Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR)

Toxicology Letters

Volumn 202, Issue 2, 2011, Pages 148-154

  Anderson, Linnea E ^a   Dring, Ann M ^a   Hamel, Laura D ^a   Stoner, Matthew A ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

CAR; CYP2B6; CYP3A4; Hepatocyte; PBR; PXR

Indexed keywords

7 (ACETOXY) 6 (4 METHOXYPHENYL)PYRROLO[2,1 D][1,5]BENZOTHIAZEPINE; 7 (DIMETHYLCARBAMOYLOXY) 6 PHENYLPYRROLO [2,1 D][1,5]BENZOTHIAZEPINE; BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; BENZOTHIAZEPINE DERIVATIVE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2B6; CYTOCHROME P450 3A4; LUCIFERASE; MESSENGER RNA; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PERIPHERAL BENZODIAZEPINE RECEPTOR; PREGNANE X RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; GENE FUNCTION; HUMAN; HUMAN CELL; LIVER CELL; METABOLIC REGULATION; PRIORITY JOURNAL; REPORTER GENE;

ARYL HYDROCARBON HYDROXYLASES; CELL LINE; CYTOCHROME P-450 CYP3A; HEPATOCYTES; HUMANS; INDOLEACETIC ACIDS; ISOQUINOLINES; LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; PYRROLES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, GABA-A; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; THIAZEPINES; TRANSFECTION;

EID: 79952625582     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.02.004     Document Type: Article

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