-
1
-
-
0033860678
-
Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)
-
Brechot C, Gozuacik D, Murakami Y, Paterlini-Brechot P, (2000) Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Semin Cancer Biol 10: 211-231.
-
(2000)
Semin Cancer Biol
, vol.10
, pp. 211-231
-
-
Brechot, C.1
Gozuacik, D.2
Murakami, Y.3
Paterlini-Brechot, P.4
-
2
-
-
37549026245
-
Synergistic antitumor activity of XIAP-shRNA and APO2L/TRAIL expressed by oncolytic adenoviruses in experimental HCC
-
Pan Q, Liu B, Liu J, Cai R, Liu X, et al. (2008) Synergistic antitumor activity of XIAP-shRNA and APO2L/TRAIL expressed by oncolytic adenoviruses in experimental HCC. Acta Oncol 47: 135-144.
-
(2008)
Acta Oncol
, vol.47
, pp. 135-144
-
-
Pan, Q.1
Liu, B.2
Liu, J.3
Cai, R.4
Liu, X.5
-
3
-
-
40749150740
-
CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway
-
Ma S, Lee TK, Zheng BJ, Chan KW, Guan XY, (2008) CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway. Oncogene 27: 1749-1758.
-
(2008)
Oncogene
, vol.27
, pp. 1749-1758
-
-
Ma, S.1
Lee, T.K.2
Zheng, B.J.3
Chan, K.W.4
Guan, X.Y.5
-
4
-
-
80052033164
-
c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma
-
You H, Ding W, Dang H, Jiang Y, Rountree CB, (2011) c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma. Hepatology 54: 879-889.
-
(2011)
Hepatology
, vol.54
, pp. 879-889
-
-
You, H.1
Ding, W.2
Dang, H.3
Jiang, Y.4
Rountree, C.B.5
-
5
-
-
70350438403
-
Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma
-
Omar HA, Sargeant AM, Weng JR, Wang D, Kulp SK, et al. (2006) Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma. Mol Pharmacol 76: 957-968.
-
(2006)
Mol Pharmacol
, vol.76
, pp. 957-968
-
-
Omar, H.A.1
Sargeant, A.M.2
Weng, J.R.3
Wang, D.4
Kulp, S.K.5
-
6
-
-
77954930632
-
IAPs from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer
-
Gyrd-Hansen M, Meier P, (2010) IAPs from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. Nat Rev Cancer 10: 561-574.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 561-574
-
-
Gyrd-Hansen, M.1
Meier, P.2
-
7
-
-
43049091895
-
IAPs: what's in a name?
-
Srinivasula S, Ashwell J, (2008) IAPs: what's in a name? Mol Cell 25 30: 123-135.
-
(2008)
Mol Cell
, vol.30
, pp. 123-135
-
-
Srinivasula, S.1
Ashwell, J.2
-
8
-
-
54249123632
-
IAP-targeted therapies for cancer
-
LaCasse EC, Mahoney DJ, Cheung HH, Plenchette S, Baird S, et al. (2008) IAP-targeted therapies for cancer. Oncogene 27: 6252-6275.
-
(2008)
Oncogene
, vol.27
, pp. 6252-6275
-
-
LaCasse, E.C.1
Mahoney, D.J.2
Cheung, H.H.3
Plenchette, S.4
Baird, S.5
-
9
-
-
49649113170
-
Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence
-
Shi YH, Ding WX, Zhou J, He JY, Xu Y, et al. (2008) Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence. Hepatology 48: 497-507.
-
(2008)
Hepatology
, vol.48
, pp. 497-507
-
-
Shi, Y.H.1
Ding, W.X.2
Zhou, J.3
He, J.Y.4
Xu, Y.5
-
10
-
-
65649130417
-
Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma
-
Augello C, Caruso L, Maggioni M, Donadon M, Montorsi M, et al. (2009) Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma. BMC Cancer 9: 125.
-
(2009)
BMC Cancer
, vol.9
, pp. 125
-
-
Augello, C.1
Caruso, L.2
Maggioni, M.3
Donadon, M.4
Montorsi, M.5
-
11
-
-
21644480008
-
High level expression of apoptosis inhibitor in hepatoma cell line expressing Hepatitis B virus
-
Lu X, Lee M, Tran T, Block T, (2005) High level expression of apoptosis inhibitor in hepatoma cell line expressing Hepatitis B virus. Int J Med Sci 2: 30-35.
