Amphiphilic poly(amino acid) based micelles applied to drug delivery: The in vitro and in vivo challenges and the corresponding potential strategies

Journal of Controlled Release

Volumn 199, Issue , 2015, Pages 84-97

  Xu, Helin ^a   Yao, Qing ^a   Cai, Cuifang ^a   Gou, Jinxin ^a   Zhang, Yu ^a   Zhong, Haijun ^b   Tang, Xing ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b NANCHANG UNIVERSITY   (China)

Author keywords

Amphiphilic poly(amino acid); Drug polymer conjugate Stability; Micelle; Non covalent interaction; Poly(aspartic acid); Poly(glutamic acid)

Indexed keywords

AMINO ACIDS; BIOCOMPATIBILITY; BIODEGRADATION; BLOCK COPOLYMERS; BLOOD; DRUG DELIVERY; DRUG INTERACTIONS; FUNCTIONAL GROUPS; HYDROPHOBICITY; MICELLES; STABILITY;

NON-COVALENT INTERACTION; POLYAMINO ACIDS; POLYASPARTIC ACID; POLYGLUTAMIC ACIDS; POLYMER CONJUGATE;

LOADING;

AMPHIPHILIC POLYAMINOACID; AMPHOPHILE; COPOLYMER; DRUG CARRIER; METAL ION; PLASMA PROTEIN; POLYAMINOACID; POLYASPARTIC ACID; POLYGLUTAMIC ACID; POLYLYSINE; UNCLASSIFIED DRUG; AMINO ACID; MICELLE; POLYMER;

ALPHA HELIX; BIOAVAILABILITY; BIOCOMPATIBILITY; BIODEGRADABILITY; CHEMICAL STRUCTURE; COVALENT BOND; CROSS LINKING; DRUG COATING; DRUG RELEASE; DRUG STABILITY; ENCAPSULATION; HEMODILUTION; HUMAN; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; ISOMERISM; MICELLE; MICELLIZATION; NONHUMAN; PHARMACOKINETICS; POLYMERIZATION; REVIEW; STATIC ELECTRICITY; SYNTHESIS; ANIMAL; CHEMISTRY; DRUG DELIVERY SYSTEM; PROCEDURES;

AMINO ACIDS; ANIMALS; DRUG DELIVERY SYSTEMS; HUMANS; MICELLES; POLYMERS;

EID: 84922122301     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.12.012     Document Type: Review

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