-
2
-
-
0027184481
-
A general two-metal-ion mechanism for catalytic RNA
-
Steitz, T. A.; Steitz, J. A. A general two-metal-ion mechanism for catalytic RNA Proc. Natl. Acad. Sci. U. S. A. 1993, 90, 6498-6502
-
(1993)
Proc. Natl. Acad. Sci. U. S. A.
, vol.90
, pp. 6498-6502
-
-
Steitz, T.A.1
Steitz, J.A.2
-
3
-
-
68949170348
-
Metalloproteins and metal sensing
-
Waldron, K. J.; Rutherford, J. C.; Ford, D.; Robinson, N. J. Metalloproteins and metal sensing Nature 2009, 460, 823-830
-
(2009)
Nature
, vol.460
, pp. 823-830
-
-
Waldron, K.J.1
Rutherford, J.C.2
Ford, D.3
Robinson, N.J.4
-
4
-
-
84892151875
-
Competition among metal ions for protein binding sites: Determinants of metal ion selectivity in proteins
-
Dudev, T.; Lim, C. Competition among metal ions for protein binding sites: Determinants of metal ion selectivity in proteins Chem. Rev. 2014, 114, 538-556
-
(2014)
Chem. Rev.
, vol.114
, pp. 538-556
-
-
Dudev, T.1
Lim, C.2
-
5
-
-
0032518374
-
A mechanism for all polymerases
-
Steitz, T. A. A mechanism for all polymerases Nature 1998, 391, 231-232
-
(1998)
Nature
, vol.391
, pp. 231-232
-
-
Steitz, T.A.1
-
6
-
-
79951678159
-
Nucleases: Diversity of structure, function and mechanism
-
Yang, W. Nucleases: Diversity of structure, function and mechanism Q. Rev. Biophys. 2011, 44, 1-93
-
(2011)
Q. Rev. Biophys.
, vol.44
, pp. 1-93
-
-
Yang, W.1
-
7
-
-
78549235443
-
Topoisomerases and site-specific recombinases: Similarities in structure and mechanism
-
Yang, W. Topoisomerases and site-specific recombinases: Similarities in structure and mechanism Crit. Rev. Biochem. Mol. Biol. 2010, 45, 520-534
-
(2010)
Crit. Rev. Biochem. Mol. Biol.
, vol.45
, pp. 520-534
-
-
Yang, W.1
-
8
-
-
21244451435
-
Crystal structures of RNase H bound to an RNA/DNA hybrid: Substrate specificity and metal-dependent catalysis
-
Nowotny, M.; Gaidamakov, S. A.; Crouch, R. J.; Yang, W. Crystal structures of RNase H bound to an RNA/DNA hybrid: Substrate specificity and metal-dependent catalysis Cell 2005, 121, 1005-1016
-
(2005)
Cell
, vol.121
, pp. 1005-1016
-
-
Nowotny, M.1
Gaidamakov, S.A.2
Crouch, R.J.3
Yang, W.4
-
9
-
-
33646004109
-
Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release
-
Nowotny, M.; Yang, W. Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release EMBO J. 2006, 25, 1924-1933
-
(2006)
EMBO J.
