Biomedical applications of nanofiber scaffolds in tissue engineering

Journal of Biomaterials and Tissue Engineering

Volumn 4, Issue 8, 2014, Pages 600-623

  Hussain, Taqadus ^a   Garg, Tarun ^a   Goyal, Amit K ^a   Rath, Goutam ^a  

^a ISF COLLEGE OF PHARMACY   (India)

Author keywords

Cell delivery; Nanofiber; Regenerative medicine; Tissue engineering

Indexed keywords

BIOLOGICAL FACTOR; CHITIN; CHITOSAN; COLLAGEN; ELASTIN; GELATIN; HYALURONIC ACID; MOLECULAR SCAFFOLD; NANOFIBER; NYLON;

BONE TISSUE; CARDIOVASCULAR PROSTHESIS AND IMPLANT; CARTILAGE; CELL INFILTRATION; CHEMICAL ANALYSIS; DEGRADATION; ELECTROSPINNING; INVENTION; LIGAMENT; MEDICAL TECHNOLOGY; MICROSCOPY; NEUROPROSTHESIS; PHASE SEPARATION; PROSTHESIS MATERIAL; REVIEW; SELF ASSEMBLY; SPECTROSCOPY; SYNTHESIS; TENDON; TISSUE ENGINEERING;

EID: 84921655144     PISSN: 21579083     EISSN: 21579091     Source Type: Journal    
DOI: 10.1166/jbt.2014.1214     Document Type: Review

References (230)

1. S. F. Badylak, D. Taylor, and K. Uygun, Whole-organ tissue engineering: Decellularization and recellularization of threedimensional matrix scaffolds. Annu. Rev. Biomed. Eng. 13, 27 (2011).
2. R. Langer and J. P. Vacanti, Tissue engineering. Science 260, 920 (1993).
3. Y. Ikada, Challenges in tissue engineering. J. R. Soc. Interface 3, 589 (2006).
4. T. Garg, O. Singh, S. Arora, and R. Murthy, Scaffold: A novel carrier for cell and drug delivery. Crit. Rev. Ther. Drug Carrier Syst. 29, 1 (2012).
5. T. Garg, S. Singh, and A. K. Goyal, Stimuli-sensitive hydrogels: An excellent carrier for drug and cell delivery. Crit. Rev. Ther. Drug Carrier Syst. 30, 369 (2013).
6. T. Dvir, B. P. Timko, D. S. Kohane, and R. Langer, Nanotechnological strategies for engineering complex tissues. Nat. Nanotechnol. 6, 13 (2011).
7. C. P. Barnes, S. A. Sell, E. D. Boland, D. G. Simpson, and G. L. Bowlin, Nanofiber technology: Designing the next generation of tissue engineering scaffolds. Adv. Drug Deliv. Rev. 59, 1413 (2007).
8. W. J. Li and R. S. Tuan, Fabrication and application of nanofibrous scaffolds in tissue engineering. Current Protocols in Cell Biology 25.2, 1 (2009).
9. S. G. Kumbar, L. S. Nair, S. Bhattacharyya, and C. T. Laurencin, Polymeric nanofibers as novel carriers for the delivery of therapeutic molecules. J. Nanosci. Nanotechnol. 6, 9 (2006).
10. J. A. Matthews, G. E. Wnek, D. G. Simpson, and G. L. Bowlin, Electrospinning of collagen nanofibers. Biomacromolecules 3, 232 (2002).
11. P. X. Ma and R. Zhang, Synthetic nano-scale fibrous extracellular matrix. J. Biomed. Mater. Res. 46, 60 (1999).
12. S. Zhang, Fabrication of novel biomaterials through molecular selfassembly. Nat. Biotechnol. 21, 1171 (2003).
13. I. K. Kwon, S. Kidoaki, and T. Matsuda, Electrospun nano- to microfiber fabrics made of biodegradable copolyesters: Structural characteristics, mechanical properties and cell adhesion potential. Biomaterials 26, 3929 (2005).
14. Q. P. Pham, U. Sharma, and A. G. Mikos, Electrospinning of polymeric nanofibers for tissue engineering applications: A review. Tissue Eng. 12, 1197 (2006).
15. H. S. Yoo, T. G. Kim, and T. G. Park, Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery. Adv. Drug Deliv. Rev. 61, 1033 (2009).
16. K. M. Woo, J.-H. Jun, V. J. Chen, J. Seo, J.-H. Baek, H.-M. Ryoo, G.-S. Kim, M. J. Somerman, and P. X. Ma, Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization. Biomaterials 28, 335 (2007).
17. S. Y. Chew, T. C. Hufnagel, C. T. Lim, and K. W. Leong, Mechanical properties of single electrospun drug-encapsulated nanofibres. Nanotechnology 17, 3880 (2006).
18. L. Yang, C. F. Fitie, K. O. van der Werf, M. L. Bennink, P. J. Dijkstra, and J. Feijen, Mechanical properties of single electrospun collagen type I fibers. Biomaterials 29, 955 (2008).
19. E. Tan and C. Lim, Physical properties of a single polymeric nanofiber. Appl. Phys. Lett. 84, 1603 (2004).
20. E. Tan and C. Lim, Nanoindentation study of nanofibers. Appl. Phys. Lett. 87, 123106 (2005).
21. E. Tan, S. Ng, and C. Lim, Tensile testing of a single ultrafine polymeric fiber. Biomaterials 26, 1453 (2005).
22. E. P. Tan and C. Lim, Effects of annealing on the structural and mechanical properties of electrospun polymeric nanofibres. Nanotechnology 17, 2649 (2006).
23. C. Lim, E. Tan, and S. Ng, Effects of crystalline morphology on the tensile properties of electrospun polymer nanofibers. Appl. Phys. Lett. 92, 141908 (2008).
24. S. Y. Chew, T. C. Hufnagel, C. T. Lim, and K. W. Leong, Mechanical properties of single electrospun drug-encapsulated nanofibres. Nanotechnology 17, 3880 (2006).
25. E. Schnell, K. Klinkhammer, S. Balzer, G. Brook, D. Klee, P. Dalton, and J. Mey, Guidance of glial cell migration and axonal growth on electrospun nanofibers of poly-epsilon-caprolactone and a collagen/poly-epsilon-caprolactone blend. Biomaterials 28, 3012 (2007).
26. X. Xin, M. Hussain, and J. J. Mao, Continuing differentiation of human mesenchymal stem cells and induced chondrogenic and osteogenic lineages in electrospun PLGA nanofiber scaffold. Biomaterials 28, 316 (2007).
27. A. K. Goyal, G. Rath, and T. Garg, Nanotechnological Approaches for Genetic Immunization. DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases 67 (2013).
28. T. Bini, S. Gao, S. Wang, A. Lim, L. B. Hai, and S. Ramakrishna, Electrospun poly (L-lactide-co-glycolide) biodegradable polymer nanofibre tubes for peripheral nerve regeneration. Nanotechnology 15, 1459 (2004).
29. F. Yang, R. Murugan, S. Wang, and S. Ramakrishna, Electrospinning of nano/micro scale poly (L-lactic acid) aligned fibers and their potential in neural tissue engineering. Biomaterials 26, 2603 (2005).
