메뉴 건너뛰기




Volumn 16, Issue 3, 2015, Pages 159-171

Chromatin regulation at the frontier of synthetic biology

Author keywords

[No Author keywords available]

Indexed keywords

CRYPTOCHROME 2; DNA BINDING PROTEIN; GENOMIC DNA; GLOBIN; HELIX LOOP HELIX PROTEIN; HISTONE; LYSINE; RAPAMYCIN; RNA; SMALL INTERFERING RNA; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; UNTRANSLATED RNA; ZINC FINGER PROTEIN; CHROMATIN;

EID: 84923642913     PISSN: 14710056     EISSN: 14710064     Source Type: Journal    
DOI: 10.1038/nrg3900     Document Type: Review
Times cited : (78)

References (130)
  • 1
    • 0034688174 scopus 로고    scopus 로고
    • Construction of a genetic toggle switch in Escherichia coli
    • Gardner, T. S., Cantor, C. R. & Collins, J. J. Construction of a genetic toggle switch in Escherichia coli. Nature 403, 339-342 (2000).
    • (2000) Nature , vol.403 , pp. 339-342
    • Gardner, T.S.1    Cantor, C.R.2    Collins, J.J.3
  • 2
    • 0034688173 scopus 로고    scopus 로고
    • A synthetic oscillatory network of transcriptional regulators
    • Elowitz, M. B. & Leibler, S. A synthetic oscillatory network of transcriptional regulators. Nature 403, 335-338 (2000).
    • (2000) Nature , vol.403 , pp. 335-338
    • Elowitz, M.B.1    Leibler, S.2
  • 3
    • 84897482912 scopus 로고    scopus 로고
    • Programmable bacteria detect and record an environmental signal in the mammalian gut
    • Kotula, J. W. et al. Programmable bacteria detect and record an environmental signal in the mammalian gut. Proc. Natl Acad. Sci. USA 111, 4838-4843 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 4838-4843
    • Kotula, J.W.1
  • 4
    • 84890224783 scopus 로고    scopus 로고
    • Synthetic mammalian gene circuits for biomedical applications
    • Ye, H., Aubel, D. & Fussenegger, M. Synthetic mammalian gene circuits for biomedical applications. Curr. Opin. Chem. Biol. 17, 910-917 (2013).
    • (2013) Curr. Opin. Chem. Biol. , vol.17 , pp. 910-917
    • Ye, H.1    Aubel, D.2    Fussenegger, M.3
  • 5
    • 0033538531 scopus 로고    scopus 로고
    • Fundamentally different logic of gene regulation in eukaryotes and prokaryotes
    • Struhl, K. Fundamentally different logic of gene regulation in eukaryotes and prokaryotes. Cell 98, 1-4 (1999).
    • (1999) Cell , vol.98 , pp. 1-4
    • Struhl, K.1
  • 6
    • 67649305191 scopus 로고    scopus 로고
    • Epigenetics in cancer: Targeting chromatin modifications
    • Ellis, L., Atadja, P. W. & Johnstone, R. W. Epigenetics in cancer: targeting chromatin modifications. Mol. Cancer Ther. 8, 1409-1420 (2009).
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 1409-1420
    • Ellis, L.1    Atadja, P.W.2    Johnstone, R.W.3
  • 7
    • 79955583542 scopus 로고    scopus 로고
    • Mapping and analysis of chromatin state dynamics in nine human cell types
    • Ernst, J. et al. Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 473, 43-49 (2011).
    • (2011) Nature , vol.473 , pp. 43-49
    • Ernst, J.1
  • 9
    • 84859218238 scopus 로고    scopus 로고
    • Chromatin-modifying enzymes as modulators of reprogramming
    • Onder, T. T. et al. Chromatin-modifying enzymes as modulators of reprogramming. Nature 483, 598-602 (2012).
    • (2012) Nature , vol.483 , pp. 598-602
    • Onder, T.T.1
  • 10
    • 84858603551 scopus 로고    scopus 로고
    • Tell-tail sign of chromatin: Histone mutations drive pediatric glioblastoma
    • Rheinbay, E., Louis, David, N., Bernstein, Bradley, E. & Suvà, Mario, L. A. Tell-tail sign of chromatin: histone mutations drive pediatric glioblastoma. Cancer Cell 21, 329-331 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 329-331
    • Rheinbay, E.1    Louis David, N.2    Bernstein Bradley, E.3    Suvà, M.L.A.4
  • 11
    • 84865248380 scopus 로고    scopus 로고
    • Chromatin organization is a major influence on regional mutation rates in human cancer cells
    • Schuster-Böckler, B. & Lehner, B. Chromatin organization is a major influence on regional mutation rates in human cancer cells. Nature 488, 504-507 (2012).
    • (2012) Nature , vol.488 , pp. 504-507
    • Schuster-Böckler, B.1    Lehner, B.2
  • 12
    • 84873310426 scopus 로고    scopus 로고
    • Genome-wide chromatin state transitions associated with developmental and environmental cues
    • Zhu, J. et al. Genome-wide chromatin state transitions associated with developmental and environmental cues. Cell 152, 642-654 (2013).
    • (2013) Cell , vol.152 , pp. 642-654
    • Zhu, J.1
  • 14
    • 84872269321 scopus 로고    scopus 로고
    • Nucleosome-driven transcription factor binding and gene regulation
    • Ballare, C. et al. Nucleosome-driven transcription factor binding and gene regulation. Mol. Cell 49, 67-79 (2013).
    • (2013) Mol. Cell , vol.49 , pp. 67-79
    • Ballare, C.1
  • 15
    • 0033529565 scopus 로고    scopus 로고
    • Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome
    • Kornberg, R. D. & Lorch, Y. Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell 98, 285-294 (1999).
    • (1999) Cell , vol.98 , pp. 285-294
    • Kornberg, R.D.1    Lorch, Y.2
  • 16
    • 0037154963 scopus 로고    scopus 로고
    • Cooperation between complexes that regulate chromatin structure and transcription
    • Narlikar, G. J., Fan, H. Y. & Kingston, R. E. Cooperation between complexes that regulate chromatin structure and transcription. Cell 108, 475-487 (2002).
