In vivo wound healing of diabetic ulcers using electrospun nanofibers immobilized with human epidermal growth factor (EGF)

Biomaterials

Volumn 29, Issue 5, 2008, Pages 587-596

  Choi, Ji Suk ^a   Leong, Kam W ^b   Yoo, Hyuk Sang ^a  

^a Kangwon National University   (South Korea)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diabetic ulcers; EGF; Electrospinning; Nanofibers; Wound healing

Indexed keywords

BIODEGRADABLE POLYMERS; CELL PROLIFERATION; ELECTROSPINNING; HISTOLOGY; IMMUNOLOGY; NANOFIBERS; POLYETHYLENE GLYCOLS; PROTEINS;

DIABETIC ULCERS; EPIDERMAL GROWTH FACTORS; WOUND HEALING; X-RAY PHOTOELECTRON SCATTERING;

DISEASES;

AMINE; EPIDERMAL GROWTH FACTOR RECEPTOR; MACROGOL; NANOFIBER; POLYCAPROLACTONE; POLYMER; RECOMBINANT EPIDERMAL GROWTH FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DIABETIC FOOT; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WOUND HEALING; X RAY PHOTOELECTRON SPECTROSCOPY;

ANIMALS; CELLS, CULTURED; DIABETIC ANGIOPATHIES; ELECTRONS; EPIDERMAL GROWTH FACTOR; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; NANOSTRUCTURES; RECOMBINANT PROTEINS; WOUND HEALING;

ANIMALIA;

EID: 36048959183     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2007.10.012     Document Type: Article

References (36)