30. C. H. Lee, H. J. Shin, I. H. Cho, Y. M. Kang, I. A. Kim, K. D. Park, and J. W. Shin, Nanofiber alignment and direction of mechanical strain affect the ECM production of human ACL fibroblast. Biomaterials 26, 1261 (2005).
31. J. S. Choi, K. W. Leong, and H. S. Yoo, In vivo wound healing of diabetic ulcers using electrospun nanofibers immobilized with human epidermal growth factor (EGF). Biomaterials 29, 587 (2008).
32. C. Xu, R. Inai, M. Kotaki, and S. Ramakrishna, Aligned biodegradable nanofibrous structure: A potential scaffold for blood vessel engineering. Biomaterials 25, 877 (2004).
33. C. Xu, R. Inai, M. Kotaki, and S. Ramakrishna, Electrospun nanofiber fabrication as synthetic extracellular matrix and its potential for vascular tissue engineering. Tissue Eng. 10, 1160 (2004).
34. E. J. Bergsma, F. R. Rozema, R. R. Bos, and W. C. de Bruijn, Foreign body reactions to resorbable poly(L-lactide) bone plates and screws used for the fixation of unstable zygomatic fractures. J. Oral Maxillofac Surg. 51, 666 (1993).
35. S. Agarwal, J. H. Wendorff, and A. Greiner, Progress in the field of electrospinning for tissue engineering applications. Adv. Mater. 21, 3343 (2009).
36. G. Goyal, T. Garg, B. Malik, G. Chauhan, G. Rath, and A. K. Goyal, Development and characterization of niosomal gel for topical delivery of benzoyl peroxide. Drug Deliv. (2013), in press.
37. C. P. Barnes, C. W. Pemble, D. D. Brand, D. G. Simpson, and G. L. Bowlin, Cross-linking electrospun type II collagen tissue engineering scaffolds with carbodiimide in ethanol. Tissue Eng. 13, 1593 (2007).
38. K. J. Shields, M. J. Beckman, G. L. Bowlin, and J. S. Wayne, Mechanical properties and cellular proliferation of electrospun collagen type II. Tissue Eng. 10, 1510 (2004).
39. J. S. Choi, S. J. Lee, G. J. Christ, A. Atala, and J. J. Yoo, The influence of electrospun aligned poly(epsilon-caprolactone)/collagen nanofiber meshes on the formation of self-aligned skeletal muscle myotubes. Biomaterials 29, 2899 (2008).
40. H. M. Powell and S. T. Boyce, Engineered human skin fabricated using electrospun collagen-PCL blends: Morphogenesis and mechanical properties. Tissue Eng. Part A 15, 2177 (2009).
41. N. Bhattarai, Z. Li, D. Edmondson, and M. Zhang, Alginate-based nanofibrous scaffolds: Structural, mechanical, and biological properties. Adv. Mater. 18, 1463 (2006).
42. H. K. Noh, S. W. Lee, J.-M. Kim, J.-E. Oh, K.-H. Kim, C.-P. Chung, S.-C. Choi, W. H. Park, and B.-M. Min, Electrospinning of chitin nanofibers: Degradation behavior and cellular response to normal human keratinocytes and fibroblasts. Biomaterials 27, 3934 (2006).
43. N. Bhattarai, D. Edmondson, O. Veiseh, F. A. Matsen, and M. Zhang, Electrospun chitosan-based nanofibers and their cellular compatibility. Biomaterials 26, 6176 (2005).
44. A. Martins, S. Chung, A. J. Pedro, R. A. Sousa, A. P. Marques, R. L. Reis, and N. M. Neves, Hierarchical starch-based fibrous scaffold for bone tissue engineering applications. Journal of Tissue Engineering and Regenerative Medicine 3, 37 (2009).
45. H. Jiang, D. Fang, B. S. Hsiao, B. Chu, and W. Chen, Optimization and characterization of dextran membranes prepared by electrospinning. Biomacromolecules 5, 326 (2004).
46. I. K. Kwon and T. Matsuda, Co-electrospun nanofiber fabrics of poly (L-lactide-co-_-caprolactone) with type I collagen or heparin. Biomacromolecules 6, 2096 (2005).
47. C. Li, C. Vepari, H.-J. Jin, H. J. Kim, and D. L. Kaplan, Electrospun silk-BMP-2 scaffolds for bone tissue engineering. Biomaterials 27, 3115 (2006).
48. L. Buttafoco, N. Kolkman, P. Engbers-Buijtenhuijs, A. Poot, P. Dijkstra, I. Vermes, and J. Feijen, Electrospinning of collagen and elastin for tissue engineering applications. Biomaterials 27, 724 (2006).
49. L. Q. Liu, D. Tasis, M. Prato, and H. D. Wagner, Tensile mechanics of electrospun multiwalled nanotube/poly(methyl methacrylate) nanofibers. Adv. Mater. 19, 1228 (2007).
50. S. Kew, J. Gwynne, D. Enea, M. Abu-Rub, A. Pandit, D. Zeugolis, R. Brooks, N. Rushton, S. Best, and R. Cameron, Regeneration and repair of tendon and ligament tissue using collagen fibre biomaterials. Acta Biomaterialia 7, 3237 (2011).
51. C. Huang, R. Chen, Q. Ke, Y. Morsi, K. Zhang, and X. Mo, Electrospun collagen-chitosan-TPU nanofibrous scaffolds for tissue engineered tubular grafts. Colloids Surf. B Biointerfaces 82, 307 (2011).
52. P. H. Warnke, M. Alamein, S. Skabo, S. Stephens, R. Bourke, P. Heiner, and Q. Liu, Primordium of an artificial Bruch’s membrane made of nanofibers for engineering of retinal pigment epithelium cell monolayers. Acta Biomater. 9, 9414 (2013).
53. S. Zhang, L. Chen, Y. Jiang, Y. Cai, G. Xu, T. Tong, W. Zhang, L. Wang, J. Ji, and P. Shi, Bi-layer collagen/microporous electrospun nanofiber scaffold improves the osteochondral regeneration. Acta Biomaterialia 9, 7236 (2013).
54. R. Chen, L. Qiu, Q. Ke, C. He, and X. Mo, Electrospinning thermoplastic polyurethane-contained collagen nanofibers for tissueengineering applications. J. Biomater. Sci. Polym. Ed. 20, 1513 (2009).
55. Y. Su, Q. Su, W. Liu, M. Lim, J. R. Venugopal, X. Mo, S. Ramakrishna, S. S. Al-Deyab, and M. El-Newehy, Controlled release of bone morphogenetic protein 2 and dexamethasone loaded in core-shell PLLACL-collagen fibers for use in bone tissue engineering. Acta Biomater. 8, 763 (2012).
56. X. Zhang, Q. Cai, H. Liu, S. Zhang, Y. Wei, X. Yang, Y. Lin, Z. Yang, and X. Deng, Calcium ion release and osteoblastic behaviour of gelatin/beta-tricalcium phosphate composite nanofibers fabricated by electrospinning. Mater. Lett. 73, 172 (2012).