, vol.25
, pp. 1924-1933
-
-
Nowotny, M.1
Yang, W.2
-
10
-
-
78649267074
-
Crystal structures of RNase H2 in complex with nucleic acid reveal the mechanism of RNA-DNA junction recognition and cleavage
-
Rychlik, M. P.; Chon, H.; Cerritelli, S. M.; Klimek, P.; Crouch, R. J.; Nowotny, M. Crystal structures of RNase H2 in complex with nucleic acid reveal the mechanism of RNA-DNA junction recognition and cleavage Mol. Cell 2010, 40, 658-670
-
(2010)
Mol. Cell
, vol.40
, pp. 658-670
-
-
Rychlik, M.P.1
Chon, H.2
Cerritelli, S.M.3
Klimek, P.4
Crouch, R.J.5
Nowotny, M.6
-
11
-
-
77953229439
-
A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases
-
Schmidt, B. H.; Burgin, A. B.; Deweese, J. E.; Osheroff, N.; Berger, J. M. A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases Nature 2010, 465, 641-644
-
(2010)
Nature
, vol.465
, pp. 641-644
-
-
Schmidt, B.H.1
Burgin, A.B.2
Deweese, J.E.3
Osheroff, N.4
Berger, J.M.5
-
12
-
-
77955334540
-
Structural basis of gate-DNA breakage and resealing by type II topoisomerases
-
Laponogov, I.; Pan, X. S.; Veselkov, D. A.; McAuley, K. E.; Fisher, L. M.; Sanderson, M. R. Structural basis of gate-DNA breakage and resealing by type II topoisomerases PLoS One 2010, 5 e11338
-
(2010)
PLoS One
, vol.5
, pp. 11338
-
-
Laponogov, I.1
Pan, X.S.2
Veselkov, D.A.3
McAuley, K.E.4
Fisher, L.M.5
Sanderson, M.R.6
-
13
-
-
61349157313
-
Ribonuclease H properties, substrate specificity and roles in retroviral reverse transcription
-
Champoux, J. J.; Schultz, S. J. Ribonuclease H properties, substrate specificity and roles in retroviral reverse transcription FEBS J. 2009, 276, 1506-1516
-
(2009)
FEBS J.
, vol.276
, pp. 1506-1516
-
-
Champoux, J.J.1
Schultz, S.J.2
-
14
-
-
0025162621
-
Three-dimensional structure of ribonuclease H from E. Coli
-
Katayanagi, K.; Miyagawa, M.; Matsushima, M.; Ishikawa, M.; Kanaya, S.; Ikehara, M.; Matsuzaki, T.; Morikawa, K. Three-dimensional structure of ribonuclease H from E. coli Nature 1990, 347, 306-309
-
(1990)
Nature
, vol.347
, pp. 306-309
-
-
Katayanagi, K.1
Miyagawa, M.2
Matsushima, M.3
Ishikawa, M.4
Kanaya, S.5
Ikehara, M.6
Matsuzaki, T.7
Morikawa, K.8
-
15
-
-
41949083183
-
Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD
-
Nowotny, M.; Cerritelli, S. M.; Ghirlando, R.; Gaidamakov, S. A.; Crouch, R. J.; Yang, W. Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD EMBO J. 2008, 27, 1172-1181
-
(2008)
EMBO J.
, vol.27
, pp. 1172-1181
-
-
Nowotny, M.1
Cerritelli, S.M.2
Ghirlando, R.3
Gaidamakov, S.A.4
Crouch, R.J.5
Yang, W.6
-
16
-
-
24644492337
-
Structural evidence for a two-metal-ion mechanism of group i intron splicing
-
Stahley, M. R.; Strobel, S. A. Structural evidence for a two-metal-ion mechanism of group I intron splicing Science 2005, 309, 1587-1590
-
(2005)
Science
, vol.309
, pp. 1587-1590
-
-
Stahley, M.R.1
Strobel, S.A.2
-
17
-
-
0037543997
-
Unified two-metal mechanism of RNA synthesis and degradation by RNA polymerase
-
Sosunov, V.; Sosunova, E.; Mustaev, A.; Bass, I.; Nikiforov, V.; Goldfarb, A. Unified two-metal mechanism of RNA synthesis and degradation by RNA polymerase EMBO J. 2003, 22, 2234-2244
-
(2003)
EMBO J.
, vol.22
, pp. 2234-2244
-
-
Sosunov, V.1
Sosunova, E.2
Mustaev, A.3
Bass, I.4
Nikiforov, V.5
Goldfarb, A.6
-
19
-
-
55549123481
-
An equivalent metal ion in one- and two-metal-ion catalysis
-
Yang, W. An equivalent metal ion in one- and two-metal-ion catalysis Nat. Struct. Mol. Biol. 2008, 15, 1228-1231
-
(2008)
Nat. Struct. Mol. Biol.
