메뉴 건너뛰기




Volumn 6, Issue 2, 2015, Pages 1157-1170

Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction

Author keywords

Brain cancer; C Myc; Glutamine addiction; Mitochondrial p32

Indexed keywords

AFIMOXIFENE; GLUCOSE; GLUTAMINE; MITOCHONDRIAL PROTEIN; MYC PROTEIN; PROTEIN P32; UNCLASSIFIED DRUG; C1QBP PROTEIN, HUMAN; CARRIER PROTEIN; IL2RG PROTEIN, MOUSE; INTERLEUKIN 2 RECEPTOR GAMMA; MYC PROTEIN, HUMAN;

EID: 84921804444     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2708     Document Type: Article
Times cited : (39)

References (60)
  • 1
    • 33749478922 scopus 로고    scopus 로고
    • Cancer's molecular sweet tooth and the Warburg effect
    • Kim JW, Dang CV. Cancer's molecular sweet tooth and the Warburg effect. Cancer Res. 2006; 66:8927-8930.
    • (2006) Cancer Res , vol.66 , pp. 8927-8930
    • Kim, J.W.1    Dang, C.V.2
  • 2
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
    • Ward PS, Thompson CB. Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate. Cancer Cell. 2012; 21:297-308.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 3
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science. 1956; 123:309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 4
    • 84866665390 scopus 로고    scopus 로고
    • Mitochondria and cancer
    • Wallace DC. Mitochondria and cancer. Nat Rev Cancer. 2012; 12:685-698.
    • (2012) Nat Rev Cancer , vol.12 , pp. 685-698
    • Wallace, D.C.1
  • 9
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA. 2007; 104:19345-19350.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19345-19350
    • DeBerardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5    Wehrli, S.6    Thompson, C.B.7
  • 11
    • 84907484052 scopus 로고    scopus 로고
    • Metabolic effect of TAp63alpha: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense
    • D'Alessandro A, Amelio I, Berkers CR, Antonov A, Vousden KH, Melino G, Zolla L. Metabolic effect of TAp63alpha: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense. Oncotarget. 2014; 5:7722-7733.
    • (2014) Oncotarget , vol.5 , pp. 7722-7733
    • D'Alessandro, A.1    Amelio, I.2    Berkers, C.R.3    Antonov, A.4    Vousden, K.H.5    Melino, G.6    Zolla, L.7
  • 14
    • 70350217425 scopus 로고    scopus 로고
    • Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling
    • Yang C, Sudderth J, Dang T, Bachoo RM, McDonald JG, DeBerardinis RJ. Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. Cancer Res. 2009; 69:7986-7993.
    • (2009) Cancer Res , vol.69 , pp. 7986-7993
    • Yang, C.1    Sudderth, J.2    Dang, T.3    Bachoo, R.M.4    McDonald, J.G.5    DeBerardinis, R.J.6
  • 16
    • 84921709704 scopus 로고    scopus 로고
    • Lipid metabolism emerges as a promising target for malignant glioma therapy
    • Guo D, Bell EH, Chakravarti A. Lipid metabolism emerges as a promising target for malignant glioma therapy. CNS oncology. 2013; 2:289-299.
    • (2013) CNS oncology , vol.2 , pp. 289-299
    • Guo, D.1    Bell, E.H.2    Chakravarti, A.3
  • 18
    • 33645732219 scopus 로고    scopus 로고
    • Molecular pathology of malignant gliomas
    • Louis DN. Molecular pathology of malignant gliomas. Annu Rev Pathol. 2006; 1:97-117.
    • (2006) Annu Rev Pathol , vol.1 , pp. 97-117
    • Louis, D.N.1
  • 19
    • 84874451397 scopus 로고    scopus 로고
    • Metabolic modulation of epigenetics in gliomas
    • Venneti S, Thompson CB. Metabolic modulation of epigenetics in gliomas. Brain pathology. 2013; 23:217-221.
    • (2013) Brain pathology , vol.23 , pp. 217-221