57. S.-H. Jegal, J.-H. Park, J.-H. Kim, T.-H. Kim, U. S. Shin, T.-I. Kim, and H.-W. Kim, Functional composite nanofibers of poly (lactideco-caprolactone) containing gelatin–apatite bone mimetic precipitate for bone regeneration. Acta Biomaterialia 7, 1609 (2011).
58. M. Li, Y. Guo, Y. Wei, A. G. MacDiarmid, and P. I. Lelkes, Electrospinning polyaniline-contained gelatin nanofibers for tissue engineering applications. Biomaterials 27, 2705 (2006).
59. S. Kocabey, H. Ceylan, A. B. Tekinay, and M. O. Guler, Glycosaminoglycan mimetic peptide nanofibers promote mineralization by osteogenic cells. Acta Biomater. 9, 9075 (2013).
60. Z. Ma, W. He, T. Yong, and S. Ramakrishna, Grafting of gelatine on electrospun poly(caprolactone) nanofibers to improve endothelial cell spreading and proliferation and to control cell Orientation. Tissue Eng. 11, 1149 (2005).
61. Z. Meng, Y. Wang, C. Ma, W. Zheng, L. Li, and Y. Zheng, Electrospinning of PLGA/gelatin randomly-oriented and aligned nanofibers as potential scaffold in tissue engineering. Mater. Sci. Eng., C 30, 1204 (2010).
62. Y. Ji, K. Ghosh, X. Z. Shu, B. Li, J. C. Sokolov, G. D. Prestwich, R. A. Clark, and M. H. Rafailovich, Electrospun threedimensional hyaluronic acid nanofibrous scaffolds. Biomaterials 27, 3782 (2006).
63. H. K. Noh, S. W. Lee, J. M. Kim, J. E. Oh, K. H. Kim, C. P. Chung, S. C. Choi, W. H. Park, and B. M. Min, Electrospinning of chitin nanofibers: Degradation behavior and cellular response to normal human keratinocytes and fibroblasts. Biomaterials 27, 3934 (2006).
64. G. Toskas, C. Cherif, R.-D. Hund, E. Laourine, B. Mahltig, A. Fahmi, C. Heinemann, and T. Hanke, Chitosan (PEO)/silica hybrid nanofibers as a potential biomaterial for bone regeneration. Carbohydr. Polym. 94, 713 (2013).
65. Y. Zhang, J. R. Venugopal, A. El-Turki, S. Ramakrishna, B. Su, and C. T. Lim, Electrospun biomimetic nanocomposite nanofibers of hydroxyapatite/chitosan for bone tissue engineering. Biomaterials 29, 4314 (2008).
66. K. Tuzlakoglu, N. Bolgen, A. J. Salgado, M. E. Gomes, E. Piskin, and R. L. Reis, Nano- and micro-fiber combined scaffolds: A new architecture for bone tissue engineering. J. Mater. Sci. Mater. Med. 16, 1099 (2005).
67. W.-J. Li, R. L. Mauck, J. A. Cooper, X. Yuan, and R. S. Tuan, Engineering controllable anisotropy in electrospun biodegradable nanofibrous scaffolds for musculoskeletal tissue engineering. J. Biomech. 40, 1686 (2007).
68. M. Zhang, Z. Wang, S. Feng, H. Xu, Q. Zhao, S. Wang, J. Fang, M. Qiao, and D. Kong, Immobilization of anti-CD31 antibody on electrospun poly(varepsilon-caprolactone) scaffolds through hydrophobins for specific adhesion of endothelial cells. Colloids Surf B Biointerfaces 85, 32 (2011).
69. S. Y. Chew, R. Mi, A. Hoke, and K. W. Leong, The effect of the alignment of electrospun fibrous scaffolds on Schwann cell maturation. Biomaterials 29, 653 (2008).
70. J. Xie, M. R. Macewan, W. Z. Ray, W. Liu, D. Y. Siewe, and Y. Xia, Radially aligned, electrospun nanofibers as dural substitutes for wound closure and tissue regeneration applications. ACS Nano 4, 5027 (2010).
71. G. Jin, M. P. Prabhakaran, D. Kai, and S. Ramakrishna, Controlled release of multiple epidermal induction factors through core-shell nanofibers for skin regeneration. Eur. J. Pharm. Biopharm. 85, 689 (2013).
72. J. Y. Lee, C. A. Bashur, A. S. Goldstein, and C. E. Schmidt, Polypyrrole-coated electrospun PLGA nanofibers for neural tissue applications. Biomaterials 30, 4325 (2009).
73. S. Sahoo, H. Ouyang, J. C.-H. Goh, T. Tay, and S. Toh, Characterization of a novel polymeric scaffold for potential application in tendon/ligament tissue engineering. Tissue Eng. 12, 91 (2006).
74. K. L. Moffat, A. S. Kwei, J. P. Spalazzi, S. B. Doty, W. N. Levine, and H. H. Lu, Novel nanofiber-based scaffold for rotator cuff repair and augmentation. Tissue Eng. Part A 15, 115 (2009).
75. X. Li, J. Xie, J. Lipner, X. Yuan, S. Thomopoulos, and Y. Xia, Nanofiber scaffolds with gradations in mineral content for mimicking the tendon-to-bone insertion site. Nano Lett. 9, 2763 (2009).
76. L. Ghasemi-Mobarakeh, M. P. Prabhakaran, M. Morshed, M. H. Nasr-Esfahani, and S. Ramakrishna, Electrical stimulation of nerve cells using conductive nanofibrous scaffolds for nerve tissue engineering. Tissue Eng. Part A 15, 3605 (2009).
77. M. C. Chen, Y. C. Sun, and Y. H. Chen, Electrically conductive nanofibers with highly oriented structures and their potential application in skeletal muscle tissue engineering. Acta Biomater. 9, 5562 (2013).
78. J. Pelipenko, P. Kocbek, B. Govedarica, R. Rošic, S. Baumgartner, and J. Kristl, The topography of electrospun nanofibers and its impact on the growth and mobility of keratinocytes. European Journal of Pharmaceutics and Biopharmaceutics 84, 401 (2013).
79. L. Jeong, I.-S. Yeo, H. N. Kim, Y. I. Yoon, D. H. Jang, S. Y. Jung, B.-M. Min, and W. H. Park, Plasma-treated silk fibroin nanofibers for skin regeneration. Int. J. Biol. Macromol. 44, 222 (2009).
80. J.-H. Lee and Y.-J. Kim, Hydroxyapatite nanofibers fabricated through electrospinning and sol–gel process. Ceram. Int. 40, 3361 (2014).
81. V. J. Mukhatyar, M. Salmerón-Sánchez, S. Rudra, S. Mukhopadaya, T. H. Barker, A. J. García, and R. V. Bellamkonda, Role of fibronectin in topographical guidance of neurite extension on electrospun fibers. Biomaterials 32, 3958 (2011).
82. H. J. Lam, S. Patel, A. Wang, J. Chu, and S. Li, In vitro regulation of neural differentiation and axon growth by growth factors and bioactive nanofibers. Tissue Engineering Part A 16, 2641 (2010).