, vol.15
, pp. 1228-1231
-
-
Yang, W.1
-
20
-
-
0032571245
-
Structural principles for the inhibition of the 3 ′-5 ′ exonuclease activity of Escherichia coli DNA polymerase i by phosphorothioates
-
Brautigam, C. A.; Steitz, T. A. Structural principles for the inhibition of the 3 ′-5 ′ exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates J. Mol. Biol. 1998, 277, 363-377
-
(1998)
J. Mol. Biol.
, vol.277
, pp. 363-377
-
-
Brautigam, C.A.1
Steitz, T.A.2
-
21
-
-
2642527026
-
DNA cleavage by Eco RV endonuclease: Two metal ions in three metal ion binding sites
-
Horton, N. C.; Perona, J. J. DNA cleavage by Eco RV endonuclease: Two metal ions in three metal ion binding sites Biochemistry 2004, 43, 6841-6857
-
(2004)
Biochemistry
, vol.43
, pp. 6841-6857
-
-
Horton, N.C.1
Perona, J.J.2
-
22
-
-
70349229163
-
On the divalent metal ion dependence of DNA cleavage by restriction endonucleases of the Eco RI family
-
Pingoud, V.; Wende, W.; Friedhoff, P.; Reuter, M.; Alves, J.; Jeltsch, A.; Mones, L.; Fuxreiter, M.; Pingoud, A. On the divalent metal ion dependence of DNA cleavage by restriction endonucleases of the Eco RI family J. Mol. Biol. 2009, 393, 140-160
-
(2009)
J. Mol. Biol.
, vol.393
, pp. 140-160
-
-
Pingoud, V.1
Wende, W.2
Friedhoff, P.3
Reuter, M.4
Alves, J.5
Jeltsch, A.6
Mones, L.7
Fuxreiter, M.8
Pingoud, A.9
-
23
-
-
34147185256
-
Investigating biological systems using first principles Car-Parrinello molecular dynamics simulations
-
Dal Peraro, M.; Ruggerone, P.; Raugei, S.; Gervasio, F. L.; Carloni, P. Investigating biological systems using first principles Car-Parrinello molecular dynamics simulations Curr. Opin. Struct. Biol. 2007, 17, 149-156
-
(2007)
Curr. Opin. Struct. Biol.
, vol.17
, pp. 149-156
-
-
Dal Peraro, M.1
Ruggerone, P.2
Raugei, S.3
Gervasio, F.L.4
Carloni, P.5
-
24
-
-
0036286854
-
The role and perspective of a initio molecular dynamics in the study of biological systems
-
Carloni, P.; Rothlisberger, U.; Parrinello, M. The role and perspective of a initio molecular dynamics in the study of biological systems Acc. Chem. Res. 2002, 35, 455-464
-
(2002)
Acc. Chem. Res.
, vol.35
, pp. 455-464
-
-
Carloni, P.1
Rothlisberger, U.2
Parrinello, M.3
-
25
-
-
33947199145
-
Role of zinc content on the catalytic efficiency of B1 metallo β-lactamases
-
Dal Peraro, M.; Vila, A. J.; Carloni, P.; Klein, M. L. Role of zinc content on the catalytic efficiency of B1 metallo β-lactamases J. Am. Chem. Soc. 2007, 129, 2808-2816
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 2808-2816
-
-
Dal Peraro, M.1
Vila, A.J.2
Carloni, P.3
Klein, M.L.4
-
26
-
-
79955045990
-
Bridging quantum mechanics and structure-based drug design
-
De Vivo, M. Bridging quantum mechanics and structure-based drug design Front. Biosci., Landmark Ed. 2011, 16, 1619-1633
-
(2011)
Front. Biosci., Landmark Ed.
