Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure

Atherosclerosis

Volumn 202, Issue 2, 2009, Pages 351-362

  Artwohl, Michaela ^a   Lindenmair, Andrea ^a   Roden, Michael ^a,b   Waldhäusl, Werner Klaus ^a   Freudenthaler, Angelika ^a   Klosner, Gabriele ^c   Ilhan, Aysegül ^a   Luger, Anton ^a   Baumgartner Parzer, Sabina M ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b HANUSCH HOSPITAL   (Austria)

^c Universitatsklinik fur Dermatologie   (Austria)

Author keywords

Apoptosis; c myc; Caspases; E2F 1; Free fatty acids; Human plasma; mad; Smooth muscle cells; XRCC1

Indexed keywords

ARACHIDONIC ACID; CASPASE; CASPASE INHIBITOR; DNA; FATTY ACID; LINOLEIC ACID; LINOLENIC ACID; LIPID; MAD PROTEIN; OLEIC ACID; PALMITIC ACID; PROTEIN DERIVATIVE; STEARIC ACID; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG; XRCC1 PROTEIN;

APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD SAMPLING; CELL DEATH; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; DNA FRAGMENTATION; ENZYME ACTIVATION; EXCISION REPAIR; FATTY ACID BLOOD LEVEL; FLOW CYTOMETRY; FOAM CELL; HUMAN; HUMAN CELL; MACROPHAGE; ONCOGENE C MYC; PLASMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; WESTERN BLOTTING;

ALPHA-LINOLENIC ACID; APOPTOSIS; ARACHIDONIC ACID; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CASPASES; CELLS, CULTURED; CYTOCHROMES C; DNA-BINDING PROTEINS; E2F1 TRANSCRIPTION FACTOR; FATTY ACIDS, NONESTERIFIED; HUMANS; LINOLEIC ACID; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; OLEIC ACID; PALMITIC ACID; PROTO-ONCOGENE PROTEINS C-MYC; REPRESSOR PROTEINS; STEARIC ACIDS; UMBILICAL CORD;

EID: 58549100464     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2008.05.030     Document Type: Article

References (49)

