Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose

PLoS ONE

Volumn 10, Issue 1, 2015, Pages

  Jung, Minjeong ^a   Lee, Jaemeun ^a   Seo, Hye Young ^a   Lim, Ji Sun ^a   Kim, Eun Kyoung ^a  

^a Daegu Gyeongbuk Institute of Science and Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; CATHEPSIN; CATHEPSIN B; CATHEPSIN D; CATHEPSIN L; GLUCOSE; INSULIN; JANUS KINASE; MESSENGER RNA; PROTEIN BCL 2; LC3 PROTEIN, RAT; MICROTUBULE ASSOCIATED PROTEIN; PROTEINASE INHIBITOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL CULTURE; CELL DEATH; CELL FRACTIONATION; CELL FUNCTION; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CULTURE MEDIUM; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INHIBITION; GLUCOTOXICITY; HYPERGLYCEMIA; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; LYSOSOME; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN PROCESSING; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; DIABETES MELLITUS; DRUG EFFECTS; ENZYMOLOGY; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CATHEPSIN B; CATHEPSIN L; CELL LINE, TUMOR; DIABETES MELLITUS; GLUCOSE; INSULIN-SECRETING CELLS; LYSOSOMES; MALE; MICROTUBULE-ASSOCIATED PROTEINS; PROTEASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84921927022     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0116972     Document Type: Article

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