Monoamine dysfunction and the pathophysiology and treatment of depression

Journal of Clinical Psychiatry

Volumn 59, Issue SUPPL. 14, 1998, Pages 11-14

  Charney, Dennis S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; CATECHOLAMINE; DESIPRAMINE; METIROSINE; SEROTONIN; SEROTONIN TRANSPORTER; TRYPTOPHAN;

ADRENERGIC SYSTEM; CATECHOLAMINE BRAIN LEVEL; DEPRESSION; DRUG RESPONSE; HUMAN; PATHOPHYSIOLOGY; PATIENT SELECTION; PRIORITY JOURNAL; REVIEW; SEROTONIN BRAIN LEVEL; SEROTONINERGIC SYSTEM;

ADRENERGIC UPTAKE INHIBITORS; ANTIDEPRESSIVE AGENTS; CARRIER PROTEINS; CATECHOLAMINES; COCAINE; DEPRESSIVE DISORDER; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MORPHOLINES; NERVE TISSUE PROTEINS; NEUROPEPTIDES; NOREPINEPHRINE; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TRYPTOPHAN;

EID: 0031690726     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (22)

1. Coppen A, Eccleston EG, Peet M. Total and free tryptophan concentration in the plasma of depressed patients. Lancet 1973;2:60-62
2. Delgado PL, Price LH, Heninger GR, et al. Neurochemistry of affective disorders. In: Paykel ES, ed. Handbook of Affective Disorders, 2nd ed. New York, NY: Churchill Livingstone; 1992:219-253
3. Anand A, Charney DS, Delgado PL, et al. Neuroendocrine and behavioral responses to intravenous m-chlorophenylpiperazine (mCPP) in depressed patients and healthy comparison subjects. Am J Psychiatry 1994;151: 1626-1630
4. Briley MS, Langer SZ, Raisman R, et al. Tritiated imipramine binding sites are decreased in platelets of untreated depressed patients. Science 1980; 209:303-305
5. Owens MJ, Nemeroff CB. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem 1994;40:288-295
6. 123I) beta-CIT: pharmacological characterization of brain uptake in nonhuman primates. Synapse 1993;13:295-309
7. Heils A, Teufel A, Petri S, et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996;66:2621-2624
8. Lesch KP, Bengel D, Heils A, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-1531
9. Delgado PL, Charney DS, Price LH, et al. Serotonin function and the mechanism of antidepressant action: reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiatry 1990;47:411-418
10. Delgado PL, Price LH, Miller HL, et al. Rapid serotonin depletion as a provocative challenge test for patients with major depression: relevance to antidepressant action and the neurobiology of depression. Psychopharmacol Bull 1991;27:321-330
11. Smith KA, Fairbum CG, Cowen PJ. Relapse of depression after rapid depletion of tryptophan. Lancet 1997;349:915-919
12. Ellenbogen MA, Young SN, Dean P, et al. Mood response to acute tryptophan depletion in healthy volunteers: sex differences and temporal stability. Neuropsychopharmacology 1996;15:465-474
13. Nishizawa S, Benkelfat C, Young SN, et al. Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci USA 1997;94:5308-5313
14. Leonard BE. Noradrenaline in basic models of depression. Eur Neuropsychopharmacol 1997;7(suppl 1):S11-S16
15. Delgado PL, Miller HL, Salomon RM, et al. Monoamines and the mechanism of antidepressant action: effects of catecholamine depletion on mood of patients treated with antidepressants. Psychopharmacol Bull 1993;29: 389-396
16. Miller HL, Delgado PL, Salomon RM, et al. Clinical and biochemical effects of catecholamine depletion on antidepressant-induced remission of depression. Arch Gen Psychiatry 1996;53:117-128
17. Blier P, de Montigny C. Current advances and trends in the treatment of depression. Trends Pharmacol Sci 1994;15:220-226
18. Nestler EJ, Terwilliger RZ, Duman RS. Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex. J Neurochem 1989;53:1644-1647
19. Nibuya M, Nestler EJ, Duman RS. Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J Neurosci 1996;16:2365-2372
20. Nomura S, Duman RS, Enna SJ. In vivo or in vitro exposure to imipramine reduces alpha 2-adrenoceptor-mediated inhibition of cyclic AMP production in rat brain cerebral cortical slices. Brain Res 1987;410:195-198
21. Nibuya M, Morinobu S, Duman RS. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 1995;15:7539-7547
22. Ur E. Grossman A. Corticotropin-releasing hormone in health and disease: an update. Acta Endocrinol (Copenh) 1992;127:193-199