    • (2002) Cell , vol.108 , pp. 475-487
    • Narlikar, G.J.1    Fan, H.Y.2    Kingston, R.E.3
  • 17
    • 84907221181 scopus 로고    scopus 로고
    • Transcription factor binding predicts histone modifications in human cell lines
    • Benveniste, D., Sonntag, H. J., Sanguinetti, G. & Sproul, D. Transcription factor binding predicts histone modifications in human cell lines. Proc. Natl Acad. Sci. USA 111, 13367-13372 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 13367-13372
    • Benveniste, D.1    Sonntag, H.J.2    Sanguinetti, G.3    Sproul, D.4
  • 18
    • 33846283384 scopus 로고    scopus 로고
    • Dynamic genome architecture in the nuclear space: Regulation of gene expression in three dimensions
    • Lanctot, C., Cheutin, T., Cremer, M., Cavalli, G. & Cremer, T. Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions. Nature Rev. Genet. 8, 104-115 (2007).
    • (2007) Nature Rev. Genet. , vol.8 , pp. 104-115
    • Lanctot, C.1    Cheutin, T.2    Cremer, M.3    Cavalli, G.4    Cremer, T.5
  • 19
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • Dunham, I. et al. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57-74 (2012).
    • (2012) Nature , vol.489 , pp. 57-74
    • Dunham, I.1
  • 20
    • 84455200582 scopus 로고    scopus 로고
    • Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells
    • Ram, O. et al. Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells. Cell 147, 1628-1639 (2011).
    • (2011) Cell , vol.147 , pp. 1628-1639
    • Ram, O.1
  • 21
    • 78650304236 scopus 로고    scopus 로고
    • Charting histone modifications and the functional organization of mammalian genomes
    • Zhou, V. W., Goren, A. & Bernstein, B. E. Charting histone modifications and the functional organization of mammalian genomes. Nature Rev. Genet. 12, 7-18 (2011).
    • (2011) Nature Rev. Genet. , vol.12 , pp. 7-18
    • Zhou, V.W.1    Goren, A.2    Bernstein, B.E.3
  • 22
    • 67650725820 scopus 로고    scopus 로고
    • The biology of chromatin remodeling complexes
    • Clapier, C. R. & Cairns, B. R. The biology of chromatin remodeling complexes. Annu. Rev. Biochem. 78, 273-304 (2009).
    • (2009) Annu. Rev. Biochem. , vol.78 , pp. 273-304
    • Clapier, C.R.1    Cairns, B.R.2
  • 23
    • 78651162036 scopus 로고
    • Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis
    • Allfrey, V. G., Faulkner, R. & Mirsky, A. E. Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis. Proc. Natl Acad. Sci. USA 51, 786-794 (1964).
    • (1964) Proc. Natl Acad. Sci. USA , vol.51 , pp. 786-794
    • Allfrey, V.G.1    Faulkner, R.2    Mirsky, A.E.3
  • 24
    • 0014430407 scopus 로고
    • Chemical studies of histone acetylation. The distribution of-N-acetyllysine in calf thymus histones
    • Vidali, G., Gershey, E. L. & Allfrey, V. G. Chemical studies of histone acetylation. The distribution of-N-acetyllysine in calf thymus histones. J. Biol. Chem. 243, 6361-6366 (1968).
    • (1968) J. Biol. Chem. , vol.243 , pp. 6361-6366
    • Vidali, G.1    Gershey, E.L.2    Allfrey, V.G.3
  • 25
    • 80052942443 scopus 로고    scopus 로고
    • Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
    • Tan, M. et al. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 146, 1016-1028 (2011).
    • (2011) Cell , vol.146 , pp. 1016-1028
    • Tan, M.1
  • 26
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • Strahl, B. D. & Allis, C. D. The language of covalent histone modifications. Nature 403, 41-45 (2000).
    • (2000) Nature , vol.403 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 27
    • 80052805267 scopus 로고    scopus 로고
    • Histone modification: Cause or cog
    • Henikoff, S. & Shilatifard, A. Histone modification: cause or cog Trends Genet. 27, 389-396 (2011).
    • (2011) Trends Genet , vol.27 , pp. 389-396
    • Henikoff, S.1    Shilatifard, A.2
  • 28
    • 84865179248 scopus 로고    scopus 로고
    • The adjustable nucleosome: An epigenetic signaling module
    • Turner, B. M. The adjustable nucleosome: an epigenetic signaling module. Trends Genet. 28, 436-444 (2012).
    • (2012) Trends Genet. , vol.28 , pp. 436-444
    • Turner, B.M.1
  • 29
    • 84904070796 scopus 로고    scopus 로고
    • Engineering chromatin states: Chemical and synthetic biology approaches to investigate histone modification function
    • Pick, H., Kilic, S. & Fierz, B. Engineering chromatin states: chemical and synthetic biology approaches to investigate histone modification function. Biochim. Biophys. Acta 1839, 644-656 (2014).
    • (2014) Biochim. Biophys. Acta , vol.1839 , pp. 644-656
    • Pick, H.1    Kilic, S.2    Fierz, B.3
  • 30
    • 0142123130 scopus 로고    scopus 로고
    • Facile synthesis of site-specifically acetylated and methylated histone proteins: Reagents for evaluation of the histone code hypothesis
    • He, S. et al. Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis. Proc. Natl Acad. Sci. USA 100, 12033-12038 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 12033-12038
    • He, S.1
  • 31
    • 84880207420 scopus 로고    scopus 로고
    • Preparing semisynthetic and fully synthetic histones H3 and H4 to modify the nucleosome core
    • Shimko, J. C., Howard, C. J., Poirier, M. G. & Ottesen, J. J. Preparing semisynthetic and fully synthetic histones H3 and H4 to modify the nucleosome core. Methods Mol. Biol. 981, 177-192 (2013).
    • (2013) Methods Mol. Biol. , vol.981 , pp. 177-192
    • Shimko, J.C.1    Howard, C.J.2    Poirier, M.G.3    Ottesen, J.J.4
  • 32
    • 84905217856 scopus 로고    scopus 로고
    • Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries
    • Nguyen, U. T. et al. Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries. Nature Methods 11, 834-840 (2014).
    • (2014) Nature Methods , vol.11 , pp. 834-840
    • Nguyen, U.T.1
  • 33
    • 70349765673 scopus 로고    scopus 로고
    • A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3K56 acetylation
    • Neumann, H. et al. A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3K56 acetylation. Mol. Cell 36, 153-163 (2009).
    • (2009) Mol. Cell , vol.36 , pp. 153-163
    • Neumann, H.1
  • 34
    • 84857451064 scopus 로고    scopus 로고
    • Designer proteins: Applications of genetic code expansion in cell biology
    • Davis, L. & Chin, J. W. Designer proteins: applications of genetic code expansion in cell biology. Nature Rev. Mol. Cell Biol. 13, 168-182 (2012).
