Intrarenal metabolomic investigation of chronic kidney disease and its TGF-β1 mechanism in induced-adenine rats using UPLC Q-TOF/HSMS/MS E

Journal of Proteome Research

Volumn 12, Issue 2, 2013, Pages 692-703

  Zhao, Ying Yong ^a   Cheng, Xian Long ^b   Wei, Feng ^b   Bai, Xu ^d   Tan, Xiao Jie ^d   Lin, Rui Chao ^b   Mei, Qibing ^c  

^a NORTHWEST UNIVERSITY   (China)

^b NATIONAL INSTITUTES FOR FOOD AND DRUG CONTROL   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^d Waters Technologies Shanghai Ltd   (China)

Author keywords

chronic kidney disease; metabolomic; MSE; TGF 1; ultra performance liquid chromatography

Indexed keywords

ADENINE; INDICAN; TRANSFORMING GROWTH FACTOR BETA1; TRIACYLGLYCEROL;

ALGORITHM; ANEMIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIREFRINGENCE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CHRONIC KIDNEY DISEASE; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; DIETARY INTAKE; FATTY ACID METABOLISM; HISTOPATHOLOGY; KIDNEY FIBROSIS; KIDNEY METABOLISM; LEUKOCYTE COUNT; MALE; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRIACYLGLYCEROL BLOOD LEVEL; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UREA NITROGEN BLOOD LEVEL;

ADENINE; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRESOLS; FATTY ACIDS, UNSATURATED; FIBROSIS; GENE EXPRESSION; INDICAN; KIDNEY FUNCTION TESTS; KIDNEY TUBULES; MALE; METABOLOME; RATS; RENAL INSUFFICIENCY, CHRONIC; SULFURIC ACID ESTERS; TANDEM MASS SPECTROMETRY; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84873374171     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr3007792     Document Type: Article

References (63)

