Effects of Praeruptorin A and Praeruptorin C, a Racemate Isolated from Peucedanum praeruptorum, on MRP2 through the CAR Pathway

Planta Medica

Volumn 79, Issue 17, 2013, Pages 1641-1647

  Zhou, Xunian ^a   Bi, Huichang ^a   Jin, Jing ^a   Niu, Lu ^a   Cai, Dake ^a   Deng, Rongrong ^a   Li, Yuhua ^a   Wang, Yongtao ^a   Huang, Min ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

constitutive androstane receptor; herb drug interaction; MRP2; Peucedanum praeruptorum; praeruptorin A; praeruptorin C; Umbelliferae

Indexed keywords

CHINESE DRUG; CONSTITUTIVE ANDROSTANE RECEPTOR; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; PRAERUPTORIN A; PRAERUPTORIN C; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CHINESE HERB; CHINESE MEDICINE; CONTROLLED STUDY; DRUG EFFECT; HERB DRUG INTERACTION; HERBAL MEDICINE; HUMAN; IN VITRO STUDY; PEUCEDANUM PRAERUPTORUM; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TRANSIENT TRANSFECTION; UPREGULATION; WESTERN BLOTTING;

APIACEAE; PEUCEDANUM PRAERUPTORUM;

APIACEAE; COUMARINS; DRUGS, CHINESE HERBAL; HEP G2 CELLS; HERB-DRUG INTERACTIONS; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; TRANSFECTION; UP-REGULATION;

EID: 84889596910     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0033-1350955     Document Type: Article

References (35)