    • (2012) Nature Rev. Mol. Cell Biol. , vol.13 , pp. 168-182
    • Davis, L.1    Chin, J.W.2
  • 36
    • 78049412986 scopus 로고    scopus 로고
    • Genetically directing-N, N-dimethyl-l-lysine in recombinant histones
    • Nguyen, D. P., Garcia Alai, M. M., Virdee, S. & Chin, J. W. Genetically directing-N, N-dimethyl-l-lysine in recombinant histones. Chem. Biol. 17, 1072-1076 (2010).
    • (2010) Chem. Biol. , vol.17 , pp. 1072-1076
    • Nguyen, D.P.1    Garcia Alai, M.M.2    Virdee, S.3    Chin, J.W.4
  • 37
    • 0041520960 scopus 로고    scopus 로고
    • An expanded eukaryotic genetic code
    • Chin, J. W. et al. An expanded eukaryotic genetic code. Science 301, 964-967 (2003).
    • (2003) Science , vol.301 , pp. 964-967
    • Chin, J.W.1
  • 38
    • 17244368913 scopus 로고    scopus 로고
    • Genomic characterization reveals a simple histone H4 acetylation code
    • Dion, M. F., Altschuler, S. J., Wu, L. F. & Rando, O. J. Genomic characterization reveals a simple histone H4 acetylation code. Proc. Natl Acad. Sci. USA 102, 5501-5506 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 5501-5506
    • Dion, M.F.1    Altschuler, S.J.2    Wu, L.F.3    Rando, O.J.4
  • 39
    • 84859579664 scopus 로고    scopus 로고
    • Mutagenesis of pairwise combinations of histone amino-terminal tails reveals functional redundancy in budding yeast
    • Kim, J. A., Hsu, J. Y., Smith, M. M. & Allis, C. D. Mutagenesis of pairwise combinations of histone amino-terminal tails reveals functional redundancy in budding yeast. Proc. Natl Acad. Sci. USA 109, 5779-5784 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 5779-5784
    • Kim, J.A.1    Hsu, J.Y.2    Smith, M.M.3    Allis, C.D.4
  • 40
    • 51549087123 scopus 로고    scopus 로고
    • Probing nucleosome function: A highly versatile library of synthetic histone H3 and H4 mutants
    • Dai, J. et al. Probing nucleosome function: a highly versatile library of synthetic histone H3 and H4 mutants. Cell 134, 1066-1078 (2008).
    • (2008) Cell , vol.134 , pp. 1066-1078
    • Dai, J.1
  • 41
    • 84872865881 scopus 로고    scopus 로고
    • Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3A-Dnmt3L single-chain fusion protein with increased DNA methylation activity
    • Siddique, A. N. et al. Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3A-Dnmt3L single-chain fusion protein with increased DNA methylation activity. J. Mol. Biol. 425, 479-491 (2013).
    • (2013) J. Mol. Biol. , vol.425 , pp. 479-491
    • Siddique, A.N.1
  • 42
    • 0022328481 scopus 로고
    • A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor
    • Brent, R. & Ptashne, M. A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor. Cell 43, 729-736 (1985).
    • (1985) Cell , vol.43 , pp. 729-736
    • Brent, R.1    Ptashne, M.2
  • 43
    • 84870583474 scopus 로고    scopus 로고
    • Epigenetic editing: Targeted rewriting of epigenetic marks to modulate expression of selected target genes
    • de Groote, M. L., Verschure, P. J. & Rots, M. G. Epigenetic editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes. Nucleic Acids Res. 40, 10596-10613 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , pp. 10596-10613
    • De Groote, M.L.1    Verschure, P.J.2    Rots, M.G.3
  • 44
    • 84879264708 scopus 로고    scopus 로고
    • TALEN, and CRISPR/Cas-based methods for genome engineering
    • Gaj, T., Gersbach, C. A. & Barbas, C. F. 3rd. ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol. 31, 397-405 (2013).
    • (2013) Trends Biotechnol. , vol.31 , pp. 397-405
    • Gaj, T.1    Gersbach, C.A.2    Zfn, F.B.C.3
  • 45
    • 84890048526 scopus 로고    scopus 로고
    • Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins
    • Maeder, M. L. et al. Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins. Nature Biotech. 31, 1137-1142 (2013).
    • (2013) Nature Biotech. , vol.31 , pp. 1137-1142
    • Maeder, M.L.1
  • 46
    • 84894248678 scopus 로고    scopus 로고
    • Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter
    • Chen, H. et al. Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter. Nucleic Acids Res. 42, 1563-1574 (2014).
    • (2014) Nucleic Acids Res. , vol.42 , pp. 1563-1574
    • Chen, H.1
  • 47
    • 0345531138 scopus 로고    scopus 로고
    • Site-selective in vivo targeting of cytosine-5 DNA methylation by zinc-finger proteins
    • Carvin, C. D., Parr, R. D. & Kladde, M. P. Site-selective in vivo targeting of cytosine-5 DNA methylation by zinc-finger proteins. Nucleic Acids Res. 31, 6493-6501 (2003).
    • (2003) Nucleic Acids Res. , vol.31 , pp. 6493-6501
    • Carvin, C.D.1    Parr, R.D.2    Kladde, M.P.3
  • 48
    • 84860561774 scopus 로고    scopus 로고
    • Epigenetic reprogramming of cancer cells via targeted DNA methylation
    • Rivenbark, A. G. et al. Epigenetic reprogramming of cancer cells via targeted DNA methylation. Epigenetics 7, 350-360 (2012).
    • (2012) Epigenetics , vol.7 , pp. 350-360
    • Rivenbark, A.G.1
  • 49
    • 84900412888 scopus 로고    scopus 로고
    • Targeted methylation of the epithelial cell adhesion molecule (EpCAM) promoter to silence its expression in ovarian cancer cells
    • Nunna, S., Reinhardt, R., Ragozin, S. & Jeltsch, A. Targeted methylation of the epithelial cell adhesion molecule (EpCAM) promoter to silence its expression in ovarian cancer cells. PLoS ONE 9, e87703 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e87703
    • Nunna, S.1    Reinhardt, R.2    Ragozin, S.3    Jeltsch, A.4
  • 50
    • 84884475055 scopus 로고    scopus 로고
    • Towards sustained silencing of HER2/neu in cancer by epigenetic editing
    • Falahi, F. et al. Towards sustained silencing of HER2/neu in cancer by epigenetic editing. Mol. Cancer Res. 11, 1029-1039 (2013).
