CD4+ natural killer T cells potently augment aortic root atherosclerosis by perforin-and granzyme b-dependent cytotoxicity

Circulation Research

Volumn 116, Issue 2, 2015, Pages 245-254

  Li, Yi ^a,b   To, Kelly ^a,b   Kanellakis, Peter ^a   Hosseini, Hamid ^a   Deswaerte, Virginie ^a   Tipping, Peter ^b   Smyth, Mark J ^c,d   Toh, Ban Hock ^b   Bobik, Alexander ^a,b   Kyaw, Tin ^a,b  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

atherosclerosis; cell death; granzymes; inflammation; natural killer T cells; perforin

Indexed keywords

CD4 ANTIGEN; CYTOTOXIN; GAMMA INTERFERON; GRANZYME B; INTERLEUKIN 21; INTERLEUKIN 4; MONOCYTE CHEMOTACTIC PROTEIN 1; PERFORIN; VASCULAR CELL ADHESION MOLECULE 1; GRANZYME; GZMB PROTEIN, MOUSE; PERFORIN, MOUSE; PORE FORMING CYTOTOXIC PROTEIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; AORTA ROOT; APOPTOSIS; ARTICLE; ATHEROGENESIS; B LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; INFLAMMATION; MACROPHAGE; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; AORTA SINUS; ATHEROSCLEROSIS; CD4+ T LYMPHOCYTE; DEFICIENCY; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; NATURAL KILLER T CELL; PATHOLOGY; PROCEDURES;

ADOPTIVE TRANSFER; ANIMALS; ATHEROSCLEROSIS; CD4-POSITIVE T-LYMPHOCYTES; GRANZYMES; MALE; MICE; MICE, KNOCKOUT; NATURAL KILLER T-CELLS; PORE FORMING CYTOTOXIC PROTEINS; SINUS OF VALSALVA;

EID: 84922337344     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.304734     Document Type: Article

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