Bundled assembly of helical nanostructures in polymeric micelles loaded with platinum drugs enhancing therapeutic efficiency against pancreatic tumor

ACS Nano

Volumn 8, Issue 7, 2014, Pages 6724-6738

  Mochida, Yuki ^a   Cabral, Horacio ^a   Miura, Yutaka ^b   Albertini, Francesco ^c   Fukushima, Shigeto ^a   Osada, Kensuke ^a,d   Nishiyama, Nobuhiro ^e   Kataoka, Kazunori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c ETH ZURICH   (Switzerland)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

cisplatin; drug delivery systems; poly(glutamic acid); polymeric micelle; secondary structure; targeted cancer therapy; helix

Indexed keywords

AMINO ACIDS; BLOCK COPOLYMERS; CHLORINE COMPOUNDS; DRUG DELIVERY; FUNCTIONAL POLYMERS; PLATINUM COMPOUNDS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYPEPTIDES; TUMORS;

CIS-PLATIN; DRUG DELIVERY SYSTEM; POLYGLUTAMIC ACIDS; POLYMERIC MICELLE; SECONDARY STRUCTURES; TARGETED CANCER THERAPY;

MICELLES;

ANTINEOPLASTIC AGENT; CISPLATIN; DRUG CARRIER; MICELLE; NANOMATERIAL; POLYMER;

ANIMAL; CHEMISTRY; FEMALE; HUMAN; MICELLE; MOLECULAR WEIGHT; MOUSE; PANCREATIC NEOPLASMS; PATHOLOGY; TISSUE DISTRIBUTION; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CISPLATIN; DRUG CARRIERS; FEMALE; HUMANS; MICE; MICELLES; MOLECULAR WEIGHT; NANOSTRUCTURES; PANCREATIC NEOPLASMS; POLYMERS; TISSUE DISTRIBUTION;

EID: 84904718743     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn500498t     Document Type: Article

References (42)