    • Venneti, S.1    Thompson, C.B.2
  • 27
    • 70849122697 scopus 로고    scopus 로고
    • Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
    • Brennan C, Momota H, Hambardzumyan D, Ozawa T, Tandon A, Pedraza A, Holland E. Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PloS one. 2009; 4:e7752.
    • (2009) PloS one , vol.4
    • Brennan, C.1    Momota, H.2    Hambardzumyan, D.3    Ozawa, T.4    Tandon, A.5    Pedraza, A.6    Holland, E.7
  • 29
    • 2942701935 scopus 로고    scopus 로고
    • Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays
    • Kim JW, Zeller KI, Wang Y, Jegga AG, Aronow BJ, O'Donnell KA, Dang CV. Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays. Mol Cell Biol. 2004; 24:5923-5936.
    • (2004) Mol Cell Biol , vol.24 , pp. 5923-5936
    • Kim, J.W.1    Zeller, K.I.2    Wang, Y.3    Jegga, A.G.4    Aronow, B.J.5    O'Donnell, K.A.6    Dang, C.V.7
  • 30
    • 84868620661 scopus 로고    scopus 로고
    • Oncogene addiction to c-MYC in myeloma cells
    • Holien T, Sundan A. Oncogene addiction to c-MYC in myeloma cells. Oncotarget. 2012; 3:739-740.
    • (2012) Oncotarget , vol.3 , pp. 739-740
    • Holien, T.1    Sundan, A.2
  • 35
    • 79957991472 scopus 로고    scopus 로고
    • Glutaminase: a hot spot for regulation of cancer cell metabolism?
    • Erickson JW, Cerione RA. Glutaminase: a hot spot for regulation of cancer cell metabolism? Oncotarget. 2010; 1:734-740.
    • (2010) Oncotarget , vol.1 , pp. 734-740
    • Erickson, J.W.1    Cerione, R.A.2
  • 37
    • 77749334738 scopus 로고    scopus 로고
    • Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation
    • Fogal V, Richardson AD, Karmali PP, Scheffler IE, Smith JW, Ruoslahti E. Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation. Mol Cell Biol. 2010; 30:1303-1318.
    • (2010) Mol Cell Biol , vol.30 , pp. 1303-1318
    • Fogal, V.1    Richardson, A.D.2    Karmali, P.P.3    Scheffler, I.E.4    Smith, J.W.5    Ruoslahti, E.6
  • 39
    • 84868109828 scopus 로고    scopus 로고
    • p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability
    • Yagi M, Uchiumi T, Takazaki S, Okuno B, Nomura M, Yoshida S, Kanki T, Kang D. p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability. Nucleic Acids Res. 2012; 40:9717-9737.
    • (2012) Nucleic Acids Res , vol.40 , pp. 9717-9737
    • Yagi, M.1    Uchiumi, T.2    Takazaki, S.3    Okuno, B.4    Nomura, M.5    Yoshida, S.6    Kanki, T.7    Kang, D.8
  • 40
    • 52049123781 scopus 로고    scopus 로고
    • Mitochondrial/cell-surface protein p32/gC1qR as a molecular target in tumor cells and tumor stroma
    • Fogal V, Zhang L, Krajewski S, Ruoslahti E. Mitochondrial/cell-surface protein p32/gC1qR as a molecular target in tumor cells and tumor stroma. Cancer Res. 2008; 68:7210-7218.
    • (2008) Cancer Res , vol.68 , pp. 7210-7218
    • Fogal, V.1    Zhang, L.2    Krajewski, S.3    Ruoslahti, E.4
  • 43
  • 44
    • 46349099384 scopus 로고    scopus 로고
    • Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-box usage in vivo
    • Kim J, Lee JH, Iyer VR. Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-box usage in vivo. PloS one. 2008; 3:e1798.
    • (2008) PloS one , vol.3
    • Kim, J.1    Lee, J.H.2    Iyer, V.R.3
  • 45
    • 0842278571 scopus 로고    scopus 로고
    • An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets
    • Zeller KI, Jegga AG, Aronow BJ, O'Donnell KA, Dang CV. An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets. Genome Biol. 2003; 4:R69.
    • (2003) Genome Biol , vol.4 , pp. R69