    • (2013) Mol. Cancer Res. , vol.11 , pp. 1029-1039
    • Falahi, F.1
  • 51
    • 0037164741 scopus 로고    scopus 로고
    • Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo
    • Snowden, A. W., Gregory, P. D., Case, C. C. & Pabo, C. O. Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo. Curr. Biol. 12, 2159-2166 (2002).
    • (2002) Curr. Biol. , vol.12 , pp. 2159-2166
    • Snowden, A.W.1    Gregory, P.D.2    Case, C.C.3    Pabo, C.O.4
  • 52
    • 84886084801 scopus 로고    scopus 로고
    • Locus-specific editing of histone modifications at endogenous enhancers
    • Mendenhall, E. M. et al. Locus-specific editing of histone modifications at endogenous enhancers. Nature Biotech. 31, 1133-1136 (2013).
    • (2013) Nature Biotech. , vol.31 , pp. 1133-1136
    • Mendenhall, E.M.1
  • 53
    • 84903942172 scopus 로고    scopus 로고
    • Using targeted chromatin regulators to engineer combinatorial and spatial transcriptional regulation
    • Keung, A. J., Bashor, C. J., Kiriakov, S., Collins, J. J. & Khalil, A. S. Using targeted chromatin regulators to engineer combinatorial and spatial transcriptional regulation. Cell 158, 110-120 (2014).
    • (2014) Cell , vol.158 , pp. 110-120
    • Keung, A.J.1    Bashor, C.J.2    Kiriakov, S.3    Collins, J.J.4    Khalil, A.S.5
  • 54
    • 77950495366 scopus 로고    scopus 로고
    • Heterodimeric DNA methyltransferases as a platform for creating designer zinc finger methyltransferases for targeted DNA methylation in cells
    • Meister, G. E., Chandrasegaran, S. & Ostermeier, M. Heterodimeric DNA methyltransferases as a platform for creating designer zinc finger methyltransferases for targeted DNA methylation in cells. Nucleic Acids Res. 38, 1749-1759 (2010).
    • (2010) Nucleic Acids Res. , vol.38 , pp. 1749-1759
    • Meister, G.E.1    Chandrasegaran, S.2    Ostermeier, M.3
  • 55
    • 84866276467 scopus 로고    scopus 로고
    • Targeted DNA methylation using an artificially bisected M.HhaI fused to zinc fingers
    • Chaikind, B., Kilambi, K. P., Gray, J. J. & Ostermeier, M. Targeted DNA methylation using an artificially bisected M.HhaI fused to zinc fingers. PLoS ONE 7, e44852 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e44852
    • Chaikind, B.1    Kilambi, K.P.2    Gray, J.J.3    Ostermeier, M.4
  • 56
    • 34548395961 scopus 로고    scopus 로고
    • Vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase
    • Nomura, W. & Barbas, C. F. 3rd. In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase. J. Am. Chem. Soc. 129, 8676-8677 (2007).
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 8676-8677
    • Nomura, W.1    Barbas, C.F.2
  • 57
    • 84884907424 scopus 로고    scopus 로고
    • CRISPR RNA-guided activation of endogenous human genes
    • Maeder, M. L. et al. CRISPR RNA-guided activation of endogenous human genes. Nature Methods 10, 977-979 (2013).
    • (2013) Nature Methods , vol.10 , pp. 977-979
    • Maeder, M.L.1
  • 58
    • 84884906690 scopus 로고    scopus 로고
    • RNA-guided gene activation by CRISPR-Cas9-based transcription factors
    • Perez-Pinera, P. et al. RNA-guided gene activation by CRISPR-Cas9-based transcription factors. Nature Methods 10, 973-976 (2013).
    • (2013) Nature Methods , vol.10 , pp. 973-976
    • Perez-Pinera, P.1
  • 59
    • 80052009948 scopus 로고    scopus 로고
    • Mechanisms for the inheritance of chromatin states
    • Moazed, D. Mechanisms for the inheritance of chromatin states. Cell 146, 510-518 (2011).
    • (2011) Cell , vol.146 , pp. 510-518
    • Moazed, D.1
  • 60
    • 84876888289 scopus 로고    scopus 로고
    • Epigenetics: Core misconcept
    • Ptashne, M. Epigenetics: core misconcept. Proc. Natl Acad. Sci. USA 110, 7101-7103 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 7101-7103
    • Ptashne, M.1
  • 61
    • 0032490917 scopus 로고    scopus 로고
    • Perinuclear localization of chromatin facilitates transcriptional silencing
    • Andrulis, E. D., Neiman, A. M., Zappulla, D. C. & Sternglanz, R. Perinuclear localization of chromatin facilitates transcriptional silencing. Nature 394, 592-595 (1998).
    • (1998) Nature , vol.394 , pp. 592-595
    • Andrulis, E.D.1    Neiman, A.M.2    Zappulla, D.C.3    Sternglanz, R.4
  • 62
    • 0029922959 scopus 로고    scopus 로고
    • Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing
    • Triolo, T. & Sternglanz, R. Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing. Nature 381, 251-253 (1996).
    • (1996) Nature , vol.381 , pp. 251-253
    • Triolo, T.1    Sternglanz, R.2
  • 63
    • 0027443405 scopus 로고
    • Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast
    • Chien, C. T., Buck, S., Sternglanz, R. & Shore, D. Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast. Cell 75, 531-541 (1993).
    • (1993) Cell , vol.75 , pp. 531-541
    • Chien, C.T.1    Buck, S.2    Sternglanz, R.3    Shore, D.4
  • 64
    • 0028941966 scopus 로고
    • Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast
    • Buck, S. W. & Shore, D. Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast. Genes Dev. 9, 370-384 (1995).
    • (1995) Genes Dev. , vol.9 , pp. 370-384
    • Buck, S.W.1    Shore, D.2
  • 65
    • 0029914961 scopus 로고    scopus 로고
    • Tethered Sir3p nucleates silencing at telomeres and internal loci in Saccharomyces cerevisiae
    • Lustig, A. J., Liu, C., Zhang, C. & Hanish, J. P. Tethered Sir3p nucleates silencing at telomeres and internal loci in Saccharomyces cerevisiae. Mol. Cell. Biol. 16, 2483-2495 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2483-2495
    • Lustig, A.J.1    Liu, C.2    Zhang, C.3    Hanish, J.P.4
  • 66
    • 84862662420 scopus 로고    scopus 로고
    • Dynamics and memory of heterochromatin in living cells
    • Hathaway, N. A. et al. Dynamics and memory of heterochromatin in living cells. Cell 149, 1447-1460 (2012).
