Prolonged circulation and in vivo efficacy of recombinant human granulocyte colony-stimulating factor encapsulated in polymeric micelles

Journal of Controlled Release

Volumn 156, Issue 1, 2011, Pages 101-108

  Harada, Mitsunori ^a   Ohuchi, Miho ^a   Hayashi, Tatsuyuki ^a   Kato, Yasuki ^a  

^a NanoCarrier Co Ltd   (Japan)

Author keywords

Efficacy; Encapsulation; G CSF; Polymeric micelles; Prolonged circulation; Release mechanism

Indexed keywords

BLOCK COPOLYMERS; BLOOD; CHEMICAL MODIFICATION; ENCAPSULATION; PHARMACOKINETICS; RATS; SIZE EXCLUSION CHROMATOGRAPHY;

EFFICACY; G-CSF; GRANULOCYTE-COLONY STIMULATING FACTOR; PHARMACOKINETIC ANALYSIS; PHARMACOKINETIC STUDIES; POLYMERIC MICELLE; RECOMBINANT HUMAN GRANULOCYTE COLONY STIMULATING FACTORS; RELEASE MECHANISM;

MICELLES;

POLYMER; POLYMERIC MICELLE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; UNCLASSIFIED DRUG; DRUG CARRIER; GLUTAMIC ACID; GRANULOCYTE COLONY STIMULATING FACTOR; MACROGOL DERIVATIVE; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHROMATOGRAPHY; CIRCULATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG RELEASE; DRUG STABILITY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BLOOD; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; DRUG FORMULATION; HALF LIFE TIME; LEUKOCYTE COUNT; MALE; MICELLE; NEUTROPHIL; SOLUBILITY; TIME; WISTAR RAT;

ANIMALS; AREA UNDER CURVE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; GLUTAMIC ACID; GRANULOCYTE COLONY-STIMULATING FACTOR; HALF-LIFE; LEUKOCYTE COUNT; MALE; MICELLES; MOLECULAR STRUCTURE; NEUTROPHILS; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SOLUBILITY; TIME FACTORS;

EID: 80855138153     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.06.024     Document Type: Article

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