1. Xiong Y. Y., Wu F. H., Wang J. S., Li J., Kong L. Y. Attenuation of airway hyperreactivity and t helper cell type 2 responses by coumarins from Peucedanum praeruptorum Dunn in a murine model of allergic airway inflammation. J Ethnopharmacol: 2012; 141 314 321
2. Wu J. Y., Fong W. F., Zhang J. X., Leung C. H., Kwong H. L., Yang M. S., Li D., Cheung H. Y. Reversal of multidrug resistance in cancer cells by pyranocoumarins isolated from Radix Peucedani. Eur J Pharmacol: 2003; 473 9 17 (Pubitemid 36851623)
3. Yu P. J., Ci W., Wang G. F., Zhang J. Y., Wu S. Y., Xu W., Jin H., Zhu Z. G., Zhang J. J., Pang J. X., Wu S. G. Praeruptorin a inhibits lipopolysaccharide-induced inflammatory response in murine macrophages through inhibition of NF-kappaB pathway activation. Phytother Res: 2011; 25 550 556
4. Wei E. H., Rao M. R., Chen X. Y., Fan L. M., Chen Q. Inhibitory effects of praeruptorin c on cattle aortic smooth muscle cell proliferation. Acta Pharmacol Sin: 2002; 23 129 132 (Pubitemid 34123324)
5. Zhao N. C., Jin W. B., Zhang X. H., Guan F. L., Sun Y. B., Adachi H., Okuyama T. Relaxant effects of pyranocoumarin compounds isolated from a Chinese medical plant, bai-hua qian-hu, on isolated rabbit tracheas and pulmonary arteries. Biol Pharm Bull: 1999; 22 984 987 (Pubitemid 29482914)
6. Suzuki T., Kobayashi Y., Uchida M. K., Sakakibara I., Okuyama T., Shibata S. Calcium antagonist-like actions of coumarins isolated from qian-hu on anaphylactic mediator release from mast cell induced by concanavalin A. J Pharmacobiodyn: 1985; 8 257 263 (Pubitemid 15055783)
7. Narasaki F., Oka M., Nakano R., Ikeda K., Fukuda M., Nakamura T., Soda H., Nakagawa M., Kuwano M., Kohno S. Human canalicular multispecific organic anion transporter (cmoat) is expressed in human lung, gastric, and colorectal cancer cells. Biochem Biophys Res Commun: 1997; 240 606 611 (Pubitemid 28271765)
8. Akita H., Suzuki H., Ito K., Kinoshita S., Sato N., Takikawa H., Sugiyama Y. Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump. Biochim Biophys Acta: 2001; 1511 7 16 (Pubitemid 32206667)
9. Bode K. A., Donner M. G., Leier I., Keppler D. Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. Biochem Pharmacol: 2002; 64 151 158 (Pubitemid 34775185)
10. Kojima H., Sakurai S., Yoshiji H., Uemura M., Yoshikawa M., Fukui H. The role of radixin in altered localization of canalicular conjugate export pump mrp2 in cholestatic rat liver. Hepatol Res: 2008; 38 202 210
11. Korita P. V., Wakai T., Shirai Y., Matsuda Y., Sakata J., Takamura M., Yano M., Sanpei A., Aoyagi Y., Hatakeyama K., Ajioka Y. Multidrug resistance-associated protein 2 determines the efficacy of cisplatin in patients with hepatocellular carcinoma. Oncol Rep: 2010; 23 965 972
12. Gan S. Y., Zhong X. Y., Xie S. M., Li S. M., Peng H., Luo F. Expression and significance of tumor drug resistance related proteins and beta-catenin in esophageal squamous cell carcinoma. Chin J Cancer: 2010; 29 300 305
13. Tzameli I., Pissios P., Schuetz E. G., Moore D. D. The xenobiotic compound 1, 4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor car. Mol Cell Biol: 2000; 20 2951 2958 (Pubitemid 30215008)
14. Wang H., LeCluyse E. L. Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes. Clin Pharmacokinet: 2003; 42 1331 1357 (Pubitemid 38045840)
15. Hernandez J. P., Mota L. C., Huang W., Moore D. D., Baldwin W. S. Sexually dimorphic regulation and induction of p 450s by the constitutive androstane receptor (car). Toxicology: 2009; 256 53 64
16. Duanmu Z., Locke D., Smigelski J., Wu W., Dahn M. S., Falany C. N., Kocarek T. A., Runge-Morris M. Effects of dexamethasone on aryl (sult1a1)- and hydroxysteroid (sult2a1)-sulfotransferase gene expression in primary cultured human hepatocytes. Drug Metab Dispos: 2002; 30 997 1004
17. Chang T. K., Waxman D. J. Synthetic drugs and natural products as modulators of constitutive androstane receptor (car) and pregnane x receptor (pxr). Drug Metab Rev: 2006; 38 51 73 (Pubitemid 43738999)
18. Kast H. R., Goodwin B., Tarr P. T., Jones S. A., Anisfeld A. M., Stoltz C. M., Tontonoz P., Kliewer S., Willson T. M., Edwards P. A. Regulation of multidrug resistance-associated protein 2 (abcc2) by the nuclear receptors pregnane x receptor, farnesoid x-activated receptor, and constitutive androstane receptor. J Biol Chem: 2002; 277 2908 2915 (Pubitemid 34953324)
