메뉴 건너뛰기




Volumn 9, Issue 2, 2015, Pages 153-168

Lipidomics applications for disease biomarker discovery in mammal models

Author keywords

Animal models; Disease biomarkers; Lipid biomarkers; Lipid profiling; Lipidome; Lipidomics; Liquid chromatography; Mass spectrometry; Metabolomics; System biology

Indexed keywords

ALPHA SYNUCLEIN; APOLIPOPROTEIN E; BIOLOGICAL MARKER; CERAMIDE; CHOLESTEROL; GANGLIOSIDE GM3; GLYCOSPHINGOLIPID; LACTOSYLCERAMIDE; LIPID; OLEIC ACID; PALMITOLEIC ACID; PHOSPHATIDIC ACID; PHOSPHATIDYLGLYCEROL; PHOSPHATIDYLINOSITOL; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID; SPHINGOMYELIN;

EID: 84923490973     PISSN: 17520363     EISSN: 17520371     Source Type: Journal    
DOI: 10.2217/BMM.14.81     Document Type: Review
Times cited : (62)

References (130)
  • 1
    • 0141653274 scopus 로고    scopus 로고
    • Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: A bridge to lipidomics
    • Han X, Gross RW. Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics. J. Lipid Res. 44(6), 1071-1079 (2003).
    • (2003) J. Lipid Res. , vol.44 , Issue.6 , pp. 1071-1079
    • Han, X.1    Gross, R.W.2
  • 3
    • 67849133745 scopus 로고    scopus 로고
    • Analytical strategies in lipidomics and applications in disease biomarker discovery
    • Hu C, van der Heijden R, Wang M, van der Greef J, Hankemeier T, Xu G. Analytical strategies in lipidomics and applications in disease biomarker discovery. J. Chromatogr. B 877(26), 2836-2846 (2009).
    • (2009) J. Chromatogr. B , vol.877 , Issue.26 , pp. 2836-2846
    • Hu, C.1    Van Der Heijden, R.2    Wang, M.3    Van Der Greef, J.4    Hankemeier, T.5    Xu, G.6
  • 4
    • 20444419500 scopus 로고    scopus 로고
    • A comprehensive classification system for lipids
    • Fahy E, Subramaniam S, Brown HA et al. A comprehensive classification system for lipids. J. Lipid Res. 46(5), 839-862 (2005).
    • (2005) J. Lipid Res. , vol.46 , Issue.5 , pp. 839-862
    • Fahy, E.1    Subramaniam, S.2    Brown, H.A.3
  • 5
    • 66349098682 scopus 로고    scopus 로고
    • Update of the LIPID MAPS comprehensive classification system for lipids
    • Fahy E, Subramaniam S, Murphy RC et al. Update of the LIPID MAPS comprehensive classification system for lipids. J. Lipid Res. 50(S), 9-14 (2009).
    • (2009) J. Lipid Res. , vol.50 , Issue.S , pp. 9-14
    • Fahy, E.1    Subramaniam, S.2    Murphy, R.C.3
  • 6
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226(1), 497-509 (1957).
    • (1957) J. Biol. Chem. , vol.226 , Issue.1 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane-Stanley, G.H.3
  • 7
    • 27644473103 scopus 로고    scopus 로고
    • Mass spectrometric analysis reveals changes in phospholipid, neutral sphingolipid and sulfatide molecular species in progressive epilepsy with mental retardation, EPMR, brain: A case study
    • Hermansson M, Käkelä R, Berghäll M, Lehesjoki AE, Somerharju P, Lahtinen U. Mass spectrometric analysis reveals changes in phospholipid, neutral sphingolipid and sulfatide molecular species in progressive epilepsy with mental retardation, EPMR, brain: a case study. J. NeuroChem. 95(3), 609-617 (2005).
    • (2005) J. NeuroChem. , vol.95 , Issue.3 , pp. 609-617
    • Hermansson, M.1    Käkelä, R.2    Berghäll, M.3    Lehesjoki, A.E.4    Somerharju, P.5    Lahtinen, U.6
  • 8
    • 84863794850 scopus 로고    scopus 로고
    • The BUME method: A novel automated chloroform-free 96-well total lipid extraction method for blood plasma
    • Löfgren L, Stahlman M, Forsberg GB, Saarinen S, Nilsson R, Hansson GI. The BUME method: a novel automated chloroform-free 96-well total lipid extraction method for blood plasma. J. Lipid Res. 53(8), 1690-1700 (2012).
    • (2012) J. Lipid Res. , vol.53 , Issue.8 , pp. 1690-1700
    • Löfgren, L.1    Stahlman, M.2    Forsberg, G.B.3    Saarinen, S.4    Nilsson, R.5    Hansson, G.I.6
  • 9
    • 0021742376 scopus 로고
    • Simultaneous extraction and preparation for high-performance liquid chromatography of prostaglandins and phospholipids
    • Saunders RD, Horrocks LA. Simultaneous extraction and preparation for high-performance liquid chromatography of prostaglandins and phospholipids. Anal. BioChem. 143(1), 71-75 (1984).
    • (1984) Anal. BioChem. , vol.143 , Issue.1 , pp. 71-75
    • Saunders, R.D.1    Horrocks, L.A.2
  • 10
    • 84879187429 scopus 로고    scopus 로고
    • Simultaneous extraction of metabolome and lipidome with methyl tert-butyl ether from a single small tissue sample for ultra-high performance liquid chromatography/mass spectrometry
    • Chen S, Hoene M, Li J et al. Simultaneous extraction of metabolome and lipidome with methyl tert-butyl ether from a single small tissue sample for ultra-high performance liquid chromatography/mass spectrometry. J. Chromatogr. A 1298, 9-16 (2013).
    • (2013) J. Chromatogr. A , vol.1298 , pp. 9-16
    • Chen, S.1    Hoene, M.2    Li, J.3
  • 11
    • 0025598219 scopus 로고
    • Separation of lipid classes by solid phase extraction
    • Kim HY, Salem N Jr. Separation of lipid classes by solid phase extraction. J. Lipid Res. 31(12), 2285-2289 (1990).
    • (1990) J. Lipid Res. , vol.31 , Issue.12 , pp. 2285-2289
    • Kim, H.Y.1    Salem, N.2
  • 12
    • 60949083130 scopus 로고    scopus 로고
    • Quantification of fatty acids as methyl esters and phospholipids in cheese samples after separation of triacylglycerides and phospholipids
    • Hauff S, Vetter W. Quantification of fatty acids as methyl esters and phospholipids in cheese samples after separation of triacylglycerides and phospholipids. Anal. Chim. Acta 636(2), 229-235 (2009).
    • (2009) Anal. Chim. Acta , vol.636 , Issue.2 , pp. 229-235
    • Hauff, S.1    Vetter, W.2
  • 13
    • 78650682562 scopus 로고    scopus 로고
    • Evaluation of methods to extract and quantify lipids from Synechocystis PCC 6803
    • Sheng J, Vannela R, Rittmann BE. Evaluation of methods to extract and quantify lipids from Synechocystis PCC 6803. Bioresour. Technol. 102(2), 1697-1703 (2011).
    • (2011) Bioresour. Technol. , vol.102 , Issue.2 , pp. 1697-1703
    • Sheng, J.1    Vannela, R.2    Rittmann, B.E.3
  • 14
    • 4544333305 scopus 로고    scopus 로고
    • Focused microwave-assisted Soxhlet extraction: Devices and applications
    • Luque-García JL, Luque de Castro MD. Focused microwave-assisted Soxhlet extraction: devices and applications. Talanta 64(3), 571-577 (2004).
    • (2004) Talanta , vol.64 , Issue.3 , pp. 571-577
    • Luque-García, J.L.1    Luque De Castro, M.D.2
  • 15
    • 1642412455 scopus 로고    scopus 로고
    • Ultrasound-assisted Soxhlet extraction: An expeditive approach for solid sample treatment. Application to the extraction of total fat from oleaginous seeds
    • Luque-García JL, Luque de Castro MD. Ultrasound-assisted Soxhlet extraction: an expeditive approach for solid sample treatment. Application to the extraction of total fat from oleaginous seeds. J. Chromatogr. A 1034(1-2), 237-242 (2004).
