Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates

Journal of Molecular Biology

Volumn 277, Issue 2, 1998, Pages 363-377

  Brautigam, Chad A ^a   Steitz, Thomas A ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

3' 5' exonuclease; Mn2+ rescue; Phosphorothioates; Two metal ion mechanism; X ray crystallography

Indexed keywords

DNA DIRECTED DNA POLYMERASE BETA; EXONUCLEASE; MAGNESIUM ION; MANGANESE; PHOSPHOROTHIOIC ACID; SINGLE STRANDED DNA; SULFUR; ZINC ION;

ARTICLE; ENZYME KINETICS; ESCHERICHIA COLI; FREEZING; NONHUMAN; PH; PRIORITY JOURNAL;

EID: 0032571245     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1586     Document Type: Article

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