1. Allen, C.; Maysinger, D.; Eisenberg, A. Nano-Engineering Block Copolymer Aggregates for Drug Delivery Colloids Surf., B 1999, 16, 3-27
2. Haag, R. Supramolecular Drug-Delivery Systems Based on Polymeric Core-Shell Architectures Angew. Chem., Int. Ed. Engl. 2004, 43, 278-282
3. Rodriguez-Hernandez, J.; Checot, F.; Gnanou, Y.; Lecommandoux, S. Toward "Smart" Nano-Objects by Self-Assembly of Block Copolymers in Solution Prog. Polym. Sci. 2005, 30, 691-724
4. Harada, A.; Kataoka, K. Supramolecular Assemblies of Block Copolymers in Aqueous Media as Nanocontainers Relevant to Biological Applications Prog. Polym. Sci. 2006, 31, 949-982
5. Carlsen, A.; Lecommandoux, S. Self-Assembly of Polypeptide-Based Block Copolymer Amphiphiles Curr. Opin. Colloid Interface Sci. 2009, 14, 329-339
6. Zayed, J. M.; Nouvel, N.; Rauwald, U.; Scherman, O. A. Chemical Complexity-Supramolecular Self-Assembly of Synthetic and Biological Building Blocks in Water Chem. Soc. Rev. 2010, 39, 2806-2816
7. Shu, J. Y.; Panganiban, B.; Xu, T. Peptide-Polymer Conjugates: From Fundamental Science to Application Annu. Rev. Phys. Chem. 2013, 64, 631-657
8. Vandermeulen, G. W. M.; Klok, H.-A. Peptide/Protein Hybrid Materials: Enhanced Control of Structure and Improved Performance through Conjugation of Biological and Synthetic Polymers Macromol. Biosci. 2004, 4, 383-398
9. Carlsen, A.; Lecommandoux, S. Self-Assembly of Polypeptide-Based Block Copolymer Amphiphiles Curr. Opin. Colloid Interface Sci. 2009, 14, 329-339
10. Osada, K.; Kataoka, K. Drug and Gene Delivery Based on Supramolecular Assembly of PEG-Polypeptide Hybrid Block Copolymers Adv. Polym. Sci. 2006, 202, 113-153
11. Kataoka, K.; Harada, A.; Nagasaki, Y. Block Copolymer Micelles for Drug Delivery: Design, Characterization and Biological Significance Adv. Drug Delivery Rev. 2001, 47, 113-131
12. Kataoka, K.; Kwon, G. S.; Yokoyama, M.; Okano, T.; Sakurai, Y. Block Copolymer Micelles as Vehicles for Drug Delivery J. Controlled Release 1993, 24, 119-132
13. Nishiyama, N.; Kataoka, K. Current State, Achievements, and Future Prospects of Polymeric Micelles as Nanocarriers for Drug and Gene Delivery Pharmacol. Ther. 2006, 112, 630-648
14. Osada, K.; Christie, R. J.; Kataoka, K. Polymeric Micelles from Poly(ethylene glycol)-Poly(amino acid) Block Copolymer for Drug and Gene Delivery J. R. Soc. Interface 2009, 6, S325-S339
15. Matsumura, Y. Preclinical and Clinical Studies of NK012, an SN-38-Incorporating Polymeric Micelles, Which Is Designed Based on EPR Effect Adv. Drug Delivery Rev. 2011, 63, 184-192
16. Matsumura, Y.; Kataoka, K. Preclinical and Clinical Studies of Anticancer Agent-Incorporating Polymer Micelles Cancer Sci. 2009, 100, 572-579
17. Plummer, R.; Wilson, R. H.; Calvert, H.; Boddy, A. V.; Griffin, M.; Sludden, J.; Tilby, M. J.; Eatock, M.; Pearson, D. G.; Ottley, C. J. et al. A Phase I Clinical Study of Cisplatin-Incorporated Polymeric Micelles (NC-6004) in Patients with Solid Tumours Br. J. Cancer 2011, 104, 593-598
18. Imahori, K.; Tanaka, J. Ultraviolet Absorption Spectra of Poly- l -Glutamic Acid J. Mol. Biol. 1959, 1, 359-364
19. Lader, H. J.; Komoroski, R. A.; Mandelkern, L. A Nuclear Magnetic Resonance Study of the Helix-Coil Transition of Poly(l -glutamic acid) Biopolymers 1977, 16, 895-905
20. Nishiyama, N.; Okazaki, S.; Cabral, H.; Miyamoto, M.; Kato, Y.; Sugiyama, Y.; Nishio, K.; Matsumura, Y.; Kataoka, K. Novel Cisplatin-Incorporated Polymeric Micelles Can Eradicate Solid Tumors in Mice Cancer Res. 2003, 63, 8977-8983
21. Schärtl, W. Light Scattering from Polymer Solutions and Nanoparticle Dispersions; Springer-Verlag: Berlin, 2007.
22. 8 Glycinato Complexes Inorg. Chem. 1965, 4, 1243-1247