    • (2004) J. Chromatogr. A , vol.1034 , Issue.1-2 , pp. 237-242
    • Luque-García, J.L.1    Luque De Castro, M.D.2
  • 16
    • 84890520793 scopus 로고    scopus 로고
    • Plasma lipidomic profiling method based on ultrasound extraction and liquid chromatography mass spectrometry
    • Pizarro C, Arenzana-Rámila I, Pérez-del-Notario N, Pérez-Matute P, González-Sáiz JM. Plasma lipidomic profiling method based on ultrasound extraction and liquid chromatography mass spectrometry. Anal. Chem. 85(24), 12085-12092 (2013).
    • (2013) Anal. Chem. , vol.85 , Issue.24 , pp. 12085-12092
    • Pizarro, C.1    Arenzana-Rámila, I.2    Pérez-Del-Notario, N.3    Pérez-Matute, P.4    González-Sáiz, J.M.5
  • 17
    • 84908885481 scopus 로고    scopus 로고
    • Development of enhanced analytical methodology for lipid analysis from sampling to detection
    • Uppsala University, Sweden
    • Isaac G. Development of enhanced analytical methodology for lipid analysis from sampling to detection. A Targeted Lipidomics Approach. Uppsala University, Sweden (2005). www.diva-portal.org/smash/get/diva2:166474
    • (2005) A Targeted Lipidomics Approach
    • Isaac, G.1
  • 19
    • 66849122694 scopus 로고    scopus 로고
    • Shotgun lipidomics of neutral lipids as an enabling technology for elucidation of lipid-related diseases
    • Gross RW, Han X. Shotgun lipidomics of neutral lipids as an enabling technology for elucidation of lipid-related diseases. Am. J. Physiol. Endocrinol. Metab. 297(2), E297-E303 (2009).
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.297 , Issue.2 , pp. E297-E303
    • Gross, R.W.1    Han, X.2
  • 20
    • 17244377704 scopus 로고    scopus 로고
    • Shotgun lipidomics-multidimensional MS analysis of cellular lipidomes
    • Han X, Gross RW. Shotgun lipidomics-multidimensional MS analysis of cellular lipidomes. Expert Rev. Proteomics 2(2), 253-264 (2005).
    • (2005) Expert Rev. Proteomics , vol.2 , Issue.2 , pp. 253-264
    • Han, X.1    Gross, R.W.2
  • 21
    • 67849130973 scopus 로고    scopus 로고
    • High-throughput shotgun lipidomics by quadrupole time-of-flight mass spectrometry
    • Stahlman M, Ejsing CS, Tarasov K, Perman J, Borén J, Ekroos K. High-throughput shotgun lipidomics by quadrupole time-of-flight mass spectrometry. J. Chromatogr. B 877(26), 2664-2672 (2009).
    • (2009) J. Chromatogr. B , vol.877 , Issue.26 , pp. 2664-2672
    • Stahlman, M.1    Ejsing, C.S.2    Tarasov, K.3    Perman, J.4    Borén, J.5    Ekroos, K.6
  • 22
    • 51249095381 scopus 로고    scopus 로고
    • Recent developments in tandem mass spectrometry for lipidomic analysis
    • Zehethofer N, Pinto DM. Recent developments in tandem mass spectrometry for lipidomic analysis. Anal. Chim. Acta 627(1), 62-70 (2008).
    • (2008) Anal. Chim. Acta , vol.627 , Issue.1 , pp. 62-70
    • Zehethofer, N.1    Pinto, D.M.2
  • 23
    • 22144478635 scopus 로고    scopus 로고
    • The emerging field of lipidomics
    • Wenk MR. The emerging field of lipidomics. Nat. Rev. Drug Discov. 4(7), 594-610 (2005).
    • (2005) Nat. Rev. Drug Discov. , vol.4 , Issue.7 , pp. 594-610
    • Wenk, M.R.1
  • 24
    • 10744230720 scopus 로고    scopus 로고
    • Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry
    • Wenk MR, Lucast L, Di Paolo G et al. Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry. Nat. BioTechnol. 21(7), 813-817 (2003).
    • (2003) Nat. BioTechnol. , vol.21 , Issue.7 , pp. 813-817
    • Wenk, M.R.1    Lucast, L.2    Di Paolo, G.3
  • 25
    • 0035063286 scopus 로고    scopus 로고
    • Quantitative determination of phospholipid compositions by ESI-MS: Effects of acyl chain length, unsaturation, and lipid concentration on instrument response
    • Koivusalo M, Haimi P, Heikinheimo L, Kostiainen R, Somerharju P. Quantitative determination of phospholipid compositions by ESI-MS: effects of acyl chain length, unsaturation, and lipid concentration on instrument response. J. Lipid Res. 42(4), 663-672 (2001).
    • (2001) J. Lipid Res. , vol.42 , Issue.4 , pp. 663-672
    • Koivusalo, M.1    Haimi, P.2    Heikinheimo, L.3    Kostiainen, R.4    Somerharju, P.5
  • 26
    • 0030962474 scopus 로고    scopus 로고
    • Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry
    • Brügger B, Erben G, Sandhoff R, Wieland FT, Lehmann WD. Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry. Proc. Natl Acad. Sci. USA 94(6), 2339-2344 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , Issue.6 , pp. 2339-2344
    • Brügger, B.1    Erben, G.2    Sandhoff, R.3    Wieland, F.T.4    Lehmann, W.D.5
  • 27
    • 0033856558 scopus 로고    scopus 로고
    • Two-dimensional analysis of phospholipids by capillary liquid chromatography/electrospray ionization mass spectrometry
    • Taguchi R, Hayakawa J, Takeuchi Y, Ishida M. Two-dimensional analysis of phospholipids by capillary liquid chromatography/electrospray ionization mass spectrometry. J. Mass Spectrom. 35(8), 953-966 (2000).
    • (2000) J. Mass Spectrom. , vol.35 , Issue.8 , pp. 953-966
    • Taguchi, R.1    Hayakawa, J.2    Takeuchi, Y.3    Ishida, M.4
  • 28
    • 14744291867 scopus 로고    scopus 로고
    • A shotgun tandem mass spectrometric analysis of phospholipids with normal-phase and/or reverse-phase liquid chromatography/electrospray ionization mass spectrometry
    • Houjou T, Yamatani K, Imagawa M, Shimizu T, Taguchi R. A shotgun tandem mass spectrometric analysis of phospholipids with normal-phase and/or reverse-phase liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun. Mass Spectrom. 19(5), 654-666 (2005).
    • (2005) Rapid Commun. Mass Spectrom. , vol.19 , Issue.5 , pp. 654-666
    • Houjou, T.1    Yamatani, K.2    Imagawa, M.3    Shimizu, T.4    Taguchi, R.5
  • 29
    • 0012696791 scopus 로고
    • Thin-layer chromatography of sterols and steroids
    • Avigan J, Goodman DS, Steinberg D. Thin-layer chromatography of sterols and steroids. J. Lipid Res. 4(1), 100-101 (1963).
    • (1963) J. Lipid Res. , vol.4 , Issue.1 , pp. 100-101
    • Avigan, J.1    Goodman, D.S.2    Steinberg, D.3
  • 30
    • 1642343850 scopus 로고    scopus 로고
    • Analysis of the phospholipid composition of bronchoalveolar lavage (BAL) fluid from man and minipig by MALDI-TOF mass spectrometry in combination with TLC
    • Sommerer D, Süss R, Hammerschmidt S, Wirtz H, Arnold K, Schiller J. Analysis of the phospholipid composition of bronchoalveolar lavage (BAL) fluid from man and minipig by MALDI-TOF mass spectrometry in combination with TLC. J. Pharm. BioMed. Anal. 35(1), 199-206 (2004).
    • (2004) J. Pharm. BioMed. Anal. , vol.35 , Issue.1 , pp. 199-206
    • Sommerer, D.1    Süss, R.2    Hammerschmidt, S.3    Wirtz, H.4    Arnold, K.5    Schiller, J.6
  • 31
    • 54549121379 scopus 로고    scopus 로고
    • Analysis of stem cell lipids by offline HPTLC-MALDI-TOF MS
    • Fuchs B, Schiller J, Süss R et al. Analysis of stem cell lipids by offline HPTLC-MALDI-TOF MS. Anal. BioAnal. Chem. 392(5), 849-860 (2008).
