Mechanism of toxicity of the branched-chain fatty acid phytanic acid, a marker of Refsum disease, in astrocytes involves mitochondrial impairment

International Journal of Developmental Neuroscience

Volumn 24, Issue 2-3, 2006, Pages 113-122

  Reiser, Georg ^a   Schönfeld, Peter ^b   Kahlert, Stefan ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b Institut für Biochemie   (Germany)

Author keywords

Mitochondria; Phytanic acid; Refsum disease

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARBONATE DEHYDRATASE II; CYTOCHROME C; FATTY ACID; MARKER; PALMITIC ACID; PHYTANIC ACID; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL TISSUE; ASTROCYTE; BRAIN MITOCHONDRION; CELL DEATH; CELL LEVEL; CONFERENCE PAPER; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECT; ELECTRON TRANSPORT; HIPPOCAMPUS; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; REFSUM DISEASE; RESPIRATORY CHAIN;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BIOLOGICAL MARKERS; BLOTTING, WESTERN; BRAIN; CALCIUM; CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYLHYDRAZONE; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIALS; MITOCHONDRIA; MODELS, BIOLOGICAL; ORGANOMETALLIC COMPOUNDS; OXYGEN; PHYTANIC ACID; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; REFSUM DISEASE; ROTENONE; SYNAPTOSOMES; TIME FACTORS; UNCOUPLING AGENTS;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 33644508363     PISSN: 07365748     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijdevneu.2005.11.002     Document Type: Conference Paper

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