Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis

Journal of Clinical Investigation

Volumn 119, Issue 11, 2009, Pages 3340-3355

  Mareninova, Olga A ^a   Hermann, Kip ^a   French, Samuel W ^b   O'Konski, Mark S ^c   Pandol, Stephen J ^a   Webster, Paul ^d   Erickson, Ann H ^e   Katunuma, Nobuhiko ^f   Gorelick, Fred S ^g   Gukovsky, Ilya ^a   Gukovskaya, Anna S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HARBOR UCLA MEDICAL CENTER   (United States)

^c Digestive Health Physicians   (United States)

^d HOUSE EAR INSTITUTE   (United States)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

^f TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^g YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; CATHEPSIN L; TRYPSIN; TRYPSINOGEN;

ACINAR CELL; ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL FRACTIONATION; CELL VACUOLE; CONTROLLED STUDY; DIET RESTRICTION; IN VITRO STUDY; LYSOSOME MEMBRANE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; STARVATION;

ANIMALS; AUTOPHAGY; CATHEPSINS; DISEASE MODELS, ANIMAL; FASTING; FEMALE; LYSOSOMES; MALE; MICE; PANCREAS; PANCREATITIS, ACUTE NECROTIZING; PROTEINS; RATS; TRYPSIN; TRYPSINOGEN; VACUOLES;

EID: 70449426665     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI38674     Document Type: Article

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