83. Y. Orlova, N. Magome, L. Liu, Y. Chen, and K. Agladze, Electrospun nanofibers as a tool for architecture control in engineered cardiac tissue. Biomaterials 32, 5615 (2011).
84. G. Uzunalli, Z. Soran, T. Erkal, Y. Dagdas, E. Dinc, A. Hondur, K. Bilgihan, B. Aydin, M. Guler, and A. Tekinay, Bioactive selfassembled peptide nanofibers for corneal stroma regeneration. Acta Biomaterialia 10, 1156 (2013).
85. N. Nagiah, L. Madhavi, R. Anitha, C. Anandan, N. T. Srinivasan, and U. T. Sivagnanam, Development and characterization of coaxially electrospun gelatin coated poly (3-hydroxybutyric acid) thin films as potential scaffolds for skin regeneration. Mater. Sci. Eng. C Mater. Biol. Appl. 33, 4444 (2013).
86. G. T. Christopherson, H. Song, and H. Q. Mao, The influence of fiber diameter of electrospun substrates on neural stem cell differentiation and proliferation. Biomaterials 30, 556 (2009).
87. H. R. Pant, P. Risal, C. H. Park, L. D. Tijing, Y. J. Jeong, and C. S. Kim, Core–shell structured electrospun biomimetic composite nanofibers of calcium lactate/nylon-6 for tissue engineering. Chem. Eng. J. 221, 90 (2013).
88. W.-J. Li, Y. J. Jiang, and R. S. Tuan, Chondrocyte phenotype in engineered fibrous matrix is regulated by fiber size. Tissue Eng. 12, 1775 (2006).
89. D. Shan, Y. Shi, S. Duan, Y. Wei, Q. Cai, and X. Yang, Electrospun magnetic poly (l-lactide)(PLLA) nanofibers by incorporating PLLA-stabilized Fe3 O 4 nanoparticles. Mater. Sci. Eng., C 33, 3498 (2013).
90. M. P. Prabhakaran, L. Ghasemi-Mobarakeh, G. Jin, and S. Ramakrishna, Electrospun conducting polymer nanofibers and electrical stimulation of nerve stem cells. J. Biosci. Bioeng. 112, 501 (2011).
91. N. Bhardwaj and S. C. Kundu, Electrospinning: A fascinating fiber fabrication technique. Biotechnol. Adv. 28, 325 (2010).
92. V. Vamvakaki, K. Tsagaraki, and N. Chaniotakis, Carbon nanofiberbased glucose biosensor. Anal. Chem. 78, 5538 (2006).
93. A. Stafiniak, B. Boratyñski, A. Baranowska-Korczyc, A. Szyszka, M. Ramiczek-Krasowska, J. Prazmowska, K. Fronc, D. Elbaum, R. Paszkiewicz, and M. Tłaczała, A novel electrospun ZnO nanofibers biosensor fabrication. Sensors and Actuators B: Chemical 160, 1413 (2011).
94. K. Sawicka, P. Gouma, and S. Simon, Electrospun biocomposite nanofibers for urea biosensing. Sensors and Actuators B: Chemical 108, 585 (2005).
95. C. P. Barnes, S. A. Sell, E. D. Boland, D. G. Simpson, and G. L. Bowlin, Nanofiber technology: Designing the next generation of tissue engineering scaffolds. Adv. Drug Deliv. Rev. 59, 1413 (2007).
96. W. J. Li, C. T. Laurencin, E. J. Caterson, R. S. Tuan, and F. K. Ko, Electrospun nanofibrous structure: A novel scaffold for tissue engineering. Journal of Biomedical Materials Research 60, 613 (2002).
97. R. Gopal, S. Kaur, Z. Ma, C. Chan, S. Ramakrishna, and T. Matsuura, Electrospun nanofibrous filtration membrane. J. Membr. Sci. 281, 581 (2006).
98. X. H. Qin and S. Y. Wang, Filtration properties of electrospinning nanofibers. J. Appl. Polym. Sci. 102, 1285 (2006).
99. F. Dotti, A. Varesano, A. Montarsolo, A. Aluigi, C. Tonin, and G. Mazzuchetti, Electrospun porous mats for high efficiency filtration. Journal of Industrial Textiles 37, 151 (2007).
100. E.-R. Kenawy, F. I. Abdel-Hay, M. H. El-Newehy, and G. E. Wnek, Processing of polymer nanofibers through electrospinning as drug delivery systems. Mater. Chem. Phys. 113, 296 (2009).
101. J. Zeng, X. Xu, X. Chen, Q. Liang, X. Bian, L. Yang, and X. Jing, Biodegradable electrospun fibers for drug delivery. J. Controlled Release 92, 227 (2003).
102. J.-P. Chen, G.-Y. Chang, and J.-K. Chen, Electrospun collagen/chitosan nanofibrous membrane as wound dressing. Colloids and Surfaces A: Physicochemical and Engineering Aspects 313, 183 (2008).
103. R. Jayakumar, M. Prabaharan, P. Sudheesh Kumar, S. Nair, and H. Tamura, Biomaterials based on chitin and chitosan in wound dressing applications. Biotechnol. Adv. 29, 322 (2011).
104. Z. Ma, M. Kotaki, and S. Ramakrishna, Electrospun cellulose nanofiber as affinity membrane. J. Membr. Sci. 265, 115 (2005).
105. Z. Ma and S. Ramakrishna, Electrospun regenerated cellulose nanofiber affinity membrane functionalized with protein A/G for IgG purification. J. Membr. Sci. 319, 23 (2008).
106. S. Lee and S. K. Obendorf, Use of electrospun nanofiber web for protective textile materials as barriers to liquid penetration. Textile Research Journal 77, 696 (2007).
107. M. Gorji, A. Jeddi, and A. Gharehaghaji, Fabrication and characterization of polyurethane electrospun nanofiber membranes for protective clothing applications. J. Appl. Polym. Sci. 125, 4135 (2012).
108. Z.-G. Wang, L.-S. Wan, Z.-M. Liu, X.-J. Huang, and Z.-K. Xu, Enzyme immobilization on electrospun polymer nanofibers: An overview. J. Mol. Catal. B: Enzym. 56, 189 (2009).
109. X. J. Huang, Z. K. Xu, L. S. Wan, C. Innocent, and P. Seta, Electrospun nanofibers modified with phospholipid moieties for enzyme immobilization. Macromol. Rapid Commun. 27, 1341 (2006).
110. I. G. Loscertales, A. Barrero, M. Marquez, R. Spretz, R. Velarde-Ortiz, and G. Larsen, Electrically forced coaxial nanojets for onestep hollow nanofiber design. J. Am. Chem. Soc. 126, 5376 (2004).
111. J. Liao, X. Guo, D. Nelson, F. Kurtis Kasper, and A. G. Mikos, Modulation of osteogenic properties of biodegradable polymer/extracellular matrix scaffolds generated with a flow perfusion bioreactor. Acta Biomaterialia 6, 2386 (2010).
112. Z. Yin, X. Chen, J. L. Chen, W. L. Shen, T. M. Hieu Nguyen, L. Gao, and H. W. Ouyang, The regulation of tendon stem cell differentiation by the alignment of nanofibers. Biomaterials 31, 2163 (2010).
