Difference in nucleocytoplasmic shuttling sequences of rat and human constitutive active/androstane receptor

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1773, Issue 6, 2007, Pages 934-944

  Kanno, Yuichiro ^a   Suzuki, Motoyoshi ^a   Miyazaki, Yukari ^a   Matsuzaki, Midori ^a   Nakahama, Takayuki ^a   Kurose, Kouichi ^b   Sawada, Jun ichi ^b   Inouye, Yoshio ^a  

^a TOHO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Constitutive androstane receptor; Nuclear export signal; Nuclear localization signal; Nucleocytoplasmic shuttling

Indexed keywords

ANDROSTANE DERIVATIVE; LEPTOMYCIN B; LEUCINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOPLASM; DRUG INHIBITION; GENE DELETION; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN MOTIF; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ALPHA KARYOPHERINS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOPLASM; FATTY ACIDS, UNSATURATED; HUMANS; NUCLEAR LOCALIZATION SIGNALS; PHOTOBLEACHING; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, ANDROGEN; SPECIES SPECIFICITY;

RATTUS;

EID: 34249705919     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2007.03.020     Document Type: Article

References (26)

1. Honkakoski P., Zelko I., Sueyoshi T., and Negishi M. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol. Cell. Biol. 18 (1998) 5652-5658
2. Chen Y., Ferguson S.S., Negishi M., and Goldstein J.A. Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter. Mol. Pharmacol. 64 (2003) 316-324
3. Goodwin B., Hodgson E., D'Costa D.J., Robertson G.R., and Liddle C. Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. Mol. Pharmacol. 62 (2002) 359-365
4. Sugatani J., Kojima H., Ueda A., Kakizaki S., Yoshinari K., Gong Q.H., Owens I.S., Negishi M., and Sueyoshi T. The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology 33 (2001) 1232-1238
5. Kawamoto T., Sueyoshi T., Zelko I., Moore R., Washburn K., and Negishi M. Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol. Cell. Biol. 19 (1999) 6318-6322
6. Kobayashi K., Sueyoshi T., Inoue K., Moore R., and Negishi M. Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells. Mol. Pharmacol. 64 (2003) 1069-1075
7. Yoshinari K., Kobayashi K., Moore R., Kawamoto T., and Negishi M. Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital. FEBS Lett. 548 (2003) 17-20
8. Kawamoto T., Sueyoshi T., Zelko I., Moore R., Washburn K., and Negishi M. Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol. Cell. Biol. 19 (1999) 6318-6322
9. Zelko I., Sueyoshi T., Kawamoto T., Moore R., and Negishi M. The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver. Mol. Cell. Biol. 21 (2001) 2838-2846
10. Kanno Y., Suzuki M., Nakahama T., and Inouye Y. Characterization of nuclear localization signals and cytoplasmic retention region in the nuclear receptor CAR. Biochim. Biophys. Acta 1745 (2005) 215-222
11. Tyagi R.K., Amazit L., Lescop P., Milgrom E., and Guiochon-Mantel A. Mechanisms of progesterone receptor export from nuclei: role of nuclear localization signal, nuclear export signal, and ran guanosine triphosphate. Mol. Endocrinol. 12 (1998) 1684-1695
12. Liu J., and DeFranco D.B. Protracted nuclear export of glucocorticoid receptor limits its turnover and does not require the exportin 1/CRM1-directed nuclear export pathway. Mol. Endocrinol. 14 (2000) 40-51
13. Saporita A.J., Zhang Q., Navai N., Dincer Z., Hahn J., Cai X., and Wang Z. Identification and characterization of a ligand-regulated nuclear export signal in androgen receptor. J. Biol. Chem. 278 (2003) 41998-42005
14. Black B., Holaska J., Rastinejad F., and Paschal B. DNA binding domains in diverse nuclear receptors function as nuclear export signals. Curr. Biol. 11 (2001) 1749-1758
15. Ikeda S., Kurose K., Jinno H., Sai K., Ozawa S., Hasegawa R., Komamura K., Kotake T., Morishita H., Kamakura S., Kitakaze M., Tomoike H., Tamura T., Yamamoto N., Kunitoh H., Yamada Y., Ohe Y., Shimada Y., Shirao K., Kubota K., Minami H., Ohtsu A., Yoshida T., Saijo N., Saito Y., and Sawada J. Functional analysis of four naturally occurring variants of human constitutive androstane receptor. Mol. Genet. Metab. 86 (2005) 314-319
16. Kanno Y., Aoki S., Mochizuki M., Mori E., Nakahama T., and Inouye Y. Expression of constitutive androstane receptor splice variants in rat liver and lung and their functional properties. Biol. Pharm. Bull. 28 (2005) 2058-2062
17. Walther R.F., Lamprecht C., Ridsdale A., Groulx I., Lee S., and Lefebvre Y.A. Nuclear export of the glucocorticoid receptor is accelerated by cell fusion-dependent release of calreticulin. J. Biol. Chem. 278 (2003) 37858-37864
18. Wolff B., Sanglier J.J., and Wang Y. Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem. Biol. 4 (1997) 139-147
19. Kudo N., Matsumori N., Taoka H., Fujiwara D., Schreiner E.P., Wolff B., Yoshida M., and Horinouchi S. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 9112-9117
20. Xia J., and Kemper B. Structural determinants of constitutive androstane receptor required for its glucocorticoid receptor interacting protein-1-mediated nuclear accumulation. J. Biol. Chem. 280 (2005) 7285-7293
21. Bogerd H.P., Fridell R.A., Benson R.E., Hua J., and Cullen B.R. Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay. Mol. Cell. Biol. 16 (1996) 4207-4214
22. Saradhi M., Sengupta A., Mukhopadhyay G., and Tyagi R.K. Pregnane and Xenobiotic Receptor (PXR/SXR) resides predominantly in the nuclear compartment of the interphase cell and associates with the condensed chromosomes during mitosis. Biochim. Biophys. Acta 1746 (2005) 85-94
23. Kawana K., Ikuta T., Kobayashi Y., Gotoh O., Takeda K., and Kawajiri K. Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR. Mol. Pharmacol. 63 (2003) 524-531
24. Squires E.J., Sueyoshi T., and Negishi M. Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver. J. Biol. Chem. 279 (2004) 49307-49314
25. Hosseinpour F., Moore R., Negishi M., and Sueyoshi T. Serine 202 regulates the nuclear translocation of constitutive active/androstane receptor. Mol. Pharmacol. 69 (2006) 1095-1102
26. Sueyoshi T., Moore R., Pascussi J.M., and Negishi M. Direct expression of fluorescent protein-tagged nuclear receptor CAR in mouse liver. Methods. Enzymol. 357 (2002) 205-213