Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice

Food Chemistry

Volumn 141, Issue 4, 2013, Pages 3627-3635

  Choi, Seoyoon ^a   Choi, Youngshim ^a   Choi, Yeji ^a   Kim, Sohee ^a   Jang, Jeehee ^a   Park, Taesun ^a  

^a Yonsei University   (South Korea)

Author keywords

Adiponectin AMPK signalling; Fatty acid oxidation; Fatty liver; Insulin signalling; Lipogenesis

Indexed keywords

ANTHROPOMETRY; BIOCHEMISTRY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENES; INSULIN; MAMMALS; OXIDATION;

ADIPONECTIN; FATTY ACID OXIDATION; FATTY LIVER; INSULIN SIGNALLING; LIPOGENESIS;

FATTY ACIDS;

ADIPOCYTE PROTEIN 2; ADIPONECTIN; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; CARNITINE PALMITOYLTRANSFERASE I; CD36 ANTIGEN; CELL PROTEIN; GLUCOSE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; LIPID; LIPOPROTEIN LIPASE; LIVER X RECEPTOR; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PIPERINE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; DOWN REGULATION; DRUG DOSE COMPARISON; FATTY ACID OXIDATION; FATTY LIVER; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; LIPID LIVER LEVEL; LIPOGENESIS; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

MUS;

ADIPOCYTE PROTEIN 2; ADIPONECTIN RECEPTOR-1; ADIPONECTIN RECEPTOR-2; ADIPONECTIN-AMPK SIGNALLING; ADIPOR1; ADIPOR2; AKT; ALANINE AMINOTRANSFERASE; ALT; AMP-ACTIVATED PROTEIN KINASE; AMPK; AP2; AREA UNDER THE CURVE; ASPARTATE AMINOSTRANSFERASE; AST; AUC; CARNITINE PALMITOYLTRANSFERASE 1; CD36; CD36 ANTIGEN; CPT1; FATTY ACID OXIDATION; FATTY LIVER; FFA; FREE FATTY ACID; G6PASE; GAPDH; GLUCOSE TRANSPORTER-2; GLUCOSE-6-PHOSPHATE DEHYDROGENASE; GLUT2; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; HFD; HIGH-FAT DIET; INSULIN RECEPTOR SUBSTRATE-1; INSULIN SIGNALLING; IRS1; LEPTIN; LIPOGENESIS; LIPOPROTEIN LIPASE; LIVER X RECEPTOR ALPHA; LXRΑ; PEPCK; PHOSPHOENOLPYRUVATE CARBOXYKINASE; PROTEIN KINASE B; REVERSE TRANSCRIPTION-POLYMERASE CHAIN REACTION; RT-PCR; S6 KINASE 1; S6K1; SREBP1C; STEROL REGULATORY ELEMENT BINDING PROTEIN-1C;

ADIPONECTIN; ALKALOIDS; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BENZODIOXOLES; DIET, HIGH-FAT; FATTY LIVER; HUMANS; INSULIN RESISTANCE; LIPOGENESIS; MALE; MICE; MICE, INBRED C57BL; PIPER NIGRUM; PIPERIDINES; PLANT EXTRACTS; POLYUNSATURATED ALKAMIDES; TRIGLYCERIDES;

EID: 84884540840     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2013.06.028     Document Type: Article

References (44)