113. A. Saraf, G. Lozier, A. Haesslein, F. K. Kasper, R. M. Raphael, L. S. Baggett, and A. G. Mikos, Fabrication of nonwoven coaxial fiber meshes by electrospinning. Tissue Engineering Part C: Methods 15, 333 (2009).
114. Y. Z. Zhang, X. Wang, Y. Feng, J. Li, C. T. Lim, and S. Ramakrishna, Coaxial electrospinning of (fluorescein isothiocyanate-conjugated bovine serum albumin)-encapsulated poly(epsilon-caprolactone) nanofibers for sustained release. Biomacromolecules 7, 1049 (2006).
115. R. Ravichandran, J. R. Venugopal, S. Sundarrajan, S. Mukherjee, and S. Ramakrishna, Poly(Glycerol sebacate)/gelatin core/shell fibrous structure for regeneration of myocardial infarction. Tissue Eng. Part A 17, 1363 (2011).
116. J. Nam, J. Johnson, J. J. Lannutti, and S. Agarwal, Modulation of embryonic mesenchymal progenitor cell differentiation via control over pure mechanical modulus in electrospun nanofibers. Acta Biomaterialia 7, 1516 (2011).
117. W.-J. Li, R. L. Mauck, and R. S. Tuan, Electrospun nanofibrous scaffolds: Production, characterization, and applications for tissue engineering and drug delivery. J. Biomed. Nanotechnol. 1, 259 (2005).
118. P. Van de Witte, P. Dijkstra, J. Van den Berg, and J. Feijen, Phase separation processes in polymer solutions in relation to membrane formation. J. Membr. Sci. 117, 1 (1996).
119. A. G. Mikos and J. S. Temenoff, Formation of highly porous biodegradable scaffolds for tissue engineering. Electronic Journal of Biotechnology 3, 23 (2000).
120. J. Zhao, W. Han, H. Chen, M. Tu, R. Zeng, Y. Shi, Z. Cha, and C. Zhou, Preparation, structure and crystallinity of chitosan nanofibers by a solid–liquid phase separation technique. Carbohydr. Polym. 83, 1541 (2011).
121. R. Zhang and P. X. Ma, Synthetic nano-fibrillar extracellular matrices with predesigned macroporous architectures. J. Biomed. Mater. Res. 52, 430 (2000).
122. X.-T. Li, Y. Zhang, and G.-Q. Chen, Nanofibrous polyhydroxyalkanoate matrices as cell growth supporting materials. Biomaterials 29, 3720 (2008).
123. X. Liu and P. X. Ma, Phase separation, pore structure, and properties of nanofibrous gelatin scaffolds. Biomaterials 30, 4094 (2009).
124. X. Liu, L. A. Smith, J. Hu, and P. X. Ma, Biomimetic nanofibrous gelatin/apatite composite scaffolds for bone tissue engineering. Biomaterials 30, 2252 (2009).
125. J. D. Hartgerink, E. Beniash, and S. I. Stupp, Self-assembly and mineralization of peptide-amphiphile nanofibers. Science 294, 1684 (2001).
126. S. Ramakrishna, K. Fujihara, W.-E. Teo, T.-C. Lim, and Z. Ma, An Introduction to Electrospinning and Nanofibers, World Scientific, Singapore (2005), Vol. 90.
127. F. Yang, W. L. Neeley, M. J. Moore, J. M. Karp, A. Shukla, R. Langer, C. Laurencin, and L. Nair, Tissue engineering: The therapeutic strategy of the twenty-first century. Nanotechnology and Tissue Engineering: The Scaffold 3 (2008).
128. M. E. Davis, J. P. Motion, D. A. Narmoneva, T. Takahashi, D. Hakuno, R. D. Kamm, S. Zhang, and R. T. Lee, Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells. Circulation 111, 442 (2005).
129. K. Jayaraman, M. Kotaki, Y. Zhang, X. Mo, and S. Ramakrishna, Recent advances in polymer nanofibers. J. Nanosci. Nanotechnol. 4, 1 (2004).
130. H. Cui, M. J. Webber, and S. I. Stupp, Self-assembly of peptide amphiphiles: From molecules to nanostructures to biomaterials. Peptide Science 94, 1 (2010).
131. S. E. Paramonov, H.-W. Jun, and J. D. Hartgerink, Self-assembly of peptide-amphiphile nanofibers: The roles of hydrogen bonding and amphiphilic packing. J. Am. Chem. Soc. 128, 7291 (2006).
132. M. A. Greenfield, J. R. Hoffman, M. Olvera de la Cruz, and S. I. Stupp, Tunable mechanics of peptide nanofiber gels. Langmuir 26, 3641 (2009).
133. Z. Chen, X. Mo, C. He, and H. Wang, Intermolecular interactions in electrospun collagen–chitosan complex nanofibers. Carbohydr. Polym. 72, 410 (2008).
134. S. Chew, Y. Wen, Y. Dzenis, and K. Leong, The role of electrospinning in the emerging field of nanomedicine. Current Pharmaceutical Design 12, 4751 (2006).
135. Z.-M. Huang, Y. Zhang, S. Ramakrishna, and C. Lim, Electrospinning and mechanical characterization of gelatin nanofibers. Polymer 45, 5361 (2004).
136. S. Sahoo, L. T. Ang, J. C. H. Goh, and S. L. Toh, Growth factor delivery through electrospun nanofibers in scaffolds for tissue engineering applications. Journal of Biomedical Materials Research Part A 93, 1539 (2010).
137. R. L. Mauck, B. M. Baker, N. L. Nerurkar, J. A. Burdick, W. J. Li, R. S. Tuan, and D. M. Elliott, Engineering on the straight and narrow: The mechanics of nanofibrous assemblies for fiber-reinforced tissue regeneration. Tissue Eng. Part B Rev. 15, 171 (2009).
138. W. J. Li, J. A. Cooper, R. L. Jr Mauck, and R. S. Tuan, Fabrication and characterization of six electrospun poly(alpha-hydroxy ester)-based fibrous scaffolds for tissue engineering applications. Acta Biomater. 2, 377 (2006).
139. R. Inai, M. Kotaki, and S. Ramakrishna, Structure and properties of electrospun PLLA single nanofibres. Nanotechnology 16, 208 (2005).
140. F. Fatehi, Natural scaffold materials used in regenerative endodontic: A review. J. Biomater. Tissue Eng. 3, 597 (2013).
141. E. Tan and C. Lim, Mechanical characterization of nanofibers—A review. Compos. Sci. Technol. 66, 1102 (2006).
142. E. P. S. Tan, C. N. Goh, C. H. Sow, and C. T. Lim, Tensile test of a single nanofiber using an atomic force microscope tip. Appl. Phys. Lett. 86 (2005).
143. A. Martins, J. V. Araujo, R. L. Reis, and N. M. Neves, Electrospun nanostructured scaffolds for tissue engineering applications. Nanomedicine (Lond) 2, 929 (2007).
144. S. J. Eichhorn and W. W. Sampson, Statistical geometry of pores and statistics of porous nanofibrous assemblies. J. R. Soc. Interface 2, 309 (2005).
