Why do divalent metal ions either promote or inhibit enzymatic reactions? The case of BamHI restriction endonuclease from combined quantum-classical simulations

Journal of Biological Chemistry

Volumn 278, Issue 7, 2003, Pages 4381-4384

  Mordasini, Tiziana ^b   Curioni, Alessandro ^b   Andreoni, Wanda ^a  

^a IBM RESEARCH ZURICH   (Switzerland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; ENZYME IMMOBILIZATION; IONS; NUCLEIC ACIDS; QUANTUM THEORY; WATER;

DIVALENT METAL IONS;

BIOCHEMISTRY;

CALCIUM; MAGNESIUM; METAL ION; NUCLEIC ACID; RESTRICTION ENDONUCLEASE; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE; WATER; DIVALENT CATION; DNA; METAL;

ARTICLE; CATALYSIS; CATALYST; DNA CLEAVAGE; ENZYME KINETICS; ENZYME MECHANISM; PRIORITY JOURNAL; QUANTUM MECHANICS; SIMULATION; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; ELECTRICITY; METABOLISM;

CALCIUM; CATIONS, DIVALENT; COMPUTER SIMULATION; DEOXYRIBONUCLEASE BAMHI; DNA; ELECTROSTATICS; MAGNESIUM; METALS; MODELS, CHEMICAL;

EID: 0038136893     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C200664200     Document Type: Article

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