    • (2008) Anal. BioAnal. Chem. , vol.392 , Issue.5 , pp. 849-860
    • Fuchs, B.1    Schiller, J.2    Süss, R.3
  • 32
    • 33746511634 scopus 로고    scopus 로고
    • Analysis of phospholipid species in rat peritoneal surface layer by liquid chromatography/electrospray ionization ion-trap mass spectrometry
    • Gao F, Tian X, Wen D, Liao J, Wang T, Liu H. Analysis of phospholipid species in rat peritoneal surface layer by liquid chromatography/electrospray ionization ion-trap mass spectrometry. Biochim. Biophys. Acta 1761(7), 667-676 (2006).
    • (2006) Biochim. Biophys. Acta , vol.1761 , Issue.7 , pp. 667-676
    • Gao, F.1    Tian, X.2    Wen, D.3    Liao, J.4    Wang, T.5    Liu, H.6
  • 33
    • 84900021388 scopus 로고    scopus 로고
    • Separation and identification of lipid classes by normal phase LC-ESI/MS/MS on a cyanopropyl column
    • Olsson P, Holmbäck J, Nilsson U. Herslöf B. Separation and identification of lipid classes by normal phase LC-ESI/MS/MS on a cyanopropyl column. Eur. J. Lipid Sci. Technol. 116(5), 653-658 (2014).
    • (2014) Eur. J. Lipid Sci. Technol. , vol.116 , Issue.5 , pp. 653-658
    • Olsson, P.1    Holmbäck, J.2    Nilsson, U.3    Herslöf, B.4
  • 34
    • 49449100014 scopus 로고    scopus 로고
    • Regioisomeric structure determination of alpha- and gamma-linolenoyldilinoleoylglycerol in blackcurrant seed oil by silver ion high-performance liquid chromatography and mass spectrometry
    • Leskinen H, Suomela JP, Pinta J, Kallio H. Regioisomeric structure determination of alpha- and gamma-linolenoyldilinoleoylglycerol in blackcurrant seed oil by silver ion high-performance liquid chromatography and mass spectrometry. Anal. Chem. 80(15), 5788-5793 (2008).
    • (2008) Anal. Chem. , vol.80 , Issue.15 , pp. 5788-5793
    • Leskinen, H.1    Suomela, J.P.2    Pinta, J.3    Kallio, H.4
  • 35
    • 49849101854 scopus 로고    scopus 로고
    • Direct separation of monoacylglycerol isomers by enantioselective high-performance liquid chromatography
    • Deng L, Nakano H, Iwasaki Y. Direct separation of monoacylglycerol isomers by enantioselective high-performance liquid chromatography. J. Chromatogr. A 1198-1199, 67-72 (2008).
    • (2008) J. Chromatogr. A , vol.1198-1199 , pp. 67-72
    • Deng, L.1    Nakano, H.2    Iwasaki, Y.3
  • 36
    • 33847414492 scopus 로고    scopus 로고
    • Novel application of reversed-phase UPLC-oaTOF-MS for lipid analysis in complex biological mixtures: A new tool for lipidomics
    • Rainville PD, Stumpf CL, Shockcor JP, Plumb RS, Nicholson JK. Novel application of reversed-phase UPLC-oaTOF-MS for lipid analysis in complex biological mixtures: a new tool for lipidomics. J. Proteome Res. 6(2), 552-558 (2007).
    • (2007) J. Proteome Res. , vol.6 , Issue.2 , pp. 552-558
    • Rainville, P.D.1    Stumpf, C.L.2    Shockcor, J.P.3    Plumb, R.S.4    Nicholson, J.K.5
  • 37
    • 84888256463 scopus 로고    scopus 로고
    • Effect of Allium macrostemon on a rat model of depression studied by using plasma lipid and acylcarnitine profiles from liquid chromatography/ mass spectrometry
    • Chen S, Wei C, Gao P et al. Effect of Allium macrostemon on a rat model of depression studied by using plasma lipid and acylcarnitine profiles from liquid chromatography/ mass spectrometry. J. Pharm. BioMed. Anal. 89, 122-129 (2014).
    • (2014) J. Pharm. BioMed. Anal. , vol.89 , pp. 122-129
    • Chen, S.1    Wei, C.2    Gao, P.3
  • 38
    • 84904907445 scopus 로고    scopus 로고
    • Ultra-performance liquid chromatography-mass spectrometry as a sensitive and powerful technology in lipidomic applications
    • Zhao YY, Wu SP, Liu S, Zhang Y, Lin RC. Ultra-performance liquid chromatography-mass spectrometry as a sensitive and powerful technology in lipidomic applications. Chem. Biol. Interact. 220, 181-192 (2014).
    • (2014) Chem. Biol. Interact. , vol.220 , pp. 181-192
    • Zhao, Y.Y.1    Wu, S.P.2    Liu, S.3    Zhang, Y.4    Lin, R.C.5
  • 39
    • 25144468977 scopus 로고    scopus 로고
    • All-in-One' analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching
    • Wrona M, Mauriala T, Bateman KP, Mortishire-Smith RJ, O'Connor D. 'All-in-One' analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching. Rapid Commun. Mass Spectrom. 19(18), 2597-2602 (2005).
    • (2005) Rapid Commun. Mass Spectrom. , vol.19 , Issue.18 , pp. 2597-2602
    • Wrona, M.1    Mauriala, T.2    Bateman, K.P.3    Mortishire-Smith, R.J.4    O'Connor, D.5
  • 40
    • 84897083718 scopus 로고    scopus 로고
    • UPLC-MSE application in disease biomarker discovery: The discoveries in proteomics to metabolomics
    • Zhao YY, Lin RC. UPLC-MSE application in disease biomarker discovery: the discoveries in proteomics to metabolomics. Chem. Biol. Interact. 215, 7-16 (2014).
    • (2014) Chem. Biol. Interact. , vol.215 , pp. 7-16
    • Zhao, Y.Y.1    Lin, R.C.2
  • 41
    • 84877887630 scopus 로고    scopus 로고
    • Metabolomics in chronic kidney disease
    • Zhao YY. Metabolomics in chronic kidney disease. Clin. Chim. Acta 422, 59-69 (2013).
    • (2013) Clin. Chim. Acta , vol.422 , pp. 59-69
    • Zhao, Y.Y.1
  • 42
    • 84901237928 scopus 로고    scopus 로고
    • Metabolomics in nephrotoxicity
    • Zhao YY, Lin RC. Metabolomics in nephrotoxicity. Adv. Clin. Chem. 65, 69-89 (2014).
    • (2014) Adv. Clin. Chem. , vol.65 , pp. 69-89
    • Zhao, Y.Y.1    Lin, R.C.2
  • 43
    • 84873374171 scopus 로고    scopus 로고
    • Intrarenal metabolomic investigation of chronic kidney disease and its TGF-β1 mechanism in induced-adenine rats using UPLC Q-TOF/ HSMS/MSE
    • Zhao YY, Cheng XL, Wei F et al. Intrarenal metabolomic investigation of chronic kidney disease and its TGF-β1 mechanism in induced-adenine rats using UPLC Q-TOF/ HSMS/MSE. J. Proteome Res. 12(2), 692-703 (2013).
    • (2013) J. Proteome Res. , vol.12 , Issue.2 , pp. 692-703
    • Zhao, Y.Y.1    Cheng, X.L.2    Wei, F.3
  • 44
    • 84862777866 scopus 로고    scopus 로고
    • Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS
    • Zhao YY, Liu J, Cheng XL, Bai X, Lin RC. Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS. Clin. Chim. Acta 413(5-6), 642-649 (2012).