145. J. Nam, Y. Huang, S. Agarwal, and J. Lannutti, Improved cellular infiltration in electrospun fiber via engineered porosity. Tissue Eng. 13, 2249 (2007).
146. Y. Zhang, H. Ouyang, C. T. Lim, S. Ramakrishna, and Z. M. Huang, Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scaffolds. J. Biomed. Mater. Res. B Appl. Biomater. 72, 156 (2005).
147. B. A. Blakeney, A. Tambralli, J. M. Anderson, A. Andukuri, D. J. Lim, D. R. Dean, and H. W. Jun, Cell infiltration and growth in a low density, uncompressed three-dimensional electrospun nanofibrous scaffold. Biomaterials 32, 1583 (2011).
148. A. Balguid, A. Mol, M. H. van Marion, R. A. Bank, C. V. Bouten, and F. P. Baaijens, Tailoring fiber diameter in electrospun poly(ε- caprolactone) scaffolds for optimal cellular infiltration in cardiovascular tissue engineering. Tissue Engineering Part A 15, 437 (2008).
149. K. Kataria, A. Sharma, T. Garg, A. K. Goyal, and G. Rath, Novel technology to improve drug loading in polymeric nanofibers. Drug Delivery Letters 4, 79 (2014).
150. Z. Yin, X. Chen, J. L. Chen, W. L. Shen, T. M. H. Nguyen, L. Gao, and H. W. Ouyang, The regulation of tendon stem cell differentiation by the alignment of nanofibers. Biomaterials 31, 2163 (2010).
151. X. Zong, H. Bien, C. Y. Chung, L. Yin, D. Fang, B. S. Hsiao, B. Chu, and E. Entcheva, Electrospun fine-textured scaffolds for heart tissue constructs. Biomaterials 26, 5330 (2005).
152. F. Yang, R. Murugan, S. Wang, and S. Ramakrishna, Electrospinning of nano/micro scale poly(L-lactic acid) aligned fibers and their potential in neural tissue engineering. Biomaterials 26, 2603 (2005).
153. D. R. Nisbet, J. S. Forsythe, W. Shen, D. I. Finkelstein, and M. K. Horne, Review paper: A review of the cellular response on electrospun nanofibers for tissue engineering. J. Biomater. Appl. 24, 7 (2009).
154. W. Teo and S. Ramakrishna, A review on electrospinning design and nanofibre assemblies. Nanotechnology 17, R89 (2006).
155. A. Theron, E. Zussman, and A. Yarin, Electrostatic field-assisted alignment of electrospun nanofibres. Nanotechnology 12, 384 (2001).
156. D. Li, Y. Wang, and Y. Xia, Electrospinning nanofibers as uniaxially aligned arrays and layer-by-layer stacked films. Adv. Mater. 16, 361 (2004).
157. D. Li and Y. Xia, Electrospinning of nanofibers: Reinventing the wheel? Adv. Mater. 16, 1151 (2004).
158. D. Yang, B. Lu, Y. Zhao, and X. Jiang, Fabrication of aligned fibrous arrays by magnetic electrospinning. Adv. Mater. 19, 3702 (2007).
159. Y. Liu, X. Zhang, Y. Xia, and H. Yang, Magnetic-field-assisted electrospinning of aligned straight and wavy polymeric nanofibers. Adv. Mater. 22, 2454 (2010).
160. M. Kaur, T. Garg, G. Rath, and A. K. Goyal, Current nanotechnological strategies for effective delivery of bioactive drug molecules in the treatment of tuberculosis. Crit. Rev. Ther. Drug Carrier Syst. 31, 49 (2014).
161. M. Kaur, B. Malik, T. Garg, G. Rath, and A. K. Goyal, Development and characterization of guar gum nanoparticles for oral immunization against tuberculosis. Drug Deliv. (2014), in press.
162. J. Zeng, A. Aigner, F. Czubayko, T. Kissel, J. H. Wendorff, and A. Greiner, Poly(vinyl alcohol) nanofibers by electrospinning as a protein delivery system and the retardation of enzyme release by additional polymer coatings. Biomacromolecules 6, 1484 (2005).
163. Y. Luu, K. Kim, B. Hsiao, B. Chu, and M. Hadjiargyrou, Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA–PEG block copolymers. J. Controlled Release 89, 341 (2003).
164. H. Cao, X. Jiang, C. Chai, and S. Y. Chew, RNA interference by nanofiber-based siRNA delivery system. J. Controlled Release 144, 203 (2010).
165. K. Kim, Y. K. Luu, C. Chang, D. Fang, B. S. Hsiao, B. Chu, and M. Hadjiargyrou, Incorporation and controlled release of a hydrophilic antibiotic using poly (lactide-co-glycolide)-based electrospun nanofibrous scaffolds. J. Controlled Release 98, 47 (2004).
166. S. Y. Chew, J. Wen, E. K. Yim, and K. W. Leong, Sustained release of proteins from electrospun biodegradable fibers. Biomacromolecules 6, 2017 (2005).
167. H. S. Yoo, T. G. Kim, and T. G. Park, Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery. Adv. Drug Deliv. Rev. 61, 1033 (2009).
168. C. Erisken, D. M. Kalyon, H. Wang, C. Ornek-Ballanco, and J. Xu, Osteochondral tissue formation through adipose-derived stromal cell differentiation on biomimetic polycaprolactone nanofibrous scaffolds with graded insulin and Beta-glycerophosphate concentrations. Tissue Eng. Part A 17, 1239 (2011).
169. E.-R. Kenawy, G. L. Bowlin, K. Mansfield, J. Layman, D. G. Simpson, E. H. Sanders, and G. E. Wnek, Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly (lactic acid), and a blend. J. Controlled Release 81, 57 (2002).
170. J. S. Choi and H. S. Yoo, Nano-inspired fibrous matrix with bi-phasic release of proteins. J. Nanosci. Nanotechnol. 10, 3038 (2010).
171. R. Kaur, T. Garg, B. Malik, U. D. Gupta, P. Gupta, G. Rath, and A. K. Goyal, Development and characterization of spray-dried porous nanoaggregates for pulmonary delivery of anti-tubercular drugs. Drug Deliv. 1 (2014), in press.
172. P. Tayalia and D. J. Mooney, Controlled growth factor delivery for tissue engineering. Adv. Mater. 21, 3269 (2009).
173. N. Parnami, T. Garg, G. Rath, and A. K. Goyal, Development and characterization of nanocarriers for topical treatment of psoriasis by using combination therapy. Artif. Cells Nanomed. Biotechnol. (2013), in press.
174. S. Koutsopoulos, L. D. Unsworth, Y. Nagai, and S. Zhang, Controlled release of functional proteins through designer selfassembling peptide nanofiber hydrogel scaffold. Proceedings of the National Academy of Sciences 106, 4623 (2009).
175. S. Liao, S. Ramakrishna, and M. Ramalingam, Development of nanofiber biomaterials and stem cells in tissue engineering. J. Biomater. Tissue Eng. 1, 111 (2011).
176. H. Singh, R. Sharma, M. Joshi, T. Garg, A. K. Goyal, and G. Rath, Transmucosal delivery of Docetaxel by mucoadhesive polymeric nanofibers. Artif. Cells Nanomed. Biotechnol. (2014), in press.
