A process-based approach to characterizing the effect of acute alprazolam challenge on visual paired associate learning and memory in healthy older adults

Human Psychopharmacology

Volumn 27, Issue 6, 2012, Pages 549-558

  Pietrzak, Robert H ^a,b,c   Scott, James Cobb ^a,b   Harel, Brian T ^c   Lim, Yen Ying ^d   Snyder, Peter J ^c,e   Maruff, Paul ^c,d  

^a VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Scientific Division   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e BROWN UNIVERSITY   (United States)

Author keywords

alprazolam; benzodiazepine; cognition; learning; memory

Indexed keywords

ALPRAZOLAM; PLACEBO;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSSOVER PROCEDURE; DISTRACTIBILITY; ERROR; EXPLORATORY BEHAVIOR; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MEMORY; NORMAL HUMAN; PAIRED ASSOCIATE LEARNING; PRIORITY JOURNAL; VISUAL PAIRED ASSOCIATE LEARNING;

AGED; AGED, 80 AND OVER; AGING; ALPRAZOLAM; ANTI-ANXIETY AGENTS; ASSOCIATION LEARNING; ATTENTION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EXPLORATORY BEHAVIOR; FEMALE; GABA AGONISTS; HUMANS; MALE; MEMORY; MEMORY, SHORT-TERM; MIDDLE AGED; REPRODUCIBILITY OF RESULTS; TASK PERFORMANCE AND ANALYSIS; VISUAL PERCEPTION;

EID: 84868545286     PISSN: 08856222     EISSN: 10991077     Source Type: Journal    
DOI: 10.1002/hup.2263     Document Type: Article

References (42)