    • (2012) Clin. Chim. Acta , vol.413 , Issue.5-6 , pp. 642-649
    • Zhao, Y.Y.1    Liu, J.2    Cheng, X.L.3    Bai, X.4    Lin, R.C.5
  • 45
    • 84870792255 scopus 로고    scopus 로고
    • Urinary metabonomics study on the protective effects of ergosta- 4,6,8(14),22-tetraen-3-one on chronic renal failure in rats using UPLC Q-TOF/MS and a novel MSE data collection technique
    • Zhao YY, Shen X, Cheng XL, Wei F, Bai X, Lin RC. Urinary metabonomics study on the protective effects of ergosta- 4,6,8(14),22-tetraen-3-one on chronic renal failure in rats using UPLC Q-TOF/MS and a novel MSE data collection technique. Process BioChem. 47(12), 1980-1987 (2012).
    • (2012) Process BioChem. , vol.47 , Issue.12 , pp. 1980-1987
    • Zhao, Y.Y.1    Shen, X.2    Cheng, X.L.3    Wei, F.4    Bai, X.5    Lin, R.C.6
  • 46
    • 84873684641 scopus 로고    scopus 로고
    • UPLC-Q-TOF/ HSMS/MSE-based metabonomics for adenine-induced changes in metabolic profiles of rat faeces and intervention effects of ergosta-4,6,8(14),22-tetraen-3-one
    • Zhao YY, Zhang L, Long FY et al. UPLC-Q-TOF/ HSMS/MSE-based metabonomics for adenine-induced changes in metabolic profiles of rat faeces and intervention effects of ergosta-4,6,8(14),22-tetraen-3-one. Chem. Biol. Interact. 301(1-3):31-38 (2013).
    • (2013) Chem. Biol. Interact. , vol.301 , Issue.1-3 , pp. 31-38
    • Zhao, Y.Y.1    Zhang, L.2    Long, F.Y.3
  • 47
    • 84877836297 scopus 로고    scopus 로고
    • Renal metabolic profiling of early renal injury and renoprotective effects of poria cocos epidermis using UPLC Q-TOF/HSMS/MSE
    • Zhao YY, Lei P, Chen DQ, Feng YL, Bai X. Renal metabolic profiling of early renal injury and renoprotective effects of poria cocos epidermis using UPLC Q-TOF/HSMS/MSE. J. Pharm. BioMed. Anal. 81-82(1), 202-209 (2013).
    • (2013) J. Pharm. BioMed. Anal. , vol.81-82 , Issue.1 , pp. 202-209
    • Zhao, Y.Y.1    Lei, P.2    Chen, D.Q.3    Feng, Y.L.4    Bai, X.5
  • 48
    • 79952023410 scopus 로고    scopus 로고
    • Multidimensional approaches in LC and MS for phospholipid bioanalysis
    • Guo X, Lankmayr E. Multidimensional approaches in LC and MS for phospholipid bioanalysis. Bioanalysis 2(6), 1109-1123 (2010).
    • (2010) Bioanalysis , vol.2 , Issue.6 , pp. 1109-1123
    • Guo, X.1    Lankmayr, E.2
  • 49
    • 80255140521 scopus 로고    scopus 로고
    • Lipid analysis and lipidomics by structurally selective ion mobility-mass spectrometry
    • Kliman M, May JC, McLean JA. Lipid analysis and lipidomics by structurally selective ion mobility-mass spectrometry. Biochim. Biophys. Acta 1811(11), 935-945 (2011).
    • (2011) Biochim. Biophys. Acta , vol.1811 , Issue.11 , pp. 935-945
    • Kliman, M.1    May, J.C.2    McLean, J.A.3
  • 50
    • 84876418939 scopus 로고    scopus 로고
    • Lipidomics as an emerging tool to predict endometrial receptivity
    • Vilella F, Ramirez LB, Simón C. Lipidomics as an emerging tool to predict endometrial receptivity. Fertil. Steril. 99(4), 1100-1106 (2013).
    • (2013) Fertil. Steril. , vol.99 , Issue.4 , pp. 1100-1106
    • Vilella, F.1    Ramirez, L.B.2    Simón, C.3
  • 51
    • 84863825622 scopus 로고    scopus 로고
    • DeSouza NM. Comparison of NMR lipid profiles in mitotic arrest and apoptosis as indicators of paclitaxel resistance in cervical cell lines
    • Zietkowski D, Payne GS, Nagy E, Mobberley MA, Ryder TA, deSouza NM. Comparison of NMR lipid profiles in mitotic arrest and apoptosis as indicators of paclitaxel resistance in cervical cell lines. Magn. Reson. Med. 68(2), 369-377 (2012).
    • (2012) Magn. Reson. Med. , vol.68 , Issue.2 , pp. 369-377
    • Zietkowski, D.1    Payne, G.S.2    Nagy, E.3    Mobberley, M.A.4    Ryder, T.A.5
  • 52
    • 0036289241 scopus 로고    scopus 로고
    • Novel NMR tools to study structure and dynamics of biomembranes
    • Gawrisch K, Eldho NV, Polozov IV. Novel NMR tools to study structure and dynamics of biomembranes. Chem. Phys. Lipids 116(1-2), 135-151 (2002).
    • (2002) Chem. Phys. Lipids , vol.116 , Issue.1-2 , pp. 135-151
    • Gawrisch, K.1    Eldho, N.V.2    Polozov, I.V.3
  • 53
    • 77954465016 scopus 로고    scopus 로고
    • Profiling brain and plasma lipids in human APOE epsilon2, epsilon3, and epsilon4 knock-in mice using electrospray ionization mass spectrometry
    • Sharman MJ, Shui G, Fernandis AZ et al. Profiling brain and plasma lipids in human APOE epsilon2, epsilon3, and epsilon4 knock-in mice using electrospray ionization mass spectrometry. J. Alzheimers Dis. 20(1), 105-111 (2010).
    • (2010) J. Alzheimers Dis. , vol.20 , Issue.1 , pp. 105-111
    • Sharman, M.J.1    Shui, G.2    Fernandis, A.Z.3
  • 54
    • 78650064098 scopus 로고    scopus 로고
    • Phospholipase D2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits
    • Oliveira TG, Chan RB, Tian H et al. Phospholipase D2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. J. Neurosci. 30(49), 16419-16428 (2010).
    • (2010) J. Neurosci. , vol.30 , Issue.49 , pp. 16419-16428
    • Oliveira, T.G.1    Chan, R.B.2    Tian, H.3
  • 55
    • 84864304733 scopus 로고    scopus 로고
    • Recent developments of genomic research in soybean
    • Chan C, Qi X, Li MW, Wong FL, Lam HM. Recent developments of genomic research in soybean. J. Genet. Genomics 39(7), 317-324 (2012).
    • (2012) J. Genet. Genomics , vol.39 , Issue.7 , pp. 317-324
    • Chan, C.1    Qi, X.2    Li, M.W.3    Wong, F.L.4    Lam, H.M.5
  • 57
    • 70349214775 scopus 로고    scopus 로고
    • Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with α-synuclein genotype
    • Rappley I, Myers DS, Milne SB et al. Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with α-synuclein genotype. J. NeuroChem. 111(1), 15-25 (2009).
    • (2009) J. NeuroChem. , vol.111 , Issue.1 , pp. 15-25
    • Rappley, I.1    Myers, D.S.2    Milne, S.B.3
  • 58
    • 72949117677 scopus 로고    scopus 로고
    • Modulation of glyco-sphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice
    • Bijl N, Sokolović M, Vrins C et al. Modulation of glyco-sphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice. Hepatology 50(5), 1431-1441 (2009).
    • (2009) Hepatology , vol.50 , Issue.5 , pp. 1431-1441
    • Bijl, N.1    Sokolović, M.2    Vrins, C.3
  • 59
    • 63349110943 scopus 로고    scopus 로고
    • Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation
    • van Eijk M, Aten J, Bijl N et al. Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation. PLoS ONE 4(3), e4723 (2009).
    • (2009) PLoS ONE , vol.4 , Issue.3 , pp. e4723
    • Van Eijk, M.1    Aten, J.2    Bijl, N.3
  • 60
    • 84880615621 scopus 로고    scopus 로고
    • Polar lipid derangements in Type 2 diabetes mellitus: Potential pathological relevance of fatty acyl heterogeneity in sphingolipids
    • Shui G, Lam SM, Stebbins J et al. Polar lipid derangements in Type 2 diabetes mellitus: potential pathological relevance of fatty acyl heterogeneity in sphingolipids. Metabolomics 9(4), 786-799 (2013).
