High therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury: Proof-of-concept

Brain Research Bulletin

Volumn 112, Issue , 2015, Pages 35-41

  Gatson, Joshua W ^a   Simpkins, James W ^b   Uteshev, Victor V ^c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Alpha7; Choline; Nicotinic; PNU 120596; PNU120596; Traumatic brain injury

Indexed keywords

1 (5 CHLORO 2,4 DIMETHOXYPHENYL) 3 (5 METHYL 3 ISOXAZOLYL)UREA; BUNGAROTOXIN RECEPTOR; CHOLINE; PLACEBO; 1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-METHYLISOXAZOL-3-YL)UREA; ANTIINFLAMMATORY AGENT; CARBANILAMIDE DERIVATIVE; CHOLINERGIC RECEPTOR STIMULATING AGENT; ISOXAZOLE DERIVATIVE; NEUROPROTECTIVE AGENT;

ADULT; ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; BRAIN NERVE CELL; BRAIN PROTECTION; CELL DAMAGE; CELL MEMBRANE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; EXTRACELLULAR SPACE; GLIA CELL; GLIOSIS; HIPPOCAMPAL CA3 REGION; IMMUNOCOMPETENT CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT MODEL; TRAUMATIC BRAIN INJURY; YOUNG ADULT; ANIMAL; BRAIN INJURIES; DISEASE MODEL; DRUG EFFECTS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TUNEL ASSAY;

ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTROCYTES; BRAIN INJURIES; CHOLINERGIC AGENTS; DISEASE MODELS, ANIMAL; GLIOSIS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; ISOXAZOLES; MALE; NEURONS; NEUROPROTECTIVE AGENTS; PHENYLUREA COMPOUNDS; RATS, SPRAGUE-DAWLEY;

EID: 84922613651     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2015.01.008     Document Type: Article

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