Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

PLoS Pathogens

Volumn 8, Issue 8, 2012, Pages

  DuBois, Rebecca M ^a   Slavish, P Jake ^a   Baughman, Brandi M ^a,b   Yun, Mi Kyung ^a   Bao, Ju ^a   Webby, Richard J ^a   Webb, Thomas R ^a,b   White, Stephen W ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIOXO 4 PHENYLBUTANOIC ACID; ANTIVIRUS AGENT; ENDONUCLEASE; FLUTAMIDE; L 735 882; L 742 001; MESSENGER RNA; MESSENGER RNA PRECURSOR; PA ENDONUCLEASE; PA ENDONUCLEASE INHIBITOR; RNA POLYMERASE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME INHIBITION; IC 50; IN VITRO STUDY; INFLUENZA VIRUS A; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; RNA CAPPING; RNA TRANSLATION; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION; VIRUS RESISTANCE; X RAY CRYSTALLOGRAPHY;

ANIMALS; CELL LINE; CHICK EMBRYO; CHICKENS; CRYSTALLOGRAPHY, X-RAY; DOGS; DRUG DESIGN; ENDORIBONUCLEASES; ENZYME INHIBITORS; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA IN BIRDS; MOLECULAR DOCKING SIMULATION; PROTEIN STRUCTURE, TERTIARY; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS;

ORTHOMYXOVIRIDAE;

EID: 84866146827     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002830     Document Type: Article

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