    • (2013) Metabolomics , vol.9 , Issue.4 , pp. 786-799
    • Shui, G.1    Lam, S.M.2    Stebbins, J.3
  • 61
    • 73149094543 scopus 로고    scopus 로고
    • The plasma lipidomic signature of nonalcoholic steatohepatitis
    • Puri P, Wiest MM, Cheung O et al. The plasma lipidomic signature of nonalcoholic steatohepatitis. Hepatology 50(6), 1827-1838 (2009).
    • (2009) Hepatology , vol.50 , Issue.6 , pp. 1827-1838
    • Puri, P.1    Wiest, M.M.2    Cheung, O.3
  • 62
    • 67649363782 scopus 로고    scopus 로고
    • Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: A role for resolvins and protectins
    • González-Périz A, Horrillo R, Ferré N et al. Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins. FASEB J. 23(6), 1946-1957 (2009).
    • (2009) FASEB J. , vol.23 , Issue.6 , pp. 1946-1957
    • González-Périz, A.1    Horrillo, R.2    Ferré, N.3
  • 63
    • 77957254806 scopus 로고    scopus 로고
    • Peroxisomal and microsomal lipid pathways associated with resistance to hepatic steatosis and reduced pro-inflammatory state
    • Hall D, Poussin C, Velagapudi VR et al. Peroxisomal and microsomal lipid pathways associated with resistance to hepatic steatosis and reduced pro-inflammatory state. J. Biol. Chem. 285(40), 31011-31023 (2010).
    • (2010) J. Biol. Chem. , vol.285 , Issue.40 , pp. 31011-31023
    • Hall, D.1    Poussin, C.2    Velagapudi, V.R.3
  • 64
    • 84863722813 scopus 로고    scopus 로고
    • Lipidomic approach to identify patterns in phospholipid profiles and define class differences in mammary epithelial and breast cancer cells
    • Dória ML, Cotrim Z, Macedo B et al. Lipidomic approach to identify patterns in phospholipid profiles and define class differences in mammary epithelial and breast cancer cells. Breast Cancer Res. Treat. 133(2), 635-648 (2012).
    • (2012) Breast Cancer Res. Treat. , vol.133 , Issue.2 , pp. 635-648
    • Dória, M.L.1    Cotrim, Z.2    Macedo, B.3
  • 65
    • 84868033745 scopus 로고    scopus 로고
    • Lipidomic analysis of phospholipids from human mammary epithelial and breast cancer cell lines
    • Dória ML, Cotrim CZ, Simoes C et al. Lipidomic analysis of phospholipids from human mammary epithelial and breast cancer cell lines. J. Cell Physiol. 228(2), 457-468 (2013).
    • (2013) J. Cell Physiol. , vol.228 , Issue.2 , pp. 457-468
    • Dória, M.L.1    Cotrim, C.Z.2    Simoes, C.3
  • 66
    • 27544501736 scopus 로고    scopus 로고
    • The effect of inhibition of Ca2+-independent phospholipase A2 on chemotherapeutic-induced death and phospholipid profiles in renal cells
    • Zhang L, Peterson BL, Cummings BS. The effect of inhibition of Ca2+-independent phospholipase A2 on chemotherapeutic-induced death and phospholipid profiles in renal cells. BioChem. Pharmacol. 70(11), 1697-1706 (2005).
    • (2005) BioChem. Pharmacol. , vol.70 , Issue.11 , pp. 1697-1706
    • Zhang, L.1    Peterson, B.L.2    Cummings, B.S.3
  • 67
    • 79951888262 scopus 로고    scopus 로고
    • Ultra-pressure liquid chromatography/tandem mass spectrometry targeted profiling of arachidonic acid and eicosanoids in human colorectal cancer
    • Mal M, Koh PK, Cheah PY, Chan EC. Ultra-pressure liquid chromatography/tandem mass spectrometry targeted profiling of arachidonic acid and eicosanoids in human colorectal cancer. Rapid Commun. Mass Spectrom. 25(6), 755-764 (2011).
    • (2011) Rapid Commun. Mass Spectrom. , vol.25 , Issue.6 , pp. 755-764
    • Mal, M.1    Koh, P.K.2    Cheah, P.Y.3    Chan, E.C.4
  • 68
    • 84881454013 scopus 로고    scopus 로고
    • Proteomic and lipidomic signatures of lipid metabolism in NASH-associated hepatocellular carcinoma
    • Muir K, Hazim A, He Y et al. Proteomic and lipidomic signatures of lipid metabolism in NASH-associated hepatocellular carcinoma. Cancer Res. 73(15), 4722-4731 (2013).
    • (2013) Cancer Res. , vol.73 , Issue.15 , pp. 4722-4731
    • Muir, K.1    Hazim, A.2    He, Y.3
  • 69
    • 55549118226 scopus 로고    scopus 로고
    • Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides
    • Chan R, Uchil PD, Jin J et al. Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides. J. Virol. 82(22), 11228-11238 (2008).
    • (2008) J. Virol. , vol.82 , Issue.22 , pp. 11228-11238
    • Chan, R.1    Uchil, P.D.2    Jin, J.3
  • 70
    • 67749095757 scopus 로고    scopus 로고
    • Triacylglycerol utilization is required for regrowth of in vitro hypoxic nonreplicating Mycobacterium bovis bacillus Calmette-Guérin
    • Low KL, Rao PS, Shui G et al. Triacylglycerol utilization is required for regrowth of in vitro hypoxic nonreplicating Mycobacterium bovis bacillus Calmette-Guérin. J. Bacteriol. 191(16), 5037-5043 (2008).
    • (2008) J. Bacteriol. , vol.191 , Issue.16 , pp. 5037-5043
    • Low, K.L.1    Rao, P.S.2    Shui, G.3
  • 71
    • 77954380461 scopus 로고    scopus 로고
    • Lipid droplet-associated proteins are involved in the biosynthesis and hydrolysis of triacylglycerol in Mycobacterium bovis bacillus Calmette- Guérin
    • Low KL, Shui G, Natter K et al. Lipid droplet-associated proteins are involved in the biosynthesis and hydrolysis of triacylglycerol in Mycobacterium bovis bacillus Calmette- Guérin. J. Biol. Chem. 285(28), 21662-21670 (2010).
    • (2010) J. Biol. Chem. , vol.285 , Issue.28 , pp. 21662-21670
    • Low, K.L.1    Shui, G.2    Natter, K.3
  • 72
    • 38449115897 scopus 로고    scopus 로고
    • Alzheimer's disease: The lipid connection
    • Hartmann T, Kuchenbecker J, Grimm MOW. Alzheimer's disease: the lipid connection. J. Neurochem. 103(S1), 159-170 (2007).
    • (2007) J. Neurochem. , vol.103 , Issue.S1 , pp. 159-170
    • Hartmann, T.1    Kuchenbecker, J.2    Grimm, M.O.W.3
  • 73
    • 42649090113 scopus 로고    scopus 로고
    • Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5- bisphosphate metabolism
    • Berman DE, Dall'Armi C, Voronov SV et al. Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5- bisphosphate metabolism. Nat. Neurosci. 11(5), 547-554 (2008).
    • (2008) Nat. Neurosci. , vol.11 , Issue.5 , pp. 547-554
    • Berman, D.E.1    Dall'armi, C.2    Voronov, S.V.3
  • 74
    • 0023860891 scopus 로고
    • Apolipoprotein e polymorphism and atherosclerosis
    • Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 8(1), 1-21 (1988).
    • (1988) Arteriosclerosis , vol.8 , Issue.1 , pp. 1-21
    • Davignon, J.1    Gregg, R.E.2    Sing, C.F.3
  • 75
    • 84878900198 scopus 로고    scopus 로고
    • Effects of high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein e 33 and 34 knock-in mice
    • Lim WL, Lam SM, Shui G et al. Effects of high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E 33 and 34 knock-in mice. NeuroBiol. Aging 34(9), 221722-221724 (2013).
