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Volumn 30, Issue 27, 2010, Pages 9228-9240

Reduced Reelin expression accelerates amyloid-β plaque formation and Tau pathology in transgenic Alzheimer's disease mice

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; REELIN; TAU PROTEIN;

EID: 77954517681     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0418-10.2010     Document Type: Article
Times cited : (106)

References (62)
  • 1
    • 0345894331 scopus 로고    scopus 로고
    • Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta
    • Beffert U, Morfini G, Bock HH, Reyna H, Brady ST, Herz J (2002) Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta. J Biol Chem 277:49958-49964.
    • (2002) J Biol Chem , vol.277 , pp. 49958-49964
    • Beffert, U.1    Morfini, G.2    Bock, H.H.3    Reyna, H.4    Brady, S.T.5    Herz, J.6
  • 2
    • 1442300201 scopus 로고    scopus 로고
    • Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission
    • Beffert U, Weeber EJ, Morfini G, Ko J, Brady ST, Tsai LH, Sweatt JD, Herz J (2004) Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. J Neurosci 24:1897-1906.
    • (2004) J Neurosci , vol.24 , pp. 1897-1906
    • Beffert, U.1    Weeber, E.J.2    Morfini, G.3    Ko, J.4    Brady, S.T.5    Tsai, L.H.6    Sweatt, J.D.7    Herz, J.8
  • 4
    • 33644512817 scopus 로고    scopus 로고
    • Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: Distinct roles in development and synaptic plasticity
    • Beffert U, Durudas A, Weeber EJ, Stolt PC, Giehl KM, Sweatt JD, Hammer RE, Herz J (2006a) Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity. J Neurosci 26:2041-2052.
    • (2006) J Neurosci , vol.26 , pp. 2041-2052
    • Beffert, U.1    Durudas, A.2    Weeber, E.J.3    Stolt, P.C.4    Giehl, K.M.5    Sweatt, J.D.6    Hammer, R.E.7    Herz, J.8
  • 6
    • 52449089987 scopus 로고    scopus 로고
    • Thirty years of Alzheimer's disease genetics: The implications of systematic meta-analyses
    • Bertram L, Tanzi RE (2008) Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nat Rev Neurosci 9:768-778.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 768-778
    • Bertram, L.1    Tanzi, R.E.2
  • 7
    • 33846047004 scopus 로고    scopus 로고
    • Pathways by which Abeta facilitates tau pathology
    • Blurton-Jones M, Laferla FM (2006) Pathways by which Abeta facilitates tau pathology. Curr Alzheimer Res 3:437-448.
    • (2006) Curr Alzheimer Res , vol.3 , pp. 437-448
    • Blurton-Jones, M.1    Laferla, F.M.2
  • 10
    • 0029686696 scopus 로고    scopus 로고
    • Evolution of the neuropathology of Alzheimer's disease
    • Braak H, Braak E (1996) Evolution of the neuropathology of Alzheimer's disease. Acta Neurol Scand Suppl 165:3-12.
    • (1996) Acta Neurol Scand Suppl , vol.165 , pp. 3-12
    • Braak, H.1    Braak, E.2
  • 13
    • 33847772938 scopus 로고    scopus 로고
    • The killing of neurons by beta-amyloid peptides, prions, and pro-inflammatory cytokines
    • Chiarini A, Dal Pra I, Whitfield JF, Armato U (2006) The killing of neurons by beta-amyloid peptides, prions, and pro-inflammatory cytokines. Ital J Anat Embryol 111:221-246.
    • (2006) Ital J Anat Embryol , vol.111 , pp. 221-246
    • Chiarini, A.1    Dal Pra, I.2    Whitfield, J.F.3    Armato, U.4
  • 14
    • 33947320450 scopus 로고    scopus 로고
    • Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease
    • Chin J, Massaro CM, Palop JJ, Thwin MT, Yu GQ, Bien-Ly N, Bender A, Mucke L (2007) Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease. J Neurosci 27:2727-2733.
    • (2007) J Neurosci , vol.27 , pp. 2727-2733
    • Chin, J.1    Massaro, C.M.2    Palop, J.J.3    Thwin, M.T.4    Yu, G.Q.5    Bien-Ly, N.6    Bender, A.7    Mucke, L.8
  • 15
    • 0028940096 scopus 로고
    • A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
    • D'Arcangelo G, Miao GG, Chen SC, Soares HD, Morgan JI, Curran T (1995) A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature 374:719-723.