, vol.16
, pp. 1619-1633
-
-
De Vivo, M.1
-
27
-
-
33644968698
-
Metadynamics as a tool for exploring free energy landscapes of chemical reactions
-
Ensing, B.; De Vivo, M.; Liu, Z. W.; Moore, P.; Klein, M. L. Metadynamics as a tool for exploring free energy landscapes of chemical reactions Acc. Chem. Res. 2006, 39, 73-81
-
(2006)
Acc. Chem. Res.
, vol.39
, pp. 73-81
-
-
Ensing, B.1
De Vivo, M.2
Liu, Z.W.3
Moore, P.4
Klein, M.L.5
-
28
-
-
77957317678
-
Understanding the effect of magnesium ion concentration on the catalytic activity of ribonuclease H through computation: Does a third metal binding site modulate endonuclease catalysis?
-
Ho, M. H.; De Vivo, M.; Dal Peraro, M.; Klein, M. L. Understanding the effect of magnesium ion concentration on the catalytic activity of ribonuclease H through computation: Does a third metal binding site modulate endonuclease catalysis? J. Am. Chem. Soc. 2010, 132, 13702-13712
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 13702-13712
-
-
Ho, M.H.1
De Vivo, M.2
Dal Peraro, M.3
Klein, M.L.4
-
29
-
-
84893473257
-
Magnesium-dependent RNA binding to the PA endonuclease domain of the avian influenza polymerase
-
Xiao, S. Y.; Klein, M. L.; LeBard, D. N.; Levine, B. G.; Liang, H. J.; MacDermaid, C. M.; Afonso-Prieto, M. Magnesium-dependent RNA binding to the PA endonuclease domain of the avian influenza polymerase J. Phys. Chem. B 2014, 118, 873-889
-
(2014)
J. Phys. Chem. B
, vol.118
, pp. 873-889
-
-
Xiao, S.Y.1
Klein, M.L.2
Lebard, D.N.3
Levine, B.G.4
Liang, H.J.5
Macdermaid, C.M.6
Afonso-Prieto, M.7
-
30
-
-
33847177326
-
Modeling the charge distribution at metal sites in proteins for molecular dynamics simulations
-
Dal Peraro, M. D.; Spiegel, K.; Lamoureux, G.; De Vivo, M.; DeGrado, W. F.; Klein, M. L. Modeling the charge distribution at metal sites in proteins for molecular dynamics simulations J. Struct. Biol. 2007, 157, 444-453
-
(2007)
J. Struct. Biol.
, vol.157
, pp. 444-453
-
-
Dal Peraro, M.D.1
Spiegel, K.2
Lamoureux, G.3
De Vivo, M.4
Degrado, W.F.5
Klein, M.L.6
-
31
-
-
84899821420
-
Recent progress in the research of small molecule HIV-1 RNase H inhibitors
-
Cao, L. L.; Song, W. G.; De Clercq, E.; Zhan, P.; Liu, X. Y. Recent progress in the research of small molecule HIV-1 RNase H inhibitors Curr. Med. Chem. 2014, 21, 1956-1967
-
(2014)
Curr. Med. Chem.
, vol.21
, pp. 1956-1967
-
-
Cao, L.L.1
Song, W.G.2
De Clercq, E.3
Zhan, P.4
Liu, X.Y.5
-
32
-
-
33846245591
-
Proton shuttles and phosphatase activity in soluble epoxide hydrolase
-
De Vivo, M.; Ensing, B.; Dal Peraro, M.; Gomez, G. A.; Christianson, D. W.; Klein, M. L. Proton shuttles and phosphatase activity in soluble epoxide hydrolase J. Am. Chem. Soc. 2007, 129, 387-394
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 387-394
-
-
De Vivo, M.1
Ensing, B.2
Dal Peraro, M.3
Gomez, G.A.4
Christianson, D.W.5
Klein, M.L.6
-
33
-
-
23844483422
-
Computational study of phosphatase activity in soluble epoxide hydrolase: High efficiency through a water bridge mediated proton shuttle
-
De Vivo, M.; Ensing, B.; Klein, M. L. Computational study of phosphatase activity in soluble epoxide hydrolase: High efficiency through a water bridge mediated proton shuttle J. Am. Chem. Soc. 2005, 127, 11226-11227
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 11226-11227
-
-
De Vivo, M.1
Ensing, B.2
Klein, M.L.3
-
34
-
-
77956306804
-
Atomistic details of the associative phosphodiester cleavage in human ribonuclease H
-
Elsasser, B.; Fels, G. Atomistic details of the associative phosphodiester cleavage in human ribonuclease H Phys. Chem. Chem. Phys. 2010, 12, 11081-11088
-
(2010)
Phys. Chem. Chem. Phys.
