Astrocytes and mitochondria from adrenoleukodystrophy protein (ABCD1)-deficient mice reveal that the adrenoleukodystrophy-associated very long-chain fatty acids target several cellular energy-dependent functions

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1852, Issue 5, 2015, Pages 925-936

  Kruska, Nicol ^a   Schönfeld, Peter ^a   Pujol, Aurora ^b,c   Reiser, Georg ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

Author keywords

Adrenoleukodystrophy (X ALD); Astrocyte; Mitochondrion; Peroxisomal disorder; Reactive oxygen species; Very long chain fatty acids (VLCFA)

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADRENOLEUKODYSTROPHY PROTEIN; CALCIUM ION; FORMAZAN; HYDROCARBON; PROTEIN; PYRIDINE NUCLEOTIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TETRAZOLIUM; UNCLASSIFIED DRUG; VERY LONG CHAIN FATTY ACID; ABC TRANSPORTER; ABCD1 PROTEIN, MOUSE; CALCIUM; FATTY ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ADRENOLEUKODYSTROPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN MITOCHONDRION; CALCIUM TRANSPORT; CELL DEATH; CELL ENERGY; CELL FUNCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENERGY METABOLISM; HUMAN; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TARGET CELL; WILD TYPE; X LINKED ADRENOLEUKODYSTROPHY; ANIMAL; APOPTOSIS; C57BL MOUSE; CELL CULTURE; CHEMISTRY; DEFICIENCY; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; GENETICS; ION TRANSPORT; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION; OXIDATIVE PHOSPHORYLATION; SPECTROFLUOROMETRY;

MUS;

ADRENOLEUKODYSTROPHY; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; ASTROCYTES; ATP-BINDING CASSETTE TRANSPORTERS; CALCIUM; CELLS, CULTURED; ENERGY METABOLISM; FATTY ACIDS; ION TRANSPORT; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; NADP; OXIDATIVE PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SPECTROMETRY, FLUORESCENCE; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 84922573084     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2015.01.005     Document Type: Article

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