    • Zeller, K.I.1    Jegga, A.G.2    Aronow, B.J.3    O'Donnell, K.A.4    Dang, C.V.5
  • 46
    • 0037197962 scopus 로고    scopus 로고
    • Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes
    • Menssen A, Hermeking H. Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes. Proc Natl Acad Sci USA. 2002; 99:6274-6279.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 6274-6279
    • Menssen, A.1    Hermeking, H.2
  • 51
    • 78049339834 scopus 로고    scopus 로고
    • MAPK signalling in cellular metabolism: stress or wellness?
    • Gehart H, Kumpf S, Ittner A, Ricci R. MAPK signalling in cellular metabolism: stress or wellness?. EMBO reports. 2010; 11:834-840.
    • (2010) EMBO reports , vol.11 , pp. 834-840
    • Gehart, H.1    Kumpf, S.2    Ittner, A.3    Ricci, R.4
  • 52
    • 79959572624 scopus 로고    scopus 로고
    • Cell-surface receptor for complement component C1q (gC1qR) is a key regulator for lamellipodia formation and cancer metastasis
    • Kim KB, Yi JS, Nguyen N, Lee JH, Kwon YC, Ahn BY, Cho H, Kim YK, Yoo HJ, Lee JS, Ko YG. Cell-surface receptor for complement component C1q (gC1qR) is a key regulator for lamellipodia formation and cancer metastasis. J Biol Chem. 2011; 286:23093-23101.
    • (2011) J Biol Chem , vol.286 , pp. 23093-23101
    • Kim, K.B.1    Yi, J.S.2    Nguyen, N.3    Lee, J.H.4    Kwon, Y.C.5    Ahn, B.Y.6    Cho, H.7    Kim, Y.K.8    Yoo, H.J.9    Lee, J.S.10    Ko, Y.G.11
  • 54
    • 0031757391 scopus 로고    scopus 로고
    • A Phase I and pharmacological study of the glutamine antagonist acivicin with the amino acid solution aminosyn in patients with advanced solid malignancies
    • Hidalgo M, Rodriguez G, Kuhn JG, Brown T, Weiss G, MacGovren JP, Von Hoff DD, Rowinsky EK. A Phase I and pharmacological study of the glutamine antagonist acivicin with the amino acid solution aminosyn in patients with advanced solid malignancies. Clin Cancer Res. 1998; 4:2763-2770.
    • (1998) Clin Cancer Res , vol.4 , pp. 2763-2770
    • Hidalgo, M.1    Rodriguez, G.2    Kuhn, J.G.3    Brown, T.4    Weiss, G.5    MacGovren, J.P.6    Von Hoff, D.D.7    Rowinsky, E.K.8
  • 55
    • 34247614521 scopus 로고    scopus 로고
    • HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
    • Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV, Semenza GL. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell. 2007; 11:407-420.
    • (2007) Cancer Cell , vol.11 , pp. 407-420
    • Zhang, H.1    Gao, P.2    Fukuda, R.3    Kumar, G.4    Krishnamachary, B.5    Zeller, K.I.6    Dang, C.V.7    Semenza, G.L.8
  • 56
    • 0037439054 scopus 로고    scopus 로고
    • c-MYC apoptotic function is mediated by NRF-1 target genes
    • Morrish F, Giedt C, Hockenbery D. c-MYC apoptotic function is mediated by NRF-1 target genes. Genes Dev. 2003; 17:240-255.
    • (2003) Genes Dev , vol.17 , pp. 240-255
    • Morrish, F.1    Giedt, C.2    Hockenbery, D.3
  • 57
    • 75149148563 scopus 로고    scopus 로고
    • Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
    • DeBerardinis RJ, Cheng T. Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene. 2010; 29:313-324.
    • (2010) Oncogene , vol.29 , pp. 313-324
    • DeBerardinis, R.J.1    Cheng, T.2
  • 58
    • 70350728803 scopus 로고    scopus 로고
    • MYC-induced cancer cell energy metabolism and therapeutic opportunities
    • Dang CV, Le A, Gao P. MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res. 2009; 15:6479-6483.
    • (2009) Clin Cancer Res , vol.15 , pp. 6479-6483
    • Dang, C.V.1    Le, A.2    Gao, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.