In vivo antitumor activity of the folate-conjugated pH-sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments

Bioconjugate Chemistry

Volumn 18, Issue 4, 2007, Pages 1131-1139

  Bae, Younsoo ^a,b   Nishiyama, Nobuhiro ^a,b   Kataoka, Kazunori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCK COPOLYMERS; CELLS; CONTROLLED DRUG DELIVERY; CYTOLOGY; DISEASES; DRUG DOSAGE; DRUG PRODUCTS; ETHYLENE GLYCOL; POLYETHYLENE GLYCOLS; POLYOLS; TARGETED DRUG DELIVERY; TUMORS;

ADRIAMYCIN; ASPARTATES; DRUG CARRIER; ENVIRONMENTALLY SENSITIVE; FOLATES; HYDRAZONES; IN-VIVO; PH SENSITIVE; POLYMERIC MICELLE; VIVO ANTI-TUMOR ACTIVITIES;

MICELLES;

AMPHOPHILE; CARBOXYLIC ACID DERIVATIVE; COPOLYMER; DAUNORUBICIN; DOXORUBICIN; DRUG CARRIER; FOLATE RECEPTOR; FOLIC ACID; HYDRAZONE DERIVATIVE; LIGAND; MACROGOL; POLYASPARTIC ACID; POLYMER;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CELL MEMBRANE; CONJUGATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG SAFETY; ENDOSOME; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; LYSOSOME; MICELLE; MOUSE; NONHUMAN; PH; SURFACE PROPERTY;

EID: 34547161854     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc060401p     Document Type: Article

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