    • (1995) Nature , vol.374 , pp. 719-723
    • D'Arcangelo, G.1    Miao, G.G.2    Chen, S.C.3    Soares, H.D.4    Morgan, J.I.5    Curran, T.6
  • 16
    • 77950363927 scopus 로고    scopus 로고
    • Colocalization of Reelin and proteolytic AbetaPP fragments in hippocampal plaques in aged wild-type mice
    • Doehner J, Madhusudan A, Konietzko U, Fritschy JM, Knuesel I (2010) Colocalization of Reelin and proteolytic AbetaPP fragments in hippocampal plaques in aged wild-type mice. J Alzheimers Dis 19:1339-1357.
    • (2010) J Alzheimers Dis , vol.19 , pp. 1339-1357
    • Doehner, J.1    Madhusudan, A.2    Konietzko, U.3    Fritschy, J.M.4    Knuesel, I.5
  • 17
    • 56349166514 scopus 로고    scopus 로고
    • Mechanisms of microglia accumulation in Alzheimer's disease: Therapeutic implications
    • El Khoury J, Luster AD (2008) Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications. Trends Pharmacol Sci 29:626-632.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 626-632
    • El Khoury, J.1    Luster, A.D.2
  • 19
    • 0029841562 scopus 로고    scopus 로고
    • Increased activity-regulating and neuroprotective efficacy of alpha- Secretase-derived secreted amyloid precursor protein conferred by a C- terminal heparin-binding domain
    • Furukawa K, Sopher BL, Rydel RE, Begley JG, Pham DG, Martin GM, Fox M, Mattson MP (1996) Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain. J Neurochem 67:1882-1896. (Pubitemid 26349661)
    • (1996) Journal of Neurochemistry , vol.67 , Issue.5 , pp. 1882-1896
    • Furukawa, K.1    Sopher, B.L.2    Rydel, R.E.3    Begley, J.G.4    Pham, D.G.5    Martin, G.M.6    Fox, M.7    Mattson, M.P.8
  • 20
    • 0035909901 scopus 로고    scopus 로고
    • The gamma-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus
    • Gao Y, Pimplikar SW (2001) The gamma-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus. Proc Natl Acad Sci U S A 98:14979-14984.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 14979-14984
    • Gao, Y.1    Pimplikar, S.W.2
  • 21
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner GG, Wong CW (1984) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120:885-890. (Pubitemid 14104991)
    • (1984) Biochemical and Biophysical Research Communications , vol.120 , Issue.3 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 24
    • 0026735070 scopus 로고
    • Targeting of cell-surface beta-amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments
    • Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ (1992) Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 357:500-503.
    • (1992) Nature , vol.357 , pp. 500-503
    • Haass, C.1    Koo, E.H.2    Mellon, A.3    Hung, A.Y.4    Selkoe, D.J.5
  • 25
    • 12944325316 scopus 로고    scopus 로고
    • Molecular heterogeneity of the dystrophin-associated protein complex in the mouse kidney nephron: Differential alterations in the absence of utrophin and dystrophin
    • DOI 10.1007/s00441-004-0999-y
    • Haenggi T, Schaub MC, Fritschy JM (2005) Molecular heterogeneity of the dystrophin-associated protein complex in the mouse kidney nephron: differential alterations in the absence of utrophin and dystrophin. Cell Tissue Res 319:299-313. (Pubitemid 40174523)
    • (2005) Cell and Tissue Research , vol.319 , Issue.2 , pp. 299-313
    • Haenggi, T.1    Schaub, M.C.2    Fritschy, J.-M.3
  • 26
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297:353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 27
    • 67049155952 scopus 로고    scopus 로고
    • Apolipoprotein E receptors in the nervous system
    • Herz J (2009) Apolipoprotein E receptors in the nervous system. Curr Opin Lipidol 20:190-196.
    • (2009) Curr Opin Lipidol , vol.20 , pp. 190-196
    • Herz, J.1
  • 28
    • 51149120624 scopus 로고    scopus 로고
    • Microglial dysfunction and defective β-amyloid clearance pathways in aging Alzheimer's disease mice
    • Hickman SE, Allison EK, El Khoury J (2008) Microglial dysfunction and defective β-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci 28:8354-8360.
    • (2008) J Neurosci , vol.28 , pp. 8354-8360
    • Hickman, S.E.1    Allison, E.K.2    El Khoury, J.3
  • 29
    • 0033213319 scopus 로고    scopus 로고
    • Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation
    • Hiesberger T, Trommsdorff M, Howell BW, Goffinet A, Mumby MC, Cooper JA, Herz J (1999) Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron 24:481-489.
