Altered γ-aminobutyric acid neurotransmission in major depressive disorder: A critical review of the supporting evidence and the influence of serotonergic antidepressants

Drug Design, Development and Therapy

Volumn 9, Issue , 2015, Pages 603-624

  Pehrson, Alan L ^a   Sanchez, Connie ^a  

^a LUNDBECK RESEARCH USA   (United States)

Author keywords

5 HT; GABA; Major depressive disorder; Serotonin

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; ANTIDEPRESSANT AGENT; CALBINDIN; CALCIUM ION; CALRETININ; FLUOXETINE; GLUTAMATE DECARBOXYLASE; NEUROPEPTIDE; PARVALBUMIN; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 3 RECEPTOR; SEROTONIN 4 RECEPTOR; SEROTONIN 5 RECEPTOR; SEROTONIN 6 RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN UPTAKE INHIBITOR; SOMATOSTATIN; VORTIOXETINE; GABAERGIC RECEPTOR AFFECTING AGENT; GLUTAMIC ACID; PIPERAZINE DERIVATIVE; SULFIDE;

BRAIN REGION; CLINICAL EFFECTIVENESS; CLINICAL FEATURE; DATA ANALYSIS; DISEASE ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; HUMAN; MAJOR DEPRESSION; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MOOD DISORDER; NEUROTRANSMISSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REVIEW; ANIMAL; BRAIN; DEPRESSIVE DISORDER, MAJOR; DRUG EFFECTS; EVIDENCE BASED MEDICINE; METABOLISM; NERVE CELL INHIBITION; PSYCHOLOGY; SYNAPTIC TRANSMISSION;

ANIMALS; ANTIDEPRESSIVE AGENTS; BRAIN; DEPRESSIVE DISORDER, MAJOR; EVIDENCE-BASED MEDICINE; FLUOXETINE; GABA AGENTS; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; HUMANS; NEURAL INHIBITION; PIPERAZINES; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; SULFIDES; SYNAPTIC TRANSMISSION;

EID: 84921780673     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S62912     Document Type: Review

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