-
(2005)
Int J Med Sci
, vol.2
, pp. 30-35
-
-
Lu, X.1
Lee, M.2
Tran, T.3
Block, T.4
-
12
-
-
27744497446
-
Targeting of X-linked inhibitor of apoptosis protein or survivin by short interfering RNAs sensitize hepatoma cells to TNF-related apoptosis-inducing ligand- and chemotherapeutic agent-induced cell death, Oncol Rep
-
Yamaguchi Y, Shiraki K, Fuke H, Inoue T, Miyashita K, et al. (2005) Targeting of X-linked inhibitor of apoptosis protein or survivin by short interfering RNAs sensitize hepatoma cells to TNF-related apoptosis-inducing ligand- and chemotherapeutic agent-induced cell death, Oncol Rep. 14: 1311-1316.
-
(2005)
, vol.14
, pp. 1311-1316
-
-
Yamaguchi, Y.1
Shiraki, K.2
Fuke, H.3
Inoue, T.4
Miyashita, K.5
-
13
-
-
35948994157
-
Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis
-
Petersen S, Wang L, Yalcin-Chin A, Li L, Peyton M, et al. (2007) Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell 12: 445-456.
-
(2007)
Cancer Cell
, vol.12
, pp. 445-456
-
-
Petersen, S.1
Wang, L.2
Yalcin-Chin, A.3
Li, L.4
Peyton, M.5
-
14
-
-
36148954336
-
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
-
Vince JE, Wong WW, Khan N, Feltham R, Chau D, et al. (2007) IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 131: 682-693.
-
(2007)
Cell
, vol.131
, pp. 682-693
-
-
Vince, J.E.1
Wong, W.W.2
Khan, N.3
Feltham, R.4
Chau, D.5
-
15
-
-
36048999753
-
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
-
Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, et al. (2007) IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell 131: 669-681.
-
(2007)
Cell
, vol.131
, pp. 669-681
-
-
Varfolomeev, E.1
Blankenship, J.W.2
Wayson, S.M.3
Fedorova, A.V.4
Kayagaki, N.5
-
16
-
-
4444243683
-
A small molecule Smac mimic potentiates APO2L/TRAIL- and TNFalpha-mediated cell death
-
Li L, Thomas RM, Suzuki H, De Brabander JK, Wang X, et al. (2004) A small molecule Smac mimic potentiates APO2L/TRAIL- and TNFalpha-mediated cell death. Science 305: 1471-1474.
-
(2004)
Science
, vol.305
, pp. 1471-1474
-
-
Li, L.1
Thomas, R.M.2
Suzuki, H.3
de Brabander, J.K.4
Wang, X.5
-
17
-
-
79956006296
-
Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with APO2L/TRAIL for cancer treatment
-
Lu J, McEachern D, Sun H, Bai L, Peng Y, et al. (2011) Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with APO2L/TRAIL for cancer treatment. Mol Cancer Ther 10: 902-914.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 902-914
-
-
Lu, J.1
McEachern, D.2
Sun, H.3
Bai, L.4
Peng, Y.5
-
18
-
-
33645640920
-
The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases
-
Eckelman BP, Salvesen GS, (2006) The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. J Biol Chem 281: 3254-3260.
-
(2006)
J Biol Chem
, vol.281
, pp. 3254-3260
-
-
Eckelman, B.P.1
Salvesen, G.S.2
-
19
-
-
73649095563
-
IAP regulation of metastasis
-
Mehrotra S, Languino LR, Raskett CM, Mercurio AM, Dohi T, et al. (2010) IAP regulation of metastasis. Cancer Cell 17: 53-64.
-
(2010)
Cancer Cell
, vol.17
, pp. 53-64
-
-
Mehrotra, S.1
Languino, L.R.2
Raskett, C.M.3
Mercurio, A.M.4
Dohi, T.5
-
20
-
-
77954930632
-
IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer
-
Gyrd-Hansen M, Meier P, (2010) IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. Nat Rev Cancer 10: 561-574.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 561-574
-
-
Gyrd-Hansen, M.1
Meier, P.2
-
21
-
-
0034616945
-
Smac, a Mitochondrial Protein that Promotes Cytochrome c-Dependent Caspase Activation by Eliminating IAP Inhibition
-
Du C, Fang M, Li Y, Li L, Wang X, (2000) Smac, a Mitochondrial Protein that Promotes Cytochrome c-Dependent Caspase Activation by Eliminating IAP Inhibition. Cell 102: 33-42.