    • (1999) Neuron , vol.24 , pp. 481-489
    • Hiesberger, T.1    Trommsdorff, M.2    Howell, B.W.3    Goffinet, A.4    Mumby, M.C.5    Cooper, J.A.6    Herz, J.7
  • 30
    • 50349092478 scopus 로고    scopus 로고
    • Regulated proteolysis of APP and ApoE receptors
    • Hoe HS, Rebeck GW (2008) Regulated proteolysis of APP and ApoE receptors. Mol Neurobiol 37:64-72.
    • (2008) Mol Neurobiol , vol.37 , pp. 64-72
    • Hoe, H.S.1    Rebeck, G.W.2
  • 31
    • 33845925306 scopus 로고    scopus 로고
    • Dab1 and Reelin effects on APP and ApoEr2 trafficking and processing
    • Hoe HS, Tran TS, Matsuoka Y, Howell BW, Rebeck GW (2006) Dab1 and Reelin effects on APP and ApoEr2 trafficking and processing. J Biol Chem 281:35176-35185.
    • (2006) J Biol Chem , vol.281 , pp. 35176-35185
    • Hoe, H.S.1    Tran, T.S.2    Matsuoka, Y.3    Howell, B.W.4    Rebeck, G.W.5
  • 33
    • 34247354614 scopus 로고    scopus 로고
    • Processing of Reelin by embryonic neurons is important for function in tissue but not in dissociated cultured neurons
    • Jossin Y, Gui L, Goffinet AM (2007) Processing of Reelin by embryonic neurons is important for function in tissue but not in dissociated cultured neurons. J Neurosci 27:4243-4252.
    • (2007) J Neurosci , vol.27 , pp. 4243-4252
    • Jossin, Y.1    Gui, L.2    Goffinet, A.M.3
  • 34
    • 34447564164 scopus 로고    scopus 로고
    • Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice
    • DOI 10.1016/j.neurobiolaging.2006.06.019, PII S0197458006002259
    • Knobloch M, Konietzko U, Krebs DC, Nitsch RM (2007) Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice. Neurobiol Aging 28:1297-1306. (Pubitemid 47081235)
    • (2007) Neurobiology of Aging , vol.28 , Issue.9 , pp. 1297-1306
    • Knobloch, M.1    Konietzko, U.2    Krebs, D.C.3    Nitsch, R.M.4
  • 37
    • 0037112942 scopus 로고    scopus 로고
    • A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling
    • Koch S, Strasser V, Hauser C, Fasching D, Brandes C, Bajari TM, Schneider WJ, Nimpf J (2002) A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling. EMBO J 21:5996-6004.
    • (2002) EMBO J , vol.21 , pp. 5996-6004
    • Koch, S.1    Strasser, V.2    Hauser, C.3    Fasching, D.4    Brandes, C.5    Bajari, T.M.6    Schneider, W.J.7    Nimpf, J.8
  • 38
    • 0036312590 scopus 로고    scopus 로고
    • Secreted Reelin molecules form homodimers
    • Kubo K, Mikoshiba K, Nakajima K (2002) Secreted Reelin molecules form homodimers. Neurosci Res 43:381-388.
    • (2002) Neurosci Res , vol.43 , pp. 381-388
    • Kubo, K.1    Mikoshiba, K.2    Nakajima, K.3
  • 39
    • 0001025605 scopus 로고    scopus 로고
    • Reelin, the extracellular matrix protein deficient in reeler mutant mice, is processed by a metalloproteinase
    • Lambert de Rouvroit C, de Bergeyck V, Cortvrindt C, Bar I, Eeckhout Y, Goffinet AM (1999) Reelin, the extracellular matrix protein deficient in reeler mutant mice, is processed by a metalloproteinase. Exp Neurol 156:214-217.
    • (1999) Exp Neurol , vol.156 , pp. 214-217
    • Lambert De Rouvroit, C.1    De Bergeyck, V.2    Cortvrindt, C.3    Bar, I.4    Eeckhout, Y.5    Goffinet, A.M.6
  • 41
    • 10344238086 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gammasecretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway
    • Liao YF, Wang BJ, Cheng HT, Kuo LH, Wolfe MS (2004) Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gammasecretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. J Biol Chem 279:49523-49532.
    • (2004) J Biol Chem , vol.279 , pp. 49523-49532
    • Liao, Y.F.1    Wang, B.J.2    Cheng, H.T.3    Kuo, L.H.4    Wolfe, M.S.5
  • 42
    • 70349213977 scopus 로고    scopus 로고
    • Accumulation of reelin-positive plaques is accompanied by a decline in basal forebrain projection neurons during normal aging
    • Madhusudan A, Sidler C, Knuesel I (2009) Accumulation of reelin-positive plaques is accompanied by a decline in basal forebrain projection neurons during normal aging. Eur J Neurosci 30:1064-1076.
