Block/homo polyplex micelle-based GM-CSF gene therapy via intraperitoneal administration elicits antitumor immunity against peritoneal dissemination and exhibits safety potentials in mice and cynomolgus monkeys

Journal of Controlled Release

Volumn 167, Issue 3, 2013, Pages 238-247

  Ohgidani, Masahiro ^a   Furugaki, Koichi ^a   Shinkai, Kentaro ^b   Kunisawa, Yumi ^a   Itaka, Keiji ^c   Kataoka, Kazunori ^c,d   Nakano, Kenji ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Block homo polyplex micelle; Granulocyte macrophage colony stimulating factor; Immunogene therapy; Intraperitoneal administration; Peritoneal dissemination; Safety evaluation test in cynomolgus monkeys

Indexed keywords

CYNOMOLGUS MONKEYS; GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTORS; IMMUNOGENE THERAPY; INTRAPERITONEAL ADMINISTRATION; PERITONEAL DISSEMINATION; POLYPLEX MICELLES;

BLOCK COPOLYMERS; DRUG PRODUCTS; GENE THERAPY; MACROPHAGES; MAMMALS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; SAFETY FACTOR; TUMORS;

MICELLES;

COPOLYMER; FIBRINOGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; LUCIFERASE; MACROGOL; PLASMID DNA; POLY[N' [N (2 AMINOETHYL) 2 AMINOETHYL]ASPARTAMIDE]; POLYMER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLUMINESCENCE; CANCER CELL CULTURE; CANCER INHIBITION; CELL ACTIVATION; CONTROLLED STUDY; DRUG DISTRIBUTION; FEMALE; FIBRINOGEN BLOOD LEVEL; GENE EXPRESSION; GENE THERAPY; HAPLORHINI; HUMAN; HUMAN CELL; IMAGING SYSTEM; IN VIVO STUDY; MALE; MICELLE; NATURAL KILLER CELL; NONHUMAN; PANCREAS CARCINOMA; PRIORITY JOURNAL; SURVIVAL RATE; TRANSGENE; TUMOR IMMUNITY;

ANIMALS; CELL LINE, TUMOR; DNA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC THERAPY; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INJECTIONS, INTRAPERITONEAL; KILLER CELLS, NATURAL; LIVER; LYMPH NODES; MACACA FASCICULARIS; MICE; MICE, INBRED BALB C; MICE, NUDE; MICELLES; PANCREATIC NEOPLASMS; POLYETHYLENE GLYCOLS; PROTEINS; RNA, MESSENGER; SPLEEN;

EID: 84874936506     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.02.006     Document Type: Article

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