1. Lameire, N.; Jager, K.; Van, Biesen, W.; de Bacquer, D.; Vanholder, R. Chronic kidney disease: a European perspective Kidney Int. 2005, 99, S30-38
2. Levey, A. S.; Atkins, R.; Coresh, J.; Cohen, E. P.; Collins, A. J.; Eckardt, K. U.; Nahas, M. E.; Jaber, B. L.; Jadoul, M.; Levin, A.; Powe, N. R.; Rossert, J.; Wheeler, D. C.; Lameire, N.; Eknoyan, G. Chronic kidney disease as a global public health problem: approaches and initiatives-a position statement from Kidney Disease Improving Global Outcomes Kidney Int. 2007, 72, 247-259
3. Meguid, E. L.; Nahas, A.; Bello, A. K. Chronic kidney disease: the global challenge Lancet 2005, 365, 331-340
4. Mori, K.; Nakao, K. Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage Kidney Int. 2007, 71, 967-970
5. Ekman, D. R.; Keun, H. C.; Eads, C. D.; Furnish, C. M.; Rockett, J. C.; Dix, D. J. Metabolomic evaluation of rat liver and testis to characterize the toxicity of triazole fungicides Metabolomics 2006, 2, 63-73
6. Yin, P.; Mohemaiti, P.; Chen, J.; Zhao, X.; Lu, X.; Yimiti, A.; Upur, H.; Xu, G. Serum metabolic profiling of abnormal savda by liquid chromatography/mass spectrometry J. Chromatogr., B 2008, 871, 322-327
7. 2 toxicity J. Proteome Res. 2006, 5, 1313-1320
8. Kellert, M.; Wagner, S.; Lutz, U.; Lutz, W. K. Biomarkers of furan exposure by metabolic profiling of rat urine with liquid chromatography-tandem mass spectrometry and principal component analysis Chem. Res. Toxicol. 2008, 21, 761-768
9. Lao, Y. M.; Jiang, J. G.; Yan, L. Application of metabonomic analytical techniques in the modernization and toxicology research of traditional Chinese medicine Br. J. Pharmacol. 2009, 157, 1128-1141
10. Aurélie, R.; Dominique, L.; Christophe, J.; Jean-François, H. Applications of liquid chromatography coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: A review Clin. Biochem. 2011, 44, 119-135
11. Theodoridis, G.; Gika, H, G.; Wilson, I. D. LC-MS-based methodology for global metabolite profiling in metabonomics/metabolomics Trend. Anal. Chem. 2008, 27, 251-260
12. Fukui, Y.; Kato, M.; Inoue, Y.; Matsubara, A.; Itoh, K. A metabonomic approach identifies human urinary phenylacetylglutamine as a novel marker of interstitial cystitis J. Chromatogr., B 2009, 877, 3806-3812
13. Zhao, Y. Y.; Cheng, X. L.; Wei, F.; Xiao, X. Y.; Sun, W. J.; Zhang, Y. M.; Lin, R. C. Serum metabonomics study of adenine-induced chronic renal failure rat by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry Biomarkers 2012, 17, 48-55
14. Wrona, M.; Mauriala, T.; Bateman, K. P.; Mortishire-Smith, R. J.; O'Connor, D. 'All-in-One' analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching Rapid Commun. Mass Spectrom. 2005, 19, 2597-2602
15. E with mass defect filtering for in vitro and in vivo metabolite identification Rapid Commun. Mass Spectrom. 2007, 21, 1485-1496
16. Rainville, P. D.; Stumpf, C. J.; Shockcor, J. P.; Plumb, R. S.; Nicholson, J. K. Novel application of reversed-phase UPLC-oaTOFMS for lipid analysis in complex biological mixture: a new tool for lipidomics J. Proteome Res. 2007, 6, 552-558
17. E data collection technique Biomarkers 2012, 17, 721-729
18. Jia, L. W.; Chen, J.; Yin, P. Y.; Lu, X.; Xu, G. W. Serum metabonomics study of chronic renal failure by ultra performance liquid chromatography coupled with Q-TOF mass spectrometry Metabolomics 2008, 4, 183-189
19. Zhao, Y. Y.; Liu, J.; Cheng, X. L.; Bai, X.; Lin, R. C. Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS Clin. Chim. Acta 2012, 413, 642-649
20. Engle, S. J.; Stockelman, M. G.; Chen, J.; Boivin, G.; Yum, M. N.; Daviest, P. M.; Ying, M. Y.; Sahota, A.; Simmondst, H. A.; Stambrook, P. J.; Tischfield, J. A. Adenine phosphoribosyltransferase-deficientmice develop 2,8-dihydroxyadenine nephrolithiasis Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 5307-5312
21. Simmonds, H. A.; Sahota, A.; Van Acker, K. J. APRT deficiency: 2,8-dihydroxyadenine lithiasis. In The metabolic and molecular bases of inherited disease, 7 th ed.; Stanbury, J. B.; Wyngaarden, J. B.; Fredrickson, D. G., Ed.; McGraw-Hill: New York, 1995.
