Charge-conversional peg-polypeptide polyionic complex nanoparticles from simple blending of a pair of oppositely charged block copolymers as an intelligent vehicle for efficient antitumor drug delivery

Molecular Pharmaceutics

Volumn 11, Issue 5, 2014, Pages 1562-1574

  Lv, Shixian ^a,c   Song, Wantong ^a   Tang, Zhaohui ^a   Li, Mingqiang ^a,c   Yu, Haiyang ^a   Hong, Hua ^b   Chen, Xuesi ^a  

^a CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^b JILIN UNIVERSITY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

charge conversion; delivery; doxorubicin; polyionic complex; polypeptide

Indexed keywords

COPOLYMER; DOXORUBICIN; NANOPARTICLE; POLY(ETHYLENE GLYCOL) B POLY(GAMMA BENZYL GLUTAMATE CO PHENYLALANINE); POLYPEPTIDE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; MACROGOL DERIVATIVE; PEPTIDE; POLYMER;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL LINE; CELL PROLIFERATION; CYTOTOXICITY ASSAY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SYNTHESIS; ENCAPSULATION; ENDOSOME; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LYSOSOME; MAXIMUM TOLERATED DOSE; MOUSE; NEOPLASM; NONHUMAN; PH; PRIORITY JOURNAL; SINGLE DRUG DOSE; SURFACE CHARGE; ANIMAL; CHEMISTRY; DRUG SCREENING; LUNG NEOPLASMS; MALE; NUDE MOUSE; PROCEDURES; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DOXORUBICIN; DRUG DELIVERY SYSTEMS; HELA CELLS; HUMANS; LUNG NEOPLASMS; MALE; MICE; MICE, NUDE; NANOPARTICLES; PEPTIDES; POLYETHYLENE GLYCOLS; POLYMERS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84899831927     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp4007387     Document Type: Article

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