177. T. Garg, G. Rath, and A. K. Goyal, Comprehensive review on additives of topical dosage forms for drug delivery. Drug Deliv. (2014), in press.
178. Y. Dong, T. Yong, S. Liao, C. K. Chan, M. M. Stevens, and S. Ramakrishna, Distinctive degradation behaviors of electrospun polyglycolide, poly(DL-lactide-co-glycolide), and poly(L-lactideco-epsilon-caprolactone) nanofibers cultured with/without porcine smooth muscle cells. Tissue Eng. Part A 16, 283 (2010).
179. A. Seidi and M. Ramalingam, Engineering of gradient biomaterials as biomimetic systems for tissue engineering. J. Biomater. Tissue Eng. 1, 139 (2011).
180. X. Zong, S. Ran, K.-S. Kim, D. Fang, B. S. Hsiao, and B. Chu, Structure and morphology changes during in vitro degradation of electrospun poly (glycolide-co-lactide) nanofiber membrane. Biomacromolecules 4, 416 (2003).
181. K. Kim, M. Yu, X. Zong, J. Chiu, D. Fang, Y. S. Seo, B. S. Hsiao, B. Chu, and M. Hadjiargyrou, Control of degradation rate and hydrophilicity in electrospun non-woven poly(D, Llactide) nanofiber scaffolds for biomedical applications. Biomaterials 24, 4977 (2003).
182. T. Garg and A. K. Goyal, Biomaterial-based scaffolds–current status and future directions. Expert Opin. Drug Deliv. 11, 767 (2014).
183. T. Garg, A. K. Goyal, S. Arora, and R. Murthy, Development, Optimization and evaluation of porous chitosan scaffold formulation of gliclazide for the treatment of type-2 diabetes mellitus. Drug Delivery Letters 2, 251 (2012).
184. T. Garg, A. Bilandi, and B. Kapoor, Scaffold: Tissue Engineering and Regenerative Medicine. International Research Journal of Pharmacy 2, 37 (2011).
185. T. Garg, Current nanotechnological approaches for an effective delivery of bio-active drug molecules in the treatment of acne. Artif, Cells Nanomed. Biotechnol. 1 (2014), in press.
186. G. Goyal, T. Garg, B. Malik, G. Rath, and A. K. Goyal, Development and characterization of nano-fiber patch for the treatment of glaucoma. Eur. J. Pharm. Sci. 53, 10 (2014).
187. Z. Xia and M. Wei, Biomimetic Fabrication of Collagen-Apatite Scaffolds for Bone Tissue Regeneration. J. Biomater. Tissue Eng. 3, 369 (2013).
188. H. Hosseinkhani, M. Hosseinkhani, A. Khademhosseini, and H. Kobayashi, Bone regeneration through controlled release of bone morphogenetic protein-2 from 3-D tissue engineered nano-scaffold. J. Controlled Release 117, 380 (2007).
189. Q. P. Pham, U. Sharma, and A. G. Mikos, Electrospun poly(epsiloncaprolactone) microfiber and multilayer nanofiber/microfiber scaffolds: Characterization of scaffolds and measurement of cellular infiltration. Biomacromolecules 7, 2796 (2006).
190. R. Ravichandran, D. Sundaramurthi, S. Gandhi, S. Sethuraman, and U. M. Krishnan, Bioinspired hybrid mesoporous silica–gelatine sandwich construct for bone tissue engineering. Microporous Mesoporous Mater. 187, 53 (2014).
191. T. T. Ruckh, K. Kumar, M. J. Kipper, and K. C. Popat, Osteogenic differentiation of bone marrow stromal cells on poly(ε-caprolactone) nanofiber scaffolds. Acta Biomaterialia 6, 2949 (2010).
192. S. S. Lee, B. J. Huang, S. R. Kaltz, S. Sur, C. J. Newcomb, S. R. Stock, R. N. Shah, and S. I. Stupp, Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds. Biomaterials 34, 452 (2013).
193. Y. Zhang, V. J. Reddy, S. Y. Wong, X. Li, B. Su, S. Ramakrishna, and C. T. Lim, Enhanced biomineralization in osteoblasts on a novel electrospun biocomposite nanofibrous substrate of hydroxyapatite/collagen/chitosan. Tissue Engineering Part A 16, 1949 (2010).
194. M. Shin, H. Yoshimoto, and J. P. Vacanti, In vivo bone tissue engineering using mesenchymal stem cells on a novel electrospun nanofibrous scaffold. Tissue Eng. 10, 33 (2004).
195. H. Yoshimoto, Y. Shin, H. Terai, and J. Vacanti, A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials 24, 2077 (2003).
196. L. Lao, Y. Wang, Y. Zhu, Y. Zhang, and C. Gao, Poly(lactide-coglycolide)/hydroxyapatite nanofibrous scaffolds fabricated by electrospinning for bone tissue engineering. J. Mater. Sci.-Mater. Med. 22, 1873 (2011).
197. M. E. Frohbergh, A. Katsman, G. P. Botta, P. Lazarovici, C. L. Schauer, U. G. Wegst, and P. I. Lelkes, Electrospun hydroxyapatitecontaining chitosan nanofibers crosslinked with genipin for bone tissue engineering. Biomaterials 33, 9167 (2012).
198. S. Kocabey, H. Ceylan, A. B. Tekinay, and M. O. Guler, Glycosaminoglycan mimetic peptide nanofibers promote mineralization by osteogenic cells. Acta Biomaterialia 9, 9075 (2013).
199. M. Kouhi, M. Morshed, J. Varshosaz, and M. H. Fathi, Poly(ε-caprolactone) incorporated bioactive glass nanoparticles and simvastatin nanocomposite nanofibers: Preparation, characterization and in vitro drug release for bone regeneration applications. Biochem. Eng. J. 228, 1057 (2013).
200. Y. Wan, G. Zuo, F. Yu, Y. Huang, K. Ren, and H. Luo, Preparation and mineralization of three-dimensional carbon nanofibers from bacterial cellulose as potential scaffolds for bone tissue engineering. Surf. Coat. Technol. 205, 2938 (2011).
201. X. Li, J. Xie, X. Yuan, and Y. Xia, Coating electrospun poly(ε-caprolactone) fibers with gelatin and calcium phosphate and their use as biomimetic scaffolds for bone tissue engineering. Langmuir 24, 14145 (2008).
202. H. R. Pant, P. Risal, C. H. Park, L. D. Tijing, Y. J. Jeong, and C. S. Kim, Synthesis, characterization, and mineralization of polyamide-6/calcium lactate composite nanofibers for bone tissue engineering. Colloids and Surfaces B: Biointerfaces 102, 152 (2013).
203. G. Vunjak-Novakovic, G. Altman, R. Horan, and D. L. Kaplan, Tissue engineering of ligaments. Annu. Rev. Biomed. Eng. 6, 131 (2004).
204. W. J. Li, R. L. Mauck, J. A. Cooper, X. Yuan, and R. S. Tuan, Engineering controllable anisotropy in electrospun biodegradable nanofibrous scaffolds for musculoskeletal tissue engineering. J. Biomech. 40, 1686 (2007).