22. Wyngaarden., J. B.; Dunn, J. T. 8-Hydroxyadenine as the metabolic intermediate in the oxidation of adenine to 2,8-dihydroxyadenine by xanthine oxidase Arch. Biochem. Biophys. 1957, 70, 150-156
23. De Vries, A.; Sperling, O. Implications of disorders of purine metabolism for the kidney and the urinary tract Ciba Found. Symp. 1977, 48, 179-206
24. Yokozawa, T.; Zheng, P. D.; Oura, H.; Koizumi, F. Animal model of adenine-induced chronic renal failure in rats Nephron 1986, 44, 230-234
25. Shankland, S. S.; Scholey, J. W.; Thai, K. Expression of transforming growth factor-β1 during diabetic renal hypertrophy Kidney Int. 1994, 46, 430-442
26. Lin, C. Y.; Wu, H.; Tjeerdema, R. S.; Viant, M. R. Evaluation of metabolite extraction strategies from tissue samples using NMR metabolomics Metabolomics 2007, 3, 55-67
27. Masson, P.; Alves, A. C.; Ebbels, T. M.; Nicholson, J. K.; Want, E. Optimization and evaluation of metabolite extraction protocols for untargeted metabolic profiling of liver samples by UPLC-MS J. Anal. Chem. 2010, 82, 7779-7786
28. Le Belle, J. E.; Harris, N. G.; Williams, S. R.; Bhakoo, K. K. A comparison of cell and tissue extraction techniques using high-resolution 1H-NMR spectroscopy NMR Biomed. 2002, 15, 37-44
29. Ma, C.; Bi, K.; Su, D.; Ji, W.; Zhang, M.; Fan, X.; Wang, C.; Chen, X. Serum and kidney metabolic changes of rat nephrotoxicity induced by Morning Glory Seed Food Chem. Toxicol. 2010, 48, 2988-2993
30. McDonald, P. D.; McCabe, D.; Alden, B. A.; Lawrence, N.; Walsh, D. P.; Iraneta, P. C.; Grumbach, E.; Xia, F.; Hong, P. Waters whitepaper, Topics in liquid chromatography: part 1 designing a reversed-phase column for polar compounds retention [Online], 2007; http://www.waters.com/webassets/cms/library/ docs/720001889en.pdf.
31. Kaori, K.; Yoshiharu, I.; Ryoko, T.; Atsuko, E.; Kenjiro, M.; Toshimitsu, N. Metabolomic analysis of uremic toxins by liquid chromatography/electrospray ionization-tandem mass spectrometry J. Chromatogr., B 2010, 878, 1662-1668
32. Kaori, K.; Yoshiharu, I.; Ryoko, T.; Atsuko, E.; Kenjiro, M.; Toshimitsu, N. Metabolomic search for uremic toxins as indicators of the effect of an oral sorbent AST-120 by liquid chromatography/tandem mass spectrometry J. Chromatogr., B 2010, 878, 2997-3002
33. Zhao, Y. Y.; Cheng, X. L.; Wei, F.; Bai, X.; Lin, R. C. Effect of ergosta-4,6,8(14),22-tetraen-3-one (ergone) on adenine-induced chronic renal failure rat: A serum metabonomics study based on ultra performance liquid chromatography/high-sensitivity mass spectrometry coupled with MassLynx i-FIT algorithm Clin. Chim. Acta 2012, 413, 1438-1445
34. E data collection technique Process Biochem. 2012, 47, 1980-1987
35. Gomez Dumm, N. T.; Giammona, A. M.; Touceda, L. A.; Raimondi, C. Lipid abnormalities in chronic renal failure patients undergoing hemodiaysis Medicina 2001, 61, 142-146
36. Jia, L.; Wang, C.; Kong, H.; Cai, Z.; Xu, G. Plasma phospholipid metabolic profiling and biomarkers of mouse IgA nephropathy Metabolomics 2006, 2, 95-104
37. Jia, L.; Wang, C.; Zhao, S.; Lu, X.; Xu, G. Metabolomic identification of potential phospholipid biomarkers for chronic glomerulonephritis by using high performance liquid chromatography-mass spectrometry J. Chromatogr., B 2007, 860, 134-140
38. Yoshioka, Y.; Tsutsumi, T.; Adachi, M.; Tokumura, A. Altered phospholipid profile in urine of rats with unilateral ureteral obstruction Metabolomics 2009, 5, 429-433
39. Dyerberg, J. Linoleate-derived polyunsaturated fatty acids and prevention of atherosclerosis Nutr. Rev. 1986, 44, 125-134
40. Nakamura, N.; Fujita, T.; Kumasaka, R.; Murakami, R.; Shimada, M.; Shimaya, Y.; Osawa, H.; Hideakiy, A.; Okumura, K. Serum lipid profile and plasma fatty acid composition in hemodialysis patients-comparison with chronic kidney disease patients In Vivo 2008, 22, 609-612
41. El-Sorr, M. H.; Shalaby, H. A. Assessment of the role of polyunsaturated fatty acids in chronic kidney disease J. Arab. Soc. Med. Res. 2010, 1, 25-30