-
(2000)
Cell
, vol.102
, pp. 33-42
-
-
Du, C.1
Fang, M.2
Li, Y.3
Li, L.4
Wang, X.5
-
22
-
-
0036205587
-
Mechanisms of Caspase Activation and Inhibition during Apoptosis
-
Shi Y, (2002) Mechanisms of Caspase Activation and Inhibition during Apoptosis. Mol Cell 9: 459-470.
-
(2002)
Mol Cell
, vol.9
, pp. 459-470
-
-
Shi, Y.1
-
23
-
-
8444220527
-
Molecular mechanisms of caspase regulation during apoptosis
-
Riedl S, Shi Y, (2004) Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol 5: 897-907.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 897-907
-
-
Riedl, S.1
Shi, Y.2
-
24
-
-
3843086358
-
Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site
-
Sun H, Nikolovska-Coleska Z, Yang CY, Xu L, Tomita Y, et al. (2004) Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site. J Med Chem 47: 4147-4150.
-
(2004)
J Med Chem
, vol.47
, pp. 4147-4150
-
-
Sun, H.1
Nikolovska-Coleska, Z.2
Yang, C.Y.3
Xu, L.4
Tomita, Y.5
-
25
-
-
37749037799
-
Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs
-
Zobel K, Wang L, Varfolomeev E, Franklin MC, Elliott LO, et al. (2006) Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol 1: 525-533.
-
(2006)
ACS Chem Biol
, vol.1
, pp. 525-533
-
-
Zobel, K.1
Wang, L.2
Varfolomeev, E.3
Franklin, M.C.4
Elliott, L.O.5
-
26
-
-
37049019494
-
Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP
-
Sun H, Nikolovska-Coleska Z, Lu J, Meagher JL, Yang CY, et al. (2007) Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP. J Am Chem Soc 129: 15279-15294.
-
(2007)
J Am Chem Soc
, vol.129
, pp. 15279-15294
-
-
Sun, H.1
Nikolovska-Coleska, Z.2
Lu, J.3
Meagher, J.L.4
Yang, C.Y.5
-
27
-
-
56449103218
-
SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP
-
Lu J, Bai L, Sun H, Nikolovska-Coleska Z, McEachern D, et al. (2008) SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Res 68: 9384-9393.
-
(2008)
Cancer Res
, vol.68
, pp. 9384-9393
-
-
Lu, J.1
Bai, L.2
Sun, H.3
Nikolovska-Coleska, Z.4
McEachern, D.5
-
28
-
-
85042587668
-
Small molecule XIAP inhibitors cooperate with APO2L/TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance
-
Fakler M, Loeder S, Vogler M, Schneider K, Jeremias I, et al. (2009) Small molecule XIAP inhibitors cooperate with APO2L/TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance. Blood 113: 1710-1722.
-
(2009)
Blood
, vol.113
, pp. 1710-1722
-
-
Fakler, M.1
Loeder, S.2
Vogler, M.3
Schneider, K.4
Jeremias, I.5
-
29
-
-
70350228525
-
Down-regulation of c-FLIP Enhances death of cancer cells by smac mimetic compound
-
Cheung HH, Mahoney DJ, Lacasse EC, Korneluk RG, (2009) Down-regulation of c-FLIP Enhances death of cancer cells by smac mimetic compound. Cancer Res 69: 7729-7738.
-
(2009)
Cancer Res
, vol.69
, pp. 7729-7738
-
-
Cheung, H.H.1
Mahoney, D.J.2
Lacasse, E.C.3
Korneluk, R.G.4
-
30
-
-
27744526342
-
A small molecule Smac-mimic compound induces apoptosis and sensitizes APO2L/TRAIL- and etoposide-induced apoptosis in breast cancer cells
-
Bockbrader KM, Tan M, Sun Y, (2005) A small molecule Smac-mimic compound induces apoptosis and sensitizes APO2L/TRAIL- and etoposide-induced apoptosis in breast cancer cells. Oncogene 24: 7381-7388.
-
(2005)
Oncogene
, vol.24
, pp. 7381-7388
-
-
Bockbrader, K.M.1
Tan, M.2
Sun, Y.3
-
31
-
-
84255192023
-
SMAC mimetic (JP1201) sensitizes non small cell lung cancers to multiple chemotherapy agents in an IAP dependent but TNFα independent manner
-
Greer R, Peyton M, Larsen J, Girard L, Xie Y, et al. (2011) SMAC mimetic (JP1201) sensitizes non small cell lung cancers to multiple chemotherapy agents in an IAP dependent but TNFα independent manner. Cancer Res 71: 7640-7648.