1. Alemdaroǧlu C., Deǧim Z., Çelebi N., Zor F., Öztürk, and Erdoǧan D. An investigation on burn wound healing in rats with chitosan gel formation containing epidermal growth factor. Burns 32 (2006) 319-327
2. Qi H., Chen W., Huang C., Li L., Chen C., Li, et al. Development of a poloxamer analogs/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin. Int J Pharm 337 (2007) 178-187
3. Lu G., and Jun H.W. Diffusion studies of methotrexate in carbopol and poloxamer gels. Int J Pharm 160 (1998) 1-9
4. Hori K., Sotozono C., Hamuro J., Yamasaki K., Kimura Y., Ozeki M., et al. Controlled-release of epidermal growth factor from cationized gelatin hydrogel enhances corneal epithelial wound healing. J Control Release 118 (2007) 169-176
5. Deitzel J.M., Kleinmeyer J., Harris D., and Tan N.C.B. The effect of processing variables on the morphology of electrospun nanofibers and textiles. Polymer 42 (2001) 261-272
6. Theron S.A., Zussman E., and Yarin A.L. Experimental investigation of the governing parameters in the electrospinnig of polymer solutions. Polymer 45 (2004) 2017-2030
7. Frenot A., and Chronakis I.S. Polymer nanofibers assembled by electrospinning. Curr Opin Colloid Interface Sci 8 (2003) 64-75
8. Kim T.G., and Park T.G. Biomimicking extracellular matrix: cell adhesive RGD peptide modified electrospun poly(d,l-lactic-co-glycolic acid) nanofiber mesh. Tissue Eng 12 2 (2006) 221-233
9. Chew S.Y., Wen Y., Dzenis Y., and Leong K.W. The role of electrospinning in the emerging field of nanomedicine. Curr Pharm Design 12 36 (2006) 4751-4770
10. Rho K.S., Jeong L., Lee G., Seo B.M., Park Y.J., Hong S.D., et al. Electrospinning of collagen nanofibers: effects on the behavior of normal human keratinocytes and early-stage wound healing. Biomaterials 27 (2006) 1452-1461
11. Venugopal J., Ma L.L., Yong T., and Ramakrishna S. In vitro study of smooth muscle cells on polycaprolactone and collagen nanofibrous matrices. Cell Biol Int 29 (2005) 861-867
12. Badami A.S., Kreke M.R., Thompson M.S., Riffle J.S., and Goldstein A.S. Effect of fiber diameter on spreading, proliferation, and differentiation of esteoblastic cells on electrospun poly(lactic acid) substrates. Biomaterials 27 (2006) 596-606
13. Rho K.S., Jeong L., Lee G., Seo B.M., Park Y.J., Hong S.D., et al. Electrospinning of collagen nanofibers: effects on the behavior of normal human keratinocytes and early-stage wound healing. Biomaterials 27 (2006) 1452-1461
14. Choi J.S., and Yoo H.S. Electrospun nanofibers surface-modified with fluorescent proteins. J Bioactive Compatible Polym 22 (2007) 508-524
15. Ignatova M., Starbova K., Markova N., Manolova N., and Rashkov I. Electrospun nano-fibre mats with antibacterial properties from quaternised chitosan and poly(vinyl alcohol). Carbohydrate Res 341 (2006) 2098-2107
16. Rheinwald J.G., and Green H. Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes. Nature 265 5593 (1977) 421-424
17. Rodeck U., Jost M., Kari C., Shih D.T., Lavker R.M., Ewert D.L., et al. EGF-R dependent regulation of keratinocyte survival. J Cell Sci 110 2 (1997) 113-121
18. Maciag T., Nemore R.E., Weinstein R., and Gilchrest B.A. An endocrine approach to the control of epidermal growth: serum-free cultivation of human keratinocytes. Science 211 4489 (1981) 1452-1454
19. Cho, Lee A.R., Leem H., Lee J., and Park K.C. Reversal of silver sulfadiazine-impaired wound healing by epidermal growth factor. Biomaterials 26 (2005) 4670-4676
20. Breuing K., Andree C., Helo G., Slama J., Liu P.Y., and Eriksson E. Growth factors in the repair of partial thickness porcine skin wounds. Plast Reconstr Surg 100 3 (1997) 657-664
21. Hashimoto K. Regulation of keratinocyte function by growth factors. J Dermatol Sci 24 Suppl 1 (2000) S46-S50
22. Umraw N., Chan Y., Gomez M., Cartotto R.C., and Fish J.S. Effective hand function assessment after burn injuries. J Burn Care Rehabil 25 1 (2004) 134-139
23. Johnson C., Engrav L.H., Heimbach D.M., and Marvin J.A. Evaluating functional hand results after deep dermal burns with total active motion measurements. J Burn Care Rehabil 1 (1980) 19-21
24. Soejima K., Nozaki M., Sasaki K., Takeuchi M., and Negishi N. Reconstruction of burn deformity using artificial dermis combined with thin split-skin grafting. Burns 23 6 (1997) 501-504
25. Fray T.R., Molloy J.E., Armitage M.P., and Sparrow J.C. Quantification of single human dermal fibroblast contraction. Tissue Eng 4 3 (1998) 281-291
26. Yoo H.S., and Park T.G. Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer. J Control Release 70 (2001) 63-70
27. Son Y.J., Jang J.S., Cho Y.W., Chung H., Parkc R.W., Kwona I.C., et al. Biodistribution and anti-tumor efficacy of doxorubicin loaded glycol-chitosan nanoaggregates by EPR effect. J Control Release 91 (2003) 135-145
28. Yoo H.S., Lee K.H., Oh J.E., and Park T.G. In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates. J Control Release 68 (2000) 419-431
29. Cribbs R.K., Luquette M.H., and Besner G.E. Acceleration of partial-thickness burn wound healing with topical application of heparin-binding EGF-like growth factor (HB-EGF). J Burn Care Rehabil 19 2 (1998) 95-101
30. Jeschke M.G., Richter G., Höfstädter F., Herndon D.N., Perez-Polo J.R., and Jauch K.W. Non-viral liposomal keratinocyte growth factor (KGF) cDNA gene transfer improves dermal and epidermal regeneration through stimulation of epithelial and mesenchymal factors. Gene Therapy 9 (2002) 1065-1074
31. Shirakata Y., Komurasaki T., Toyoda H., Hanakawa Y., Yamasaki K., Tokumaru S., et al. Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes. J Biol Chem 275 8 (2000) 5748-5753
32. Hashimoto K., Higashiyama S., Asada H., Hashimura E., Kobayashi T., Sudo K., et al. Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes. J Biol Chem 269 31 (1994) 20060-20066
33. Carpenter G. Receptors for epidermal growth factor and other polypeptide mitogens. Annu Rev Biochem 56 (1987) 881-914
34. Carpenter G. The EGF receptor: a nexus for trafficking and signaling. Bioessays 22 8 (2000) 697-707
35. Solitaire A.D., James J.M., and Jennifer L.W. Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration. Biomaterials 26 16 (2005) 3227-3234
36. Yoon J.J., Chung H.J., Lee H.J., and Park T.G. Heparin immobilized biodegradable scaffolds for local and sustained release of angiogenic growth factor. J Biomed Mater Res Part A 79A (2006) 934-942