    • (2009) Eur J Neurosci , vol.30 , pp. 1064-1076
    • Madhusudan, A.1    Sidler, C.2    Knuesel, I.3
  • 43
    • 0023633015 scopus 로고
    • Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR
    • McGeer PL, Itagaki S, Tago H, McGeer EG (1987) Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR. Neurosci Lett 79:195-200. (Pubitemid 17144469)
    • (1987) Neuroscience Letters , vol.79 , Issue.1-2 , pp. 195-200
    • McGeer, P.L.1    Itagaki, S.2    Tago, H.3    McGeer, E.G.4
  • 45
    • 33947168671 scopus 로고    scopus 로고
    • Reelin signaling facilitates maturation of CA1 glutamatergic synapses
    • Qiu S, Weeber EJ (2007) Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J Neurophysiol 97:2312-2321.
    • (2007) J Neurophysiol , vol.97 , pp. 2312-2321
    • Qiu, S.1    Weeber, E.J.2
  • 46
    • 33845606845 scopus 로고    scopus 로고
    • Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus
    • Qiu S, Zhao LF, Korwek KM, Weeber EJ (2006) Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus. J Neurosci 26:12943-12955.
    • (2006) J Neurosci , vol.26 , pp. 12943-12955
    • Qiu, S.1    Zhao, L.F.2    Korwek, K.M.3    Weeber, E.J.4
  • 49
    • 0029101491 scopus 로고
    • Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
    • Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376:775-778.
    • (1995) Nature , vol.376 , pp. 775-778
    • Rogaev, E.I.1    Sherrington, R.2    Rogaeva, E.A.3    Levesque, G.4    Ikeda, M.5    Liang, Y.6    Chi, H.7    Lin, C.8    Holman, K.9    Tsuda, T.10
  • 51
    • 27644547658 scopus 로고    scopus 로고
    • Neuropsychology in Alzheimer's disease and other dementia research
    • Savla GN, Palmer BW (2005) Neuropsychology in Alzheimer's disease and other dementia research. Curr Opin Psychiatry 18:621-627. (Pubitemid 41578729)
    • (2005) Current Opinion in Psychiatry , vol.18 , Issue.6 , pp. 621-627
    • Savla, G.N.1    Palmer, B.W.2
  • 52
    • 0034516988 scopus 로고    scopus 로고
    • Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein
    • Selkoe DJ (2000) Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. Ann N Y Acad Sci 924:17-25.
    • (2000) Ann N Y Acad Sci , vol.924 , pp. 17-25
    • Selkoe, D.J.1
  • 57
    • 5444275067 scopus 로고    scopus 로고
    • The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor
    • von Rotz RC, Kohli BM, Bosset J, Meier M, Suzuki T, Nitsch RM, Konietzko U (2004) The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J Cell Sci 117:4435-4448.
    • (2004) J Cell Sci , vol.117 , pp. 4435-4448
    • Von Rotz, R.C.1    Kohli, B.M.2    Bosset, J.3    Meier, M.4    Suzuki, T.5    Nitsch, R.M.6    Konietzko, U.7
  • 58
    • 5344277556 scopus 로고    scopus 로고
    • Deciphering the molecular basis of memory failure in Alzheimer's disease
    • Walsh DM, Selkoe DJ (2004) Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron 44:181-193.
    • (2004) Neuron , vol.44 , pp. 181-193
    • Walsh, D.M.1    Selkoe, D.J.2
  • 60
    • 33748471099 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease: Driving force, bystander or beneficial response?
    • Wyss-Coray T (2006) Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat Med 12:1005-1015.
    • (2006) Nat Med , vol.12 , pp. 1005-1015
    • Wyss-Coray, T.1
  • 61
    • 33947512432 scopus 로고    scopus 로고
    • Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice
    • Yamamoto M, Kiyota T, Horiba M, Buescher JL, Walsh SM, Gendelman HE, Ikezu T (2007) Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. Am J Pathol 170:680-692.
    • (2007) Am J Pathol , vol.170 , pp. 680-692
    • Yamamoto, M.1    Kiyota, T.2    Horiba, M.3    Buescher, J.L.4    Walsh, S.M.5    Gendelman, H.E.6    Ikezu, T.7
  • 62
    • 34547173322 scopus 로고    scopus 로고
    • Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors
    • Yasui N, Nogi T, Kitao T, Nakano Y, Hattori M, Takagi J (2007) Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors. Proc Natl Acad Sci U S A 104:9988-9993.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 9988-9993
    • Yasui, N.1    Nogi, T.2    Kitao, T.3    Nakano, Y.4    Hattori, M.5    Takagi, J.6


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