The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells

Acta Pharmacologica Sinica

Volumn 30, Issue 12, 2009, Pages 1648-1658

  Zhou, Qian Mei ^a   Wang, Song ^a   Zhang, Hui ^a   Lu, Yi Yu ^a   Wang, Xiu Feng ^a   Motoo, Yoshiharu ^b   Su, Shi Bing ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Baicalein; Baicalin; Breast cancer cells; Combination therapy

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACRIDINE ORANGE; BAICALEIN; BAICALIN; CASPASE 3; CASPASE 9; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CELL ASSAY; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL STRUCTURE; CELL VIABILITY; CHRONOTHERAPY; CONTROLLED STUDY; DNA DETERMINATION; DNA FRAGMENTATION; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME REGULATION; FEMALE; FLOW CYTOMETRY; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SYNTHESIS REGULATION; STAINING; WESTERN BLOTTING;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG SYNERGISM; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FLAVANONES; FLAVONOIDS; HUMANS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 74949106101     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.166     Document Type: Article

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