1. Baratta, J. L., Ngo, A., Lopez, B., Kasabwalla, N., Longmuir, K. J., & Robertson, R. T. (2009). Cellular organization of normal mouse liver: A histological, quantitative immunocytochemical, and fine structural analysis. Histochemistry and Cell Biology, 131(6), 713-726
2. Beaton, M. D. (2012). Current treatment options for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Canadian Journal of Gastroenterology, 266), 353-357
3. Bhardwaj, R. K., Glaeser, H., Becquemont, L., Klotz, U., Gupta, S. K., & Fromm, M. F. (2002). Piperine, a major constituent of black pepper, inhibits human Pglycoprotein and CYP3A4. Journal of Pharmacology and Experimental Therapeutics, 302(2), 645-650 (Pubitemid 34787231)
4. Bugianesi, E., Gastaldelli, A., Vanni, E., Gambino, R., Cassader, M., Baldi, S., et al. (2005). Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: Sites and mechanisms. Diabetologia, 48(4), 634-642 (Pubitemid 40591217)
5. Bugianesi, E., Pagotto, U., Manini, R., Vanni, E., Gastaldelli, A., de Iasio, R., et al. (2005). Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity. Journal of Clinical Endocrinology and Metabolism, 90(6), 3498-3504 (Pubitemid 41014319)
6. Casado, A., Rodriguez, V. M., Portillo, M. P., Macarulla, M. T., Abecia, L. C., Echevarria, E., et al. (2003). Sibutramine decreases body weight gain and increases energy expenditure in obese Zucker rats without changes in NPY and orexins. Nutritional Neuroscience, 6(2), 103-111
7. DeAngelis, R. A., Markiewski, M. M., Taub, R., & Lambris, J. D. (2005). A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NFkappaB inhibitor, IkappaBalpha. Hepatology, 42(5), 1148-1157 (Pubitemid 43112682)
8. Derosa, G., Maffioli, P., Ferrari, I., Palumbo, I., Randazzo, S., D?Angelo, A., et al. (2010). Effects of one year treatment of sibutramine on insulin resistance parameters in type 2 diabetic patients. Journal of Pharmacy & Pharmaceutical Sciences, 13(3), 378-390
9. Folch, J., Lees, M., & Sloane Stanley, G. H. (1957). A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry, 226(1), 497-509
10. Fruhbeck, G., Gomez-Ambrosi, J., Muruzabal, F. J., & Burrell, M. A. (2001). The adipocyte: A model for integration of endocrine and metabolic signaling in energy metabolism regulation. American Journal of Physiology, Endocrinology and Metabolism, 280(6), E827-E847 (Pubitemid 32553225)
11. Haigis, M. C., & Sinclair, D. A. (2010). Mammalian sirtuins: Biological insights and disease relevance. Annual Review of Pathology: Mechanisms of Disease, 5, 253-295
12. Hsu, C. L., & Yen, G. C. (2007). Effect of gallic acid on high fat diet-induced dyslipidaemia, hepatosteatosis and oxidative stress in rats. British Journal of Nutrition, 98(4), 727-735
13. Hui, J. M., Hodge, A., Farrell, G. C., Kench, J. G., Kriketos, A., & George, J. (2004). Beyond insulin resistance in NASH: TNF-alpha or adiponectin? Hepatology, 40(1), 46-54 (Pubitemid 38868922)
14. Jwa, H., Choi, Y., Park, U. H., Um, S. J., Yoon, S. K., & Park, T. (2012). Piperine, an LXRalpha antagonist, protects against hepatic steatosis and improves insulin signaling in mice fed a high-fat diet. Biochemical Pharmacology, 84(11), 1501-1510
15. Kawano, A., Nakamura, H., Hata, S., Minakawa, M., Miura, Y., & Yagasaki, K. (2009). Hypoglycemic effect of aspalathin, a rooibos tea component from Aspalathus linearis, in type 2 diabetic model db/db mice. Phytomedicine, 16(5), 437-443
16. Klaus S., Pultz, S., Thone-Reineke, C., & Wolfram, S. (2005). Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation. International Journal of Obesity (London), 29(6), 615-623 (Pubitemid 40769483)
17. Lafontan, M., & Viguerie, N. (2006). Role of adipokines in the control of energy metabolism: Focus on adiponectin. Current Opinion in Pharmacology, 6(6), 580-585 (Pubitemid 44660944)
18. Lam, B., & Younossi, Z. M. (2010). Treatment options for nonalcoholic fatty liver disease. Therapeutic Advances in Gastroenterology, 3(2), 121-137
19. McMahon, F. G., Fujioka, K., Singh, B. N., Mendel, C. M., Rowe, E., Rolston, K., Johnson, F., & Mooradian, A. D. (2000). Efficacy and safety of sibutramine in obese white and African American patients with hypertension: A 1-year, double-blind, placebo-controlled, multicenter trial. Archives of Internal Medicine, 160(14), 2185-2191 (Pubitemid 30482726)
20. Mittal, R., & Gupta, R. L. (2000). In vitro antioxidant activity of piperine. Methods and Findings in Experimental and Clinical Pharmacology, 22(5), 271-274 (Pubitemid 30664411)
21. Musso, G., Gambino, R., Biroli, G., Carello, M., Faga, E., Pacini, G., et al. (2005). Hypoadiponectinemia predicts the severity of hepatic fibrosis and pancreatic Beta-cell dysfunction in nondiabetic nonobese patients with nonalcoholic steatohepatitis. American Journal of Gastroenterology, 100(11), 2438-2446
