In vitro pharmacological characterization of a novel allosteric modulator of α7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3- propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile

Journal of Pharmacology and Experimental Therapeutics

Volumn 330, Issue 1, 2009, Pages 257-267

  Malysz, John ^a   Grønlien, Jens Halvard ^b   Anderson, David J ^a   Håkerud, Monika ^b   Thorin Hagene, Kirsten ^b   Ween, Hilde ^b   Wetterstrand, Caroline ^b   Briggs, Clark A ^a   Faghih, Ramin ^a   Bunnelle, William H ^a   Gopalakrishnan, Murali ^a  

^a ABBOTT LABORATORIES   (United States)

^b Research and Development   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 CHLORO 2 HYDROXYPHENYL) 3 (2 CHLORO 5 TRIFLUOROMETHYLPHENYL)UREA; 1 (5 CHLORO 2,4 DIMETHOXYPHENYL) 3 (5 METHYLISOXAZOL 3 YL)UREA; 2,2 DIMETHYL 5 (6 PHENYLPYRIDAZIN 3 YL) 5 AZA 2 AZONIABICYCLO[2.2.1]HEPTANE; 4 [5 (4 CHLOROPHENYL) 2 METHYL 3 PROPIONYL 1H PYRROL 1 YL]BENZENESULFONAMIDE; 4 NAPHTHALEN 1 YL 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE 8 SULFONIC ACID AMIDE; A 585539; A 867744; ALPHA3BETA4 ACETYLCHOLINE RECEPTOR; ALPHA7 NEURONAL ACETYLCHOLINE RECEPTOR; CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR STIMULATING AGENT; METHYLLYCACONITINE; NICOTINE; PNU 120596; SEROTONIN; SEROTONIN 3A RECEPTOR; TRITIUM; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CALCIUM TRANSPORT; CHIMERA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENTATE GYRUS; DESENSITIZATION; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; FEMALE; GRANULE CELL; HIPPOCAMPUS; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNEURON; LIGAND BINDING; MALE; NEUROTRANSMISSION; NONHUMAN; PATCH CLAMP; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ALLOSTERIC REGULATION; ANIMALS; CELL LINE; CHOLINERGIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; SULFONAMIDES; XENOPUS LAEVIS;

EID: 67649840644     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.151886     Document Type: Article

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