004) Neuroscience , vol.124 , pp. 725-733
    • Sullivan, P.M.1    Mace, B.E.2    Maeda, N.3    Schmechel, D.E.4
  • 64
    • 0032168460 scopus 로고    scopus 로고
    • Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females
    • Raber, J. et al. Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females. Proc. Natl. Acad. Sci. USA 95, 10914-10919 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10914-10919
    • Raber, J.1
  • 65
    • 84871742808 scopus 로고    scopus 로고
    • Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice
    • Leung, L. et al. Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice. PLoS ONE 7, e53569 (2012).
    • (2012) PLoS ONE , vol.7
    • Leung, L.1
  • 66
    • 64749092065 scopus 로고    scopus 로고
    • Engineered lentiviral vector targeting astrocytes in vivo
    • Colin, A. et al. Engineered lentiviral vector targeting astrocytes in vivo. Glia 57, 667-679 (2009).
    • (2009) Glia , vol.57 , pp. 667-679
    • Colin, A.1
  • 67
    • 79960361861 scopus 로고    scopus 로고
    • Monitoring astrocyte calcium microdomains with improved membrane targeted GCaMP reporters
    • Shigetomi, E., Kracun, S. & Khakh, B.S. Monitoring astrocyte calcium microdomains with improved membrane targeted GCaMP reporters. Neuron Glia Biol. 6, 183-191 (2010).
    • (2010) Neuron Glia Biol. , vol.6 , pp. 183-191
    • Shigetomi, E.1    Kracun, S.2    Khakh, B.S.3
  • 68
    • 0030948362 scopus 로고    scopus 로고
    • Retargeting of cytosolic proteins to the plasma membrane by the Lck protein tyrosine kinase dual acylation motif
    • Zlatkine, P., Mehul, B. & Magee, A.I. Retargeting of cytosolic proteins to the plasma membrane by the Lck protein tyrosine kinase dual acylation motif. J. Cell Sci. 110, 673-679 (1997).
    • (1997) J. Cell Sci. , vol.110 , pp. 673-679
    • Zlatkine, P.1    Mehul, B.2    Magee, A.I.3
  • 69
    • 84861674567 scopus 로고    scopus 로고
    • Genetic ablation of Nrf2/antioxidant response pathway in Alexander disease mice reduces hippocampal gliosis but does not impact survival
    • Hagemann, T.L., Jobe, E.M. & Messing, A. Genetic ablation of Nrf2/antioxidant response pathway in Alexander disease mice reduces hippocampal gliosis but does not impact survival. PLoS ONE 7, e37304 (2012).
    • (2012) PLoS ONE , vol.7
    • Hagemann, T.L.1    Jobe, E.M.2    Messing, A.3
  • 70
    • 84863582122 scopus 로고    scopus 로고
    • Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: Implications for neurogenesis
    • Saaltink, D.J., Havik, B., Verissimo, C.S., Lucassen, P.J. & Vreugdenhil, E. Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: Implications for neurogenesis. J. Comp. Neurol. 520, 2805-2823 (2012).
    • (2012) J. Comp. Neurol. , vol.520 , pp. 2805-2823
    • Saaltink, D.J.1    Havik, B.2    Verissimo, C.S.3    Lucassen, P.J.4    Vreugdenhil, E.5
  • 71
    • 70350550208 scopus 로고    scopus 로고
    • Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases
    • Spencer, B. et al. Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J. Neurosci. 29, 13578-13588 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 13578-13588
    • Spencer, B.1
  • 72
    • 84881113966 scopus 로고    scopus 로고
    • Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice
    • Marxreiter, F. et al. Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice. Neurobiol. Dis. 59, 38-51 (2013).
    • (2013) Neurobiol. Dis. , vol.59 , pp. 38-51
    • Marxreiter, F.1
  • 73
    • 79957628653 scopus 로고    scopus 로고
    • The timing for neuronal maturation in the adult hippocampus is modulated by local network activity
    • Piatti, V.C. et al. The timing for neuronal maturation in the adult hippocampus is modulated by local network activity. J. Neurosci. 31, 7715-7728 (2011).
    • (2011) J. Neurosci. , vol.31 , pp. 7715-7728
    • Piatti, V.C.1
  • 74
    • 84866093038 scopus 로고    scopus 로고
    • Experience-dependent regulation of NG2 progenitors in the developing barrel cortex
    • Mangin, J.M., Li, P., Scafidi, J. & Gallo, V. Experience-dependent regulation of NG2 progenitors in the developing barrel cortex. Nat. Neurosci. 15, 1192-1194 (2012).