    • (2013) NeuroBiol. Aging , vol.34 , Issue.9 , pp. 221722-221724
    • Lim, W.L.1    Lam, S.M.2    Shui, G.3
  • 76
    • 39749106531 scopus 로고    scopus 로고
    • Endosomes and lysosomes play distinct roles in sulfatide-induced neuroblastoma apoptosis: Potential mechanisms contributing to abnormal sulfatide metabolism in related neuronal diseases
    • Zeng Y, Cheng H, Jiang X, Han X. Endosomes and lysosomes play distinct roles in sulfatide-induced neuroblastoma apoptosis: potential mechanisms contributing to abnormal sulfatide metabolism in related neuronal diseases. BioChem. J. 410(1), 81-92 (2008).
    • (2008) BioChem. J. , vol.410 , Issue.1 , pp. 81-92
    • Zeng, Y.1    Cheng, H.2    Jiang, X.3    Han, X.4
  • 77
    • 54949130109 scopus 로고    scopus 로고
    • Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease
    • Sanchez-Mejia RO, Newman JW, Toh S et al. Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease. Nat. Neurosci. 11(11), 1311-1318, (2008).
    • (2008) Nat. Neurosci. , vol.11 , Issue.11 , pp. 1311-1318
    • Sanchez-Mejia, R.O.1    Newman, J.W.2    Toh, S.3
  • 78
    • 0029037421 scopus 로고
    • Amyloid-beta protein (25-35) stimulation of phospholipases A, C and D activities of La-N-2 cells
    • Singh IN, McCartney DG, Kanfer JN. Amyloid-beta protein (25-35) stimulation of phospholipases A, C and D activities of La-N-2 cells. Febs Lett. 365(2-3), 125-128 (1995).
    • (1995) Febs Lett. , vol.365 , Issue.2-3 , pp. 125-128
    • Singh, I.N.1    McCartney, D.G.2    Kanfer, J.N.3
  • 79
    • 0033570728 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2-mediated regulation of phospholipase D2 in leukocyte cell lines
    • Kim JH, Lee BD, Kim Y, Lee SD, Suh PG, Ryu SH. Cytosolic phospholipase A2-mediated regulation of phospholipase D2 in leukocyte cell lines. J. Immunol. 163(10), 5462-5470 (1999).
    • (1999) J. Immunol. , vol.163 , Issue.10 , pp. 5462-5470
    • Kim, J.H.1    Lee, B.D.2    Kim, Y.3    Lee, S.D.4    Suh, P.G.5    Ryu, S.H.6
  • 80
    • 0033669319 scopus 로고    scopus 로고
    • In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies
    • Gai WP, Yuan HX, Li XQ, Power JT, Blumbergs PC, Jensen PH. In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies. Exp. Neurol. 166(2), 324-333 (2000).
    • (2000) Exp. Neurol. , vol.166 , Issue.2 , pp. 324-333
    • Gai, W.P.1    Yuan, H.X.2    Li, X.Q.3    Power, J.T.4    Blumbergs, P.C.5    Jensen, P.H.6
  • 81
    • 77956393934 scopus 로고    scopus 로고
    • Alpha-synuclein, lipids and Parkinson's disease
    • Ruipérez V, Darios F, Davletov B. Alpha-synuclein, lipids and Parkinson's disease. Prog. Lipid Res. 49(4), 420-428 (2009).
    • (2009) Prog. Lipid Res. , vol.49 , Issue.4 , pp. 420-428
    • Ruipérez, V.1    Darios, F.2    Davletov, B.3
  • 82
    • 33646451063 scopus 로고    scopus 로고
    • Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization
    • Bosco DA, Fowler DM, Zhang Q et al. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nat. Chem. Biol. 2(5), 249-253 (2006).
    • (2006) Nat. Chem. Biol. , vol.2 , Issue.5 , pp. 249-253
    • Bosco, D.A.1    Fowler, D.M.2    Zhang, Q.3
  • 83
    • 43549104227 scopus 로고    scopus 로고
    • Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease
    • Bar-On P, Crews L, Koob AO et al. Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease. J. NeuroChem. 105(5), 1656-1667 (2008).
    • (2008) J. NeuroChem. , vol.105 , Issue.5 , pp. 1656-1667
    • Bar-On, P.1    Crews, L.2    Koob, A.O.3
  • 85
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos MH, Lavedan C, Leroy E et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276(5321), 2045-2047 (1997).
    • (1997) Science , vol.276 , Issue.5321 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3
  • 86
    • 0031990490 scopus 로고
    • Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
    • Kruger R, Kuhn W, Muller T et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat. Genet. 18(2), 106-108 (1988).
    • (1988) Nat. Genet. , vol.18 , Issue.2 , pp. 106-108
    • Kruger, R.1    Kuhn, W.2    Muller, T.3
  • 87
    • 10744230149 scopus 로고    scopus 로고
    • The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
    • Zarranz JJ, Alegre J, Gomez-Esteban JC et al. The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol. 55(2), 164-173 (2004).
    • (2004) Ann. Neurol. , vol.55 , Issue.2 , pp. 164-173
    • Zarranz, J.J.1    Alegre, J.2    Gomez-Esteban, J.C.3
  • 88
    • 0242300619 scopus 로고    scopus 로고
    • Alpha-synuclein locus triplication causes Parkinson's disease
    • Singleton AB, Farrer M, Johnson J et al. Alpha-synuclein locus triplication causes Parkinson's disease. Science 302(5646), 841 (2003).
    • (2003) Science , vol.302 , Issue.5646 , pp. 841
    • Singleton, A.B.1    Farrer, M.2    Johnson, J.3
  • 89
    • 4644236043 scopus 로고    scopus 로고
    • Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease
    • Ibanez P, Bonnet AM, Debarges B et al. Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. Lancet 364(9440), 1169-1171 (2004).
    • (2004) Lancet , vol.364 , Issue.9440 , pp. 1169-1171
    • Ibanez, P.1    Bonnet, A.M.2    Debarges, B.3
  • 91
    • 84897073371 scopus 로고    scopus 로고
    • Urinary metabolomics on the biochemical profiles in diet-induced hyperlipidemia rat using ultra-performance liquid chromatography coupled with quadrupole time-of-flight synapt high-definition mass spectrometry
    • 184162
    • Miao H, Chen H, Zhang X et al. Urinary metabolomics on the biochemical profiles in diet-induced hyperlipidemia rat using ultra-performance liquid chromatography coupled with quadrupole time-of-flight synapt high-definition mass spectrometry. J. Anal. Methods Chem. 184162 (2014) (2014).
    • (2014) J. Anal. Methods Chem. , Issue.2014
    • Miao, H.1    Chen, H.2    Zhang, X.3
  • 92
    • 0014352063 scopus 로고
    • A colorimetric method for estimating serum triglycerides
    • Fletcher MJ. A colorimetric method for estimating serum triglycerides. Clin. Chim. Acta 22(3), 393-397 (1968).
    • (1968) Clin. Chim. Acta , vol.22 , Issue.3 , pp. 393-397
    • Fletcher, M.J.1
  • 93
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
    • Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27(10), 1047-1053 (2004).
    • (2004) Diabetes Care , vol.27 , Issue.10 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 94
    • 78049407128 scopus 로고    scopus 로고
    • Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity
    • Li J, Romestaing C, Han X et al. Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity. Cell Metab. 12(2), 154-165 (2010).
    • (2010) Cell Metab. , vol.12 , Issue.2 , pp. 154-165
    • Li, J.1    Romestaing, C.2    Han, X.3
  • 95
    • 27444437321 scopus 로고    scopus 로고
    • Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    • Cinti S, Mitchell G, Barbatelli G et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid Res. 46(11), 2347-2355 (2005).
    • (2005) J. Lipid Res. , vol.46 , Issue.11 , pp. 2347-2355
    • Cinti, S.1    Mitchell, G.2    Barbatelli, G.3
  • 96
    • 77951914765 scopus 로고    scopus 로고
    • Membrane microdomains and insulin resistance
    • Inokuchi JI. Membrane microdomains and insulin resistance. FEBS Lett. 584(9), 1864-1871 (2010).
    • (2010) FEBS Lett. , vol.584 , Issue.9 , pp. 1864-1871
    • Inokuchi, J.I.1
  • 97
    • 63249117466 scopus 로고    scopus 로고
    • Plasma ceramides are elevated in obese subjects with Type 2 diabetes and correlate with the severity of insulin resistance
    • Haus JM, Kashyap, SR, Kasumov T et al. Plasma ceramides are elevated in obese subjects with Type 2 diabetes and correlate with the severity of insulin resistance. Diabetes 58(2), 337-343 (2009).
