Permissive role of brain allopregnanolone content in the regulation of pentobarbital-induced righting reflex loss

Neuropharmacology

Volumn 38, Issue 7, 1999, Pages 955-963

  Matsumoto, Kinzo ^a,b   Uzunova, Veska ^a   Pinna, Graziano ^a,c   Taki, Kazuhiro ^b   Uzunov, Doncho P ^a   Watanabe, Hroshi ^b   Mienville, Jean Marc ^a   Guidotti, Alessandro ^a   Costa, Erminio ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b Toyama Medical and Pharmaceutical University   (Japan)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Allopregnanolone; Gas chromatography; HPLC; Mass spectroscopy; Pentobarbital

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; FENCLONINE; FLUOXETINE; IONOTROPIC RECEPTOR; PENTOBARBITAL; PREGNENOLONE; PROGESTERONE; SKF 105111; STEROID 5ALPHA REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DRUG EFFECT; FRONTAL CORTEX; GABAERGIC TRANSMISSION; GAS CHROMATOGRAPHY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RIGHTING REFLEX; SOCIAL ISOLATION;

ANIMALS; FLUOXETINE; MALE; MICE; PENTOBARBITAL; PREFRONTAL CORTEX; PREGNANOLONE; REFLEX, ABNORMAL; SEROTONIN UPTAKE INHIBITORS; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 0033009306     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00018-0     Document Type: Article

References (29)

1. Barbaccia M.L., Roscetti G., Trabucchi M. et al. The effects of inhibitors of GABAergic transmission and stress on brain and plasma allopregnanolone concentrations. Br. J. Pharmacol. 120:1997;1582-1588.
2. Baulieu E.E., Robel P. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. Proc. Natl. Acad. Sci. USA. 95:1998;4089-4091.
3. Baulieu E.E., Robel P. Neurosteroids: a new brain function? J. Steroid. Biochem. Mol. Biol. 37:1990;395-403.
4. Britton K.T., Koob G.F. Premenstrual steroids? Nature. 392:1998;869-870.
5. Cheney D.L., Uzunov D.P., Costa E. et al. Gas chromatographic-mass fragmentographic quantitation of 3α-hydroxy-5α-pregnan-20-one (allopregnanolone) and its precursors in blood and brain of adrenalectomized and castrated rats. J. Neurosci. 15:1995;4641-4650.
6. Edwards F.A., Konnerth A., Sakmann B. et al. A thin slice preparation for patch clamp recordings from neurons of the mammalian central nervous system. Pflugers Arch. 414:1989;600-612.
7. Fuller R.W., Wong D.T. Serotonin uptake and serotonin uptake inhibition. Ann. N.Y. Acad. Sci. 600:1990;68-78.
8. A receptor complex. The pharmacological properties and therapeutic potential of epalons. Crit. Rev. Neurobiol. 9:1995;207-227.
9. Gorman J.M. et al. An open trial of fluoxetine in the treatment of panic attacks. J. Clin. Psychopharmacol. 7:1987;329-332.
10. Griffin L.D., Compagnone N., Mellon S. Selective serotonin reuptake inhibitors-induced alteration in 3α-hydroxysteroid dehydrogenase activity in brain. Neurosci. Abstr. 24:1998;1012.
11. Guidotti A., Costa E. Can the antidysphoric and anxiolytic profiles of SSRIs be related to their ability to increase brain 3α,5α-tetrahydroprogesterone (ALLO) availability? Biol. Psychiatry. 44:1998;865-873.
12. Guidotti, A., Uzunov, D.P., Auta, J., et al., 1996. Application of gas chromatography mass fragmentography with negative ion chemical ionization technology to measure neurosteroids and their biosynthesis rate in the rat brain. In: Genaani, A.R., Petraglia, F., Purdy, R.H. (Eds.), The Brain: Source and Target for six Steroid Hormones. The Parthenon Publishing Group, New York, pp. 25-41.
13. Hyttel J. Effect of a specific 5-HT uptake inhibitor, citalopram (Lu 10-171), on 3H-5-HT uptake in rat brain synaptosomes in vitro. Psychopharmacology. 60:1978;13-18.
14. Karavolas H.J., Hodges D.R. Metabolism of progesterone and related steroids by neural and neuroendocrine structures. Costa E., Paul S.M. Neurosteroids and Brain Function. 8:1991;135-145 Thieme, New York.
15. A receptor function. Trends Pharmacol. Sci. 16(9):1996;295-303.
16. Matsumoto K., Mizowaki M., Suchitra T. et al. Central antinociceptive effects of mitragynine in mice: contribution of descending noradrenergic and serotonergic systems. Eur. J. Pharmacol. 317:1996;75-81.
17. Matsumoto K., Ojima K., Watanabe H. Neurosteroidal modulation of social isolation-induced decrease in pentobarbital sleep in mice. Brain Res. 708:1996;1-6.
18. McEwen B.S. Non-genomic and genomic effects of steroids on neural activity. Trends Pharmacol. Sci. 12:1991;141-147.
19. Mienville J.M., Barker J.L. Potassium current expression during prenatal corticogenesis in the rat. Neuroscience. 81:1997;163-172.
20. Olsen R.W. Drug interactions at the GABA receptor-ionophore complex. Ann. Rev. Pharmacol. Toxicol. 22:1982;245-277.
21. A Receptors and Anxiety from Neurobiology to Treatment. Advances in Biochemical Psychopharmacology. 48:1995;57-74 Ravens, New York.
22. Paul S.M., Purdy R.H. Neuroactive steroids. FASEB J. 6:1992;2311-2322.
23. A receptor subunit composition? Recept. Channel. 1:1993;135-142.
24. A receptors. Neuron. 4:1990;759-765.
25. Purdy R.H., Morrow A.L., Moore P.H. Jr. et al. Stress-induced elevation of γ-aminobutyric acid type A receptor-active steroids in the rat brain. Proc. Natl. Acad. Sci. USA. 88:1991;4553-4557.
26. Shiu G.K., Nemoto E.M. Simple, rapid and sensitive reversed-phase high-performance liquid chromatographic method for thiopental and pentobarbital determination in plasma and brain tissue. J. Chromatogr. 227(1):1982;207-212.
27. Stark P., Fuller R.W., Wong D.T The pharmacologic profile of fluoxetine. J. Clin. Psychiatry. 46:1985;7-13.
28. Uzunov D.P., Copper T.B, Costa E. et al. Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography. Proc. Natl. Acad. Sci. USA. 93:1996;12599-12604.
29. Uzunova V., Sheline Y., Davis J.M. et al. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proc. Natl. Acad. Sci. USA. 95:1998;3239-3244.