Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR)

Toxicology Letters

Volumn 233, Issue 2, 2015, Pages 68-77

  Carazo Fernández, Alejandro ^a   Smutny, Tomas ^a   Hyrsová, Lucie ^a   Berka, Karel ^b   Pavek, Petr ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

Constitutive androstane receptor; Cytochrome P450; Flavonoids; Gene regulation; Nuclear receptors

Indexed keywords

BAICALEIN; CHRYSIN; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2B6; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; EPIDERMAL GROWTH FACTOR RECEPTOR; GALANGIN; PHENOBARBITAL; TRANSCRIPTION FACTOR ELK 1; CELL RECEPTOR; ELK1 PROTEIN, HUMAN; FLAVANONE DERIVATIVE; FLAVONOID;

ARTICLE; ASSAY; AUTOPHOSPHORYLATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIGAND BINDING; LIVER CELL; PHOSPHORYLATION; PRIORITY JOURNAL; AGONISTS; BINDING SITE; CELL LINE; DRUG EFFECTS; GENETICS; METABOLISM; PROTEIN TRANSPORT;

BINDING SITES; CELL LINE; CYTOCHROME P-450 CYP2B6; ETS-DOMAIN PROTEIN ELK-1; FLAVANONES; FLAVONOIDS; HEPATOCYTES; HUMANS; PHENOBARBITAL; PROTEIN TRANSPORT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84922151590     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2015.01.013     Document Type: Article

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