    • (2009) Diabetes , vol.58 , Issue.2 , pp. 337-343
    • Haus, J.M.1    Kashyap, S.R.2    Kasumov, T.3
  • 98
    • 70949101414 scopus 로고    scopus 로고
    • Link between plasma ceramides, inflammation and insulin resistance: Association with serum IL-6 concentration in patients with coronary heart disease
    • de Mello VDF, Lankinen M, Schwab U et al. Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease. Diabetologia 52(12), 2612-2615 (2009).
    • (2009) Diabetologia , vol.52 , Issue.12 , pp. 2612-2615
    • De Mello Vdf1    Lankinen, M.2    Schwab, U.3
  • 99
    • 79955487247 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
    • Holland WL, Bikman BT, Wang LP et al. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J. Clin. Invest. 121(5), 1858-1870 (2011).
    • (2011) J. Clin. Invest. , vol.121 , Issue.5 , pp. 1858-1870
    • Holland, W.L.1    Bikman, B.T.2    Wang, L.P.3
  • 100
    • 0036479215 scopus 로고    scopus 로고
    • Ganglioside GM3 participates in the pathological conditions of insulin resistance
    • Tagami S, Inokuchi Ji JI, Kabayama K et al. Ganglioside GM3 participates in the pathological conditions of insulin resistance. J. Biol. Chem. 277(5), 3085-3092 (2002).
    • (2002) J. Biol. Chem. , vol.277 , Issue.5 , pp. 3085-3092
    • Tagami, S.1    Inokuchi Ji, J.I.2    Kabayama, K.3
  • 101
    • 35348926769 scopus 로고    scopus 로고
    • Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance
    • Kabayama K, Sato T, Saito K et al. Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance. Proc. Natl Acad. Sci. USA 104(34), 13678-13683 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.34 , pp. 13678-13683
    • Kabayama, K.1    Sato, T.2    Saito, K.3
  • 103
    • 33744948514 scopus 로고    scopus 로고
    • Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
    • Malhi H, Bronk SF, Werneburg NW, Gores GJ. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J. Biol. Chem. 281(17), 12093-12101 (2006).
    • (2006) J. Biol. Chem. , vol.281 , Issue.17 , pp. 12093-12101
    • Malhi, H.1    Bronk, S.F.2    Werneburg, N.W.3    Gores, G.J.4
  • 104
    • 51549107903 scopus 로고    scopus 로고
    • Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism
    • Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 134(6), 933-944 (2008).
    • (2008) Cell , vol.134 , Issue.6 , pp. 933-944
    • Cao, H.1    Gerhold, K.2    Mayers, J.R.3    Wiest, M.M.4    Watkins, S.M.5    Hotamisligil, G.S.6
  • 105
    • 73849109435 scopus 로고    scopus 로고
    • Thiazolidinediones and the liver in humans
    • Yki-Jarvinen H. Thiazolidinediones and the liver in humans. Curr. Opin. Lipidol. 20(6), 477-483 (2009).
    • (2009) Curr. Opin. Lipidol. , vol.20 , Issue.6 , pp. 477-483
    • Yki-Jarvinen, H.1
  • 106
    • 0018665496 scopus 로고
    • Inhibition of prostaglandin biosynthesis by eicosapentaenoic acid
    • Culp BR, Titus BG, Lands WE. Inhibition of prostaglandin biosynthesis by eicosapentaenoic acid. Prostaglandins Med. 3(5), 269-278 (1979).
    • (1979) Prostaglandins Med. , vol.3 , Issue.5 , pp. 269-278
    • Culp, B.R.1    Titus, B.G.2    Lands, W.E.3
  • 107
    • 59649097994 scopus 로고    scopus 로고
    • Regulatory effects of arachidonate 5-lipoxygenase on hepatic MTP activity and VLDL-TG and ApoB secretion in obese mice
    • López-Parra M, Titos E, Horrillo R et al. Regulatory effects of arachidonate 5-lipoxygenase on hepatic MTP activity and VLDL-TG and ApoB secretion in obese mice. J. Lipid Res. 49(12), 2513-2523 (2008).
    • (2008) J. Lipid Res. , vol.49 , Issue.12 , pp. 2513-2523
    • López-Parra, M.1    Titos, E.2    Horrillo, R.3
  • 108
    • 54049137639 scopus 로고    scopus 로고
    • Atherosclerosis: Evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators
    • Merched AJ, Ko K, Gotlinger KH, Serhan CN, Chan L. Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators. FASEB J. 22(10), 3595-3606 (2008).
    • (2008) FASEB J. , vol.22 , Issue.10 , pp. 3595-3606
    • Merched, A.J.1    Ko, K.2    Gotlinger, K.H.3    Serhan, C.N.4    Chan, L.5
  • 109
    • 67849083480 scopus 로고    scopus 로고
    • Lipid-based biomarkers for cancer
    • Fernandis AZ, Wenk MR. Lipid-based biomarkers for cancer. J. Chromatogr. B 877(26), 2830-2835 (2009).
    • (2009) J. Chromatogr. B , vol.877 , Issue.26 , pp. 2830-2835
    • Fernandis, A.Z.1    Wenk, M.R.2
  • 110
    • 41949099869 scopus 로고    scopus 로고
    • Dissecting lipid raft facilitated cell signaling pathways in cancer
    • Patra SK. Dissecting lipid raft facilitated cell signaling pathways in cancer. Biochim. Biophys. Acta Rev. Cancer 1785(2), 182-206 (2008).
    • (2008) Biochim. Biophys. Acta Rev. Cancer , vol.1785 , Issue.2 , pp. 182-206
    • Patra, S.K.1
  • 111
    • 0141954157 scopus 로고    scopus 로고
    • Choline phospholipid metabolism: A target in cancer cells?
    • Ackerstaff E, Glunde K, Bhujwalla ZM. Choline phospholipid metabolism: a target in cancer cells? J. Cell BioChem. 90(3), 525-533 (2003).
    • (2003) J. Cell BioChem. , vol.90 , Issue.3 , pp. 525-533
    • Ackerstaff, E.1    Glunde, K.2    Bhujwalla, Z.M.3
  • 112
    • 3042523481 scopus 로고    scopus 로고
    • Lysophosphatidic acid stimulates ovarian cancer cell migration via a Ras-MEK kinase 1 pathway
    • Bian D, Su S, Mahanivong C et al. Lysophosphatidic acid stimulates ovarian cancer cell migration via a Ras-MEK kinase 1 pathway. Cancer Res. 64(12), 4209-4217 (2004).
    • (2004) Cancer Res. , vol.64 , Issue.12 , pp. 4209-4217
    • Bian, D.1    Su, S.2    Mahanivong, C.3
  • 113
    • 2542496901 scopus 로고    scopus 로고
    • Inactivation of endoplasmic reticulum bound Ca2+-independent phospholipase A2 in renal cells during oxidative stress
    • Cummings BS, Gelasco AK, Kinsey GR, McHowat J, Schnellmann RG. Inactivation of endoplasmic reticulum bound Ca2+-independent phospholipase A2 in renal cells during oxidative stress. J. Am. Soc. Nephrol. 15(6), 1441-1451 (2004).
    • (2004) J. Am. Soc. Nephrol. , vol.15 , Issue.6 , pp. 1441-1451
    • Cummings, B.S.1    Gelasco, A.K.2    Kinsey, G.R.3    McHowat, J.4    Schnellmann, R.G.5
  • 114
    • 84878125516 scopus 로고    scopus 로고
    • Molecular lipidomics of exosomes released by PC-3 prostate cancer cells
    • Llorente A, Skotland T, Sylvänne T et al. Molecular lipidomics of exosomes released by PC-3 prostate cancer cells. Biochim. Biophys. Acta 1831(7), 1302-1309 (2013).
