Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-α

Carcinogenesis

Volumn 32, Issue 6, 2011, Pages 897-903

  Weylandt, Karsten H ^a,b   Krause, Lena F ^a,b   Gomolka, Beate ^b   Chiu, Cheng Ying ^b   Bilal, Süleyman ^a,b   Nadolny, Anja ^a,b   Waechter, Simon F ^a,b   Fischer, Andreas ^b   Rothe, Michael ^c   Kang, Jing X ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c LIPIDOMIX GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

17 HYDROXYDOCOSAHEXAENOIC ACID; 18 HYDROXYEICOSAPENTAENOIC ACID; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYCLOOXYGENASE 2; DIETHYLNITROSAMINE; LIPID MEDIATOR; LIPOPOLYSACCHARIDE; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; FIBROGENESIS; HEPATITIS; LIPIDOMICS; LIVER CARCINOGENESIS; LIVER FIBROSIS; MACROPHAGE; MALE; MEDIATOR RELEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TUMOR VOLUME; WILD TYPE;

EID: 79958204979     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr049     Document Type: Article

References (23)

1. El-Serag, H.B. et al. (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 132, 2557-2576.
2. El-Serag, H.B. et al. (2008) Diagnosis and treatment of hepatocellular carcinoma. Gastroenterology, 134, 1752-1763.
3. Pikarsky, E. et al. (2004) NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature, 431, 461-466.
4. Sakurai, T. et al. (2006) Inaugural article: loss of hepatic NF-{kappa}B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc. Natl Acad. Sci. USA, 103, 10544-10551.
5. Maeda, S. et al. (2005) IKKbeta couples hepatocyte death to cytokinedriven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell, 121, 977-990.
6. Luedde, T. et al. (2007) Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell, 11, 119-132.
7. Weylandt, K.H. et al. (2005) Rethinking lipid mediators. Lancet, 366, 618-620.
8. Schmocker, C. et al. (2007) Omega-3 fatty acids alleviate chemically induced acute hepatitis by suppression of cytokines. Hepatology, 45, 864-869.
9. Gonzalez-Periz, A. et al. (2006) Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA. FASEB J., 20, 2537-2539.
10. Puri, P. et al. (2009) The plasma lipidomic signature of nonalcoholic steatohepatitis. Hepatology, 50, 1827-1838.
11. Puri, P. et al. (2007) A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology, 46, 1081-1090.
12. Kang, J.X. et al. (2004) Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids. Nature, 427, 504.
13. Kang, J.X. (2007) Fat-1 transgenic mice: a new model for omega-3 research. Prostaglandins Leukot. Essent. Fatty Acids, 77, 263-267.
14. Griffitts, J. et al. (2010) Non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis model omega-3 fatty acids prevent liver neoplasia. Biochim. Biophys. Acta, 1801, 1133-1144.
15. Lim, K. et al. (2009) Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase- Mol. Cancer Ther., 8, 3046-3055.
16. Ishak, K. et al. (1995) Histological grading and staging of chronic hepatitis. J. Hepatol., 22, 696-699.
17. Knodell, R.G. et al. (1981) Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology, 1, 431-435.
18. Rivera, J. et al. (2004) Measurement of 20-hydroxyeicosatetraenoic acid in human urine by gas chromatography-mass spectrometry. Clin. Chem., 50, 224-226.
19. Jelinska, M. et al. (2003) Effects of dietary linseed, evening primrose or fish oils on fatty acid and prostaglandin E2 contents in the rat livers and 7, 12-dimethylbenz[a]anthracene-induced tumours. Biochim. Biophys. Acta, 1637, 193-199.
20. Kim, Y. et al. (2000) Modulation of liver microsomal monooxygenase system by dietary n-6/n-3 ratios in rat hepatocarcinogenesis. Nutr. Cancer, 37, 65-72.
21. Lii, C.K. et al. (2000) Suppression of altered hepatic foci development by a high fish oil diet compared with a high corn oil diet in rats. Nutr. Cancer, 38, 50-59.
22. Serhan, C.N. et al. (2008) Endogenous pro-resolving and anti-inflammatory lipid mediators: a newpharmacologic genus. Br. J. Pharmacol., 153 (suppl. 1), S200-S215.
23. Gleissman, H. et al. (2009) Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates. FASEB J., 24, 906-915.