19. Okada K., Shoda J., Kano M., Suzuki S., Ohtake N., Yamamoto M., Takahashi H., Utsunomiya H., Oda K., Sato K., Watanabe A., Ishii T., Itoh K., Yamamoto M., Yokoi T., Yoshizato K., Sugiyama Y., Suzuki H. Inchinkoto, a herbal medicine, and its ingredients dually exert mrp2/mrp2-mediated choleresis and nrf2-mediated antioxidative action in rat livers. Am J Physiol Gastrointest Liver Physiol: 2007; 292 G1450 G1463 (Pubitemid 47084670)
20. Huang W., Zhang J., Moore D. D. A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor car. J Clin Invest: 2004; 113 137 143 (Pubitemid 38541640)
21. Li L. H., Stanton J. D., Tolson A. H., Luo Y., Wang H. B. Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane x receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. Pharm Res: 2009; 26 872 882
22. Huang L., Bi H. C., Liu Y. H., Wang Y. T., Xue X. P., Huang M. CAR-mediated up-regulation of CYP3a4 expression in LS174 t cells by Chinese herbal compounds. Drug Metab Pharmacokinet: 2011; 26 331 340
23. Suzuki S., Ogawa E. Experimental studies on the carbonic anhydrase activity. Xiv. Effect of aldosterone and actinomycin D in vitro on carbonic anhydrase from liver and kidney of mice. Biochem Pharmacol: 1971; 20 771 782
24. Wang Q. Q., Zhang Z. Y., Xiao J. Y., Yi C., Li L. Z., Huang Y., Yun J. P. Knockdown of nucleophosmin induces s-phase arrest in hepg2 cells. Chin J Cancer: 2011; 30 853 860
25. Masuyama H., Nakatsukasa H., Hiramatsu Y. Effect of oncostatin m on uridine diphosphate-5′-glucuronosyltransferase 1a1 through cross talk with constitutive androstane receptor. Mol Endocrinol: 2010; 24 745 753
26. Huang W., Zhang J., Chua S. S., Qatanani M., Han Y., Granata R., Moore D. D. Induction of bilirubin clearance by the constitutive androstane receptor (car). Proc Natl Acad Sci USA: 2003; 100 4156 4161 (Pubitemid 36418173)
27. Nies A. T., Keppler D. The apical conjugate efflux pump abcc2 (mrp2). Pflugers Arch: 2007; 453 643 659 (Pubitemid 46192536)
28. Parks D. J., Blanchard S. G., Bledsoe R. K., Chandra G., Consler T. G., Kliewer S. A., Stimmel J. B., Willson T. M., Zavacki A. M., Moore D. D., Lehmann J. M. Bile acids: natural ligands for an orphan nuclear receptor. Science: 1999; 284 1365 1368 (Pubitemid 29289664)
29. Jedlitschky G., Leier I., Buchholz U., Hummel-Eisenbeiss J., Burchell B., Keppler D. Atp-dependent transport of bilirubin glucuronides by the multidrug resistance protein mrp1 and its hepatocyte canalicular isoform mrp2. Biochem J: 1997; 327 305 310 (Pubitemid 27455494)
30. Qadri I., Hu L. J., Iwahashi M., Al-Zuabi S., Quattrochi L. C., Simon F. R. Interaction of hepatocyte nuclear factors in transcriptional regulation of tissue specific hormonal expression of human multidrug resistance-associated protein 2 (abcc2). Toxicol Appl Pharmacol: 2009; 234 281 292
31. Courtois A., Payen L., Guillouzo A., Fardel O. Up-regulation of multidrug resistance-associated protein 2 (mrp2) expression in rat hepatocytes by dexamethasone. FEBS Lett: 1999; 459 381 385 (Pubitemid 29467372)
32. Vollrath V., Wielandt A. M., Iruretagoyena M., Chianale J. Role of nrf2 in the regulation of the mrp2 (abcc2) gene. Biochem J: 2006; 395 599 609
33. Kubitz R., Huth C., Schmitt M., Horbach A., Kullak-Ublick G., Haussinger D. Protein kinase c-dependent distribution of the multidrug resistance protein 2 from the canalicular to the basolateral membrane in human hepg2 cells. Hepatology: 2001; 34 340 350 (Pubitemid 32702347)
34. Breeuwer P., Drocourt J. L., Bunschoten N., Zwietering M. H., Rombouts F. M., Abee T. Characterization of uptake and hydrolysis of fluorescein diacetate and carboxyfluorescein diacetate by intracellular esterases in saccharomyces cerevisiae, which result in accumulation of fluorescent product. Appl Environ Microbiol: 1995; 61 1614 1619
35. Zamek-Gliszczynski M. J., Xiong H., Patel N. J., Turncliff R. Z., Pollack G. M., Brouwer K. L. Pharmacokinetics of 5 (and 6)-carboxy-2′,7′- dichlorofluorescein and its diacetate promoiety in the liver. J Pharmacol Exp Ther: 2003; 304 801 809 (Pubitemid 36152359)