22. Musso, G., Gambino, R., Durazzo, M., Biroli, G., Carello, M., Faga, E., et al. (2005). Adipokines in NASH: Postprandial lipid metabolism as a link between adiponectin and liver disease. Hepatology, 42(5), 1175-1183 (Pubitemid 43112685)
23. Okumura, Y., Narukawa, M., & Watanabe, T. (2010). Adiposity suppression effect in mice due to black pepper and its main pungent component, piperine. Bioscience, Biotechnology, and Biochemistry, 74(8), 1545-1549
24. Pessin, J. E., & Saltiel, A. R. (2000). Signaling pathways in insulin action: Molecular targets of insulin resistance. Journal of Clinical Investigation, 106(2), 165-169 (Pubitemid 30483117)
25. Pittas, A. G., Joseph, N. A., & Greenberg, A. S. (2004). Adipocytokines and insulin resistance. Journal of Clinical Endocrinology and Metabolism, 89(2), 447-452 (Pubitemid 38269842)
26. Postic, C., & Girard, J. (2008). The role of the lipogenic pathway in the development of hepatic steatosis. Diabetes & Metabolism, 34(6 Pt 2), 643-648
27. Rafiq, N., & Younossi, Z. M. (2008). Effects of weight loss on nonalcoholic fatty liver disease. Seminars in Liver Disease, 28(4), 427-433
28. Reagan-Shaw, S., Nihal, M., & Ahmad, N. (2008). Dose translation from animal to human studies revisited. The FASEB Journal, 22(3), 659-661 (Pubitemid 351348146)
29. Reddy, J. K., & Rao, M. S. (2006). Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. American Journal of Physiology. Gastrointestinal and Liver Physiology, 290(5), G852-G858
30. Sabuncu, T., Nazligul, Y., Karaoglanoglu M., Ucar, E., & Kilic, F. B. (2003). The effects of sibutramine and orlistat on the ultrasonographic findings, insulin resistance and liver enzyme levels in obese patients with non-alcoholic steatohepatitis. Romanian Journal of Gastroenterology, 12(3), 189-192 (Pubitemid 37152602)
31. Samuel, V. T., Liu, Z. X., Qu, X., Elder, B. D., Bilz, S., Befroy, D., et al. (2004). Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. Journal of Biological Chemistry, 279(31), 32345-32353 (Pubitemid 39014687)
32. Selvendiran, K., Banu, S. M., & Sakthisekaran, D. (2004). Protective effect of piperine on benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice. Clinica Chimica Acta, 350(1-2), 73-78 (Pubitemid 39458248)
33. Selvendiran, K., Singh, J. P., Krishnan, K. B., & Sakthisekaran, D. (2003). Cytoprotective effect of piperine against benzo[a]pyrene induced lung cancer with reference to lipid peroxidation and antioxidant system in Swiss albino mice. Fitoterapia, 74(1-2), 109-115 (Pubitemid 36287253)
34. Shah, S. S., Shah, G. B., Singh, S. D., Gohil, P. V., Chauhan, K., Shah, K. A., et al. (2011). Effect of piperine in the regulation of obesity-induced dyslipidemia in high-fat diet rats. Indian Journal of Pharmacology, 43(3), 296-299
35. Shulman, G. I. (2000). Cellular mechanisms of insulin resistance. Journal of Clinical Investigation, 106(2), 171-176 (Pubitemid 30483118)
36. Sukhodub, A., Jovanovic, S., Du, Q., Budas, G., Clelland, A. K., Shen, M., et al. (2007). AMP-activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP-sensitive K(+) channels. Journal of Cellular Physiology, 210(1), 224-236 (Pubitemid 44904718)
37. Suliburska, J., Bogdanski, P., Szulinska, M., & Pupek-Musialik, D. (2012). Short-term effects of sibutramine on mineral status and selected biochemical parameters in obese women. Biological Trace Element Research, 149(2), 163-170
38. Targher, G., Bertolini, L., Rodella, S., Zoppini, G., Scala, L., Zenari, L., et al. (2006). Associations between plasma adiponectin concentrations and liver histology in patients with nonalcoholic fatty liver disease. Clinical Endocrinology (Oxford), 64(6), 679-683 (Pubitemid 43775007)
39. Taylor, G. R., Kropp, K. D., & Molina, T. C. (1978). Microflora analysis of a child with severe combined immune deficiency. Infection and Immunity, 19(2), 385-390 (Pubitemid 8291049)
40. Wang, C., Mao, X., Wang, L., Liu, M., Wetzel, M. D., Guan, K. L., et al. (2007). Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1. Journal of Biological Chemistry, 282(11), 7991-7996 (Pubitemid 47093602)
41. Wattanathorn, J., Chonpathompikunlert, P., Muchimapura, S., Priprem, A., & Tankamnerdthai, O. (2008). Piperine, the potential functional food for mood and cognitive disorders. Food and Chemical Toxicology, 46(9), 3106-3110
42. Weeke, P., Andersson, C., Fosbol, E. L., Brendorp, B., Kober, L., Sharma, A. M., et al. (2010). The weight lowering effect of sibutramine and its impact on serum lipids in cardiovascular high risk patients with and without type 2 diabetes mellitus-An analysis from the SCOUT lead-in period. BMC Endocrine Disorders, 10(3), 1-9
43. Whitehead, J. P., Richards, A A., Hickman, I. J., Macdonald, G. A., & Prins, J. B. (2006). Adiponectin-A key adipokine in the metabolic syndrome. Diabetes, Obesity & Metabolism, 8(3), 264-280.
44. Yu X. X.,Murray S. F.,Pandey S. K.,Booten, S. L.,Bao, D.,Song, X. Z. et al. 2005 Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice.Hepatology 42(2) 362-371 (Pubitemid 41061089)