Tetracyclines cause cell stress-dependent ATF4 activation and mTOR inhibition

Experimental Cell Research

Volumn 320, Issue 2, 2014, Pages 281-289

  Brüning, Ansgar ^a   Brem, German J ^a   Vogel, Marianne ^a   Mylonas, Ioannis ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

ATF4; Doxycycline; Endoplasmic reticulum stress; Magnesium; Minocycline; MTOR

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ACTIVATING TRANSCRIPTION FACTOR 4; CHALONE; CYTOKINE; DOXYCYCLINE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INHIBIN; INHIBIN E; MAGNESIUM ION; MAMMALIAN TARGET OF RAPAMYCIN; MINOCYCLINE; NELFINAVIR; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL METABOLISM; CELL STRAIN HEPG2; CELL SURVIVAL; CELL VIABILITY; CELLULAR STRESS RESPONSE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; EUKARYOTIC CELL; FEMALE; HELA CELL; HUMAN; HUMAN CELL; LONG TERM EXPOSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EUKARYOTA;

ATF4; DOXYCYCLINE; ENDOPLASMIC RETICULUM STRESS; MAGNESIUM; MINOCYCLINE; MTOR;

ACTIVATING TRANSCRIPTION FACTOR 4; CACO-2 CELLS; CELL PROLIFERATION; CELL SURVIVAL; HELA CELLS; HEP G2 CELLS; HUMANS; INHIBIN-BETA SUBUNITS; STRESS, PHYSIOLOGICAL; TETRACYCLINES; TOR SERINE-THREONINE KINASES; TRANSCRIPTIONAL ACTIVATION;

EID: 84890860646     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2013.11.012     Document Type: Article

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