VCAM-1 is critical in atherosclerosis

Journal of Clinical Investigation

Volumn 107, Issue 10, 2001, Pages 1209-1210

  Ley, Klaus ^a   Huo, Yuqing ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL MODEL; ATHEROGENESIS; ATHEROSCLEROSIS; DISEASE MODEL; GENE MUTATION; HUMAN; INFLAMMATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; NOTE; PRIORITY JOURNAL;

EID: 0035024867     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI13005     Document Type: Note

References (21)

1. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes
2. High affinity, very late antigen-4 subsets expressed on T calls are mandatory for spontaneous adhesion strengthening but not for rolling on VCAM-1 in shear flow
3. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis
4. Upregulation of VCAM-1 and ICAM-1 at atherosderosis-prone sites on the endothelium in the apoe-deficient mouse
5. Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis
6. 4 integrin and ICAM-1 markedly attenuate macrophage homing to atherosclerotic plaques in apoE-deficient mice
7. Blocking very late antigen-4 integrin decreases leukocyte entry and fatty streak formation in mice fed an atherogenic diet
8. Minimally modified low-density lipoprotein induces monocyte adhesion to endothelial connecting segment-1 by activating beta 1 integrin
9. Direct demonstration of P-selectin-and VCAM-1-dependent mononuclear cell rolling in early atherosclerotic lesions of apolipoprotein E-deficient mice
10. Role of vascular cell adhesion molecule-1 and fibronectin connecting segment-1 in monocyte rolling and adhesion on early atherosclerotic lesions
11. Targeted disruption of the murine VCAM-1 gene: Essential role of VCAM-1 in chorioallantoic fusion and placentation
12. Deficiency of inflammatory cell adhesion molecules protects against atherosclerosis in mice
13. P-Selectin or intercellular adhesion molecule (ICAM)-I deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice
14. Prominent role of P-selectin in the development of advanced atherosclerosis in ApoE-deficient mice
15. Absence of P-selectin delays fatty streak formation in mice
16. A major role for VCAM-1, but nor ICAM-1, in early atherosclerosis
17. Conditional vascular cell adhesion molecule 1 deletion in mice. impaired lymphocyte migration to bone marrow
18. Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs B cell localization and T cell-dependent humoral immune response
19. A mouse model of human familial hypercholesterolemia: Markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet
20. Arterial iniury increases expression of inflammatory adhesion molecules in the carotid arteries of apolipoprotein-E-deficient mice
21. Monoclonal antibody against vascular cell adhesion molecule-1 inhibits neointimal formation after periadventitial carotid artery injury in genetically hypercholesterolemic mice