, vol.12
, pp. 11081-11088
-
-
Elsasser, B.1
Fels, G.2
-
35
-
-
79958776843
-
Catalytic mechanism of RNA backbone cleavage by ribonuclease H from quantum mechanics/molecular mechanics simulations
-
Rosta, E.; Nowotny, M.; Yang, W.; Hummer, G. Catalytic mechanism of RNA backbone cleavage by ribonuclease H from quantum mechanics/molecular mechanics simulations J. Am. Chem. Soc. 2011, 133, 8934-8941
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 8934-8941
-
-
Rosta, E.1
Nowotny, M.2
Yang, W.3
Hummer, G.4
-
36
-
-
50249094329
-
Phosphodiester cleavage in ribonuclease H occurs via an associative two-metal-aided catalytic mechanism
-
De Vivo, M.; Dal Peraro, M.; Klein, M. L. Phosphodiester cleavage in ribonuclease H occurs via an associative two-metal-aided catalytic mechanism J. Am. Chem. Soc. 2008, 130, 10955-10962
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 10955-10962
-
-
De Vivo, M.1
Dal Peraro, M.2
Klein, M.L.3
-
37
-
-
84865102002
-
Contemporary challenges in the design of topoisomerase II inhibitors for cancer chemotherapy
-
Bailly, C. Contemporary challenges in the design of topoisomerase II inhibitors for cancer chemotherapy Chem. Rev. 2012, 112, 3611-3640
-
(2012)
Chem. Rev.
, vol.112
, pp. 3611-3640
-
-
Bailly, C.1
-
38
-
-
84873655744
-
Molecular simulations highlight the role of metals in catalysis and inhibition of type II topoisomerase
-
Palermo, G.; Stenta, M.; Cavalli, A.; Dal Peraro, M.; De Vivo, M. Molecular simulations highlight the role of metals in catalysis and inhibition of type II topoisomerase J. Chem. Theory Comput. 2013, 9, 857-862
-
(2013)
J. Chem. Theory Comput.
, vol.9
, pp. 857-862
-
-
Palermo, G.1
Stenta, M.2
Cavalli, A.3
Dal Peraro, M.4
De Vivo, M.5
-
39
-
-
79960676884
-
Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide
-
Wu, C. C.; Li, T. K.; Farh, L.; Lin, L. Y.; Lin, T. S.; Yu, Y. J.; Yen, T. J.; Chiang, C. W.; Chan, N. L. Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide Science 2011, 333, 459-462
-
(2011)
Science
, vol.333
, pp. 459-462
-
-
Wu, C.C.1
Li, T.K.2
Farh, L.3
Lin, L.Y.4
Lin, T.S.5
Yu, Y.J.6
Yen, T.J.7
Chiang, C.W.8
Chan, N.L.9
-
40
-
-
33644968200
-
Two-metal-ion mechanism for hammerhead-ribozyme catalysis
-
Leclerc, F.; Karplus, M. Two-metal-ion mechanism for hammerhead-ribozyme catalysis J. Phys. Chem. B 2006, 110, 3395-3409
-
(2006)
J. Phys. Chem. B
, vol.110
, pp. 3395-3409
-
-
Leclerc, F.1
Karplus, M.2
-
41
-
-
33644970162
-
Double-metal-ion/single-metal-ion mechanisms of the cleavage reaction of ribozymes: First-principles molecular dynamics simulations of a fully hydrated model system
-
Boero, M.; Tateno, M.; Terakura, K.; Oshiyama, A. Double-metal-ion/single-metal-ion mechanisms of the cleavage reaction of ribozymes: First-principles molecular dynamics simulations of a fully hydrated model system J. Chem. Theory Comput. 2005, 1, 925-934
-
(2005)