    • (2012) Cell , vol.149 , pp. 1447-1460
    • Hathaway, N.A.1
  • 67
    • 0025119575 scopus 로고
    • The SNF5 protein of Saccharomyces cerevisiae is a glutamine-and proline-rich transcriptional activator that affects expression of a broad spectrum of genes
    • Laurent, B. C., Treitel, M. A. & Carlson, M. The SNF5 protein of Saccharomyces cerevisiae is a glutamine-and proline-rich transcriptional activator that affects expression of a broad spectrum of genes. Mol. Cell. Biol. 10, 5616-5625 (1990).
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 5616-5625
    • Laurent, B.C.1    Treitel, M.A.2    Carlson, M.3
  • 68
    • 33846686888 scopus 로고    scopus 로고
    • Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes
    • Li, F. et al. Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes. Nucleic Acids Res. 35, 100-112 (2007).
    • (2007) Nucleic Acids Res. , vol.35 , pp. 100-112
    • Li, F.1
  • 69
    • 44349168309 scopus 로고    scopus 로고
    • Heritable gene repression through the action of a directed DNA methyltransferase at a chromosomal locus
    • Smith, A. E., Hurd, P. J., Bannister, A. J., Kouzarides, T. & Ford, K. G. Heritable gene repression through the action of a directed DNA methyltransferase at a chromosomal locus. J. Biol. Chem. 283, 9878-9885 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 9878-9885
    • Smith, A.E.1    Hurd, P.J.2    Bannister, A.J.3    Kouzarides, T.4    Ford, K.G.5
  • 70
    • 84928130154 scopus 로고    scopus 로고
    • Epigenetic inheritance uncoupled from sequence-specific recruitment
    • Ragunathan, K., Jih, G. & Moazed, D. Epigenetic inheritance uncoupled from sequence-specific recruitment. Science http://dx.doi.org/10.1126/science.1258699 (2014).
    • (2014) Science
    • Ragunathan, K.1    Jih, G.2    Moazed, D.3
  • 71
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird, A. DNA methylation patterns and epigenetic memory. Genes Dev. 16, 6-21 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 6-21
    • Bird, A.1
  • 72
    • 84913620157 scopus 로고    scopus 로고
    • Analysis of an artificial zinc finger epigenetic modulator: Widespread binding but limited regulation
    • Grimmer, M. R. et al. Analysis of an artificial zinc finger epigenetic modulator: widespread binding but limited regulation. Nucleic Acids Res. 42, 10856-10868 (2014).
    • (2014) Nucleic Acids Res. , vol.42 , pp. 10856-10868
    • Grimmer, M.R.1
  • 73
    • 84903545084 scopus 로고    scopus 로고
    • Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
    • Kuscu, C., Arslan, S., Singh, R., Thorpe, J. & Adli, M. Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease. Nature Biotech. 32, 677-683 (2014).
    • (2014) Nature Biotech. , vol.32 , pp. 677-683
    • Kuscu, C.1    Arslan, S.2    Singh, R.3    Thorpe, J.4    Adli, M.5
  • 74
    • 84903943282 scopus 로고    scopus 로고
    • Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs
    • Smith, C. et al. Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs. Cell Stem Cell 15, 12-13 (2014).
    • (2014) Cell Stem Cell , vol.15 , pp. 12-13
    • Smith, C.1
  • 75
    • 84911465571 scopus 로고    scopus 로고
    • Target specificity of the CRISPR-Cas9 system
    • Wu, X., Kriz, A. J. & Sharp, P. A. Target specificity of the CRISPR-Cas9 system. Quantitative Biol. 2, 59-70 (2014).
    • (2014) Quantitative Biol. , vol.2 , pp. 59-70
    • Wu, X.1    Kriz, A.J.2    Sharp, P.A.3
  • 76
    • 80052766645 scopus 로고    scopus 로고
    • An unbiased genome-wide analysis of zinc-finger nuclease specificity
    • Gabriel, R. et al. An unbiased genome-wide analysis of zinc-finger nuclease specificity. Nature Biotech. 29, 816-823 (2011).
    • (2011) Nature Biotech. , vol.29 , pp. 816-823
    • Gabriel, R.1
  • 77
    • 84897954502 scopus 로고    scopus 로고
    • Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity
    • Guilinger, J. P. et al. Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity. Nature Methods 11, 429-435 (2014).
    • (2014) Nature Methods , vol.11 , pp. 429-435
    • Guilinger, J.P.1
  • 78
    • 80052293623 scopus 로고    scopus 로고
    • Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection
    • Pattanayak, V., Ramirez, C. L., Joung, J. K. & Liu, D. R. Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection. Nature Methods 8, 765-770 (2011).
    • (2011) Nature Methods , vol.8 , pp. 765-770
    • Pattanayak, V.1    Ramirez, C.L.2    Joung, J.K.3    Liu, D.R.4
  • 79
    • 84923266604 scopus 로고    scopus 로고
    • GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
    • Tsai, S. Q. et al. GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases. Nature Biotech. http://dx.doi.org/10.1038/nbt.3117 (2014).
    • (2014) Nature Biotech.
    • Tsai, S.Q.1
  • 80
    • 84902210542 scopus 로고    scopus 로고
    • Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
    • Guilinger, J. P., Thompson, D. B. & Liu, D. R. Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification. Nature Biotech. 32, 577-582 (2014).
    • (2014) Nature Biotech. , vol.32 , pp. 577-582
    • Guilinger, J.P.1    Thompson, D.B.2    Liu, D.R.3
  • 81
    • 84902204289 scopus 로고    scopus 로고
    • Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
    • Tsai, S. Q. et al. Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing. Nature Biotech. 32, 569-576 (2014).
    • (2014) Nature Biotech. , vol.32 , pp. 569-576
    • Tsai, S.Q.1
  • 82
    • 84864634066 scopus 로고    scopus 로고
    • A synthetic biology framework for programming eukaryotic transcription functions
    • Khalil, A. S. et al. A synthetic biology framework for programming eukaryotic transcription functions. Cell 150, 647-658 (2012).
    • (2012) Cell , vol.150 , pp. 647-658
    • Khalil, A.S.1
  • 83
    • 84896929630 scopus 로고    scopus 로고
    • Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
    • Fu, Y., Sander, J. D., Reyon, D., Cascio, V. M. & Joung, J. K. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nature Biotech. 32, 279-284 (2014).
