Doxorubicin-loaded amphiphilic polypeptide-based nanoparticles as an efficient drug delivery system for cancer therapy

Acta Biomaterialia

Volumn 9, Issue 12, 2013, Pages 9330-9342

  Lv, Shixian ^a,b   Li, Mingqiang ^a,b   Tang, Zhaohui ^a   Song, Wantong ^a,b   Sun, Hai ^a   Liu, Huaiyu ^c   Chen, Xuesi ^a  

^a CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c JILIN UNIVERSITY   (China)

Author keywords

Doxorubicin hydrochloride; Drug delivery; Electrostatic interaction; pH sensitive; Poly(amino acids)

Indexed keywords

AMINO ACIDS; BLOCK COPOLYMERS; CELL CULTURE; CELL PROLIFERATION; CONTROLLED DRUG DELIVERY; DISEASES; DYNAMIC LIGHT SCATTERING; ELECTROSTATICS; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; MOTION PICTURE EXPERTS GROUP STANDARDS; ONCOLOGY; POLYETHYLENE GLYCOLS; TARGETED DRUG DELIVERY;

AMPHIPHILICS; CANCER THERAPY; DOXORUBICIN; DOXORUBICIN HYDROCHLORIDE; EFFICIENT DRUG DELIVERY; L-PHENYLALANINE; MAXIMUM TOLERATED DOSE; PH SENSITIVE; POLY(AMINO ACID); POLY(AMINO ACIDS);

NANOPARTICLES;

AMPHOPHILE; COPOLYMER; DOXORUBICIN; METHOXY POLY(ETHYLENE GLYCOL) BETA POLY(LEVO GLUTAMIC ACID CO LEVO PHENYLALANINE); NANOPARTICLE; POLYGLUTAMIC ACID; POLYPEPTIDE; SELF ASSEMBLED MONOLAYER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER THERAPY; CELL PROLIFERATION; CELL VIABILITY; CHEMICAL STRUCTURE; CIRCULATION TIME; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; CULTURE MEDIUM; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG STABILITY; ENDOCYTOSIS; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; LIGHT SCATTERING; LUNG NON SMALL CELL CANCER; MALE; MAXIMUM TOLERATED DOSE; MOUSE; NICK END LABELING; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SINGLE DRUG DOSE; STATIC ELECTRICITY; SURFACE CHARGE; SURVIVAL RATE; SYNTHESIS; TRANSMISSION ELECTRON MICROSCOPY; TUMOR VOLUME; TUMOR XENOGRAFT; WEIGHT CHANGE; ZETA POTENTIAL;

MUS MUSCULUS;

DOXORUBICIN HYDROCHLORIDE; DRUG DELIVERY; ELECTROSTATIC INTERACTION; PH SENSITIVE; POLY(AMINO ACIDS);

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE, TUMOR; DOXORUBICIN; DRUG DELIVERY SYSTEMS; ENDOCYTOSIS; GLUTAMIC ACID; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MAXIMUM TOLERATED DOSE; MICE; MICE, INBRED BALB C; MICE, NUDE; NANOPARTICLES; NEOPLASMS; PEPTIDES; POLYETHYLENE GLYCOLS; SOLUTIONS; SURFACE-ACTIVE AGENTS; TREATMENT OUTCOME; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84887185910     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.08.015     Document Type: Article

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