J. Chem. Theory Comput.
, vol.1
, pp. 925-934
-
-
Boero, M.1
Tateno, M.2
Terakura, K.3
Oshiyama, A.4
-
42
-
-
77951976539
-
Structures of influenza A proteins and insights into antiviral drug targets
-
Das, K.; Aramini, J. M.; Ma, L. C.; Krug, R. M.; Arnold, E. Structures of influenza A proteins and insights into antiviral drug targets Nat. Struct. Mol. Biol. 2010, 17, 530-538
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 530-538
-
-
Das, K.1
Aramini, J.M.2
Ma, L.C.3
Krug, R.M.4
Arnold, E.5
-
43
-
-
67249100913
-
Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site
-
Yuan, P.; Bartlam, M.; Lou, Z.; Chen, S.; Zhou, J.; He, X.; Lv, Z.; Ge, R.; Li, X.; Deng, T.; Fodor, E.; Rao, Z.; Liu, Y. Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site Nature 2009, 458, 909-913
-
(2009)
Nature
, vol.458
, pp. 909-913
-
-
Yuan, P.1
Bartlam, M.2
Lou, Z.3
Chen, S.4
Zhou, J.5
He, X.6
Lv, Z.7
Ge, R.8
Li, X.9
Deng, T.10
Fodor, E.11
Rao, Z.12
Liu, Y.13
-
44
-
-
84866146827
-
Structural and biochemical basis for development of influenza virus inhibitors targeting the PA endonuclease
-
DuBois, R. M.; Slavish, P. J.; Baughman, B. M.; Yun, M. K.; Bao, J.; Webby, R. J.; Webb, T. R.; White, S. W. Structural and biochemical basis for development of influenza virus inhibitors targeting the PA endonuclease PLoS Pathog. 2012, 8 e1002830
-
(2012)
PLoS Pathog.
, vol.8
, pp. 1002830
-
-
Dubois, R.M.1
Slavish, P.J.2
Baughman, B.M.3
Yun, M.K.4
Bao, J.5
Webby, R.J.6
Webb, T.R.7
White, S.W.8
-
45
-
-
84866177810
-
Structural analysis of specific metal chelating inhibitor binding to the endonuclease domain of influenza pH1N1 (2009) polymerase
-
Kowalinski, E.; Zubieta, C.; Wolkerstorfer, A.; Szolar, O. H.; Ruigrok, R. W.; Cusack, S. Structural analysis of specific metal chelating inhibitor binding to the endonuclease domain of influenza pH1N1 (2009) polymerase PLoS Pathog. 2012, 8 e1002831
-
(2012)
PLoS Pathog.