    • (2012) Nat. Neurosci. , vol.15 , pp. 1192-1194
    • Mangin, J.M.1    Li, P.2    Scafidi, J.3    Gallo, V.4
  • 75
    • 77952573750 scopus 로고    scopus 로고
    • Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease
    • Olabarria, M., Noristani, H.N., Verkhratsky, A. & Rodriguez, J.J. Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease. Glia 58, 831-838 (2010).
    • (2010) Glia , vol.58 , pp. 831-838
    • Olabarria, M.1    Noristani, H.N.2    Verkhratsky, A.3    Rodriguez, J.J.4
  • 76
    • 18244394288 scopus 로고    scopus 로고
    • Activation of protease-activated receptor-1 triggers astrogliosis after brain injury
    • Nicole, O. et al. Activation of protease-activated receptor-1 triggers astrogliosis after brain injury. J. Neurosci. 25, 4319-4329 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 4319-4329
    • Nicole, O.1
  • 77
    • 77956621143 scopus 로고    scopus 로고
    • Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases
    • Moritz, A. et al. Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases. Sci. Signal. 3, ra64 (2010).
    • (2010) Sci. Signal. , vol.3 , pp. ra64
    • Moritz, A.1
  • 78
    • 0035837274 scopus 로고    scopus 로고
    • beta-amyloid deposits in transgenic mice expressing human beta-amyloid precursor protein have the same characteristics as those in Alzheimer's disease
    • Terai, K. et al. beta-amyloid deposits in transgenic mice expressing human beta-amyloid precursor protein have the same characteristics as those in Alzheimer's disease. Neuroscience 104, 299-310 (2001).
    • (2001) Neuroscience , vol.104 , pp. 299-310
    • Terai, K.1
  • 79
    • 84906934662 scopus 로고    scopus 로고
    • Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia
    • Kir, S. et al. Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature 513, 100-104 (2014).
    • (2014) Nature , vol.513 , pp. 100-104
    • Kir, S.1
  • 80
    • 80052719486 scopus 로고    scopus 로고
    • Increasing CREB function in the CA1 region of dorsal hippocampus rescues the spatial memory deficits in a mouse model of Alzheimer's disease
    • Yiu, A.P., Rashid, A.J. & Josselyn, S.A. Increasing CREB function in the CA1 region of dorsal hippocampus rescues the spatial memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 36, 2169-2186 (2011).
    • (2011) Neuropsychopharmacology , vol.36 , pp. 2169-2186
    • Yiu, A.P.1    Rashid, A.J.2    Josselyn, S.A.3
  • 81
    • 15744405759 scopus 로고    scopus 로고
    • Parathyroid hormone receptor trafficking contributes to the activation of extracellular signal-regulated kinases but is not required for regulation of cAMP signaling
    • Syme, C.A., Friedman, P.A. & Bisello, A. Parathyroid hormone receptor trafficking contributes to the activation of extracellular signal-regulated kinases but is not required for regulation of cAMP signaling. J. Biol. Chem. 280, 11281-11288 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 11281-11288
    • Syme, C.A.1    Friedman, P.A.2    Bisello, A.3
  • 82
    • 55449133376 scopus 로고    scopus 로고
    • Epstein-Barr nuclear antigen 1 contributes to nasopharyngeal carcinoma through disruption of PML nuclear bodies
    • Sivachandran, N., Sarkari, F. & Frappier, L. Epstein-Barr nuclear antigen 1 contributes to nasopharyngeal carcinoma through disruption of PML nuclear bodies. PLoS Pathog. 4, e1000170 (2008).
    • (2008) PLoS Pathog. , vol.4
    • Sivachandran, N.1    Sarkari, F.2    Frappier, L.3
  • 83
    • 78650248298 scopus 로고    scopus 로고
    • Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice
    • Yang, Y. et al. Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice. Glia 59, 200-207 (2011).
    • (2011) Glia , vol.59 , pp. 200-207
    • Yang, Y.1
  • 84
    • 84903362440 scopus 로고    scopus 로고
    • Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain
    • Coppieters, N. et al. Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain. Neurobiol. Aging 35, 1334-1344 (2014).
    • (2014) Neurobiol. Aging , vol.35 , pp. 1334-1344
    • Coppieters, N.1
  • 85
    • 77954517681 scopus 로고    scopus 로고
    • Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice
    • Kocherhans, S. et al. Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice. J. Neurosci. 30, 9228-9240 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 9228-9240
    • Kocherhans, S.1


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