The Smac mimetic RMT5265.2HCL induces apoptosis in EBV and HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the mitochondrial release of cytochrome C and Smac

Leukemia Research

Volumn 36, Issue 6, 2012, Pages 784-790

  Ramachandiran, Sampath ^a   Cain, Joan ^a   Liao, Albert ^a   He, Yanjuan ^a   Guo, Xiangxue ^a   Boise, Lawrence H ^a   Fu, Haian ^a   Ratner, Lee ^b   Khoury, Hanna Jean ^a   Bernal Mizrachi, Leon ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

EBV; HHV 8; HTLV 1; Lymphomas; Smac mimetics; XIAP

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CYTOCHROME C; ETOPOSIDE; MITOCHONDRIAL PROTEIN; RMT5265.2HCL; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL CELL; APOPTOSIS; ARTICLE; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG STRUCTURE; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; INTRACELLULAR TRANSPORT; LYMPHOMA CELL; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN SECRETION; PROTEIN TRANSPORT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOMIMETICS; CELL LINE, TUMOR; CELL TRANSFORMATION, VIRAL; CYTOCHROMES C; DELTARETROVIRUS INFECTIONS; DIPEPTIDES; EPSTEIN-BARR VIRUS INFECTIONS; HEK293 CELLS; HERPESVIRUS 4, HUMAN; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOMA, T-CELL; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MODELS, BIOLOGICAL; TETRAZOLES; UP-REGULATION; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84862776560     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2011.12.024     Document Type: Article

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