-
(2011)
Cancer Res
, vol.71
, pp. 7640-7648
-
-
Greer, R.1
Peyton, M.2
Larsen, J.3
Girard, L.4
Xie, Y.5
-
32
-
-
77950806356
-
Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer
-
Dineen S, Roland C, Greer R, Carbon J, Toombs J, et al. (2010) Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer. Cancer Res 70: 2852-2861.
-
(2010)
Cancer Res
, vol.70
, pp. 2852-2861
-
-
Dineen, S.1
Roland, C.2
Greer, R.3
Carbon, J.4
Toombs, J.5
-
33
-
-
77956712168
-
Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner
-
Probst B, Liu L, Ramesh V, Li L, Sun H, et al. (2010) Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner. Cell Death Differ 17: 1645-1654.
-
(2010)
Cell Death Differ
, vol.17
, pp. 1645-1654
-
-
Probst, B.1
Liu, L.2
Ramesh, V.3
Li, L.4
Sun, H.5
-
34
-
-
34447308516
-
Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells
-
Weisberg E, Kung A, Wright R, Moreno D, Catley L, et al. (2007) Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells. Mol Cancer Ther 6: 1951-1961.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1951-1961
-
-
Weisberg, E.1
Kung, A.2
Wright, R.3
Moreno, D.4
Catley, L.5
-
35
-
-
23244459828
-
Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma
-
Fandy TE, Shankar S, Ross DD, Sausville E, Srivastava RK, (2005) Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma. Neoplasia 7: 646-657.
-
(2005)
Neoplasia
, vol.7
, pp. 646-657
-
-
Fandy, T.E.1
Shankar, S.2
Ross, D.D.3
Sausville, E.4
Srivastava, R.K.5
-
36
-
-
0036861915
-
Gemcitabine and doxorubicin for the treatment of patients with advanced hepatocellular carcinoma: a phase I-II trial
-
Yang TS, Wang CH, Hsieh RK, Chen JS, Fung MC, (2002) Gemcitabine and doxorubicin for the treatment of patients with advanced hepatocellular carcinoma: a phase I-II trial. Ann Oncol 13: 1771-1778.
-
(2002)
Ann Oncol
, vol.13
, pp. 1771-1778
-
-
Yang, T.S.1
Wang, C.H.2
Hsieh, R.K.3
Chen, J.S.4
Fung, M.C.5
-
37
-
-
84857358680
-
Are there opportunities for chemotherapy in the treatment of hepatocellular cancer?
-
Asghar U, Meyer T, (2012) Are there opportunities for chemotherapy in the treatment of hepatocellular cancer? J Hepatol 56: 686-695.
-
(2012)
J Hepatol
, vol.56
, pp. 686-695
-
-
Asghar, U.1
Meyer, T.2
-
38
-
-
77956627711
-
The role of signaling pathways in the development and treatment of hepatocellular carcinoma
-
Whittaker S, Marais R, Zhu AX, (2010) The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene 29: 4989-5005.
-
(2010)
Oncogene
, vol.29
, pp. 4989-5005
-
-
Whittaker, S.1
Marais, R.2
Zhu, A.X.3
-
39
-
-
44349160724
-
Nitrosylcobalamin potentiates the anti-Neoplastic effects of chemotherapeutic agents via suppression of survival signaling
-
Bauer JA, Lupica JA, Schmidt H, Morrison BH, Haney RM, et al. (2007) Nitrosylcobalamin potentiates the anti-Neoplastic effects of chemotherapeutic agents via suppression of survival signaling. PLoS One 12: 1310-1321.
-
(2007)
PLoS One
, vol.12
, pp. 1310-1321
-
-
Bauer, J.A.1
Lupica, J.A.2
Schmidt, H.3
Morrison, B.H.4
Haney, R.M.5
-
40
-
-
78751552761
-
Lupeol targets liver tumor-initiating cells through phosphatase and tensin homolog modulation
-
Lee TK, Castilho A, Cheung VC, Tang KH, Ma S, et al. (2011) Lupeol targets liver tumor-initiating cells through phosphatase and tensin homolog modulation. Hepatology 53: 160-170.
-
(2011)
Hepatology
, vol.53
, pp. 160-170
-
-
Lee, T.K.1
Castilho, A.2
Cheung, V.C.3
Tang, K.H.4
Ma, S.5
|