23. Nishiyama, N.; Yokoyama, M.; Aoyagi, T.; Okano, T.; Sakurai, Y.; Kataoka, K. Preparation and Characterization of Self-Assembled Polymer-Metal Complex Micelle from cis -Dichlorodiammineplatinum(II) and Poly(ethylene glycol)-Poly(α,β-aspartic acid) Block Copolymer in an Aqueous Medium Langmuir 1999, 15, 377-383
24. Kuntz, I. D. Hydration of Macromolecules. III. Hydration of Polypeptides J. Am. Chem. Soc. 1971, 93, 514-516
25. Yotsuyanagi, T.; Usami, M.; Noda, Y.; Nagata, M. Computational Consideration of Cisplatin Hydrolysis and Acid Dissociation in Aqueous Media: Effect of Total Drug Concentrations Int. J. Pharm. 2002, 246, 95-104
26. Schuck, P. Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling Biophys. J. 2000, 78, 1606-1619
27. Pauling, L.; Corey, R. B.; Branson, H. R. The Structure of Proteins: Two Hydrogen-Bonded Helical Configurations of the Polypeptide Chain Proc. Natl. Acad. Sci. U. S. A. 1951, 37, 205-211
28. Bellomo, E. G.; Wyrsta, M. D.; Pakstis, L.; Pochan, D. J.; Deming, T. J. Stimuli-Responsive Polypeptide Vesicles by Conformation-Specific Assembly Nat. Mater. 2004, 3, 244-248
29. Rodríguez-Hernández, J.; Lecommandoux, S. Reversible Inside-Out Micellization of pH-Responsive and Water-Soluble Vesicles Based on Polypeptide Diblock Copolymers J. Am. Chem. Soc. 2005, 127, 2026-2027
30. Osada, K.; Cabral, H.; Mochida, Y.; Lee, S.; Nagata, K.; Matsuura, T.; Yamamoto, M.; Anraku, Y.; Kishimura, A.; Nishiyama, N. et al. Bioactive Polymeric Metallosomes Self-Assembled through Block Copolymer-Metal Complexation J. Am. Chem. Soc. 2012, 134, 13172-13175
31. Lund, R.; Shu, J.; Xu, T. A Small-Angle X-Ray Scattering Study of α-Helical Bundle-Forming Peptide-Polymer Conjugates in Solution: Chain Conformations Macromolecules 2013, 46, 1625-1632
32. Floudas, G.; Papadopoulos, P. Hierarchical Self-Assembly of Poly (γ-benzyl- l -glutamate)-Poly (ethylene glycol)-Poly (γ-benzyl- l -glutamate) Rod-Coil-Rod Triblock Copolymers Macromolecules 2003, 36, 3673-3683
33. Lau, S. Y. M.; Taneja, A. K.; Hodges, S. Synthesis of a Model Protein of Defined Secondary and Quaternary Structure J. Biol. Chem. 1984, 259, 13253-13261
34. Matsumura, Y.; Maeda, H. A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs Cancer Res. 1986, 46, 6387-6392
35. Choi, H. S.; Liu, W.; Misra, P.; Tanaka, E.; Zimmer, J. P.; Itty Ipe, B.; Bawendi, M. G.; Frangioni, J. V. Renal Clearance of Quantum Dots Nat. Biotechnol. 2007, 25, 1165-1170
36. Moghimi, S. M.; Hunter, A. C.; Murray, J. C. Long-Circulating and Target-Specific Nanoparticles: Theory to Practice Pharmacol. Rev. 2001, 53, 283-318
37. American Cancer Society. Cancer Facts & Figures 2011; American Cancer Society: Atlanta, GA, 2011.
38. Gref, R.; Lück, M.; Quellec, P.; Marchand, M.; Dellacherie, E.; Harnisch, S.; Blunk, T.; Müller, R. 'Stealth' Corona-Core Nanoparticles Surface Modified by Polyethylene Glycol (PEG): Influences of the Corona (PEG Chain Length and Surface Density) and of the Core Composition on Phagocytic Uptake and Plasma Protein Adsorption Colloids Surf., B 2000, 18, 301-313
39. Uchino, H.; Matsumura, Y.; Negishi, T.; Koizumi, F.; Hayashi, T.; Honda, T.; Nishiyama, N.; Kataoka, K.; Naito, S.; Kakizoe, T. Cisplatin-Incorporating Polymeric Micelles (NC-6004) Can Reduce Nephrotoxicity and Neurotoxicity of Cisplatin in Rats Br. J. Cancer 2005, 93, 678-687
40. Greenfield, N.; Fasman, G. D. Computed Circular Dichroism Spectra for the Evaluation of Protein Conformation Biochemistry 1969, 8, 4108-4116
41. Chen, Y. H.; Yang, J. T.; Chau, K. H. Determination of the Helix and β Form of Proteins in Aqueous Solution by Circular Dichroism Biochemistry 1974, 13, 3350-3559
42. Cassim, J. Y.; Yang, J. T. Critical Comparison of the Experimental Optical Activity of Helical Polypeptides and the Predictions of the Molecular Exciton Model Biopolymers 1970, 9, 1475-1502