42. Baggio, B.; Musacchio, E.; Priante, G. Polyunsaturated fatty acids and renal fibrosis: pathophysiologic link and potential clinical implications J. Nephrol. 2005, 18, 362-367
43. Priante, G.; Musacchio, E.; Valvason, C.; Baggio, B. EPA and DHA suppress AngII- and arachidonic acid-induced expression of profibrotic genes in human mesangial cells J. Nephrol. 2009, 22, 137-143
44. Niwa, T.; Ise, M. Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis J. Lab. Clin. Med. 1994, 124, 96-104
45. Niwa, T.; Ise, M.; Miyazaki, T. An oral sorbent reduces overload of indoxyl sulphate and gene expression of TGF-beta1 in uraemic rat kidneys Am. J. Nephrol. 1994, 14, 207-212
46. Miyazaki, T.; Ise, M.; Seo, H.; Niwa, T. Indoxyl sulfate increases the gene expressions of TGF-1, TIMP-1 and pro-1(I) collagen in uremic rat kidneys Kidney Int. 1997, 52, S15-22
47. Miyazaki, T.; Ise, M.; Hirata, M.; Endo, K.; Ito, Y.; Seo, H. Indoxyl sulfate stimulates renal synthesis of transforming growth factor-beta 1 and progression of renal failure Kidney Int. 1997, 52, S211-214
48. Martinez, A. W.; Recht, N. S.; Hostetter, T. H.; Meyer, T. W.; Niwa, T. Removal of p-cresol sulfate by hemodialysis J. Am. Soc. Nephrol. 2005, 16, 3430-3436
49. Schepers, E.; Meert, N.; Glorieux, G.; Goeman, J.; Van der Eycken, J.; Vanholder, R. p-Cresylsulphate, the main in vivo metabolite of p-cresol, activates leucocyte free radical production Nephrol. Dial. Transplant. 2007, 22, 592-596
50. Niwa, T. Indoxyl sulfate is a nephro-vascular toxin J. Ren. Nutr. 2010, 20, S2-6
51. Barreto, F. C.; Barreto, D. V.; Liabeuf, S.; Meert, N.; Glorieux, G.; Temmar, M.; Choukroun, G.; Vanholder, R.; Massy, Z. A. Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients Clin. J. Am. Soc. Nephrol. 2009, 4, 1551-1558
52. Wikoff, W. R.; Anfora, A. T.; Liu, J.; Schultz, P. G.; Lesley, S. A.; Peters, E. C.; Siuzdak, G. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 3698-3703
53. Tsutsumi, Y.; Deguchi, T.; Takano, M.; Takadate, A.; Lindup, W. E.; Otagiri, M. Renal disposition of a furan dicarboxylic acid and other uremic toxins in the rat J. Pharmacol. Exp. Ther. 2002, 303, 880-887
54. Taki, K.; Nakamura, S.; Miglinas, M.; Enomoto, A.; Niwa, T. Accumulation of indoxyl sulfate in OAT1/3-positive tubular cells in kidneys of patients with chronic renal failure J. Ren. Nutr. 2006, 16, 199-203
55. Toshimitsu, N.; Naohito, T.; Hideo, Y. RNA metabolism in uremic patients: Accumulation of modified ribonucleosides in uremic serum Kidney Int. 1998, 53, 1801-1806
56. Young, E. G.; Wentworth, H. P.; Hawkins, W. W. The absorption and excretion of allantoin in mammals J. Pharmacol. Exp. Ther. 1944, 81, 1-9
57. Kastenbauer, S.; Koedel, U.; Becker, B. F.; Pfister, H. W. Oxidative stress in bacterial meningitis in humans Neurology 2002, 58, 186-191
58. Matrens, M. E.; Storey, B. T.; Lee, C. P. Generation of allantoin from the oxidation of urate by cytochromec and its possible role in Reye's syndrome Arch. Biochem. Biophys. 1987, 252, 91-96
59. Radim, R.; Rubbo, H.; Thomson, L.; Prodanov, E. Luminol chemiluminis-cence using xanthine and hypoxanthine as xanthine oxidase substrates Free Radic. Biol. Med. 1990, 8, 121-126
60. Zinellu, A.; Sotgia, S.; Pisanu, E.; Loriga, G.; Deiana, L.; Satta, A. E.; Carru, C. LDL S-homocysteinylation decrease in chronic kidney disease patients undergone lipid lowering therapy Eur. J. Pharm. Sci. 2012, 47, 117-123
61. Roman, K.; Pavla, Z. Allantoin as a marker of oxidative stress in human erythrocytes Clin. Chem. Lab. Med. 2008, 46, 1270-1274
62. Rahman, A.; Ahmed, S.; Vasenwala, S. M.; Athar, M. Glyceryl trinitrate, a nitric oxide donor, abrogates ferric nitrilotriacetate-induced oxidative stress and renal damage Arch. Biochem. Biophys. 2003, 418, 71-79
63. Maldonado, P.; Barrera, D.; Medina, C. O.; Hernandez, P. R.; Ibarra, R. M.; Pedraza, C.J. Aged garlic extract attenuates gentamicin induced renal damage and oxidative stress in rats Life Sci. 2003, 73, 2543-2556