205. W. He, T. Yong, W. E. Teo, Z. Ma, and S. Ramakrishna, Fabrication and endothelialization of collagen-blended biodegradable polymer nanofibers: Potential vascular graft for blood vessel tissue engineering. Tissue Eng. 11, 1574 (2005).
206. H. Cho, S. Balaji, A. Q. Sheikh, J. R. Hurley, Y. F. Tian, J. H. Collier, T. M. Crombleholme, and D. A. Narmoneva, Regulation of endothelial cell activation and angiogenesis by injectable peptide nanofibers. Acta Biomater. 8, 154 (2012).
207. J. Kisiday, M. Jin, B. Kurz, H. Hung, C. Semino, S. Zhang, and A. Grodzinsky, Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: Implications for cartilage tissue repair. Proceedings of the National Academy of Sciences 99, 9996 (2002).
208. M. A. da Silva, A. Crawford, J. Mundy, A. Martins, J. V. Araújo, P. V. Hatton, R. L. Reis, and N. M. Neves, Evaluation of extracellular matrix formation in polycaprolactone and starch-compounded polycaprolactone nanofiber meshes when seeded with bovine articular chondrocytes. Tissue Engineering Part A 15, 377 (2008).
209. S. Shanmugasundaram, H. Chaudhry, and T. L. Arinzeh, Microscale versus nanoscale scaffold architecture for mesenchymal stem cell chondrogenesis. Tissue Engineering Part A 17, 831 (2010).
210. J. K. Wise, A. L. Yarin, C. M. Megaridis, and M. Cho, Chondrogenic differentiation of human mesenchymal stem cells on oriented nanofibrous scaffolds: Engineering the superficial zone of articular cartilage. Tissue Eng. Part A 15, 913 (2009).
211. W. J. Li, K. G. Danielson, P. G. Alexander, and R. S. Tuan, Biological response of chondrocytes cultured in three-dimensional nanofibrous poly(epsilon-caprolactone) scaffolds. J. Biomed. Mater. Res. A 67, 1105 (2003).
212. W. J. Li, R. Tuli, X. Huang, P. Laquerriere, and R. S. Tuan, Multilineage differentiation of human mesenchymal stem cells in a threedimensional nanofibrous scaffold. Biomaterials 26, 5158 (2005).
213. W. J. Li, H. Chiang, T. F. Kuo, H. S. Lee, C. C. Jiang, and R. S. Tuan, Evaluation of articular cartilage repair using biodegradable nanofibrous scaffolds in a swine model: A pilot study. Journal of Tissue Engineering and Regenerative Medicine 3, 1 (2009).
214. W. J. Li, R. Tuli, C. Okafor, A. Derfoul, K. G. Danielson, D. J. Hall, and R. S. Tuan, A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells. Biomaterials 26, 599 (2005).
215. A. W. Tan, A. Dalilottojari, B. Pingguan-Murphy, R. Ahmad, and S. Akbar, In vitro chondrocyte interactions with TiO2 nanofibers grown on Ti–6Al–4V substrate by oxidation. Ceram. Int. 40, 8301 (2014).
216. K. Zhang, W. Jinglei, C. Huang, and X. Mo, Fabrication of silk fibroin/P(LLA-CL) aligned nanofibrous scaffolds for nerve tissue engineering. Macromolecular Materials and Engineering 298, 565 (2013).
217. H. S. Koh, T. Yong, C. K. Chan, and S. Ramakrishna, Enhancement of neurite outgrowth using nano-structured scaffolds coupled with laminin. Biomaterials 29, 3574 (2008).
218. J. M. Corey, D. Y. Lin, K. B. Mycek, Q. Chen, S. Samuel, E. L. Feldman, and D. C. Martin, Aligned electrospun nanofibers specify the direction of dorsal root ganglia neurite growth. J. Biomed. Mater. Res. A 83, 636 (2007).
219. L. Ghasemi-Mobarakeh, M. P. Prabhakaran, M. Morshed, M. H. Nasr-Esfahani, and S. Ramakrishna, Electrical stimulation of nerve cells using conductive nanofibrous scaffolds for nerve tissue engineering. Tissue Engineering Part A 15, 3605 (2009).
220. S. Patel, K. Kurpinski, R. Quigley, H. Gao, B. S. Hsiao, M. M. Poo, and S. Li, Bioactive nanofibers: Synergistic effects of nanotopography and chemical signaling on cell guidance. Nano Lett. 7, 2122 (2007).
221. C. C. Silvia Panseri, J. Lowery, and U. D. Carro, Electrospun micro- and nanofiber tubes for functional nervous regeneration in sciatic nerve transections. BMC Biotechnol. 8, 39 (2008).
222. F. Yang, R. Murugan, S. Ramakrishna, X. Wang, Y. X. Ma, and S. Wang, Fabrication of nano-structured porous PLLA scaffold intended for nerve tissue engineering. Biomaterials 25, 1891 (2004).
223. G. A. Silva, C. Czeisler, K. L. Niece, E. Beniash, D. A. Harrington, J. A. Kessler, and S. I. Stupp, Selective differentiation of neural progenitor cells by high-epitope density nanofibers. Science 303, 1352 (2004).
224. N. L. Angeloni, C. W. Bond, Y. Tang, D. A. Harrington, S. Zhang, S. I. Stupp, K. E. McKenna, and C. A. Podlasek, Regeneration of the cavernous nerve by Sonic hedgehog using aligned peptide amphiphile nanofibers. Biomaterials 32, 1091 (2011).
225. G. T. Christopherson, H. Song, and H. Q. Mao, The influence of fiber diameter of electrospun substrates on neural stem cell differentiation and proliferation. Biomaterials 30, 556 (2009).
226. R. Ravichandran, J. R. Venugopal, S. Sundarrajan, S. Mukherjee, R. Sridhar, and S. Ramakrishna, Composite poly-l-lactic acid/poly-(ε)-dl-aspartic acid/collagen nanofibrous scaffolds for dermal tissue regeneration. Mater. Sci. Eng., C 32, 1443 (2012).
227. Z. Xie, C. B. Paras, H. Weng, P. Punnakitikashem, L. C. Su, K. Vu, L. Tang, J. Yang, and K. T. Nguyen, Dual growth factor releasing multi-functional nanofibers for wound healing. Acta Biomaterialia 9, 9351 (2013).
228. G. Jin, M. P. Prabhakaran, D. Kai, M. Kotaki, and S. Ramakrishna, Electrospun photosensitive nanofibers: Potential for photocurrent therapy in skin regeneration. Photochemical and Photobiological Sciences 12, 124 (2013).
229. B. Ma, J. Xie, J. Jiang, and J. Wu, Sandwich-type fiber scaffolds with square arrayed microwells and nanostructured cues as microskin grafts for skin regeneration. Biomaterials 35, 630 (2014).
230. M. C. Chen, Y. C. Sun, and Y. H. Chen, Electrically conductive nanofibers with highly oriented structures and their potential application in skeletal muscle tissue engineering. Acta Biomaterialia 9, 5562 (2013).