1. Ahmed S, Mitchell J, Arnold R, Nestor PJ, Hodges JR,. 2008. Predicting rapid clinical progression in amnestic mild cognitive impairment. Dement Geriatr Cogn Disord 25: 170-177.
2. Baddeley AD,. 2004. Your Memory: A User's Guide. Firefly Books: Buffalo, NY.
3. Barbee JG, Black FW, Kehoe CE, Todorov AA,. 1991. A comparison of the single-dose effects of alprazolam, buspirone, and placebo upon memory function. J Clin Psychopharmacol 11: 351-356.
4. Barbee JG, Black FW, Todorov AA,. 1992. Differential effects of alprazolam and buspirone upon acquisition, retention, and retrieval processes in memory. J Neuropsychiatry Clin Neurosci 4: 308-314.
5. Bertz RJ, Kroboth PD, Kroboth FJ, et al,. 1997. Alprazolam in young and elderly men: sensitivity and tolerance to psychomotor, sedative and memory effects. J Pharmacol Exp Ther 281: 1317-1329.
6. Blackwell AD, Sahakian BJ, Vesey R, Semple JM, Robbins TW, Hodges JR,. 2004. Detecting dementia: novel neuropsychological markers of preclinical Alzheimer's disease. Dement Geriatr Cogn Disord 17: 42-48.
7. Block RI, Berchou R,. 1984. Alprazolam and lorazepam effects on memory acquisition and retrieval processes. Pharmacol Biochem Behav 20: 233-241.
8. Brandt J, Aretouli E, Neijstrom E, et al,. 2009. Selectivity of executive function deficits in mild cognitive impairment. Neuropsychology 23: 607-618.
9. Chang YL, Jacobson MW, Fennema-Notestine C, et al,. 2010. Level of executive function influences verbal memory in amnestic mild cognitive impairment and predicts prefrontal and posterior cingulate thickness. Cereb Cortex 20: 1305-1313.
10. Cohen J,. 1988. Statistical Power Analysis for the Behavioral Sciences, 2nd edn. Lawrence Erlbaum: Hillsdale, NJ.
11. De Jager C, Blackwell AD, Budge MM, Sahakian BJ,. 2005. Predicting cognitive decline in healthy older adults. Am J Geriatr Psychiatry 13: 735-740.
12. Eichenbaum H, Alvarez P, Ramus SJ,. 2000. Animal models of amnesia. In Handbook of Neuropsychology: Memory and Its Disorders, Vol 2, 2nd edn, Cermak LS, (ed). Elsevier: Amsterdam; 1-24.
13. Fowler KS, Saling MM, Conway EL, Semple JM, Louis WJ,. 2002. Paired associate performance in the early detection of DAT. J Int Neuropsychol Soc 8: 58-71.
14. Fredrickson A, Snyder PJ, Cromer J, Thomas E, Lewis M, Maruff P,. 2008. The use of effect sizes to characterize the nature of cognitive change in psychopharmacological studies: an example with scopolamine. Hum Psychopharmacol 23: 425-436.
15. Greenblatt DJ, von Moltke LL, Harmatz JS, Ciraulo DA, Shader RI,. 1993. Alprazolam pharmacokinetics, metabolism, and plasma levels: clinical implications. J Clin Psychiatry 54 (Suppl): 4-11.
16. Gutnikov SA, Ma YY, Gaffan D,. 1997. Temporo-frontal disconnection impairs visual-visual paired association learning but not configural learning in Macaca monkeys. Eur J Neurosci 9: 1524-1529.
17. Harel BT, Darby D, Pietrzak RH, Ellis KA, Snyder PJ, Maruff P,. 2011. Examining the nature of impairment in visual paired associate learning in amnestic mild cognitive impairment. Neuropsychology 25: 752-762.
18. de Jager CA, Budge MM,. 2005. Stability and predictability of the classification of mild cognitive impairment as assessed by episodic memory test performance over time. Neurocase 11: 72-79.
19. Leufkens TR, Vermeeren A, Smink BE, van Ruitenbeek P, Ramaekers JG,. 2007. Cognitive, psychomotor and actual driving performance in healthy volunteers after immediate and extended release formulations of alprazolam 1 mg. Psychopharmacology 191: 951-959.
20. Machulda MM, Senjem ML, Weigand SD, et al,. 2009. Functional magnetic resonance imaging changes in amnestic and nonamnestic mild cognitive impairment during encoding and recognition tasks. J Int Neuropsychol Soc 15: 372-382.
21. Martin SB, Smith CD, Collins HR, Schmitt FA, Gold BT,. 2010. Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment. Neurobiol Aging 31: 1099-1106.
22. Maruff P, Collie A, Darby D, Weaver-Cargin J, Masters C, Currie J,. 2004. Subtle memory decline over 12 months in mild cognitive impairment. Dement Geriatr Cogn Disord 18: 342-348.
23. Maruff P, Thomas E, Cysique L, et al,. 2009. Validity of the CogState brief battery: relationship to standardized tests and sensitivity to cognitive impairment in mild traumatic brain injury, schizophrenia, and AIDS dementia complex. Arch Clin Neuropsychol 24: 165-178.
24. Mitchell J, Arnold R, Dawson K, Nestor PJ, Hodges JR,. 2009. Outcome in subgroups of mild cognitive impairment (MCI) is highly predictable using a simple algorithm. J Neurol 256: 1500-1509.
25. O'Donnell J, Pietrzak RH, Ellis K, Snyder PJ, Maruff, P,. 2011. Understanding failure of visual paired associate learning in amnestic mild cognitive impairment. J Clin Exp Neuropsychol 33: 1069-1078.
26. Owen AM, Sahakian BJ, Semple J, Polkey CE, Robbins TW,. 1990. Visuo-spatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in man. Neuropsychologia 33: 1-24.
27. Pietrzak RH, Fredrickson A, Snyder PJ, Maruff P,. 2010. A comparison of statistical approaches used to evaluate change in cognitive function following pharmacologic challenge: an example with lorazepam. Hum Psychopharmacol 25: 335-341.
28. Pompéia S, Pradella-Hallinan M, Manzano GM, Bueno OF,. 2008. Effects of lorazepam on visual perceptual abilities. Hum Psychopharmacol 23: 183-192.
29. Poreh A,. 2006. The Quantified Process Approach to Neuropsychological Assessment. Taylor & Francis: New York.
30. Rey A,. 1964. L'examen Clinique En Psychologie. Presses Universitaires de France: Paris.
31. Satzger W, Engel RR, Ferguson E, Kapfhammer H, Eich FX, Hippius H,. 1990. Effects of single doses of alpidem, lorazepam, and placebo on memory and attention in healthy young and elderly volunteers. Pharmacopsychiatry 23 (Suppl 3): 114-119.
32. Smith RB, Kroboth PD, Vanderlugt JT, Phillips JP, Juhl RP,. 1984. Pharmacokinetics and pharmacodynamics of alprazolam after oral and IV administration. Psychopharmacology 84: 452-456.
33. Snyder PJ, Werth J, Giordani B, Caveney AF, Feltner D, Maruff P,. 2005. A method for determining the magnitude of change across different cognitive functions in clinical trials: the effects of acute administration of two different doses alprazolam. Hum Psychopharmacol 20: 263-273.
34. Stark CE, Squire LR,. 2001. Simple and associative recognition memory in the hippocampal region. Learn Mem 8: 190-197.
35. Stewart SA,. 2005. The effects of benzodiazepines on cognition. J Clin Psychiatry 66 (Suppl 2): 9-13.
36. Swainson R, Hodges JR, Galton CJ, et al,. 2001. Early detection and differential diagnosis of Alzheimer's disease and depression with neuropsychological tasks. Dement Geriatr Cogn Disord 12: 265-280.
37. Taffe MA, Weed MR, Gutierrez T, Davis SA, Gold LH,. 2004. Modeling a task that is sensitive to dementia of the Alzheimer's type: individual differences in acquisition of a visuo-spatial paired-associate learning task in rhesus monkeys. Behav Brain Res 149: 123-133.
38. Vermeeren A, Jackson JL, Muntjewerff ND, Quint PJ, Harrison EM, O'Hanlon JF,. 1995. Comparison of acute alprazolam (0.25, 0.50 and 1.0 mg) effects versus those of lorazepam 2 mg and placebo on memory in healthy volunteers using laboratory and telephone tests. Psychopharmacology 118: 1-9.
39. Verster JC, Volkerts ER, Verbaten MN,. 2002. Effects of alprazolam on driving ability, memory functioning and psychomotor performance: a randomized, placebo-controlled study. Neuropsychopharmacology 27: 260-269.
40. Whitwell JL, Przybelski SA, Weigand SD, et al,. 2007. 3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's disease. Brain 130: 1777-1786.
41. Young AB, Chu D,. 1990. Distribution of GABAA and GABAB receptors in mammalian brain: potential targets for drug development. Drug Dev Res 21: 161-167.
42. Yuan R, Flockhart DA, Balian JD,. 1999. Pharmacokinetic and pharmacodynamic consequences of metabolism-based drug interactions with alprazolam, midazolam, and triazolam. J Clin Pharmacol 39: 1109-1125.