Identification of STAT1 and STAT3 specific inhibitors using comparative virtual screening and docking validation

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Szelag, Malgorzata ^a   Czerwoniec, Anna ^a   Wesoly, Joanna ^a   Bluyssen, Hans A R ^a  

^a ADAM MICKIEWICZ UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

3 (6 BROMO 2 PYRIDINYL) 2 CYANO N (1 PHENYLETHYL)ACRYLAMIDE; BP 1102; CPD 188; CPD 30 12; CUCURBITACIN E; CUCURBITACIN Q; CURCUMIN; FLLL 32; HJC 0123; LLL 12; NATURAL PRODUCT; OPB 31121; PROTEIN INHIBITOR; PROTEIN SH2; S 3I 201; S 3I 2011066; STAT1 PROTEIN; STAT1 PROTEIN INHIBITOR; STAT3 PROTEIN; STAT3 PROTEIN INHIBITOR; STX 0119; TYROSINE; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; MOLECULAR LIBRARY; PROTEIN BINDING; STAT1 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; COMPARATIVE STUDY; COMPUTER MODEL; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SCREENING; LIGAND BINDING; MOLECULAR DOCKING; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN FUNCTION; VALIDATION STUDY; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; HIGH THROUGHPUT SCREENING; HUMAN; MOLECULAR GENETICS; MOLECULAR LIBRARY; PHARMACOLOGY;

AMINO ACID SEQUENCE; BINDING SITES; BIOLOGICAL PRODUCTS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; SMALL MOLECULE LIBRARIES; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR;

EID: 84923352598     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0116688     Document Type: Article

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