1. Fagot-Campagna A., Balkau B., Simon D., et al. High free fatty acid concentration: an independent risk factor for hypertension in the Paris Prospective Study. Int J Epidemiol 27 (1998) 808-813
2. Opie L.H., and Walfish P.G. Plasma free fatty acid concentrations in obesity. N Engl J Med 268 (1963) 757-760
3. Reaven G.M., Hollenbeck C., Jeng C.Y., Wu M.S., and Chen Y.D. Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes 37 (1988) 1020-1024
4. Armstrong K.A., Hiremagalur B., Haluska B.A., et al. Free fatty acids are associated with obesity, insulin resistance, and atherosclerosis in renal transplant recipients. Transplantation 80 (2005) 937-944
5. Pilz S., Scharnagl H., Tiran B., et al. Free fatty acids are independently associated with all-cause and cardiovascular mortality in subjects with coronary artery disease. J Clin Endocrinol Metab 91 (2006) 2542-2547
6. Staiger H., Staiger K., Stefan N., et al. Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells. Diabetes 53 (2004) 3209-3216
7. Park H.J., Lee Y.W., Hennig B., and Toborek M. Linoleic acid-induced VCAM-1 expression in human microvascular endothelial cells is mediated by the NF-kappa B-dependent pathway. Nutr Cancer 41 (2001) 126-134
8. Artwohl M., Roden M., Waldhäusl W., Freudenthaler A., and Baumgartner-Parzer S.M. Free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular endothelial cells. FASEB J 18 (2004) 146-148
9. Lu G., Morinelli T.A., Meier K.E., Rosenzweig S.A., and Egan B.M. Oleic acid-induced mitogenic signaling in vascular smooth muscle cells. A role for protein kinase C. Circ Res 79 (1996) 611-618
10. Greene E.L., Lu G., Zhang D., and Egan B.M. Signaling events mediating the additive effects of oleic acid and angiotensin II on vascular smooth muscle cell migration. Hypertension 37 (2001) 308-312
11. Kockx M.M., and Herman A.G. Apoptosis in atherosclerosis: beneficial or detrimental?. Cardiovasc Res 45 (2000) 736-746
12. -/- mice after adenovirus-mediated transfer of p53. Circulation 105 (2002) 2064-2070
13. Rössig L., Dimmeler S., and Zeiher A.M. Apoptosis in the vascular wall and atherosclerosis. Basic Res Cardiol 96 (2001) 11-22
14. Idel S., Ellinghaus P., Wolfrum C., et al. Branched chain fatty acids induce nitric oxide-dependent apoptosis in vascular smooth muscle cells. J Biol Chem 277 (2002) 49319-49325
15. Pilane C.M., and LaBelle E.F. Arachidonic acid release by cPLA2 may be causally related to NO-induced apoptosis in vascular smooth muscle cells. J Cell Physiol 191 (2002) 191-197
16. Diep Q.N., Touyz R.M., and Schiffrin E.L. Docosohexaenoic acid, a peroxisome proliferator-activated receptor-α ligand, induces apoptosis in vascular smooth muscle cells by stimulation of p38 mitogen-activated protein kinase. Hypertension 36 (2000) 851-855
17. Diep Q.N., Intengan H.D., and Schiffrin E.L. Endothelin-1 attenuates omega3 fatty acid-induced apoptosis by inhibition of caspase 3. Hypertension 35 (2000) 287-291
18. Stingl H., Raffesberg W., Nowotny P., Waldhäusl W., and Roden M. Reduction of plasma leptin concentrations by arginine but not lipid infusion in humans. Obes Res 10 (2002) 1111-1119
19. Roden M., Krssak M., Stingl H., et al. Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans. Diabetes 48 (1999) 358-364
20. Artwohl M., Graier W., Roden M., et al. Diabetic low-density lipoprotein triggers apoptosis in vascular endothelial cells. Diabetes 52 (2003) 1240-1247
21. Artwohl M., Lindenmair A., Maier C., et al. Free fatty acids differently affect apoptosis of micro- versus macrovascular endothelial cells (Abstract). Exp Clin Endocrinol Diabetes 115 (2007) S48
22. Chung B.H., Hennig B., Cho B.H., and Darnell B.E. Effect of the fat composition of a single meal on the composition and cytotoxic potencies of lipolytically-releasable free fatty acids in postprandial plasma. Atherosclerosis 141 (1998) 321-332
23. Roden M., Price T.B., Perseghin G., et al. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 97 (1996) 2859-2865
24. Oram J.F., and Bornfeldt K.E. Direct effects of long-chain non-esterified fatty acids on vascular cells and their relevance to macrovascular complications of diabetes. Front Biosci 9 (2004) 1240-1253
25. Kurioka S., Murakami Y., Nishiki M., Sohmiya M., Koshimura K., and Kato Y. Relationship between visceral fat accumulation and anti-lipolytic action of insulin in patients with type 2 diabetes mellitus. Endocr J 49 (2002) 459-464