    • (2014) Nature Biotech. , vol.32 , pp. 279-284
    • Fu, Y.1    Sander, J.D.2    Reyon, D.3    Cascio, V.M.4    Joung, J.K.5
  • 84
    • 0142027810 scopus 로고    scopus 로고
    • Zinc-finger protein-targeted gene regulation: Genomewide single-gene specificity
    • Tan, S. et al. Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity. Proc. Natl Acad. Sci. USA 100, 11997-12002 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 11997-12002
    • Tan, S.1
  • 85
    • 79961005102 scopus 로고    scopus 로고
    • Synthetic reversal of epigenetic silencing
    • Haynes, K. A. & Silver, P. A. Synthetic reversal of epigenetic silencing. J. Biol. Chem. 286, 27176-27182 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 27176-27182
    • Haynes, K.A.1    Silver, P.A.2
  • 86
    • 84859836380 scopus 로고    scopus 로고
    • Chromatin as an expansive canvas for chemical biology
    • Fierz, B. & Muir, T. W. Chromatin as an expansive canvas for chemical biology. Nature Chem. Biol. 8, 417-427 (2012).
    • (2012) Nature Chem. Biol. , vol.8 , pp. 417-427
    • Fierz, B.1    Muir, T.W.2
  • 87
    • 36448949026 scopus 로고    scopus 로고
    • Multivalent engagement of chromatin modifications by linked binding modules
    • Ruthenburg, A. J., Li, H., Patel, D. J. & Allis, C. D. Multivalent engagement of chromatin modifications by linked binding modules. Nature Rev. Mol. Cell Biol. 8, 983-994 (2007).
    • (2007) Nature Rev. Mol. Cell Biol. , vol.8 , pp. 983-994
    • Ruthenburg, A.J.1    Li, H.2    Patel, D.J.3    Allis, C.D.4
  • 88
    • 84882976110 scopus 로고    scopus 로고
    • Optical control of mammalian endogenous transcription and epigenetic states
    • Konermann, S. et al. Optical control of mammalian endogenous transcription and epigenetic states. Nature 500, 472-476 (2013).
    • (2013) Nature , vol.500 , pp. 472-476
    • Konermann, S.1
  • 89
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein, B. E. et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125, 315-326 (2006).
    • (2006) Cell , vol.125 , pp. 315-326
    • Bernstein, B.E.1
  • 90
    • 0022483705 scopus 로고
    • The presence of nucleosomes on a DNA template prevents initiation by RNA polymerase II in vitro
    • Knezetic, J. A. & Luse, D. S. The presence of nucleosomes on a DNA template prevents initiation by RNA polymerase II in vitro. Cell 45, 95-104 (1986).
    • (1986) Cell , vol.45 , pp. 95-104
    • Knezetic, J.A.1    Luse, D.S.2
  • 91
    • 0023663417 scopus 로고
    • Nucleosomes inhibit the initiation of transcription but allow chain elongation with the displacement of histones
    • Lorch, Y., LaPointe, J. W. & Kornberg, R. D. Nucleosomes inhibit the initiation of transcription but allow chain elongation with the displacement of histones. Cell 49, 203-210 (1987).
    • (1987) Cell , vol.49 , pp. 203-210
    • Lorch, Y.1    Lapointe, J.W.2    Kornberg, R.D.3
  • 92
    • 0024261583 scopus 로고
    • Nucleosome loss activates yeast downstream promoters in vivo
    • Han, M. & Grunstein, M. Nucleosome loss activates yeast downstream promoters in vivo. Cell 55, 1137-1145 (1988).
    • (1988) Cell , vol.55 , pp. 1137-1145
    • Han, M.1    Grunstein, M.2
  • 93
    • 84867371116 scopus 로고    scopus 로고
    • A functional evolutionary approach to identify determinants of nucleosome positioning: A unifying model for establishing the genome-wide pattern
    • Hughes, A. L., Jin, Y., Rando, O. J. & Struhl, K. A functional evolutionary approach to identify determinants of nucleosome positioning: a unifying model for establishing the genome-wide pattern. Mol. Cell 48, 5-15 (2012).
    • (2012) Mol. Cell , vol.48 , pp. 5-15
    • Hughes, A.L.1    Jin, Y.2    Rando, O.J.3    Struhl, K.4
  • 94
    • 0001079085 scopus 로고
    • Artificial nucleosome positioning sequences
    • Shrader, T. E. & Crothers, D. M. Artificial nucleosome positioning sequences. Proc. Natl Acad. Sci. USA 86, 7418-7422 (1989).
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 7418-7422
    • Shrader, T.E.1    Crothers, D.M.2
  • 95
    • 0026561427 scopus 로고
    • Artificial nucleosome positioning sequences tested in yeast minichromosomes: A strong rotational setting is not sufficient to position nucleosomes in vivo
    • Tanaka, S., Zatchej, M. & Thoma, F. Artificial nucleosome positioning sequences tested in yeast minichromosomes: a strong rotational setting is not sufficient to position nucleosomes in vivo. EMBO J. 11, 1187-1193 (1992).
    • (1992) EMBO J. , vol.11 , pp. 1187-1193
    • Tanaka, S.1    Zatchej, M.2    Thoma, F.3
  • 96
    • 84862984796 scopus 로고    scopus 로고
    • Manipulating nucleosome disfavoring sequences allows fine-tune regulation of gene expression in yeast
    • Raveh-Sadka, T. et al. Manipulating nucleosome disfavoring sequences allows fine-tune regulation of gene expression in yeast. Nature Genet. 44, 743-750 (2012).
    • (2012) Nature Genet. , vol.44 , pp. 743-750
    • Raveh-Sadka, T.1
  • 97
    • 43449096915 scopus 로고    scopus 로고
    • Chromatin decouples promoter threshold from dynamic range
    • Lam, F. H., Steger, D. J. & O'Shea, E. K. Chromatin decouples promoter threshold from dynamic range. Nature 453, 246-250 (2008).