    • (2013) Biochim. Biophys. Acta , vol.1831 , Issue.7 , pp. 1302-1309
    • Llorente, A.1    Skotland, T.2    Sylvänne, T.3
  • 116
    • 0034671806 scopus 로고    scopus 로고
    • COX-2 is expressed in human pulmonary, colonic, and mammary tumors
    • Soslow RA, Dannenberg AJ, Rush D et al. COX-2 is expressed in human pulmonary, colonic, and mammary tumors. Cancer 89(12), 2637-2645 (2000).
    • (2000) Cancer , vol.89 , Issue.12 , pp. 2637-2645
    • Soslow, R.A.1    Dannenberg, A.J.2    Rush, D.3
  • 117
    • 58149187464 scopus 로고    scopus 로고
    • Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model
    • Melstrom LG1, Bentrem DJ, Salabat MR et al. Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model. Clin. Cancer Res. 14(20), 6525-6530 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.20 , pp. 6525-6530
    • Melstrom Ist, L.G.1    Bentrem, D.J.2    Salabat, M.R.3
  • 118
    • 84881317197 scopus 로고    scopus 로고
    • Emerging importance of omega-3 fatty acids in the innate immune response: Molecular mechanisms and lipidomic strategies for their analysis
    • Maskrey BH, Megson IL, Rossi AG, Whitfield PD. Emerging importance of omega-3 fatty acids in the innate immune response: Molecular mechanisms and lipidomic strategies for their analysis. Mol. Nutr. Food Res. 57(8), 1390-1400 (2013).
    • (2013) Mol. Nutr. Food Res. , vol.57 , Issue.8 , pp. 1390-1400
    • Maskrey, B.H.1    Megson, I.L.2    Rossi, A.G.3    Whitfield, P.D.4
  • 119
    • 79958204979 scopus 로고    scopus 로고
    • Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-α
    • Weylandt KH, Krause LF, Gomolka B et al. Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-α. Carcinogenesis 32(6), 897-903 (2011).
    • (2011) Carcinogenesis , vol.32 , Issue.6 , pp. 897-903
    • Weylandt, K.H.1    Krause, L.F.2    Gomolka, B.3
  • 120
    • 85047694402 scopus 로고    scopus 로고
    • Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
    • Horie Y, Suzuki A, Kataoka E et al. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J. Clin. Invest. 113(12), 1774-1783 (2014).
    • (2014) J. Clin. Invest. , vol.113 , Issue.12 , pp. 1774-1783
    • Horie, Y.1    Suzuki, A.2    Kataoka, E.3
  • 121
    • 84873471978 scopus 로고    scopus 로고
    • Cancer biomarkers and mass spectrometry-based analyses of phospholipids in body fluids
    • Jelonek K, Ros M, Pietrowska1 M, Widlak P. Cancer biomarkers and mass spectrometry-based analyses of phospholipids in body fluids. Clin. Lipidol. 8(1), 137-150 (2013).
    • (2013) Clin. Lipidol. , vol.8 , Issue.1 , pp. 137-150
    • Jelonek, K.1    Ros, M.2    Pietrowska, M.3    Widlak, P.4
  • 122
    • 71849083577 scopus 로고    scopus 로고
    • Lipids in host-pathogen interactions: Pathogens exploit the complexity of the host cell lipidome
    • van der Meer-Janssen YP, van Galen J, Batenburg JJ, Helms JB. Lipids in host-pathogen interactions: pathogens exploit the complexity of the host cell lipidome. Prog. Lipid Res. 49(1), 1-26 (2010).
    • (2010) Prog. Lipid Res. , vol.49 , Issue.1 , pp. 1-26
    • Van Der Meer-Janssen, Y.P.1    Van Galen, J.2    Batenburg, J.J.3    Helms, J.B.4
  • 123
    • 0027325411 scopus 로고
    • Lipid composition and fluidity of the human immunodeficiency virus envelope and host cell plasma membranes
    • Aloia RC, Tian H, Jensen FC. Lipid composition and fluidity of the human immunodeficiency virus envelope and host cell plasma membranes. Proc. Natl Acad. Sci. USA 90(11), 5181-5185 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , Issue.11 , pp. 5181-5185
    • Aloia, R.C.1    Tian, H.2    Jensen, F.C.3
  • 124
    • 33746625935 scopus 로고    scopus 로고
    • Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly
    • Saad JS, Miller J, Tai J, Kim A, Ghanam RH, Summers MF. Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly. Proc. Natl Acad. Sci. USA 103(30), 11364-11369 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.30 , pp. 11364-11369
    • Saad, J.S.1    Miller, J.2    Tai, J.3    Kim, A.4    Ghanam, R.H.5    Summers, M.F.6
  • 125
    • 33847747061 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis virulence: Lipids inside and out
    • Ehrt S, Schnappinger D. Mycobacterium tuberculosis virulence: lipids inside and out. Nat. Med. 13(3), 284-285 (2007).
    • (2007) Nat. Med. , vol.13 , Issue.3 , pp. 284-285
    • Ehrt, S.1    Schnappinger, D.2
  • 126
    • 84910064935 scopus 로고    scopus 로고
    • UPLC-based metabonomics applications for discovering biomarkers of diseases in clinical chemistry
    • Zhao YY, Cheng XL, Vaziri ND, Liu S, Lin RC. UPLC-based metabonomics applications for discovering biomarkers of diseases in clinical chemistry. Clin. BioChem. 47(15), 16-26 (2014).
    • (2014) Clin. BioChem. , vol.47 , Issue.15 , pp. 16-26
    • Zhao, Y.Y.1    Cheng, X.L.2    Vaziri, N.D.3    Liu, S.4    Lin, R.C.5
  • 127
    • 84863012683 scopus 로고    scopus 로고
    • Serum metabonomics study of adenine-induced chronic renal failure rat by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
    • Zhao YY, Cheng XL, Wei F et al. Serum metabonomics study of adenine-induced chronic renal failure rat by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Biomarkers 17(1), 48-55 (2012).
    • (2012) Biomarkers , vol.17 , Issue.1 , pp. 48-55
    • Zhao, Y.Y.1    Cheng, X.L.2    Wei, F.3
  • 128
    • 84875473637 scopus 로고    scopus 로고
    • Ultra performance liquid chromatography-based metabonomic study of therapeutic effect of the surface layer of Poria cocos on adenine-induced chronic kidney disease provides new insight into anti-fibrosis mechanism
    • Zhao YY, Feng YL, Bai X, Tan XJ, Lin RC, Mei Q. Ultra performance liquid chromatography-based metabonomic study of therapeutic effect of the surface layer of Poria cocos on adenine-induced chronic kidney disease provides new insight into anti-fibrosis mechanism. PLoS ONE 8(3), e59617 (2013).
    • (2013) PLoS ONE , vol.8 , Issue.3 , pp. e59617
    • Zhao, Y.Y.1    Feng, Y.L.2    Bai, X.3    Tan, X.J.4    Lin, R.C.5    Mei, Q.6
  • 129
    • 84879419775 scopus 로고    scopus 로고
    • Urinary metabonomic study of the surface layer of poria cocos as an effective treatment for chronic renal injury in rats
    • Zhao YY, Li HT, Feng YL, Bai X, Lin RC. Urinary metabonomic study of the surface layer of poria cocos as an effective treatment for chronic renal injury in rats. J. Ethnopharmacol. 148(2), 403-410 (2013).
    • (2013) J. Ethnopharmacol. , vol.148 , Issue.2 , pp. 403-410
    • Zhao, Y.Y.1    Li, H.T.2    Feng, Y.L.3    Bai, X.4    Lin, R.C.5
  • 130
    • 84870520174 scopus 로고    scopus 로고
    • Application of faecal metabonomics on an experimental model of tubulointerstitial fibrosis by ultra performance liquid chromatography/high-sensitivity mass spectrometry with MSE data collection technique
    • Zhao YY, Cheng XL, Wei F, Bai X, Lin RC. Application of faecal metabonomics on an experimental model of tubulointerstitial fibrosis by ultra performance liquid chromatography/high-sensitivity mass spectrometry with MSE data collection technique. Biomarkers 17(8), 721-729 (2012).
    • (2012) Biomarkers , vol.17 , Issue.8 , pp. 721-729
    • Zhao, Y.Y.1    Cheng, X.L.2    Wei, F.3    Bai, X.4    Lin, R.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.