COX-2 is expressed in human pulmonary, colonic, and mammary tumors

Cancer

Volumn 89, Issue 12, 2000, Pages 2637-2645

  Soslow, Robert A ^a,c   Dannenberg, Andrew J ^a   Rush, Demaretta ^a   Woerner, B M ^a   Nasir Khan, K ^a   Masferrer, J ^b   Koki, Alane T ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b PFIZER INC   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Breast carcinoma; Cancer prevention; Colon carcinoma; COX 2; Cyclooxygenase; Immunohistochemistry; Lung carcinoma

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; MONOCLONAL ANTIBODY; PARAFFIN; POLYCLONAL ANTIBODY;

ADULT; AGED; ARTICLE; BREAST TUMOR; CANCER CELL; CARCINOGENESIS; CARCINOMA IN SITU; CELL PROLIFERATION; COLON ADENOCARCINOMA; COLON ADENOMA; COLON TUMOR; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTRADUCTAL CARCINOMA; LUNG ADENOCARCINOMA; LUNG SQUAMOUS CELL CARCINOMA; LUNG TUMOR; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BREAST; BREAST NEOPLASMS; COLON; COLONIC NEOPLASMS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; LUNG; LUNG NEOPLASMS; MEMBRANE PROTEINS; NEOPLASMS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 0034671806     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0142(20001215)89:12<2637::AID-CNCR17>3.0.CO;2-B     Document Type: Article

References (55)

1. Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: A potential mechanism for inflammatory angiogenesis
2. Regulation of the immune response by prostaglandins
3. Towards a better aspirin
4. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines
5. Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester
6. Regulation of cylooxygenase-2 in aortic smooth muscle cells
7. Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells
8. Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells
9. Dose-related inhibition of colon carcinogenesis by dietary piroxicam, a nonsteroidal antiinflammatory drug during different stages of rat colon tumor development
10. Antitumoral activity of indomethacin on experimental esophageal tumors
11. Further studies on the therapeutic effect of indomethacin on esophageal tumors
12. Delay in hamster buccal pouch carcinogenesis by aspirin and indomethacin
13. Inhibition of lung tumorigenesis by sulindac
14. Inhibition of mammary carcino-genesis by flurbiprofen, a non-steroidal antiinflammatory agent
15. Aspirin and the risk of colorectal cancer in women
16. Aspirin and reduced risk of esophageal cancer
17. The specific cyclooxygenase-2 inhibitor, celecoxib, causes adenoma regression in the APC mutant Min mouse model
18. Evaluation of cyclooxygenase-2 inhibitors for potential chemopreventive properties in colon carcinogenesis
19. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis
20. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis
21. Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition
22. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
23. Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels
24. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor
25. A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors
26. Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent
27. The sulfide metabolite of sulindac prevents tumors and restores enterocyte apoptosis in a murine model of familial adenomatous polyposis
28. The role of COX-2 in intestinal cancer
29. Ackerman's surgical pathology
30. TNM classification of malignant tumors
31. Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer
32. Application of tyramide signal amplification to immunohistochemistry: A potent method to localize antigens that are not detectable by ordinary methods
33. Applications of a signal amplification technique for light microscopy
34. Potential utility of COX-2 inhibitors in chemoprevention and chemotherapy
35. Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas
36. Expression of cyclooxygenase-2 in human lung carcinoma
37. Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: Up-regulation of interleukin 10 and down-regulation of interleukin 12 production
38. Cyclooxygenase-2 (COX-2) and cytosolic phospholipase (cPLA2) are overexpressed in human nonsmall cell lung cancer (NSCLC) [abstract]
39. Expression of cyclooxygenase-1 and -2 in human colorectal cancer
40. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
41. Cyclooxygenase-1 and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas and in azoxymethane induced colonic tumours in rats
42. Heterogeneous distribution of COX-2 over-expression in human colon carcinoma cells
43. Increased expression of cylooxygenase-2 to -1 in human colorectal cancers and adenomas, but not in hyperplastic polyps
44. Why is cyclooxygenase-2 expressed in neuroendocrine cells of the human alimentary tract?
45. Dominance of cyclooxygenase-2 in the regulation of pancreatic islet prostaglandin synthesis
46. Differential expression and regulation of cyclooxygenase-1 and -2 in two human breast cancer cell lines
47. Expression of cyclooxygenase- 1 and cyclooxygenase-2 in human breast cancer
48. Cyclooxygenase-2 gene expression in human breast cancer
49. Incidence of and treatment for ductal carcinoma in situ of the breast
50. Landscaping the cancer terrain
51. Effect of NSAIDs on proliferation of gastric cancer cells in vitro: Possible implication of cyclooxygenase-2 in cancer development
52. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandinendoperoxide synthase-2
53. Angiogenesis inhibition as a drug target for disease: An update
54. 2and angiogenesis
55. Aspirin and the potential role of prostaglandins in colon cancer [review]