    • (2008) Nature , vol.453 , pp. 246-250
    • Lam, F.H.1    Steger, D.J.2    O'Shea, E.K.3
  • 98
    • 78651107675 scopus 로고    scopus 로고
    • Nucleosome-mediated cooperativity between transcription factors
    • Mirny, L. A. Nucleosome-mediated cooperativity between transcription factors. Proc. Natl Acad. Sci. USA 107, 22534-22539 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 22534-22539
    • Mirny, L.A.1
  • 99
    • 0033121285 scopus 로고    scopus 로고
    • UASrpg can function as a heterochromatin boundary element in yeast
    • Bi, X. & Broach, J. R. UASrpg can function as a heterochromatin boundary element in yeast. Genes Dev. 13, 1089-1101 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 1089-1101
    • Bi, X.1    Broach, J.R.2
  • 100
    • 1342282911 scopus 로고    scopus 로고
    • Formation of boundaries of transcriptionally silent chromatin by nucleosome-excluding structures
    • Bi, X., Yu, Q., Sandmeier, J. J. & Zou, Y. Formation of boundaries of transcriptionally silent chromatin by nucleosome-excluding structures. Mol. Cell. Biol. 24, 2118-2131 (2004).
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 2118-2131
    • Bi, X.1    Yu, Q.2    Sandmeier, J.J.3    Zou, Y.4
  • 101
    • 0035254535 scopus 로고    scopus 로고
    • RNA polymerase III and RNA polymerase II promoter complexes are heterochromatin barriers in Saccharomyces cerevisiae
    • Donze, D. & Kamakaka, R. T. RNA polymerase III and RNA polymerase II promoter complexes are heterochromatin barriers in Saccharomyces cerevisiae. EMBO J. 20, 520-531 (2001).
    • (2001) EMBO J. , vol.20 , pp. 520-531
    • Donze, D.1    Kamakaka, R.T.2
  • 102
    • 0037205232 scopus 로고    scopus 로고
    • Chromatin boundaries in budding yeast: The nuclear pore connection
    • Ishii, K., Arib, G., Lin, C., Van Houwe, G. & Laemmli, U. K. Chromatin boundaries in budding yeast: the nuclear pore connection. Cell 109, 551-562 (2002).
    • (2002) Cell , vol.109 , pp. 551-562
    • Ishii, K.1    Arib, G.2    Lin, C.3    Van Houwe, G.4    Laemmli, U.K.5
  • 103
    • 84903146392 scopus 로고    scopus 로고
    • A chromatin-based mechanism for limiting divergent noncoding transcription
    • Marquardt, S. et al. A chromatin-based mechanism for limiting divergent noncoding transcription. Cell 157, 1712-1723 (2014).
    • (2014) Cell , vol.157 , pp. 1712-1723
    • Marquardt, S.1
  • 104
    • 0035316574 scopus 로고    scopus 로고
    • Chromosome territories, nuclear architecture and gene regulation in mammalian cells
    • Cremer, T. & Cremer, C. Chromosome territories, nuclear architecture and gene regulation in mammalian cells. Nature Rev. Genet. 2, 292-301 (2001).
    • (2001) Nature Rev. Genet. , vol.2 , pp. 292-301
    • Cremer, T.1    Cremer, C.2
  • 105
    • 0035804267 scopus 로고    scopus 로고
    • Telomere looping permits gene activation by a downstream UAS in yeast
    • de Bruin, D., Zaman, Z., Liberatore, R. A. & Ptashne, M. Telomere looping permits gene activation by a downstream UAS in yeast. Nature 409, 109-113 (2001).
    • (2001) Nature , vol.409 , pp. 109-113
    • De Bruin, D.1    Zaman, Z.2    Liberatore, R.A.3    Ptashne, M.4
  • 106
    • 0037018849 scopus 로고    scopus 로고
    • Telomere looping permits repression at a distance yeast
    • Zaman, Z., Heid, C. & Ptashne, M. Telomere looping permits repression "at a distance" in yeast. Curr. Biol. 12, 930-933 (2002).
    • (2002) Curr. Biol. , vol.12 , pp. 930-933
    • Zaman, Z.1    Heid, C.2    Ptashne, M.3
  • 107
    • 84861964135 scopus 로고    scopus 로고
    • Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor
    • Deng, W. et al. Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell 149, 1233-1244 (2012).
    • (2012) Cell , vol.149 , pp. 1233-1244
    • Deng, W.1
  • 108
    • 84908439526 scopus 로고    scopus 로고
    • Reactivation of developmentally silenced globin genes by forced chromatin looping
    • Deng, W. et al. Reactivation of developmentally silenced globin genes by forced chromatin looping. Cell 158, 849-860 (2014).
    • (2014) Cell , vol.158 , pp. 849-860
    • Deng, W.1
  • 109
    • 84922113550 scopus 로고    scopus 로고
    • The special case of gene therapy pricing
    • Brennan, T. A. & Wilson, J. M. The special case of gene therapy pricing. Nature Biotech. 32, 874-876 (2014).
    • (2014) Nature Biotech. , vol.32 , pp. 874-876
    • Brennan, T.A.1    Wilson, J.M.2
  • 110
    • 79960980390 scopus 로고    scopus 로고
    • Variegated gene expression caused by cell-specific long-range DNA interactions
    • Noordermeer, D. et al. Variegated gene expression caused by cell-specific long-range DNA interactions. Nature Cell Biol. 13, 944-951 (2011).
    • (2011) Nature Cell Biol. , vol.13 , pp. 944-951
    • Noordermeer, D.1
  • 111
    • 70349873824 scopus 로고    scopus 로고
    • Comprehensive mapping of long-range interactions reveals folding principles of the human genome
    • Lieberman-Aiden, E. et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 326, 289-293 (2009).
    • (2009) Science , vol.326 , pp. 289-293
    • Lieberman-Aiden, E.1
  • 112
    • 84886777912 scopus 로고    scopus 로고
    • Chromosomal contact permits transcription between coregulated genes
    • Fanucchi, S., Shibayama, Y., Burd, S., Weinberg, M. S. & Mhlanga, M. M. Chromosomal contact permits transcription between coregulated genes. Cell 155, 606-620 (2013).
    • (2013) Cell , vol.155 , pp. 606-620
    • Fanucchi, S.1    Shibayama, Y.2    Burd, S.3    Weinberg, M.S.4    Mhlanga, M.M.5
  • 113
    • 84869002200 scopus 로고    scopus 로고
    • Nuclear aggregation of olfactory receptor genes governs their monogenic expression
    • Clowney, E. J. et al. Nuclear aggregation of olfactory receptor genes governs their monogenic expression. Cell 151, 724-737 (2012).
    • (2012) Cell , vol.151 , pp. 724-737
    • Clowney, E.J.1
  • 114
    • 69949150953 scopus 로고    scopus 로고
    • Recruiting a microtubule-binding complex to DNA directs chromosome segregation in budding yeast
    • Lacefield, S., Lau, D. T. & Murray, A. W. Recruiting a microtubule-binding complex to DNA directs chromosome segregation in budding yeast. Nature Cell Biol. 11, 1116-1120 (2009).