26. Guo Z., Hensrud D.D., Johnson C.M., and Jensen M.D. Regional postprandial fatty acid metabolism in different obesity phenotypes. Diabetes 48 (1999) 1586-1592
27. Masson M., Niedergang C., Schreiber V., Muller S., Menissier-de Murcia J., and de Murcia G. XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol Cell Biol 18 (1998) 3563-3571
28. Rose J.L., Reeves K.C., Likhotvorik R.I., and Hoyt D.G. Base excision repair proteins are required for integrin-mediated suppression of bleomycin-induced DNA breakage in murine lung endothelial cells. J Pharmacol Exp Ther 321 (2007) 318-326
29. Rossi M.L., Marziliano N., Merlini P.A., et al. Different quantitative apoptotic traits in coronary atherosclerotic plaques from patients with stable angina pectoris and acute coronary syndromes. Circulation 110 (2004) 1767-1773
30. Helbing C.C., Wellington C.L., Gogela-Spehar M., Cheng T., Pinchbeck G.G., and Johnston R.N. Quiescence versus apoptosis: Myc abundance determines pathway of exit from the cell cycle. Oncogene 17 (1998) 1491-1501
31. Dean M., Levine R.A., Ran W., Kindy M.S., Sonenshein G.E., and Campisi J. Regulation of c-myc transcription and mRNA abundance by serum, growth factors and cell contact. J Biol Chem 261 (1986) 9161-9166
32. Lee L.A., Resar L.M., and Dang C.V. Cell density and paradoxical transcriptional properties of c-Myc and Max in cultured mouse fibroblasts. J Clin Invest 95 (1995) 900-904
33. Weinberg R.A. E2F and cell proliferation: a world turned upside down. Cell 85 (1996) 457-459
34. Eischen C.M., Packham G., Nip J., et al. Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1. Oncogene 20 (2001) 6983-6993
35. Macdonald K., and Bennett M.R. cdc25A is necessary but not sufficient for optimal c-myc-induced apoptosis and cell proliferation of vascular smooth muscle cells. Circ Res 84 (1999) 820-830
36. Shelat H.S., Liu T., Hickman-Bick D.L., et al. Growth suppression of human coronary vascular smooth muscle cells by gene transfer of the transcription factor E2F-1. Circulation 103 (2001) 407-414
37. Bennett M.R., Macdonald K., Chan S., Boyle J.J., and Weissberg P.L. Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaques. Circ Res 82 (1998) 704-712
38. Vega F., Panizo A., Pardo-Mindán J., and Diez J. Susceptibility to apoptosis measured by MYC, BCL-2, and BAX expression in arterioles and capillaries of adult spontaneously hypertensive rats. Am J Hypertens 12 (1999) 815-820
39. Hilker M., Langin T., Hake U., et al. Gene expression profiling of human stenotic aorto-coronary bypass grafts by cDNA array analysis. Eur J Cardiothorac Surg 23 (2003) 620-625
40. Negoro N., Inariba H., Inoue T., Kanayama Y., and Takeda T. Expression of c-myc proto-oncogene in hearts and cultured smooth muscle cells of spontaneously hypertensive rats. J Hypertens 6 (1988) S128-130
41. Matsumura I., Tanaka H., and Kanakura Y. E2F1 and c-myc in cell growth and death. Cell Cycle 2 (2003) 333-338
42. Askari B., Carroll M.A., Capparelli M., Kramer F., Gerrity R.G., and Bornfeldt K.E. Oleate and linoleate enhance the growth-promoting effects of insulin-like growth factor-I through a phospholipase D-dependent pathway in arterial smooth muscle cells. J Biol Chem 277 (2002) 36338-36344
43. Gehring S., Rottmann S., Menkel A.R., Mertsching J., Krippner-Heidenreich A., and Lüscher B. Inhibition of proliferation and apoptosis by the transcriptional repressor Mad1. J Biol Chem 275 (2000) 10413-10420
44. Dersch K., Ichijo H., Bhakdi S., and Husmann M. Fatty acids liberated from low-density lipoprotein trigger endothelial apoptosis via mitogen-activated protein kinases. Cell Death Differ 12 (2005) 1107-1114
45. Eiselein L., Wilson D.W., Lamé M.W., and Rutledge J.C. Lipolysis products from triglyceride-rich lipoproteins increase endothelial permeability, perturb zonula occludens-1 and F-actin, and induce apoptosis. Am J Physiol Heart Circ Physiol 292 (2007) H2745-H2753
46. Meerarani P., Ramadass P., Toborek M., Bauer H.C., Bauer H., and Hennig B. Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha. Am J Clin Nutr 71 (2000) 81-87
47. Marfella R., Di Filippo C., Baldi A., et al. The vascular smooth muscle cells apoptosis in asymptomatic diabetic carotid plaques: role of glycemic control. J Am Coll Cardiol 47 (2006) 2118-2120
48. Nieminen A.I., Partanen J.I., Hau A., and Klefstrom J. c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis. EMBO J 26 (2007) 1055-1067
49. Sohn D., Schulze-Osthoff K., and Janicke R.U. Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis. J Biol Chem 280 (2005) 5267-5273