, vol.8
, pp. 1002831
-
-
Kowalinski, E.1
Zubieta, C.2
Wolkerstorfer, A.3
Szolar, O.H.4
Ruigrok, R.W.5
Cusack, S.6
-
46
-
-
0033608967
-
Metal ion catalysis of RNA cleavage by the influenza virus endonuclease
-
Doan, L.; Handa, B.; Roberts, N. A.; Klumpp, K. Metal ion catalysis of RNA cleavage by the influenza virus endonuclease Biochemistry 1999, 38, 5612-5619
-
(1999)
Biochemistry
, vol.38
, pp. 5612-5619
-
-
Doan, L.1
Handa, B.2
Roberts, N.A.3
Klumpp, K.4
-
47
-
-
0035831544
-
2+ ions reveals two divalent metals bound in the active site
-
2+ ions reveals two divalent metals bound in the active site J. Biol. Chem. 2001, 276, 7266-7271
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 7266-7271
-
-
Goedken, E.R.1
Marqusee, S.2
-
48
-
-
84896819934
-
Calcium inhibition of ribonuclease H1 two-metal ion catalysis
-
Rosta, E.; Yang, W.; Hummer, G. Calcium inhibition of ribonuclease H1 two-metal ion catalysis J. Am. Chem. Soc. 2014, 136, 3137-3144
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 3137-3144
-
-
Rosta, E.1
Yang, W.2
Hummer, G.3
-
49
-
-
0038136893
-
Why do divalent metal ions either promote or inhibit enzymatic reactions? the case of Bam HI restriction endonuclease from combined quantum-classical simulations
-
Mordasini, T.; Curioni, A.; Andreoni, W. Why do divalent metal ions either promote or inhibit enzymatic reactions? The case of Bam HI restriction endonuclease from combined quantum-classical simulations J. Biol. Chem. 2003, 278, 4381-4384
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 4381-4384
-
-
Mordasini, T.1
Curioni, A.2
Andreoni, W.3
-
51
-
-
33846799362
-
Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease IV
-
Ivanov, I.; Tainer, J. A.; McCammon, J. A. Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease IV Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 1465-1470
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 1465-1470
-
-
Ivanov, I.1
Tainer, J.A.2
McCammon, J.A.3
-
52
-
-
77953924511
-
Structure and mechanism of human DNA polymerase eta
-
Biertumpfel, C.; Zhao, Y.; Kondo, Y.; Ramon-Maiques, S.; Gregory, M.; Lee, J. Y.; Masutani, C.; Lehmann, A. R.; Hanaoka, F.; Yang, W. Structure and mechanism of human DNA polymerase eta Nature 2010, 465, 1044-1048
-
(2010)
Nature
, vol.465
, pp. 1044-1048
-
-
Biertumpfel, C.1
Zhao, Y.2
Kondo, Y.3
Ramon-Maiques, S.4
Gregory, M.5
Lee, J.Y.6
Masutani, C.7
Lehmann, A.R.8
Hanaoka, F.9
Yang, W.10
-
53
-
-
84863676249
-
Watching DNA polymerase eta make a phosphodiester bond
-
Nakamura, T.; Zhao, Y.; Yamagata, Y.; Hua, Y. J.; Yang, W. Watching DNA polymerase eta make a phosphodiester bond Nature 2012, 487, 196-201
-
(2012)
Nature
, vol.487
, pp. 196-201
-
-
Nakamura, T.1
Zhao, Y.2
Yamagata, Y.3
Hua, Y.J.4
Yang, W.5
-
54
-
-
84877867629
-
Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta
-
Zhao, Y.; Gregory, M. T.; Biertumpfel, C.; Hua, Y. J.; Hanaoka, F.; Yang, W. Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 8146-8151
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 8146-8151
-
-
Zhao, Y.1
Gregory, M.T.2
Biertumpfel, C.3
Hua, Y.J.4
Hanaoka, F.5
Yang, W.6
-
55
-
-
84923072898
-
Visualizing phosphodiester-bond hydrolysis by an endonuclease
-
Molina, R.; Stella, S.; Redondo, P.; Gomez, H.; Marcaida, M. J.; Orozco, M.; Prieto, J.; Montoya, G. Visualizing phosphodiester-bond hydrolysis by an endonuclease Nat. Struct. Mol. Biol. 2015, 22, 65-72 10.1038/nsmb.2932
-
(2015)
Nat. Struct. Mol. Biol.
, vol.22
, pp. 65-72
-
-
Molina, R.1
Stella, S.2
Redondo, P.3
Gomez, H.4
Marcaida, M.J.5
Orozco, M.6
Prieto, J.7
Montoya, G.8
-
56
-
-
68949195832
-
Design of functional metalloproteins
-
Lu, Y.; Yeung, N.; Sieracki, N.; Marshall, N. M. Design of functional metalloproteins Nature 2009, 460, 855-862
-
(2009)
Nature
, vol.460
, pp. 855-862
-
-
Lu, Y.1
Yeung, N.2
Sieracki, N.3
Marshall, N.M.4
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