    • (2009) Nature Cell Biol. , vol.11 , pp. 1116-1120
    • Lacefield, S.1    Lau, D.T.2    Murray, A.W.3
  • 115
    • 67649939154 scopus 로고    scopus 로고
    • Synthetic heterochromatin bypasses RNAi and centromeric repeats to establish functional centromeres
    • Kagansky, A. et al. Synthetic heterochromatin bypasses RNAi and centromeric repeats to establish functional centromeres. Science 324, 1716-1719 (2009).
    • (2009) Science , vol.324 , pp. 1716-1719
    • Kagansky, A.1
  • 116
    • 84923686052 scopus 로고    scopus 로고
    • Tethering sister centromeres to each other suggests the spindle checkpoint detects stretch within the kinetochore
    • Nannas, N. J. & Murray, A. W. Tethering sister centromeres to each other suggests the spindle checkpoint detects stretch within the kinetochore. PLoS Genet. 10, e1004492 (2014).
    • (2014) PLoS Genet. , vol.10 , pp. e1004492
    • Nannas, N.J.1    Murray, A.W.2
  • 117
    • 40749122641 scopus 로고    scopus 로고
    • Transcriptional repression mediated by repositioning of genes to the nuclear lamina
    • Reddy, K. L., Zullo, J. M., Bertolino, E. & Singh, H. Transcriptional repression mediated by repositioning of genes to the nuclear lamina. Nature 452, 243-247 (2008).
    • (2008) Nature , vol.452 , pp. 243-247
    • Reddy, K.L.1    Zullo, J.M.2    Bertolino, E.3    Singh, H.4
  • 118
    • 84875703872 scopus 로고    scopus 로고
    • Single-cell dynamics of genome-nuclear lamina interactions
    • Kind, J. et al. Single-cell dynamics of genome-nuclear lamina interactions. Cell 153, 178-192 (2013).
    • (2013) Cell , vol.153 , pp. 178-192
    • Kind, J.1
  • 119
    • 0033774318 scopus 로고    scopus 로고
    • Functional dissection of in vivo interchromosome association in Saccharomyces cerevisiae
    • Aragon-Alcaide, L. & Strunnikov, A. V. Functional dissection of in vivo interchromosome association in Saccharomyces cerevisiae. Nature Cell Biol. 2, 812-818 (2000).
    • (2000) Nature Cell Biol. , vol.2 , pp. 812-818
    • Aragon-Alcaide, L.1    Strunnikov, A.V.2
  • 120
    • 84894063115 scopus 로고    scopus 로고
    • Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system
    • Chen, B. et al. Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Cell 155, 1479-1491 (2013).
    • (2013) Cell , vol.155 , pp. 1479-1491
    • Chen, B.1
  • 121
    • 0033552946 scopus 로고    scopus 로고
    • Robustness in bacterial chemotaxis
    • Alon, U., Surette, M. G., Barkai, N. & Leibler, S. Robustness in bacterial chemotaxis. Nature 397, 168-171 (1999).
    • (1999) Nature , vol.397 , pp. 168-171
    • Alon, U.1    Surette, M.G.2    Barkai, N.3    Leibler, S.4
  • 122
    • 0030797355 scopus 로고    scopus 로고
    • Robustness in simple biochemical networks
    • Barkai, N. & Leibler, S. Robustness in simple biochemical networks. Nature 387, 913-917 (1997).
    • (1997) Nature , vol.387 , pp. 913-917
    • Barkai, N.1    Leibler, S.2
  • 123
    • 80053132391 scopus 로고    scopus 로고
    • Synthetic chromosome arms function in yeast and generate phenotypic diversity by design
    • Dymond, J. S. et al. Synthetic chromosome arms function in yeast and generate phenotypic diversity by design. Nature 477, 471-476 (2011).
    • (2011) Nature , vol.477 , pp. 471-476
    • Dymond, J.S.1
  • 124
    • 84900314611 scopus 로고    scopus 로고
    • CRISPR-Cas systems for editing, regulating and targeting genomes
    • Sander, J. D. & Joung, J. K. CRISPR-Cas systems for editing, regulating and targeting genomes. Nature Biotech. 32, 347-355 (2014).
    • (2014) Nature Biotech. , vol.32 , pp. 347-355
    • Sander, J.D.1    Joung, J.K.2
  • 125
    • 84904995490 scopus 로고    scopus 로고
    • Illuminating cell signalling with optogenetic tools
    • Tischer, D. & Weiner, O. D. Illuminating cell signalling with optogenetic tools. Nature Rev. Mol. Cell Biol. 15, 551-558 (2014).
    • (2014) Nature Rev. Mol. Cell Biol. , vol.15 , pp. 551-558
    • Tischer, D.1    Weiner, O.D.2
  • 126
    • 84875537133 scopus 로고    scopus 로고
    • Epigenetic reprogramming in cancer
    • Suva, M. L., Riggi, N. & Bernstein, B. E. Epigenetic reprogramming in cancer. Science 339, 1567-1570 (2013).
    • (2013) Science , vol.339 , pp. 1567-1570
    • Suva, M.L.1    Riggi, N.2    Bernstein, B.E.3
  • 127
    • 77957970498 scopus 로고    scopus 로고
    • Epigenetic modifications in pluripotent and differentiated cells
    • Meissner, A. Epigenetic modifications in pluripotent and differentiated cells. Nature Biotech. 28, 1079-1088 (2010).
    • (2010) Nature Biotech. , vol.28 , pp. 1079-1088
    • Meissner, A.1
  • 128
    • 33646923128 scopus 로고    scopus 로고
    • Tethering RITS to a nascent transcript initiates RNAi-and heterochromatin-dependent gene silencing
    • Buhler, M., Verdel, A. & Moazed, D. Tethering RITS to a nascent transcript initiates RNAi-and heterochromatin-dependent gene silencing. Cell 125, 873-886 (2006).
    • (2006) Cell , vol.125 , pp. 873-886
    • Buhler, M.1    Verdel, A.2    Moazed, D.3
  • 129
    • 84881668417 scopus 로고    scopus 로고
    • Translating dosage compensation to trisomy 21
    • Jiang, J. et al. Translating dosage compensation to trisomy 21. Nature 500, 296-300 (2013).
    • (2013) Nature , vol.500 , pp. 296-300
    • Jiang, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.