Proteomic and lipidomic signatures of lipid metabolism in NASH-associated Hepatocellular carcinoma

Cancer Research

Volumn 73, Issue 15, 2013, Pages 4722-4731

  Muir, Kyle ^a   Hazim, Antonious ^a   He, Ying ^b   Peyressatre, Marion ^a   Kim, Do Young ^a,c   Song, Xiaoling ^a   Beretta, Laura ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; ACYL COENZYME A SYNTHETASE LIGASE 1; ACYL COENZYME A SYNTHETASE LIGASE 2; ADRENIC ACID; CERVONIC ACID; ELOVL6 PROTEIN; ERUCIC ACID; FATTY ACID DESATURASE 2; HEPTADECANOIC ACID; ICOSAPENTAENOIC ACID; LIGNOCERIC ACID; LINOLEIC ACID; LONG CHAIN FATTY ACID COENZYME A LIGASE; MONOUNSATURATED FATTY ACID; OLEIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; OSBOND ACID; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SATURATED FATTY ACID; STEAROYL COENZYME A DESATURASE 1; STEAROYL COENZYME A DESATURASE 2; UNCLASSIFIED DRUG; VACCENIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; LIPID COMPOSITION; LIPID METABOLISM; LIPIDOMICS; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS; TUMOR VOLUME; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; DISEASE MODELS, ANIMAL; FATTY LIVER; HUMANS; LIPID METABOLISM; LIVER NEOPLASMS; MICE; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; PROTEOME; PTEN PHOSPHOHYDROLASE;

EID: 84881454013     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-3797     Document Type: Article

References (20)

1. El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007;132:2557-76.
2. Horie Y, Suzuki A, Kataoka E, Sasaki T, Hamada K, Sasaki J, et al. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 2004;113:1774-83.
3. Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, et al. Liverspecific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity. Proc Natl Acad Sci U S A 2004;101:2082-7.
4. Lai KKY, Shang S, Lohia N, Booth GC, Masse DJ, Fausto N, et al. Extracellular matrix dynamics in hepatocarcinogenesis: a comparative proteomics study of PDGFC transgenic and Pten null mouse models. PLoS Genet 2011;7:e1002147.
5. Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology 2005;42:1208-36.
6. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957;226:497-509.
7. Schlierf G, Wood P. Quantitative determination of plasma free fatty acids and triglycerides by thin-layer chromatography. J Lipid Res 1965;6:317-9.
8. Lepage G, Roy CC. Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res 1986;27:114-20.
9. Lai KK, Kolippakkam D, Beretta L. Comprehensive and quantitative proteome profiling of the mouse liver and plasma. Hepatology 2008;47:1043-51.
10. Furuta E, Okuda H, Kobayashi A, Watabe K. Metabolic genes in cancer: their roles in tumor progression and clinical implications. Biochim Biophys Acta 2010;1805:141-52.
11. Mashima T, Seimiya H, Tsuruo T. De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy. Br J Cancer 2009;100:1369-72.
12. Calvisi DF, Wang C, Ho C, Ladu S, Lee SA, Mattu S, et al. Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Gastroenterology 2011;140:1071-83.
13. Watanabe S, Horie Y, Suzuki A. Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma. Hepatol Res 2005;33:161-6.
14. Vinciguerra M, Veyrat-Durebex C, Moukil MA, Rubbia-Brandt L, Rohner-Jeanrenaud F, Foti M. PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism. Gastroenterology 2008;134:268-80.
15. Green CD, Ozguden-Akkoc CG, Wang Y, Jump DB, Olson LK. Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species. J Lipid Res 2010;51:1871-7.
16. Ishii D, Ying TH, Mahara A, Murakami S, Yamaoka T, Lee WK, et al. In vivo tissue response and degradation behavior of PLLA and stereocomplexed PLA nanofibers. Biomacromolecules 2009;10: 237-42.
17. Sawada N, Inoue M, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, et al. Consumption of n-3 fatty acids and fish reduces risk of hepatocellular carcinoma. Gastroenterology 2012;142:1468-75.
18. Puri P, Baillie RA, Wiest MM, Mirshahi F, Choudhury J, Cheung O, et al. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology 2007;46:1081-90.
19. Puri P, Wiest MM,Cheung O, Mirshahi F, Sargeant C, Min HK, et al. The plasma lipidomic signature of nonalcoholic steatohepatitis. Hepatology 2009;50:1827-38.
20. Patterson AD, Maurhofer O, Beyoglu D, Lanz C, Krausz KW, Pabst T, et al. Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling. Cancer Res 2011;71: 6590-600.